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Cited by 3Paraquat toxicity studies and treatmentsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Paraquat and Iron-Dependent Lipid Peroxidation : NADPH Versus NADPH-Generating Systems

Fernandez, Y., Anglade, F., Mitjavila, S.·2000·Biological Trace Element Research
DOI 10.1385/bter:74:3:191
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Abstract

The aim of this work was to study the effect of paraquat (P2+) on NADPH iron-dependent lipid peroxidation (basal peroxidation) either in the presence of NADPH or in the presence of NADPH-generating systems. When NADPH is present, P2+ potentiates NADPH iron-dependent lipid peroxidation, but use of NADPH-generating systems cancels this effect. This may be attributed to certain components in NADPH-generating systems such as glucose-6-phosphate and sodium isocitrate, which act as iron chelators. The binding of iron by these molecules facilitates its reduction and enhances its reactivity toward dioxygen molecules, leading to the formation of reactive species capable of initiating lipid peroxidation, such as Fe3+-O2-*. Under these conditions of rapid basal peroxidation, any additional reduction of iron(III) by a reduced form of P2+ (P+*) has no apparent effect on the peroxidation itself, probably because the initial reaction between iron(II) and O2 followed by initiation of the peroxidation are both rate-limiting steps in the process. Consequently, any alteration of the composition of the reacting mixture (e.g., buffers or the generating system) must be taken into consideration because the formation of new iron chelates can change the rate of basal peroxidation and will modify the effect of redoxcycling molecules.

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Metadata

Authors
Fernandez, Y., Anglade, F., & Mitjavila, S.
Affiliations
  • Institut National de la Recherche Agronomique (FR)
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2000
Volume
74
Issue
3
Pages
191-202
ISSN
0163-4984 (ISSN-L)
DOI
10.1385/bter:74:3:191
OpenAlex
W2048973558
Cited by
3
References
23
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
paraquat, iron-dependent lipid peroxidation, NADPH, NADPH-generating system, iron chelation, glucose-6-phosphate, iron reduction, reactive oxygen species, redox cycling, oxidative stress
MeSH terms
Animals, Herbicides, Iron, Kinetics, Male, Microsomes, Liver, NADP, Oxidation-Reduction, Oxygen, Oxygen Consumption, Paraquat, Time Factors, Lipid Peroxidation, Rats, Wistar, Rats

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CoChat. (2026). Citation check: Paraquat and Iron-Dependent Lipid Peroxidation : NADPH Versus NADPH-Generating Systems. https://app.cochat.ai/papers/10.1385/bter:74:3:191
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Fernandez, Y., Anglade, F., & Mitjavila, S. (2000). Paraquat and Iron-Dependent Lipid Peroxidation : NADPH Versus NADPH-Generating Systems. Biological Trace Element Research. https://doi.org/10.1385/bter%3A74%3A3%3A191