Factors Associated with Fatal Hemoptysis in Cancer Patients
Abstract
We reviewed the clinical outcome of 58 patients with hemoptysis associated with either a hematologic or solid malignancy. Pulmonary hemorrhage causing death (fatal hemoptysis) occurred in 36 percent of these patients. Fatal hemoptysis occurred in six of eight patients with a hematologic malignancy and a fungal pneumonia. Examination of pathologic specimens from five of these patients revealed fungal invasion of blood vessels. An inflammatory response was absent in three, suggesting that granulocytes are not required for fungal-induced tissue destruction. In patients with a bronchogenic tumor, fatal hemoptysis occurred in six of seven patients with a necrotic squamous cell carcinoma. In contrast, hemoptysis was fatal in only two of ten patients with metastatic lung disease. We conclude that hemoptysis in cancer patients with a fungal pneumonia is an ominous sign that may warrant aggressive interventions to prevent a fatal complication.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rarely, after aspiration of oropharyngeal material, primary pneumonia due to Candida may develop.
“Rarely, after aspiration of oropharyngeal material, primary pneumonia due to Candida may develop [176, 181,182].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [181]
Cites
Feinleib, M., & Zar, J. H. (1975) · Journal of the American Statistical Association · doi:10.2307/2285423 · Cited by 12,671 · see citing works
The Quantitative Relation between Platelet Count and Hemorrhage in Patients with Acute Leukemia
Gaydos, L. A., Freireich, E. J., & Mantel, N. (1962) · New England Journal of Medicine · doi:10.1056/nejm196205032661802 · Cited by 534 · see citing works
Stover, D. E., ZAMAN, M. B., HAJDU, S. I., et al. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-1-1 · Cited by 517 · see citing works
Causes of Death in Acute Leukemia
Hersh, E. M. (1965) · JAMA · doi:10.1001/jama.1965.03090020019005 · Cited by 497 · see citing works
Treatment of Hemoptysis by Embolization of Bronchial Arteries
Rémy, J., Arnaud, A., Fardou, H., et al. (1977) · Radiology · doi:10.1148/122.1.33 · Cited by 414 · see citing works
CAUSES OF DEATH IN ADULTS WITH ACUTE LEUKEMIA
CHANG, H.-Y., Rodriguez, V., Narboni, G., Bodey, G. P., Luna, M. A., & Freireich, E. J. (1976) · Medicine · doi:10.1097/00005792-197605000-00005 · Cited by 302 · see citing works
Candida tropicalis: A Major Pathogen in Immunocompromised Patients
Wingard, J. R., MERZ, W. G., & SARAL, R. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-4-539 · Cited by 297 · see citing works
Fisher, B. D., Armstrong, D., Yu, B., & GOLD, J. W. M. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90208-4 · Cited by 288 · see citing works
Management of massive hemoptysis by bronchial artery embolization.
Uflacker, R., Kaemmerer, A., Neves, C., et al. (1983) · Radiology · doi:10.1148/radiology.146.3.6828674 · Cited by 190 · see citing works
The Role of Bronchoalveolar Lavage in the Diagnosis of Invasive Pulmonary Aspergillosis
Kahn, F. W., Jones, J. M., & England, D. M. (1986) · American Journal of Clinical Pathology · doi:10.1093/ajcp/86.4.518 · Cited by 184 · see citing works
Massive hemoptysis. Review of 123 cases.
Conlan, A. A., Ss, H., Lp, K., Nicolaou, N., & Pool, R. (1983) · PubMed · Cited by 172 · see citing works
Primary pulmonary cavitating carcinomas
Chaudhuri, M. R. (1973) · Thorax · doi:10.1136/thx.28.3.354 · Cited by 167 · see citing works
Clinical Manifestations of Lung Cancer
Hyde, L., & Hyde, C. I. (1974) · CHEST Journal · doi:10.1378/chest.65.3.299 · Cited by 161 · see citing works
Cytotoxic drug-induced lung disease
Sostman, H. D., Matthay, R. A., & Putman, C. E. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90424-7 · Cited by 156 · see citing works
Conlan, A. A., Ss, H., Lp, K., Nicolaou, N., & Pool, R. (1983) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38908-1 · Cited by 149 · see citing works
Ara-C lung: Noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia
Haupt, H. M., Hutchins, G. M., & Moore, G. W. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90759-2 · Cited by 145 · see citing works
Lynch, H. T., Mulcahy, G. M., Harris, R. E., Guirgis, H. A., & Lynch, J. F. (1978) · Cancer · doi:10.1002/1097-0142(197805)41:5 · Cited by 140 · see citing works
Albelda, S. Μ., Talbot, G. H., Gerson, S. L., Miller, W. T., & Cassileth, P. A. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90853-2 · Cited by 134 · see citing works
Albelda, S. Μ., Talbot, G. H., Gerson, S. L., et al. (1985) · PubMed · doi:10.1164/arrd.1985.131.1.115 · Cited by 131 · see citing works
Absorption and Metabolism of Aspirin Administered in Enteric-Coated Tablets
Leonards, J. R. (1965) · JAMA · doi:10.1001/jama.1965.03090020013004 · Cited by 128 · see citing works
Pathologic Features in the Human Alimentary Tract Associated with Invasiveness of Candida Tropicalis
Walsh, T. J., & Merz, W. G. (1986) · American Journal of Clinical Pathology · doi:10.1093/ajcp/85.4.498 · Cited by 116 · see citing works
Self-citationDiagnosis of Pulmonary Hemorrhage in the Immunocompromised Host
Kahn, F. W., Jones, J. M., & England, D. M. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.1.155 · Cited by 93 · see citing works
Springmeyer, S. C., Silvestri, R. C., SALE, G. E., et al. (1982) · PubMed · doi:10.1164/arrd.1982.126.5.763 · Cited by 88 · see citing works
An Endotoxin from Aspergillus Fumigatus
Henrici, A. T. (1939) · The Journal of Immunology · doi:10.4049/jimmunol.36.4.319 · Cited by 85 · see citing works
Cancer and total mortality among active mormons
Enstrom, J. E. (1978) · Cancer · doi:10.1002/1097-0142(197810)42:4 · Cited by 85 · see citing works
Elastase production in clinical isolates of Aspergillus
Rhodes, J. C., Bode, R. B., & McCuan-Kirsch, C. M. (1988) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/0732-8893(88)90036-3 · Cited by 85 · see citing works
Laser in Treatment of Lung Cancer
Gelb, A. F., & Epstein, J. D. (1984) · CHEST Journal · doi:10.1378/chest.86.5.662 · Cited by 76 · see citing works
Aspergillosis and mucormycosis: two types of opportunistic fungal pneumonia.
Libshitz, H. I., & Pagani, J. (1981) · Radiology · doi:10.1148/radiology.140.2.7019958 · Cited by 71 · see citing works
Laser Therapy in Patients with Primary Lung Cancer
Arabian, A. A., & Spagnolo, S. V. (1984) · CHEST Journal · doi:10.1378/chest.86.4.519 · Cited by 49 · see citing works
Good, C. A., & Holman, C. B. (1960) · Diseases of the Chest · doi:10.1378/chest.37.3.289 · Cited by 34 · see citing works
Pathogenesis of massive pulmonary hemorrhage in acute leukemia.
Smith, L. J., & Katzenstein, A. L. (1982) · PubMed · Cited by 27 · see citing works
Pathogenesis of Massive Pulmonary Hemorrhage in Acute Leukemia
Smith, L. J. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340250109016 · Cited by 26 · see citing works
Granulofilamentous inclusions in a meningioma
Goldman, J. E., Horoupian, D. S., & Johnson, T. (1980) · Cancer · doi:10.1002/1097-0142(19800701)46:1 · Cited by 23 · see citing works
The surgical management of fungal pulmonary infections in children with acute myelogenous leukemia
Shamberger, R. C., Weinstein, H. J., Grier, H. E., et al. (1985) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(85)80052-x · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Self-citationPractice Guidelines for the Treatment of Candidiasis
Rex, J. H., Walsh, T. J., Sobel, J. D., Filler, S. G., Pappas, P. G., Dismukes, W. E., & Edwards, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313749 · Cited by 927 · see citing works
Self-citationBerenguer, J., Allende, M. C., Lee, J. W., Garrett, K., Lyman, C., Ali, N. M., Bacher, J., Pizzo, P. A., & Walsh, T. J. (1995) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.152.3.7663787 · Cited by 183 · see citing works
Self-citation
- Authors
- Panos, R. J., Barr, L. F., Walsh, T. J., & Silverman, H. J.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Silverman, Henry J.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 94
- Issue
- 5
- Pages
- 1008-1013
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2047050927
- Cited by
- 59
- References
- 34
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- pulmonary hemorrhage, fungal pneumonia, hematologic malignancies, solid tumors, squamous cell carcinoma, metastatic lung disease, granulocytes, prognostic factors
- MeSH terms
- Aged, Carcinoma, Bronchogenic, Hemoptysis, Humans, Leukemia, Lung Diseases, Fungal, Lung Neoplasms, Lymphoma, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
