Effects of Long-term Clonidine Administration on the Hemodynamic and Neuroendocrine Postural Responses of Patients with Dysautonomia
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Treatments that improve symptoms of POTS might decrease the occurrence of syncope.
“Treatments that improve symptoms of POTS might decrease the occurrence of syncope, although this is unknown (24,514–523).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [518]
A small prospective study of POTS patients who failed beta-blockers demonstrated reductions in upright norepinephrine levels and increased plasma volume by 12% on doses of clonidine 0.3-0.4 mg/day.
“a small prospective study of patients who failed beta-blockers demonstrated reductions in upright norepinephrine levels and increased plasma volume by 12% on doses of clonidine 0.3-0.4 mg/day (86).”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [86]
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Sheldon, R. S., Grubb, B. P., Olshansky, B., Shen, W.-K., Calkins, H., Brignole, M., Raj, S. R., Krahn, A. D., Morillo, C. A., Stewart, J. M., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.03.029 · Cited by 1,013 · see citing works
“Clonidine is an alpha-2 agonist that can stabilize hemodynamics in patients with high sympathetic nervous system involvement.(47) Methyldopa is sometimes better tolerated.”
Background2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245 · see citing works
Pediatric Disorders of Orthostatic Intolerance
Stewart, J. M., Boris, J. R., Chelimsky, G., Fischer, P. R., Fortunato, J. E., Grubb, B. P., Heyer, G. L., Jarjour, I. T., Medow, M. S., Numan, M. T., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-1673 · Cited by 222 · see citing works
Mitral valve prolapse: causes, clinical manifestations, and management
Devereux, R. B., Kramer-Fox, R., & Kligfield, P. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-4-305 · Cited by 180 · see citing works
Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome
Raj, S. R., Black, B. K., Biaggioni, I., Harris, P. A., & Robertson, D. (2005) · Circulation · doi:10.1161/circulationaha.104.497594 · Cited by 171 · see citing works
Taub, P. R., Zadourian, A., Lo, H. C., Ormiston, C. K., Golshan, S., & Hsu, J. C. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.12.029 · Cited by 122 · see citing works
Postural orthostatic tachycardia syndrome: mechanisms and new therapies
Mar, P. L., & Raj, S. R. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-041818-011630 · Cited by 122 · see citing works
Pharmacotherapy for postural tachycardia syndrome
Miller, A. J., & Raj, S. R. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.008 · Cited by 91 · see citing works
Postural Orthostatic Tachycardia Syndrome: Prevalence, Pathophysiology, and Management
Zadourian, A., Doherty, T. A., Swiatkiewicz, I., & Taub, P. R. (2018) · Drugs · doi:10.1007/s40265-018-0931-5 · Cited by 90 · see citing works
Treatment of postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia
Kanjwal, M. Y., Kosinski, D. J., & Grubb, B. P. (2003) · Current Cardiology Reports · doi:10.1007/s11886-003-0098-9 · Cited by 25 · see citing works
- Authors
- Gaffney, F. A., Lane, L. B., Pettinger, W., & Blomqvist, C. G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Gaffney, F. Andrew
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1983-02
- Volume
- 83
- Issue
- 2
- Pages
- 436-438
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W4243063525
- Cited by
- 36
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 7 · 2015: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- clonidine, orthostatic intolerance, autonomic dysfunction, mitral valve prolapse, plasma norepinephrine, catecholamines, systemic vascular resistance, cardiac output, plasma volume
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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