The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Inflammatory Cytokines in the BAL of Patients With ARDS
Abstract
Background Inflammatory cytokines (ICs) are important modulators of injury and repair. ICs have been found to be elevated in the BAL of patients with both early and late ARDS. We tested the hypothesis that recurrent injury to the alveolocapillary barrier and amplification of intra-alveolar fibroproliferation observed in nonresolving ARDS is related to a persistent inflammatory response. For this purpose, we obtained serial measurements of BAL IC and correlated these levels with lung injury score (LIS), BAL indexes of endothelial permeability (albumin, total protein [TP]), and outcome.Methods We prospectively studied 27 consecutive patients with severe medical ARDS. Using enzyme-linked immunosorbent assay methods, levels of tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL) 1 beta, 2, 4, 6, and 8 were measured at frequent intervals in both plasma and BAL. In 22 patients, bilateral BAL was obtained on day 1 of ARDS and at weekly intervals when possible. Right and left BALs were analyzed separately for IC levels, total cell count and differential, albumin, TP, and quantitative bacterial cultures.Results On day 1 of ARDS, the 10 nonsurvivors had significantly higher (p = 0.0002) BAL TNF-alpha, IL-1 beta, IL-6, and IL-8 levels, which remained persistently elevated over time, indicating a continuous injury process. In contrast, the 12 survivors had a lesser elevation and a rapid reduction over time. Initial BAL IL-2 and IL-4 levels were significantly higher in patients with sepsis (p = 0.006); both increased over time in survivors and nonsurvivors. BAL levels of TNF-alpha, IL-1 beta, IL-6, and IL-8 correlated with BAL albumin and TP concentrations but not with LIS or ratio of arterial oxygen tension to inspired oxygen concentration. BAL: plasma ratios were elevated for all measured cytokines, suggesting a pulmonary origin. On day 1 of ARDS, nonsurvivors had significantly higher (p = 0.04) BAL: plasma ratios for TNF-alpha, IL-1 beta, IL-6, and IL-8. Over time, BAL:plasma ratios for TNF-alpha, IL-1 beta and IL-6 remained elevated in nonsurvivors and decreased in survivors.Conclusions Our findings indicate that an unfavorable outcome in ARDS is associated with an initial, exaggerated, pulmonary inflammatory response that persists unabated over time. Plasma IC levels parallel changes in BAL IC levels. The BAL:plasma ratio results suggest, but do not prove, a pulmonary origin for IC production. BAL TNF-alpha, IL-1 beta, and IL-8 levels correlated with BAL indices of endothelial permeability. In survivors, reduction in BAL IC levels over time was associated with a decline in BAL albumin and TP levels, suggesting effective repair of the endothelial surface. These findings support a causal relationship between degree and duration of lung inflammation and progression of fibroproliferation in ARDS.
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“The cells of innate immunity (macrophages and neutrophils) increase in number and activation, which causes the alveolar concentration of molecules related to the host stress response to increase.”
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Citations
Cites
Biometry: The Principles and Practice of Statistics in Biological Research
Sokal, R. R., & Rohlf, F. J. (1969) · Cited by 20,963
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317
Biometry. The Principles and Practice of Statistics in Biological Research
Fienberg, S. E., Sokal, R. R., Rohlf, F. J., Rohlf, F. J., & Sokal, R. R. (1970) · Biometrics · doi:10.2307/2529087 · Cited by 9,363
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
An Expanded Definition of the Adult Respiratory Distress Syndrome
Murray, J. F., Matthay, M. A., Luce, J. M., & Flick, M. R. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.3.720 · Cited by 2,641
Bone, R. C. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-457 · Cited by 1,357
Prognosis in Acute Organ-System Failure
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Annals of Surgery · doi:10.1097/00000658-198512000-00004 · Cited by 1,220
Waage, A., Brandtzaeg, P., Halstensen, A. I., Kierulf, P., & Espevik, T. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.333 · Cited by 1,175
Waage, A., Halstensen, A. I., & Espevik, T. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91728-4 · Cited by 1,085
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
Casey, L. C., Balk, R. A., & Bone, R. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-8-199310150-00001 · Cited by 1,039
Flagged first, then by citations
1 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Meduri, 1993, Late ARDS, New Horizons, 1, 563
- Meduri, 1995, The fibroproliferative phase of late ARDS, Semin Respir Infect, 10, 152
- Gunther, 1994, Evaluation of intrapulmonary interleukin-8 in patients with sepsis-induced adult respiratory distress syndrome, Am J Resp Crit Care Med, 149, A427
- Chollett-Martin, 1993, Increased IL-8 levels in plasma and bronchoalveolar lavage fluid during the adult respiratory distress syndrome, Infect Immun, 61, 4553
- Brunson, 1993, Pneumonia in ARDS: diagnostic and prognostic value of bilateral bronchoscopic sampling, Am Rev Respir Dis, 147, A355
- Maunder, 1989, Determinants of survival in the adult respiratory distress syndrome (ARDS), Am Rev Respir Dis, A220
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Items 601–694 of 694
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Hybertson, B. M., & Repine, J. E. (1997) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13450-4_7 · Cited by 1
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Malarewicz, J., Kirchacker, R., & Annane, D. (2004) · Le Praticien en Anesthésie Réanimation · doi:10.1016/s1279-7960(04)98154-5 · Cited by 1
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Ramírez, P., Menéndez, R., & Torres, A. (2007) · Clinical Pulmonary Medicine · doi:10.1097/01.cpm.0000257584.73243.8d · Cited by 1
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Tremblay, L. N., & Slutsky, A. S. (1998) · Springer eBooks · doi:10.1007/978-1-4419-8634-4_36 · Cited by 1
Bauer, T. T., Ewig, S., Filella, X., & Torres, A. (1999) · Intensivmedizin und Notfallmedizin · doi:10.1007/s003900050281 · Cited by 1
Dreyfuss, D., Ricard, J.-D., & de Lassence, A. (2000) · Réanimation Urgences · doi:10.1016/s1164-6756(00)90045-8 · Cited by 1
Pulmonary coagulation and fibrinolysis in acute lung injury and pneumonia
Choi, G., Wolthuis, E. K., Levi, M. M., van der Poll, T., & Schultz, M. J. (2005) · Clinical Intensive Care · doi:10.1080/09563070500039378 · Cited by 1
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Hood, M. I. (2012) · Cited by 1
Haitsma, J. J., Schultz, M. J., & Slutsky, A. S. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7216-0186-1.50023-5 · Cited by 1
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Cegolon, L., Einollahi, B., Imanizadeh, S., Rezapour, M., Javanbakht, M., Nikpouraghdam, M., Abolghasemi, H., & Mastrangelo, G. (2021) · Research Square · doi:10.21203/rs.3.rs-447329/v1 · Cited by 1
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Ács, N., Bánhidy, F. G., & Czeizel, A. E. (2010) · Springer eBooks · doi:10.1007/978-90-481-8620-4_11 · Cited by 1
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Feldman, C. H. (1998) · Sepsis · doi:10.1023/a:1009733224900 · Cited by 1
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Brander, L., Slutsky, A. S., & Zhang, H. A. (2007) · Springer eBooks · doi:10.1007/88-470-0351-2_35
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Cockrill, B. A., & Kazemi, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-22435-0_19
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Patterson, C. E., & Matthay, M. A. (2005) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(05)35016-8
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Okkonen, M. (2012) · Työväentutkimus Vuosikirja
Zwischenberger, J. B., Alpard, S. K., & Bidani, A. (2001) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)02425-5
Papadakos, P. J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199904000-00054
Fortenberry, J. D. (2003) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000075643.00862.78
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Christie, J. M. (1999) · Seminars in Anesthesia Perioperative Medicine and Pain · doi:10.1016/s0277-0326(99)80015-4
Transbarrier Ion and Fluid Transport
Downs, C. A., & Helms, M. N. (2015) · Springer eBooks · doi:10.1007/978-3-319-18392-3_6
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Ismaiel, N. (2011) · DalSpace (Dalhousie University)
Influence of Mechanical Ventilation on Organ Dysfunction
Whitehead, T., & Slutsky, A. S. (2002) · Update in intensive care and emergency medicine · doi:10.1007/978-3-642-56107-8_26
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Haslett, C., & Donnelly, S. C. (1998) · Update in intensive care and emergency medicine · doi:10.1007/978-3-642-60733-2_7
Masterson, C. H. (2013) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16476
lung injury of different etiologies Sources of alveolar soluble TNF receptors during acute
Patel, V., van Rooijen, N., O'Dea, K. P., Takata, M., Dorr, A. D., Wilson, M. R., Wakabayashi, K., Waite, A., Patel, B. V., Woods, S., et al. (2015)
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Esper, R. C. (2000) · Medicina Crítica
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Chiche, J. (1998) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-642-72038-3_38
Espada, O., Rodríguez, C., Madrid, M. L. T., & Vaquero, J. (2009)
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Tai, T. L., Ma, H., & Eaton, D. C. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3366-2_18
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Brock, M. S. (2015) · Scholarship@Western (Western University)
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Espada, O., Rodríguez, C., Madrid, M. L. T., & Vaquero, J. (2009)
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Einstein, R. (2001)
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Numa, A. H., & Newth, C. J. L. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-3695-5.50048-1
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Bai, C., Pan, J., Bao, X., Liu, Y., Zhang, W., & Zhang, L. (2016) · Saudi Journal of Engineering and Technology · doi:10.21276/sjeat.2016.1.2.4
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Meduri, G. U. (1999) · Springer eBooks · doi:10.1007/978-88-470-2145-7_69
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Kreuer, S., & Pannen, B. H. J. (2012)
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Faubel, S. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803014-1.00007-8
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Lee, D. Y. (2013) · TSpace (University of Toronto)
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Vadlamudi, M. (2019) · Scholarly Commons (University of the Pacific)
Severo, L., Aquino, P. L. D. R., Diniz, A. M. S., de Lima, L. F. G., Marques, J. C. T., Dias, A. J. A., Júnior, F. M. D. O., Rabelo, N. N., & Filho, H. R. C. D. A. (2020) · doi:10.25259/aujmsr_19_2020
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Verma, A. K. (2020) · doi:10.35248/2157-7439.20.10.545
Elsayed, Y. M. H. (2022) · Endocrinology and Disorders · doi:10.31579/2640-1045/113
Song, C. E., Eaton, D. C., & Jain, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00094-9
Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100778
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Borham, M. M., & Elkher, M. A. (2022) · Al-Azhar International Medical Journal /Al-Azhar International Medical Journal · doi:10.21608/aimj.2022.124682.1859
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Bieber, E. J., Sanfilippo, J. S., Horowitz, I., & Shafi, M. I. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139628938.023
Grasso, S., Mascia, L., & Ranieri, V. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06959-8.00093-5
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Faro, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139628938.028
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Davidson, D. (1996) · International Journal of Obstetric Anesthesia · doi:10.1016/s0959-289x(96)80045-8
Sordillo, P. P., Allaire, A., Bouchard, A., Salvail, D., & Labbé, S. M. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2087689
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Geilen, J., Kainz, M., Zapletal, B., Geleff, S., Wisser, W., Bohle, B., Schweiger, T., Schultz, M. J., & Tschernko, E. (2022) · Research Square · doi:10.21203/rs.3.rs-1977827/v1
Rajbanshi, L. K., Rayamajhi, A. J., Bajracharya, A., & Shah, R. K. (2022) · Journal of College of Medical Sciences-Nepal · doi:10.3126/jcmsn.v18i3.47897
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Hein, A., & Wai, Y. H. (2022) · Cureus · doi:10.7759/cureus.32347
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Tulli, G., & Zuanetti, G. (2022) · Springer eBooks · doi:10.1007/978-3-031-14612-1_7
Sanwal, R., Joshi, K., Ditmans, M., Tsai, S. S. H., & Lee, W. L. (2023) · doi:10.32920/24026667.v1
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Ogawa, F. (2023) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.34.662
Sindrome da distress respiratorio acuto
Garnier, M. (2025) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(24)49997-0
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Garnier, M. (2025) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(24)49898-8
Viola, H., Chen, L.-H., Jo, S., Washington, K., Selva, C., Li, A., Feng, D., Giacalone, V. D., Stephenson, S. T., Cottrill, K. A., et al. (2025) · APL Bioengineering · doi:10.1063/5.0220367 · Cited by 1
Ferré, M. M. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Petersen, A. G., Lind, P., Jensen, A.-S. B., Eggertsen, M. A., Granfeldt, A., & Simonsen, U. (2021) · Figshare · doi:10.6084/m9.figshare.14446014
Petersen, A. G., Lind, P., Jensen, A.-S. B., Eggertsen, M. A., Granfeldt, A., & Simonsen, U. (2021) · Figshare · doi:10.6084/m9.figshare.14446011
Petersen, A. G., Lind, P., Jensen, A.-S. B., Eggertsen, M. A., Granfeldt, A., & Simonsen, U. (2021) · Figshare · doi:10.6084/m9.figshare.14446017
Sara, R., Bakht, M., Javadi, A., Foroughi, F., Marashi, S. M. A., & Nikkhahi, F. (2024) · Figshare · doi:10.6084/m9.figshare.26612276
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Cereda, M. F., & Pesenti, A. M. (1999) · Springer eBooks · doi:10.1007/978-88-470-2273-7_21
Additional file 1 of Unilateral acute lung injury in pig: a promising animal model
Geilen, J., Kainz, M., Zapletal, B., Geleff, S., Wisser, W., Bohle, B., Schweiger, T., Schultz, M. J., & Tschernko, E. (2022) · Figshare · doi:10.6084/m9.figshare.21629217
Tang, M., Meng, Q., Huang, Z., Qing, Y., & Lei, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1799042
Unat, D. S., Unat, Ö. S., & Turan, N. E. (2026) · Anatolian Current Medical Journal · doi:10.38053/acmj.1907249
The pseudoproteinase iRhom2 critically promotes acute lung inflammationPreprint
Lux, C., Kahveci-Türköz, S., Schun, K., Babendreyer, A., Martin, C., Kašpárek, P., Sedláček, R., Düsterhöft, S., & Ludwig, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730404
Aykenar, B., Ayhan, A., Issı, S., Kılıç, M. D., & Zeyneloğlu, P. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-04020-6
Janssen, W. J., Lapinig, M., Wynn, E., Aguilar, M., Mould, K. J., Hume, P. S., McClendon, J. D., Lee, F. F.-Y., Moore, C. M., & Alper, S. (2026) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00128.2026
Wei, J., Cao, W., Liu, Z.-F., Liu, Z., Cao, Z.-Z., Xiu, L., Li, J.-L., Tang, M.-M., Hua, D.-X., Fu, L., et al. (2026) · Canadian Respiratory Journal · doi:10.1155/carj/1600008
Advances in Dynamic Assessment Techniques for Lung Injury in Acute Respiratory Distress Syndrome
高, 丽. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1682876
Source-renewing ectopic ApoB-TRL lipolysis in non-resolving ARDS: a testable spatial hypothesis
Liu, Y., & Shi, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1859209
Xu, Z., Bi, X., Xiao, Z., Li, Y., Liu, X., Ou, X., Hu, Q., Qiao, Q., Tang, L., Li, X., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c13453
Colunga-Biancatelli, R. M. L., Solopov, P. A., Day, T., Austin, D. E., Yu-Shan, A. E., Scanderi, M. G. T., Sharlow, E. R., Lazo, J. S., & Catravas, J. D. (2026) · Research Square · doi:10.21203/rs.3.rs-11120002/v1
Metadata
- Authors
- Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., & Postlethwaite, A.
- Affiliations
- University of Tennessee Health Science Center (US)
- Memphis VA Medical Center (US)
- Corresponding author
- Meduri, G. Umberto
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 108
- Issue
- 5
- Pages
- 1303-1314
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2153354364
- Cited by
- 695
- References
- 72
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 14 · 2023: 23 · 2022: 44 · 2021: 47 · 2020: 51 · 2019: 19 · 2018: 12 · 2017: 18 · 2016: 18 · 2015: 23 · 2014: 16 · 2013: 21 · 2012: 20
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (5M01RR-00211, M01RR000211)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- acute respiratory distress syndrome, inflammatory cytokines, bronchoalveolar lavage, TNF-α, interleukin-6, interleukin-8, IL-1β, interleukin-2, IL-4, endothelial permeability, sepsis, lung injury score
- MeSH terms
- Adult, Bronchoalveolar Lavage Fluid, Cell Membrane Permeability, Endothelium, Female, Humans, Inflammation, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Proteins, Respiratory Distress Syndrome, Cytokines, Hospital Mortality, Disease Progression
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