Cited by 324Inflammatory Bowel DiseaseCytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Involvement of IL–6 in the pathogenesis of inflammatory bowel disease and colon cancer

Atreya, Raja, Neurath, Markus F.·2005·Clinical Reviews in Allergy & Immunology

Open this paper in CoChat — free account

Abstract

Inflammatory bowel disease (IBD), which consists of Crohn's disease and ulcerative colitis, is defined as a chronic inflammation of the gastrointestinal tract. The etiopathogenetic mechanisms underlying the development of IBD are still not completely understood, and the therapeutic strategies used thus far have been limited to mostly evidence-based principles. There is growing evidence that the pro-inflammatory cytokine interleukin (IL)-6 plays a crucial part in the uncontrolled intestinal inflammatory process, which is a main characteristic of IBD. There is elevated production of IL-6 and its soluble receptor (sIL-6R) by intestinal macrophages and CD4+T-cells. The increased formation of IL-6-sIL-6R complexes that interact with gp130 on the membrane of CD4+T-cells (trans-signaling) lead to an increased expression and nuclear translocation of STAT3, which causes the induction of anti-apoptotic genes, such as Bcl-xl. This leads to an augmented resistance of lamina propria T-cells to apoptosis. The ensuing T-cell expansion contributes to the perpetuation of chronic intestinal inflammation. This understanding concerning the predominant pathogenic role of an IL-6-dependent inflammatory cascade may lead to the development of new therapeutic strategies in the treatment of this disease. Recent studies have also suggested a potential role of IL-6-sIL-6R in the pathogenesis of colon cancer and, therefore, imply a possible novel therapeutic strategy targeting the sIL-6R and ensuing IL-6 trans-signaling.

Integrity signals

Registry

Crossref · 10.1385/criai:28:3:187

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
Eaden, J., Abrams, K. R., & Mayberry, J. F. (2001) · Gut · doi:10.1136/gut.48.4.526 · Cited by 2,948
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059
Ulcerative Colitis and Colorectal Cancer
Ekbom, A., Helmick, C. G., Zack, M. M., & Adami, H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231802 · Cited by 1,794
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Antibodies to interleukin 12 abrogate established experimental colitis in mice.
Neurath, M., Fuss, I. J., Kelsall, B. L., Stuber, E. R., & Strober, W. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1281 · Cited by 1,334
Self-citation
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., et al. (2000) · Nature Medicine · doi:10.1038/75068 · Cited by 1,293
Self-citation
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
Fuss, I. J., Neurath, M. F., Boirivant, M., Klein, J. S., de la Motte, C., Strong, S. A., Fiocchi, C., & Strober, W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1261 · Cited by 1,227
Self-citation
Inflammatory Bowel Disease
Podolsky, D. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251306 · Cited by 1,226

Flagged first, then by citations

Show all 57 references

Sorted by citations

Items 201–300 of 324

Bringing to Light the Risk of Colorectal Cancer in Inflammatory Bowel Disease: Mucosal Glycosylation as a Key Player
Leite-Gomes, E., Dias, A. M., Azevedo, C. M., Santos‐Pereira, B., Magalhães, M., Garrido, M., Amorim, R., Lago, P. M., Marcos‐Pinto, R., & Pinho, S. S. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab291 · Cited by 13
Targeted regulation of a lymphocyte-endothelial-interleukin-6 axis by thermal stress
Evans, S. S., Fisher, D. T., Skitzki, J. J., & Chen, Q. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730701772498 · Cited by 14
Cytokines and Chemokines inMycobacterium tuberculosisInfection
Domingo-Gonzalez, R., Prince, O. A., Cooper, A. M., & Khader, S. A. (2017) · ASM Press eBooks · doi:10.1128/9781555819569.ch2 · Cited by 15
A novel gut-restricted RIPK1 inhibitor, SZ-15, ameliorates DSS-induced ulcerative colitis
Zeng, Y., Peng, J., Gao, X., Tian, D., Zhan, W., Liu, J., Hu, X., Sheng, H., Tian, S.-T., Qiu, L., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175381 · Cited by 16
Grape Processing Waste: Effects on Inflammatory Bowel Disease and Colorectal Cancer
Laurindo, L. F., Direito, R., Otoboni, A. M. M. B., Goulart, R. A., Quesada, K. R., & Barbalho, S. M. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2168281 · Cited by 13
How the Western Diet Thwarts the Epigenetic Efforts of Gut Microbes in Ulcerative Colitis and Its Association with Colorectal Cancer
Majumder, A., & Bano, S. (2024) · Biomolecules · doi:10.3390/biom14060633 · Cited by 13
Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production
Wang, X., Li, D., Meng, Z., Kim, K., & Oh, S. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2109.09054 · Cited by 13
Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice
Duan, M., Zhang, W., Yang, Y., Su, X., Xu, D.-Y., Yan, Y.-L., & Gao, Q. (2016) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.195552 · Cited by 13
Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells
Pereira, J., Bessa, C., Matos, P., & Jordan, P. (2022) · Cancers · doi:10.3390/cancers14061393 · Cited by 12
Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation
Baral, R., Bose, A., Ray, C., Paul, S., Pal, S., Haque, E., Mishra, B., Pal, D., Nagpal, J. K., Panda, C. K., et al. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.03.002 · Cited by 12
Synthesis and evaluation of 6-heteroarylamino-2,4,5-trimethylpyridin-3-ols as inhibitors of TNF-α-induced cell adhesion and inflammatory bowel disease
Park, S. W., Banskota, S., Gurung, P., Jin, Y. J., Kang, H.-E., Chaudhary, C. L., Lee, S. Y., Jeong, B., Kim, J., & Nam, T. (2018) · MedChemComm · doi:10.1039/c8md00156a · Cited by 12
Insights into the molecular mechanisms and therapeutic implications of interleukin-6 for inflammatory bowel disease
Tie, Y., Chen, M., & Zhang, S. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002792 · Cited by 12
Baricitinib relieves DSS-induced ulcerative colitis in mice by suppressing the NF-κB and JAK2/STAT3 signalling pathways
Wu, Q., Liu, Y., Liang, J., Dai, A., Du, B., Xi, X., Jin, L., & Guo, Y. (2024) · Inflammopharmacology · doi:10.1007/s10787-023-01396-6 · Cited by 11
S/O/W Emulsion with CAPE Ameliorates DSS-Induced Colitis by Regulating NF-κB Pathway, Gut Microbiota and Fecal Metabolome in C57BL/6 Mice
Wei, X., Dai, J., Liu, R., Wan, G., Gu, S., Du, Y., Yang, X., Wang, L., Huang, Y., Chen, P., et al. (2024) · Nutrients · doi:10.3390/nu16081145 · Cited by 11
Influence ofSlc11a1(formerlyNramp1) on DSS-induced colitis in mice
Jiang, H., Gilchrist, D. S., Popoff, J.-F., Jamieson, S. E., Truscott, M., White, J. K., & Blackwell, J. M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0708397 · Cited by 11
Dysregulation of IL6/IL6R-STAT3-SOCS3 signaling pathway in IBD-associated colorectal dysplastic lesions as compared to sporadic colorectal adenomas in non-IBD patients
Gui, X. S., Iacucci, M., & Ghosh, S. K. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153211 · Cited by 12
Therapeutic potential of Capparis spinosa in experimental model of acute acetic acid-induced colitis: Anti-inflammatory and antioxidant effects
HosseiniRavesh, F., Ghalibaf, A. M., Askari, V. R., Fayedeh, F., Rahimi, V. B., Etemad, L., & Taherzadeh, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32836 · Cited by 10
Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis
Li, F., Zou, Y.-Y., & Li, X. (2010) · The Surgeon · doi:10.1016/j.surge.2010.03.003 · Cited by 10
Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK1 and NK2 tachykinin receptors
Dai, L., Perera, D. S., Burcher, E., & Liu, L. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102061 · Cited by 10
Anti-inflammatory Activities of Taxifolin from Opuntia humifusa in Lipopolysaccharide Stimulated RAW 264.7 Murine Macrophages
Kim, J.-Y., Lee, Y., An, H.-J., Lee, J.-D., & Yi, Y. (2015) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2015.038 · Cited by 10
Contribution of Interleukin‐6/gp130 Signaling in Hepatocytes to the Inflammatory Response in Mice Infected with Streptococcus pyogenes
Klein, C., Medina, E., Sander, L., Dierssen, U., Roskams, T., Mueller, W., Trautwein, C., & Goldmann, O. (2007) · The Journal of Infectious Diseases · doi:10.1086/520090 · Cited by 11
Simultaneous Treatment of 5-Aminosalicylic Acid and Treadmill Exercise More Effectively Improves Ulcerative Colitis in Mice
Jin, J., Ko, I., Hwang, L., Kim, S., Jee, Y., Jeon, H., Park, S. B., & Jeon, J. W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105076 · Cited by 9
Circulating IL6 is involved in the infiltration of M2 macrophages and CD8+ T cells
Huang, J., Xiao, R., Shi, S., Li, Q., Li, M., Xiao, M., Wang, Y., Yang, Y., Li, W., & Tang, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-92817-9 · Cited by 9
Nutrition and the gut microbiome: a symbiotic dialogue influencing health and disease
Ray, S., & Shankaran, P. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1761992 · Cited by 12
Anti-Colitic Effect of an Exopolysaccharide Fraction from Pediococcus pentosaceus KFT-18 on Dextran Sulfate Sodium-Induced Colitis through Suppression of Inflammatory Mediators
Lee, J., Chung, K., Shin, J., Jung, S.-H., Lee, S., Lee, M.-K., Hong, H., Rhee, Y. K., & Lee, K. (2022) · Polymers · doi:10.3390/polym14173594 · Cited by 9
IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation
Gong, H., Ma, S., Liu, S., Liu, Y., Jin, Z., Zhu, Y., Song, Y., Lei, L., Hu, B., Mei, Y., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02724 · Cited by 9
Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach
Arunachalam, K., Damazo, A. S., Macho, A., Matchado, M. S., Pavan, E., Figueiredo, F. D. F., Oliveira, D. M., Duckworth, C. A., Thangaraj, P., Leonti, M., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114490 · Cited by 9
mRNA expression of adipocytokines and glucocorticoid-related genes are associated with downregulation of E-cadherin mRNA in colorectal adenocarcinomas
Størkson, R. H., Aamodt, R., Vetvik, K. K., Pietiläinen, K. H., Bukholm, G., Jónsdóttir, K., Vollan, H. S., Sonerud, T., Lüders, T., Jacobsen, M., et al. (2012) · International Journal of Colorectal Disease · doi:10.1007/s00384-012-1442-6 · Cited by 10
GLP-1 and IL-6 regulates obesity in the gut and brain
Yang, K., Wu, Y., He, Y., Dai, J.-X., Luo, Y.-L., Xie, J.-H., & Ding, W. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123339 · Cited by 8
Meprin β expression modulates the interleukin‐6 mediated JAK2‐STAT3 signaling pathway in ischemia/reperfusion‐induced kidney injury
Abousaad, S., Ahmed, F., Abouzeid, A., & Ongeri, E. M. (2022) · Physiological Reports · doi:10.14814/phy2.15468 · Cited by 7
The emerging role of hypoxia and environmental factors in inflammatory bowel disease
Villareal, L., & Xue, X. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae004 · Cited by 9
Anti-Osteoporotic Effects of n-trans-Hibiscusamide and Its Derivative Alleviate Ovariectomy-Induced Bone Loss in Mice by Regulating RANKL-Induced Signaling
Lim, H. J., Park, E.-J., Won, Y., Bak, S. G., Cheong, S. H., Lee, S. W., Lee, S. W., Lee, S., & Rho, M. (2021) · Molecules · doi:10.3390/molecules26226820 · Cited by 8
Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on Oncostatin M signaling
Guihard, P. J., Danger, Y., Royer, B. B.-L., David, E., Brion, R., Delécrin, J., Richards, C., Chevalier, S., Rédiní, F., Heymann, D., et al. (2012) · Bone · doi:10.1016/j.bone.2012.02.242 · Cited by 8
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice
Liong, S., Miles, M. A., Mohsenipour, M., Liong, F., Hill‐Yardin, E. L., & Selemidis, S. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00062.2023 · Cited by 7
Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Kim, S. Y., Park, M.-J., Kwon, J.-E., Choi, S., Seo, H.-B., Jung, K. A., Choi, J., Baek, J.-A., Lee, H. H., Lee, B., et al. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.11.001 · Cited by 7
Assessment of Dietary Adequacy and Quality in a Sample of Patients with Crohn’s Disease
Karachaliou, A., Yannakoulia, M., Bletsa, M., Mantzaris, G. J., Archavlis, E. J., Karampekos, G., Tzouvala, M., Bamias, G., Kokkotis, G., & Kontogianni, M. D. (2022) · Nutrients · doi:10.3390/nu14245254 · Cited by 7
Association between Inflammatory Bowel Disease and Subsequent Development of Restless Legs Syndrome and Parkinson’s Disease: A Retrospective Cohort Study of 35,988 Primary Care Patients in Germany
Loosen, S. H., Yaqubi, K., May, P., Konrad, M., Gollop, C., Luedde, T., Kostev, K., & Roderburg, C. (2023) · Life · doi:10.3390/life13040897 · Cited by 7
The tale of antibiotics beyond antimicrobials: Expanding horizons
Yadav, S., Shah, D., Dalai, P., & Agrawal-Rajput, R. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156285 · Cited by 8
Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer
Park, K., Kim, K.-Y., Oh, T. W., Kang, D., Kim, E., Yang, Y. R., Seo, Y., Yeul, J., & Suh, P. (2017) · Oncotarget · doi:10.18632/oncotarget.23430 · Cited by 7
Cytokines and Nitric Oxide in Immunopathogenesis of IBD and Potential Therapeutic Approaches
Soufli, I., Toumi, R., Rafa, H., & Touil–Boukoffa, C. (2016) · InTech eBooks · doi:10.5772/65001 · Cited by 7
Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata
Cho, J., Kweon, H.-S., Huh, S., & Sadra, A. (2018) · Animal Cells and Systems · doi:10.1080/19768354.2018.1476409 · Cited by 7
Associations between Interleukin-6 Genetic Polymorphisms and Levels of Autoantibodies to 60-kDa Heat-Shock Proteins
Kiszel, P., Füst, G., Pessi, T., Hurme, M., & Prohászka, Z. (2006) · Human Heredity · doi:10.1159/000096095 · Cited by 7
Neuroprotective gene profile in the brain of magnesium-deficient mice
German-Fattal, M., Lecerf, F., Sabbagh, F., Maurois, P., Durlach, J., & Bac, P. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.007 · Cited by 7
Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice
Collier, C. A., Foncerrada, S., Clevenger, A. J., Shetty, A. K., & Raghavan, S. A. (2023) · Advanced Biology · doi:10.1002/adbi.202200254 · Cited by 5
Bacteria-assisted metal antitumor immunotherapy
Guo, J., Liang, J., Chen, Z., Pan, Y., He, Y., & Chao, H. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216938 · Cited by 6
Novel plant-derived compounds modulate gut microbiome dysbiosis in colitis mice: A potential therapeutic avenue for inflammatory bowel disease
Rahaman, M. M., Yeshi, K., Bappi, M. H., Islam, Z., Wangchuk, P., & Sarker, S. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128343 · Cited by 6
Understanding the mechanism of ulcerative colitis-induced colorectal cancer and revealing the potential of Dillenia Indica in its management
Paul, S., Hmar, E. B. L., & Sharma, H. K. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100161 · Cited by 6
The association between diarrhea and serum cytokines in patients with gynecologic cancer treated with surgery and pelvic chemoradiotherapy
Eom, K., Wee, C. W., Song, C., Kim, I. A., Js, K., Kim, K., Suh, D. H., No, J. H., Kim, Y. B., & Park, J. S. (2021) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2021.05.010 · Cited by 6
Exogenous carcinoembryonic antigen-related cell adhesion molecule 1 suppresses 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in mice
Yu, J. H., Lin, L., Lin, Y., & Zheng, C. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.01.025 · Cited by 6
Association of atrial fibrillation with outcomes in patients hospitalized with inflammatory bowel disease: an analysis of the National Inpatient Sample
Rahman, E. U., Gayam, V. B. R., Garlapati, P. R., Patel, N., Farah, F., Elhamdani, A., Khan, A., Okhumale, P. I., Aronow, W. S., & El-Hamdani, M. O. (2021) · Archives of Medical Science - Atherosclerotic Diseases · doi:10.5114/amsad.2021.105256 · Cited by 6
Local Immune Changes in Early Stages of Inflammation and Carcinogenesis Correlate with the Collagen Scaffold Changes of the Colon Mucosa
Čaja, F., Stakheev, D., Chernyavskiy, O., Kubínová, L., Křižan, J., Dvořák, J., Rossmann, P., Štëpánková, R., Makovický, P., Makovický, P., et al. (2021) · Cancers · doi:10.3390/cancers13102463 · Cited by 6
Cytokines and Inflammatory Bowel Disease
de Zoeten, E. F., & Fuss, I. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5061-0_3 · Cited by 6
[The role of IL-6/sIL-6R complex and its natural inhibitor sgp130 in modulation of inflammatory process].
Augustyniak, D., Majkowska-Skrobek, G., Basiewicz-Worsztynowicz, B., & Jankowski, A. (2006) · PubMed · Cited by 6
The importance of growth differentiation factor 15 and interleukin 6 serum levels in inflammatory bowel diseases
Koureta, E., Karatzas, P. S., Kanellopoulos, P. N., Papapanagiotou, A., Lekakis, V., Bamias, G., Karamanolis, G. P., Vlachogiannakos, J., Papavassiliou, A. G., & Papatheodoridis, G. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01057-4 · Cited by 5
Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives
Naganuma, M., Takeno, M., Çelık, A. F., Moots, R. J., Pinton, P., & Hisamatsu, T. (2025) · Biomedicines · doi:10.3390/biomedicines13010247 · Cited by 6
Meprin β activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury
Abousaad, S., Ahmed, F., Abouzeid, A., Adhiambo, C., & Ongeri, E. M. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04224-x · Cited by 5
Modulation of gut microbiota and its metabolite Equol by Huaier granule suppresses hepatocellular carcinoma via the gut-liver axis
Wei, X., Huang, H., Wang, F., Tan, P., Wang, Z., Qiu, X., Zhang, R., Gao, Y., Tu, P., & Hu, Z. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00919-7 · Cited by 5
Influence of food emulsifiers on cellular function and inflammation, a preliminary study
Dufrusine, B., Lisio, C. D., Maurizio, A., Sallese, M., Laurenzi, V. D., & Dainese, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1197686 · Cited by 5
Phytochemical composition and safety of Vernonia Amygdalina ethanolic extract with anti-colon cancer properties
Hasibuan, P. A. Z., Syahputra, R. A., Hey‐Hawkins, E., Lubis, M. F., Rohani, A. S., & Palevi, S. A. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101205 · Cited by 5
Retocolite ulcerativa e citocinas: uma revisão da literatura
Cavalcante, R. M. S., de Moura, M. S. B., Bráz, D. C., & Nogueira, N. D. N. (2020) · Research Society and Development · doi:10.33448/rsd-v9i9.7145 · Cited by 4
Dietary Supplementation of Haskap Berry (Lonicera caerulea L.) Anthocyanins and Probiotics Attenuate Dextran Sulfate Sodium-Induced Colitis: Evidence from an Experimental Animal Model
Dharmawansa, K. V. S., Stadnyk, A. W., & Rupasinghe, H. P. V. (2024) · Foods · doi:10.3390/foods13131987 · Cited by 4
MLIF inhibits inflammation and maintains intestinal flora homeostasis in a dextran sulfate sodium (DSS)-induced colitis mouse model
Ma, Y., Jing, J., Gao, Y., Yu, Y., Mao, J., Zhang, Y., & Li, T. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115545 · Cited by 4
Histopathology Analysis of Benign Colorectal Diseases and Colorectal Cancer in Hatyai Hospital, Songkhla, Thailand
Kotepui, M., Piwkham, D., Songsri, A., & Charoenkijkajorn, L. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.4.2667 · Cited by 5
Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway
Kim, G.-B., Seo, K., Youn, J.-U., Kwon, I. K., Park, J., Park, K., & Kim, J. (2023) · Molecules · doi:10.3390/molecules28083554 · Cited by 4
Woodfordia fruticosa fermented with lactic acid bacteria impact on foodborne pathogens adhesion and cytokine production in HT-29 cells
Lee, E., & Lee, K. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1346909 · Cited by 4
Novel Dietary Proteins Selectively Affect Intestinal Health In Vitro after Clostridium difficile-Secreted Toxin A Exposure
Jochems, P. G. M., Garssen, J., Rietveld, P. C. S., Govers, C., Tomassen, M. M. M., Wichers, H. J., van Bergenhenegouwen, J., & Masereeuw, R. (2020) · Nutrients · doi:10.3390/nu12092782 · Cited by 4
Expresión del gen de IL-6 y TNF-a en la mucosa rectal de pacientes con colitis ulcerosa crónica idiopática y controles
Fonseca-Camarillo, G., Villeda-Ramírez, M. A., Sánchez‐Muñoz, F., Barreto‐Zúñiga, R., Domínguez‐López, A., Uribe, M., & Yamamoto-Furusho, J. K. (2009) · Revista Portuguesa de Pneumologia · Cited by 4
Experiment-based Computational Model Predicts that IL-6 Trans-Signaling Plays a Dominant Role in IL-6 mediated signaling in Endothelial CellsPreprint
Song, M., Wang, Y., Annex, B. H., & Popel, A. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.03.526721 · Cited by 4
New insights into Th9 cells in inflammatory bowel diseases
Neurath, M. F. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.102013 · Cited by 3
Self-citation
Bifidobacterium breve B2798 and Its Heat-Killed Cells Alleviate Inflammation in Rats with DSS Model by Modulating Gut Microbiota
Feng, C., Zhao, Y., He, Q., Yu, J., & Sun, Z. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10648-6 · Cited by 3
Expression of IL-6 and TNF-α in benign prostatic hyperplasia combined with histological inflammation
Wang, L., Liu, Z., Yang, L., Zhao, H., Yue, C., Li, J., & Han, L. (2016) · Discussion of Clinical Cases · doi:10.14725/dcc.v3n1p11 · Cited by 3
IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease
Gonçalves, B. P., Flauzino, T., Inoue, C. J., de Paula, J. C. C., Galvão, T. C., de Alcantara, C. C., Miyazaki, P. K., Rosa, L., Westmore, S., Lozovoy, M. A. B., et al. (2020) · International Journal of Colorectal Disease · doi:10.1007/s00384-020-03743-3 · Cited by 3
Allogeneic activation is attenuated in a model of mouse lung perfused with magnesium-deficient blood
Sabbagh, F., Lecerf, F., Maurois, P., Bac, P., & German-Fattal, M. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.09.002 · Cited by 3
Dendritic cell-based immunotherapy: A promising approach for treatment of cancer
Murugaiyan, G., Basak, S. K., & Saha, B. (2005) · Cited by 3
A human microbiome-derived therapeutic for ulcerative colitis promotes mucosal healing and immune homeostasisPreprint
Cuív, P. Ó., Ljungberg, J. K., Zhou, J., Nissen, M. D., Krueger, A., Boyd, J. A., Bongers, M., Jeimy, J. L., Vivian, C., Reich, E., et al. (2025) · medRxiv · doi:10.1101/2025.04.18.25325957 · Cited by 3
Signaling pathways and molecular mechanisms of lupeol in colorectal cancer: A comprehensive review
Farooqi, M. A., & Sahu, K. K. (2026) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2025.101270 · Cited by 3
Xiaoyao-Qingluoyin Cure Adjuvant-Induced Arthritis by Easing LPS Response-Related Pathway-Mediated Immune Abnormality
Li, D., Xie, C.-Q., Wu, Y., Shi, C., Ji, C.-F., Hu, Y., Liao, Q., & Li, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8536998 · Cited by 2
Enterolignans Improve the Expression of Iron-Related Genes in a Cellular Model of Inflammatory Bowel Disease
Bonuccelli, O., Gogna, A., Mitola, S. M. F., Abate, G., Ferrari, F., Bertagna, F., Francesco, M. A. D., Monti, E., Bresciani, R., & Biasiotto, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211153 · Cited by 2
Cytokines and Inflammatory Bowel Disease
de Zoeten, E. F., & Fuss, I. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-49215-5_3 · Cited by 2
Beyond Olive Oil: Active Components and Health Aspects of Some Less Studied Mediterranean Plant Products
Kalogeropoulos, N., Chiou, A., Kaliora, A., Karathanos, V., & Andrikopoulos, N. (2012) · ACS symposium series · doi:10.1021/bk-2012-1093.ch013 · Cited by 1
Class Ib MHC–Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine
Dasgupta, S., Maricic, I., Tang, J., Wandro, S., Weldon, K. C., Carpenter, C. S., Eckmann, L., Rivera–Nieves, J., Sandborn, W. J., Knight, R. D., et al. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100090 · Cited by 2
Early alpha-synuclein accumulation, oxidative stress and inflammation in the proximal colon of c-rel-/- mouse model of Parkinson's disease
Parrella, E., Gennari, M. M., Abate, G., Pucci, M., Schioppa, T., Bosisio, D., Tirelli, E., Benarese, M., Vegezzi, G., Silletti, M., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107182 · Cited by 2
Rhamnogalacturonan rich fractions isolated from Saururus chinensis alleviate ulcerative colitis via regulation of MAPK/NF-κB pathway and tight junction
Kim, T. E., Son, S., Rho, Y., & Shin, K. (2026) · Nutrition Research and Practice · doi:10.4162/nrp.2026.20.2.182 · Cited by 1
Clinical, Biological, and Laboratory Parameters as Predictors of Severity of Clinical Outcome and Response to Anti–TNF–Alpha Treatment in Ulcerative Colitis
Olsen, T., & Florholme, J. (2011) · InTech eBooks · doi:10.5772/28096 · Cited by 1
Rs531564 polymorphism in microRNA‐214 regulates interleukin‐6R expression in anal fissure patients to affect the risk of anal abscess formation
Liu, J., Li, C., Yin, P., Guo, X., & Liu, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28970 · Cited by 1
A Comparative Study on the Ameliorative Effects of Aqueous Extract of Two Varieties of Hibiscus on the Intestinal Epithelial Barrier in Bowel Inflammation
Ahmed, R. A., & Sheir, M. A. (2021) · Egyptian Academic Journal of Biological Sciences. B, Zoology · doi:10.21608/eajbsz.2021.173200 · Cited by 1
Cytokines and Inflammatory Bowel Disease
de Zoeten, E. F., & Fuss, I. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-73481-1_3 · Cited by 1
Alleviating Gut Inflammation with Latilactobacillus curvatus Isolated from Kimchi
Kim, S., Wang, X., & Oh, S. (2021) · Trends in Agriculture & Life Sciences · doi:10.29335/tals.2021.59.29 · Cited by 1
A Network Pharmacology Study of the Active Components of Fufang Huangbai Ye for the Treatment of Ulcerative Colitis
Ke, J., Yang, J., Jiang, X.-L., & Wang, L. (2023) · ChemistrySelect · doi:10.1002/slct.202303868 · Cited by 1
Mathematical Approach in Colitis-Related Colon Cancer Genomics
Iqbal, P., Khaliq, R., & Sheergojri, A. R. (2021) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-3580-6.ch008 · Cited by 1
Detection of the Inflammatory Bowel Diseases via Machine Learning Methods
Kim, E., Kouznetsova, V. L., & Tsigelny, I. F. (2021) · Lecture notes in networks and systems · doi:10.1007/978-3-030-82199-9_42 · Cited by 1
IL6 (interleukin 6 (interferon beta 2))
MacLeod, R., & Nagel, S. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/38448 · Cited by 1
Role of NLRP3 in colitis and colitis associated colorectal cancer
Perera, A. P. (2019) · UTAS Research Repository · doi:10.25959/100.00034330 · Cited by 1
Development of a dual flow microfluidic device for the study of barrier systems
Baldwin, L. (2020) · Repository@Hull (Worktribe) (University of Hull) · Cited by 1
The Macrophage Migration Inhibitory Factor Homolog of Entamoeba histolytica Binds to
Moonah, S. N., Abhyankar, M. M., Haque, R., Petri, W. A., & Bangladesh, D. (2014)
Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
Manning, J. (2014) · Cork Open Research Archive (University College Cork, Ireland)
Thymic involution perturbs negative selection and leads to chronic inflammation
Coder, B. (2015) · Digital Commons @ UNT Health Science Center
Bone Marrow Dendritic Cells Tumor Exosomes Inhibit Differentiation of
Zhang, H., Kimberly, R. P., Grizzle, W. E., Falkson, C. I., Liu, Y., Zhang, L., Li, C., Cong, Y., Yu, S., Liu, C., et al. (2013)
Investigation of ADAM17 and ADAMTS-1, -4 and -5 in liver carcinoma.
Turner, S. (2009) · SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University)
Novel Therapeutic Approaches for Inflammatory Bowel disease
Fiteih, Y. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r34h4s

Authors: Atreya, R., & Neurath, M. F.
Affiliations: Johannes Gutenberg University Mainz (DE)
Corresponding author: Neurath, Markus F.
ORCID: Atreya, Raja
Neurath, Markus F.
Venue: Clinical Reviews in Allergy & Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005
Volume: 28
Issue: 3
Pages: 187-196
ISSN: 1080-0549 (ISSN-L)
DOI: 10.1385/criai:28:3:187
OpenAlex: W2024255214
Cited by: 324
References: 57
Citations by year: 2026: 11 · 2025: 16 · 2024: 21 · 2023: 23 · 2022: 22 · 2021: 25 · 2020: 22 · 2019: 9 · 2018: 17 · 2017: 13 · 2016: 20 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 12
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Locations: Clinical Reviews in Allergy & Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: interleukin-6, inflammatory bowel disease, Crohn's disease, ulcerative colitis, colon cancer, soluble IL-6 receptor, IL-6 trans-signaling, gp130, STAT3, Bcl-xL, T cell apoptosis, intestinal inflammation, CD4+ T cells, macrophages, anti-apoptotic genes
MeSH terms: Animals, Humans, Colorectal Neoplasms, Inflammatory Bowel Diseases, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Involvement of IL–6 in the pathogenesis of inflammatory bowel disease and colon cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks