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Cited by 370Electrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsBone Tissue Engineering Materials

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Applications of Polymer Nanofibers in Biomedicine and Biotechnology

Venugopal, J., Ramakrishna, S.·2005·Applied Biochemistry and Biotechnology
DOI 10.1385/abab:125:3:147
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Abstract

Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and internal molecular structures. A wide range of biodegradable biopolymers can be electrospun into mats with specific fiber arrangement and structural integrity. Through secondary processing, the nanofiber surface can be functionalized to display specific biochemical characteristics. It is hypothesized that the large surface area of nanofibers with specific surface chemistry facilitates attachment of cells and control of their cellular functions. These features of nanofiber mats are morphologically and chemically similar to the extracellular matrix of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, effective mechanical properties, and specific biochemical properties. The current emphasis of research is on exploiting such properties and focusing on determining appropriate conditions for electrospinning various polymers and biopolymers for eventual applications including multifunctional membranes, biomedical structural elements (scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, vascular grafts), protective shields in specialty fabrics, and filter media for submicron particles in the separation industry. This has resulted in the recent applications for polymer nanofibers in the fie…

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Crossref · 10.1385/abab:125:3:147

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Metadata

Authors
Venugopal, J., & Ramakrishna, S.
Affiliations
National University of Singapore (SG)
Corresponding author
Venugopal, J.
ORCID
Venue
Applied Biochemistry and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2005
Volume
125
Issue
3
Pages
147-158
ISSN
0273-2289 (ISSN-L)
DOI
10.1385/abab:125:3:147
OpenAlex
W2028926100
Semantic Scholar
910237e5fc820a2842072c3c12d8a8ceafb189f4
Cited by
370
References
46
Citations by year
2026: 7 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 17 · 2021: 18 · 2020: 21 · 2019: 33 · 2018: 20 · 2017: 19 · 2016: 25 · 2015: 20 · 2014: 18 · 2013: 22 · 2012: 17
FWCI
7.69
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Biochemistry and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
polymer nanofibers, electrospinning, biodegradable biopolymers, nanofiber mats, extracellular matrix mimicry, cell attachment, surface functionalization, tissue engineering scaffolds, wound dressings, drug delivery, artificial organs, vascular grafts, multifunctional membranes, protective fabrics
MeSH terms
Biocompatible Materials, Biomedical Engineering, Biotechnology, Particle Size, Polymers, Drug Delivery Systems, Cell Culture Techniques, Tissue Engineering, Nanostructures

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