Treatment of postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia
Abstract
Postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia are two clinically different entities but with significant overlap of symptoms. Treatment by and large is medical; however, other modalities of treatment are being evaluated.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency
Shannon, J. R., Flattem, N. L., Jordan, J., Jacob, G., Black, B. K., Biaggioni, I., Blakely, R. D., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420803 · Cited by 594 · see citing works
Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548 · see citing works
The neuropathic postural tachycardia syndrome
Jacob, G., Costa, F., Shannon, J. R., Robertson, R. M., Wathen, M., Stein, M., Biaggioni, I., Ertl, A., Black, B., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431404 · Cited by 398 · see citing works
Postural tachycardia syndrome (POTS)
Lamotte, G., & Low, P. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00118-6 · Cited by 300 · see citing works
Pharmacologic distinction of different orthostatic hypotension syndromes
Polinsky, R. J., Kopin, I. J., Ebert, M. H., & Weise, V. K. (1981) · Neurology · doi:10.1212/wnl.31.1.1 · Cited by 295 · see citing works
Autonomic failure: A textbook of clinical disorders of the autonomic nervous system
Toole, J. F. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90257-y · Cited by 289 · see citing works
Treatment of Orthostatic Hypotension with Erythropoietin
Hoeldtke, R. D., & Streeten, D. H. P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290904 · Cited by 226 · see citing works
Radiofrequency catheter modification of the sinus node for “inappropriate” sinus tachycardia
Lee, R. J., Kalman, J. M., Fitzpatrick, A. P., Epstein, L. M., Fisher, W. G., Olgin, J. E., Lesh, M. D., & Scheinman, M. M. (1995) · Circulation · doi:10.1161/01.cir.92.10.2919 · Cited by 213 · see citing works
Clinical autonomic disorders : evaluation and management
Low, P. A. (1997) · Cited by 202 · see citing works
Mechanism of ”inappropriate” sinus tachycardia. Role of sympathovagal balance
Morillo, C. A., Klein, G. J., Thakur, R. K., Li, H., Zardini, M., & Yee, R. (1994) · Circulation · doi:10.1161/01.cir.90.2.873 · Cited by 193 · see citing works
Mathias, C. J., Fosbraey, P., Costa, D., Thornley, A., & Bannister, R. (1986) · BMJ · doi:10.1136/bmj.293.6543.353 · Cited by 190 · see citing works
The Anemia of Primary Autonomic Failure and its Reversal with Recombinant Erythropoietin
Biaggioni, I., Robertson, D., Krantz, S., Jones, M., & Haile, V. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-3-199408010-00004 · Cited by 182 · see citing works
Clinical Autonomic Disorders: Evaluation and Management
Bergen, D. C. (1993) · JAMA · doi:10.1001/jama.1993.03510160112042 · Cited by 145 · see citing works
Idiopathic Orthostatic Intolerance and Postural Tachycardia Syndromes
Jacob, G., & Biaggioni, I. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199902000-00003 · Cited by 136 · see citing works
<b>Inappropriate Sinus Tachycardia</b>: Evaluation and Therapy
KRAHN, A. D., YEE, R., KLEIN, G. J., & MORILLO, C. (1995) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1995.tb00391.x · Cited by 110 · see citing works
The Postural Orthostatic Tachycardia Syndrome:
Kanjwal, Y., KOSINSKI, D. J., & Grubb, B. P. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00262.x · Cited by 103 · see citing works
Self-citationPrimer on the Autonomic Nervous System
Appenzeller, O. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)60037-x · Cited by 92 · see citing works
Grubb, B. P., & Karas, B. J. (1998) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/a:1009792000490 · Cited by 77 · see citing works
Self-citationGrubb, B. P., KOSINSKI, D. J., & Kanjwal, Y. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.t01-1-00155.x · Cited by 69 · see citing works
Self-citationSHEN, W., LOW, P. A., JAHANGIR, A., MUNGER, T. M., FRIEDMAN, P. A., OSBORN, M. J., STANTON, M. S., PACKER, D. L., REA, R. F., & HAMMILL, S. C. (2001) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2001.00217.x · Cited by 69 · see citing works
Refractory paroxysmal sinus tachycardia: Management by subtotal right atrial exclusion
Yee, R. K., Guiraudon, G. M., Gardner, M. J., Gulamhusein, S. S., & Klein, G. J. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80026-1 · Cited by 61 · see citing works
The Use of Methylphenidate in the Treatment of Refractory Neurocardiogenic Syncope
Grubb, B. P., KOSINSKI, D. J., Mouhaffel, A., & Pothoulakis, A. (1996) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1996.tb03367.x · Cited by 59 · see citing works
Self-citationGrubb, B. P., Kanjwal, M. Y., & KOSINSKI, D. J. (2001) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/a:1009845521949 · Cited by 51 · see citing works
Self-citationPossible relationship between chronic fatigue and postural tachycardia syndromes
Lorenzo, F., Hargreaves, J., & Kakkar, V. V. (1996) · Clinical Autonomic Research · doi:10.1007/bf02556297 · Cited by 47 · see citing works
Gaffney, F. A. (1983) · CHEST Journal · doi:10.1378/chest.83.2_supplement.436 · Cited by 43 · see citing works
(2012) · SpringerReference · doi:10.1007/springerreference_109856 · Cited by 42 · see citing works
Grubb, B. P., Karas, B. J., KOSINSKI, D. J., & BOEHM, K. (1999) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/a:1009813312936 · Cited by 40 · see citing works
Self-citationGaffney, F. A., Lane, L. B., Pettinger, W., & Blomqvist, C. G. (1983) · Chest · doi:10.1378/chest.83.2.436 · Cited by 36 · see citing works
Clinical features and investigation of the primary autonomic failure syndromes
Bannister, R. (1992) · Medical Entomology and Zoology · Cited by 35 · see citing works
Syncope: Mechanisms and Management
Meissner, M. D. (1999) · Circulation · doi:10.1161/01.cir.99.15.2061 · Cited by 33 · see citing works
Sinus node artery occlusion for treatment of chronic nonparoxysmal sinus tachycardia
de Paola, Â. A. V., Horowitz, L. N., Vattimo, A. C. A., Marques, F. B. R., Miyamoto, M. H., Ferreira, D. F., Terzian, A. B., Cirenza, C., de Souza, I. A., Portugal, O. P., et al. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91410-6 · Cited by 21 · see citing works
Paraneoplastic Autonomic Dysfunction
Khurana, R. K. (2004) · Elsevier eBooks · doi:10.1016/b978-012589762-4/50106-7 · Cited by 11 · see citing works
KARCH, M. R., Shinbane, J. S., Kalman, J. M., Lee, R. J., & Lesh, M. D. (2000) · Cardiac Electrophysiology Review · doi:10.1023/a:1009978817051 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Postural Tachycardia Syndrome: A Concise Guide to Diagnosis and Management
Grubb, B. P., Kanjwal, Y., & KOSINSKI, D. J. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.00318.x · Cited by 154 · see citing works
Self-citationPostural Orthostatic Tachycardia Syndrome: A Clinical Review
Johnson, J. N., Mack, K. J., Kuntz, N. L., Brands, C. K., Porter, C. J., & Fischer, P. R. (2010) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.07.002 · Cited by 119 · see citing works
Inappropriate sinus tachycardia
Olshansky, B., & Sullivan, R. M. (2019) · EP Europace · doi:10.1093/europace/euy128 · Cited by 80 · see citing works
Orthostatic intolerance and the headache patient
Mack, K. J., Johnson, J. N., & Rowe, P. C. (2010) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2010.04.006 · Cited by 47 · see citing works
Inappropriate Sinus Tachycardia
Femenía, F., Baranchuk, A. M., & Morillo, C. A. (2011) · Cardiology in Review · doi:10.1097/crd.0b013e31822f0b3e · Cited by 39 · see citing works
(2010) · PubMed · Cited by 34 · see citing works
The utility of Valsalva maneuver in the diagnoses of orthostatic disorders
Palamarchuk, I. S., Baker, J. R., & Kimpinski, K. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00290.2015 · Cited by 24 · see citing works
Dizziness and Vertigo in the Adolescent
Taylor, J. W., & Goodkin, H. P. (2011) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2011.01.004 · Cited by 22 · see citing works
New‐Onset Orthostatic Intolerance Following Bariatric Surgery
Billakanty, S. R., Kligman, M. D., Kanjwal, Y., KOSINSKI, D. J., Maly, G., Karabin, B. L., & Grubb, B. P. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01103.x · Cited by 22 · see citing works
Self-citationPostural Tachycardia, Orthostatic Intolerance, and the Chronic Fatigue Syndrome
Grubb, B. P., Calkins, H. G., & Rowe, P. C. (2005) · Wiley eBooks · doi:10.1002/9780470994801.ch13 · Cited by 21 · see citing works
Self-citationComorbid health conditions in women with syncope
Ulaş, Ü. H., Chelimsky, T. C., Chelimsky, G. G., Mandawat, A., McNeeley, K., & Alshekhlee, A. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-010-0070-x · Cited by 18 · see citing works
Taquicardia sinusal inapropiada: actualización
Morillo, C. A., & Guzmán, J. C. (2007) · Revista Española de Cardiología · Cited by 15 · see citing works
Johnson, J. N., Bonnichsen, C. R., Julsrud, P. R., Burkhart, H. M., & Hagler, D. J. (2011) · Cardiology in the Young · doi:10.1017/s1047951111000606 · Cited by 11 · see citing works
Inappropriate sinus tachycardia: an examination of existing definitions
Hou, C. R., Olshansky, B., Cortez, D., Duval, S., & Benditt, D. G. (2022) · EP Europace · doi:10.1093/europace/euac057 · Cited by 9 · see citing works
Differences in cardiac autonomic function contributes to heart rate abnormalities in POTS and IST
Corkal, J. C., Palamarchuk, I. S., & Kimpinski, K. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.09.016 · Cited by 8 · see citing works
Conventional management of inappropriate sinus tachycardia
Olshansky, B., & Sullivan, R. M. (2015) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-0034-0 · Cited by 5 · see citing works
The postural tachycardia syndrome: When to consider it in adolescents
Grubb, B. P. (2006) · Cited by 4 · see citing works
Self-citationYeolekar, A. M., & Yeolekar, M. E. (2016) · Indian Journal of Medical Specialities · doi:10.1016/j.injms.2015.12.003 · Cited by 2 · see citing works
Dizziness and Vertigo in the Adolescent
Goodkin, H. P., Taylor, J. W., & Ramirez‐Montealegre, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-55136-6.00006-x · Cited by 1 · see citing works
Busmer, L., Kavi, L., & West, J. (2012) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2012.7.5.206 · Cited by 1 · see citing works
Sinoatrial Reentrant Tachycardia: Inappropriate Sinus Tachycardia
Dick, M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2739-5_7
Evaluation and Management of Syncope
Bindra, P. S., Marchlinski, F. E., & Lin, D. (2008) · Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine · doi:10.4137/ccrpm.s490
Sinoatrial Reentrant Tachycardia
Dick, M. (2006) · Developments in cardiovascular medicine · doi:10.1007/0-387-29170-9_7
Guias de ablacion de arritmias cardiacas de la Federacion Argentina de Cardiologia
Keegan, R. O., Aguinaga, L., Secchi, J., Pozzer, D. L., Valentino, M., Femenía, F., Río, A. D., Feo, M. D., Bravo, A., & Martellotto, A. (2012)
Hypoglycemic Flash as a potential shared metabolic trigger for episodic autonomic disorders
Shigeto, M. (2026) · Medical Hypotheses · doi:10.1016/j.mehy.2026.112124
- Authors
- Kanjwal, M. Y., Kosinski, D. J., & Grubb, B. P.
- ORCID
- Grubb, Blair P.
- Venue
- Current Cardiology Reports
- Published
- 2003-09
- Volume
- 5
- Issue
- 5
- Pages
- 402-406
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- OpenAlex
- W2083560082
- Cited by
- 25
- References
- 34
- Citations by year
- 2026: 1 · 2022: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Cardiology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- postural orthostatic tachycardia syndrome, inappropriate sinus tachycardia, autonomic dysfunction, medical treatment, symptom overlap, treatment options
- MeSH terms
- Blood Pressure, Headache, Heart Rate, Humans, Hypotension, Orthostatic, Posture, Syndrome, Tachycardia, Tachycardia, Sinus, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review