Serum free fatty acid biomarkers of lung cancer

Liu, Jinbo; Mazzone, Peter J.; Cata, Juan P.; Kurz, Andrea; Bauer, Maria; Mascha, Edward J.; Sessler, Daniel I.

doi:10.1378/chest.13-2568

Cited by 89Cancer, Lipids, and MetabolismLung Cancer Diagnosis and TreatmentFatty Acid Research and Health

Serum free fatty acid biomarkers of lung cancer

Liu, Jinbo, Mazzone, Peter J., Cata, Juan P., Kurz, Andrea, Bauer, Maria, Mascha, Edward J., Sessler, Daniel I.·2014·Chest

DOI 10.1378/chest.13-2568

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Abstract

Background Lung cancer is the leading cause of cancer-related mortality. Surgical removal of the tumor at an early stage can be curative. However, lung cancer diagnosis at an early stage remains challenging. There is evidence that free fatty acids play a role in cancer development.Methods Serum samples from 55 patients with lung cancer were propensity matched with samples from 165 similar pulmonary patients without known cancer. Patients were propensity matched on age, sex, smoking history, family history of lung cancer, and chronic diseases that might affect free fatty acid levels.Results Free fatty acids arachidonic acid (AA) and linoleic acid (LA) and their metabolites hydroxyeicosatetraenoic acids (HETEs)(5-HETE, 11-HETE, 12-HETE, and 15-HETE) were an estimated 1.8- to 3.3-fold greater in 37 patients with adenocarcinoma vs 111 patients without cancer (all P < .001). Areas under the receiver operating characteristic curve were significantly > 0.50, discriminating patients with lung cancer and control subjects for six of eight biomarkers and two of seven phospholipids tested, and ranged between 0.69 and 0.82 (all P < .001) for patients with lung cancer vs control subjects. AA, LA, and 15-HETE had observed sensitivity and specificity > 0.70 at the best cutpoint. Concentrations of free fatty acids and their metabolites were similar in 18 patients with squamous cell carcinoma and 54 control subjects without cancer.Conclusions Serum fatty acids and their metabolites demonstrate good sensitivity and specificity for the identification of adenocarcinoma of the lung.

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In observational studies and RCTs, legume consumption improves CVD risk factors (waist circumference, cholesterol, BP, CRP, glucose) and is protective against T2DM.
“In observational studies and RCTs consumption of legumes improves CVD risk factors, such as waist circumference, cholesterol, BP, C-reactive protein, glucose; and is protective against T2DM (224–231).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [228]
In a meta-analysis of 26 RCTs, 130 g legumes/day reduced LDL-C by 0.17 mmol/L (95% CI -0.25 to -0.09).
“A meta-analysis of 26 RCTs (1,037 participants) finds that 130 grams legumes/d (~1 serving) reduced LDL-C by 0.17 mmol/L (95% CI: −0.25, −0.09) (228).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [228]

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Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507 · see citing works

Authors: Liu, J., Mazzone, P. J., Cata, J. P., Kurz, A., Bauer, M., Mascha, E. J., & Sessler, D. I.
Affiliations: Cleveland Clinic (US)
Corresponding author: Sessler, Daniel I.
ORCID: Liu, Jinbo
Mazzone, Peter J.
Cata, Juan P.
Kurz, Andrea
Bauer, Maria
Mascha, Edward J.
Sessler, Daniel I.
Venue: Chest
Publisher: Elsevier BV
Published: 2014-09
Volume: 146
Issue: 3
Pages: 670-679
ISSN: 0012-3692 (ISSN-L)
DOI: 10.1378/chest.13-2568
OpenAlex: W2131103345
Cited by: 89
References: 51
Citations by year: 2026: 3 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 3
FWCI: 1.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: CHEST Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Cleveland Clinic
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: lung cancer, serum free fatty acids, hydroxyeicosatetraenoic acids, arachidonic acid, linoleic acid, 15-hydroxyeicosatetraenoic acid, lung adenocarcinoma, squamous cell carcinoma, tumor markers, early cancer detection, phospholipids
MeSH terms: Adenocarcinoma, Adult, Aged, Fatty Acids, Nonesterified, Fatty Acids, Unsaturated, Female, Humans, Hydroxyeicosatetraenoic Acids, Lung Neoplasms, Male, Middle Aged, Phospholipids, Sensitivity and Specificity, Biomarkers, Case-Control Studies, Area Under Curve, Linoleic Acid

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Serum free fatty acid biomarkers of lung cancer

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