The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Applications of Polymer Nanofibers in Biomedicine and Biotechnology
Abstract
Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and internal molecular structures. A wide range of biodegradable biopolymers can be electrospun into mats with specific fiber arrangement and structural integrity. Through secondary processing, the nanofiber surface can be functionalized to display specific biochemical characteristics. It is hypothesized that the large surface area of nanofibers with specific surface chemistry facilitates attachment of cells and control of their cellular functions. These features of nanofiber mats are morphologically and chemically similar to the extracellular matrix of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, effective mechanical properties, and specific biochemical properties. The current emphasis of research is on exploiting such properties and focusing on determining appropriate conditions for electrospinning various polymers and biopolymers for eventual applications including multifunctional membranes, biomedical structural elements (scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, vascular grafts), protective shields in specialty fabrics, and filter media for submicron particles in the separation industry. This has resulted in the recent applications for polymer nanofibers in the fie…
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“Moreover, an improvement in the mechanical properties of PCL can be achieved by copolymerization with PLA, enabling its use for orthopedic applications, such as the repair of bone defects [106].”
From Green Copolymers Based on Poly(Lactic Acid)—Short Review (2021) · cites this paper as [106]
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Cites
Multilineage potential of adult human mesenchymal stem cells
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A review on polymer nanofibers by electrospinning and their applications in nanocomposites
Huang, Z., Zhang, Y., Kotaki, M., & Ramakrishna, S. (2003) · Composites Science and Technology · doi:10.1016/s0266-3538(03)00178-7 · Cited by 7,567
Self-citationCaplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Electrospun nanofibrous structure: A novel scaffold for tissue engineering
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A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
Yoshimoto, H., Shin, Y.-S., Terai, H., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00635-x · Cited by 1,975
Structure and process relationship of electrospun bioabsorbable nanofiber membranes
Zong, X., Kim, K., Fang, D., Ran, S., Hsiao, B. S., & Chu, B. (2002) · Polymer · doi:10.1016/s0032-3861(02)00275-6 · Cited by 1,931
Biomedical applications of polymer-composite materials: a review
Ramakrishna, S., Mayer, J., Wintermantel, E., & Leong, K. W. (2001) · Composites Science and Technology · doi:10.1016/s0266-3538(00)00241-4 · Cited by 1,642
Self-citationPolymer nanofibers assembled by electrospinning
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Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering
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Electrospinning: A Fascinating Method for the Preparation of Ultrathin Fibers
Greiner, A., & Wendorff, J. H. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604646 · Cited by 4,260
Malafaya, P. B., Silva, G. A., & Reis, R. L. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.012 · Cited by 1,400
Nanostructured materials for applications in drug delivery and tissue engineering
Goldberg, M. S., Langer, R., & Jia, X. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207779996931 · Cited by 1,068
Regenerative Endodontics: A Review of Current Status and a Call for Action
Murray, P. E., Garcı́a-Godoy, F., & Hargreaves, K. (2007) · Journal of Endodontics · doi:10.1016/j.joen.2006.09.013 · Cited by 1,001
A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages
Zahedi, P., Rezaeian, I., Siadat, S. O. R., Jafari, S. H., & Supaphol, P. (2009) · Polymers for Advanced Technologies · doi:10.1002/pat.1625 · Cited by 906
Metadata
- Authors
- Venugopal, J., & Ramakrishna, S.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Venugopal, J.
- Venue
- Applied Biochemistry and Biotechnology
- Published
- 2005
- Volume
- 125
- Issue
- 3
- Pages
- 147-158
- ISSN
- 0273-2289 (ISSN-L)
- OpenAlex
- W2028926100
- Semantic Scholar
- 910237e5fc820a2842072c3c12d8a8ceafb189f4
- Cited by
- 370
- References
- 46
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 17 · 2021: 18 · 2020: 21 · 2019: 33 · 2018: 20 · 2017: 19 · 2016: 25 · 2015: 20 · 2014: 18 · 2013: 22 · 2012: 17
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Biochemistry and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- polymer nanofibers, electrospinning, biodegradable biopolymers, nanofiber mats, extracellular matrix mimicry, cell attachment, surface functionalization, tissue engineering scaffolds, wound dressings, drug delivery, artificial organs, vascular grafts, multifunctional membranes, protective fabrics
- MeSH terms
- Biocompatible Materials, Biomedical Engineering, Biotechnology, Particle Size, Polymers, Drug Delivery Systems, Cell Culture Techniques, Tissue Engineering, Nanostructures
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