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Cited by 263Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyRespiratory Support and Mechanisms

The DOI matches its Crossref record; 31 of the 34 references it cites were found in a registry or an index.

Exercise Training Decreases Ventilatory Requirements and Exercise-Induced Hyperinflation at Submaximal Intensities in Patients With COPD

Porszasz, Janos, Emtner, Margareta, Goto, Shinichi, Somfay, Attila, Whipp, Brian J., Casaburi, Richard·2005·Chest
DOI 10.1378/chest.128.4.2025
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Abstract

Study objectives We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance. Methods Twenty-four patients with COPD (mean FEV(1), 36.4 +/- 8.5% of predicted [+/- SD]) undertook a high-intensity cycle ergometer exercise training program for 45 min, three times a week for 7 weeks. Before and after training, the patients performed both an incremental exercise test to maximum and a constant work rate (CWR) test on a cycle ergometer at 75% of the peak work rate obtained in the pretraining incremental test. Ventilatory variables were measured breath-by-breath, and inspiratory capacity (IC) was measured every 2 min to assess changes in end-expiratory lung volume. Results After training, the increase in peak oxygen uptake was not statistically significant; however, the peak work rate increased by 12.9 +/- 10.3 W (p < 0.01). For the CWR test performed at the same work rate both before and after training, ventilation and breathing frequency (f) were lower after training (average, 1.97 L/min and 3.2 breaths/min, respectively; p < 0.01) and IC was greater (by an average of 133 mL, p < 0.05), signifying decreased hyperinflation. The increase in IC at the point of termination in the shortest CWR test for each individual (defined as isotime) correlated well with both the decreased f (r = 0.63, p = 0.001) and with the increase in CWR exercise endurance (average, 13.1 min, r = 0.46, p = 0.023). Conclusions Exercise training in patients with severe COPD dramatically improves submaximal exercise endurance. Decreased dynamic hyperinflation may, in part, mediate the improvement in exercise endurance by delaying the attainment of a critically high inspiratory lung volume.

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Metadata

Authors
Porszasz, J., Emtner, M., Goto, S., Somfay, A., Whipp, B. J., & Casaburi, R.
Affiliations
  • Uppsala University (SE)
  • Tokyo Women's Medical University (JP)
  • University of Szeged (HU)
  • The Lundquist Institute (US)
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2005-10
Volume
128
Issue
4
Pages
2025-2034
ISSN
0012-3692 (ISSN-L)
DOI
10.1378/chest.128.4.2025
OpenAlex
W2129477026
Cited by
262
References
34
Citations by year
2026: 8 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 20 · 2014: 14 · 2013: 23 · 2012: 10
FWCI
13.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
chronic obstructive pulmonary disease, exercise training, inspiratory capacity, end-expiratory lung volume, peak work rate, respiratory rate, peak oxygen uptake
MeSH terms
Aged, Exercise Test, Female, Forced Expiratory Volume, Humans, Male, Oxygen Consumption, Physical Fitness, Residual Volume, Vital Capacity, Exercise, Pulmonary Disease, Chronic Obstructive

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