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Cited by 101Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory and Cough-Related Research

Dynamic Hyperinflation During Bronchoconstriction in Asthma

Lougheed, M. Diane, Fisher, Thomas, O’Donnell, Denis E.·2006·Chest
DOI 10.1378/chest.130.4.1072
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Abstract

Objective The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma. Patients and methods Subjects with asthma (n = 116) underwent baseline spirometry and lung volume measurement followed by high-dose methacholine challenge testing (MCT) [maximum decrease in FEV(1) of 50% from baseline]. Dyspnea intensity (Borg scale) was measured after each dose of methacholine. Qualitative descriptors of breathlessness and functional residual capacity (FRC) were measured at the doses nearest to the provocative concentration of methacholine causing a 20% fall in FEV (PC(20)) and at the highest dose of methacholine (maximum response). Results FEV(1) decreased by 24.7 +/- 0.7% (mean +/- SEM) at the dose nearest to PC(20) and by 46.1 +/- 1.1% at maximum response. Inspiratory capacity decreased by 0.62 +/- 0.04 L at the dose nearest to PC(20) and 1.06 +/- 0.06 L at maximum response. The descriptor clusters "inspiratory difficulty," "chest tightness," "unsatisfied inspiration," and "work" were selected at the dose nearest to PC(20) but were more frequently selected at maximum response (p Conclusions Four dominant qualities of dyspnea in asthma (inspiratory difficulty, chest tightness, unsatisfied inspiration, and work) were reported early in the course of MCT and evolved in parallel, becoming more prevalent at maximum response. Significant DH accompanied even mild…

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  • Thoracic dominant breathing is linked to asthma, COPD, heart failure and panic disorder.

    “| Thoracic dominant breathing | 4 | [11, 47–49] | Asthma COPD Heart failure Panic disorder |”

    From Dysfunctional breathing: a review of the literature and proposal for classification (2016) · cites this paper as [49]

  • Thoracic dominant breathing often occurs in patients with increasing ventilation needs such as cardiac or respiratory disease or decreased abdominal compliance such as morbid obesity, but in their absence it can be termed dysfunctional.

    “This type of breathing often occurs in patients with increasing ventilation needs such as those with cardiac or respiratory disease or those with decreased abdominal compliance such as the morbidly obese, but in their absence it can be termed dysfunctional [11, 48, 49].”

    From Dysfunctional breathing: a review of the literature and proposal for classification (2016) · cites this paper as [49]

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Authors
Lougheed, M. D., Fisher, T., & O’Donnell, D. E.
Affiliations
Queen's University (CA)
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2006-10
Volume
130
Issue
4
Pages
1072-1081
ISSN
0012-3692 (ISSN-L)
DOI
10.1378/chest.130.4.1072
OpenAlex
W2116008397
Cited by
101
References
2
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 7
FWCI
4.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords
asthma, bronchoconstriction, methacholine challenge, dyspnea, chest tightness, functional residual capacity, inspiratory capacity, airflow obstruction, respiratory sensation, quality of life
MeSH terms
Adult, Airway Resistance, Inhalation, Asthma, Bronchial Provocation Tests, Dose-Response Relationship, Drug, Dyspnea, Female, Humans, Lung, Lung Compliance, Lung Volume Measurements, Male, Plethysmography, Spirometry, Statistics as Topic, Work of Breathing, Bronchoconstriction, Methacholine Chloride

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