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Cited by 67Adrenal Hormones and DisordersStress Responses and CortisolAdrenal and Paraganglionic Tumors

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Cortical-chromaffin cell interactions in the adrenal gland

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Schinner, Sven, Bornstein, Stefan R.·2005·Endocrine Pathology
DOI 10.1385/ep:16:2:091
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Abstract

Adrenal catecholamines and steroids are important regulators of the stress response, immune function, blood pressure, and energy homeostasis. Historically, the two cell populations within the adrenal gland—the steroid-producing adrenocortical cells and the catecholamine-producing chromaffin cells—have been regarded as two independent endocrine systems. Research on adrenal physiology and pathophysiology has therefore largely focused on the individual understanding of each cell type. However, adrenal cortex and medulla appear to be interwoven and show multiple contact zones without separation by connective tissue or interstitial membranes. In vitro studies, animal models, and the analysis of human adrenal pathophysiology have demonstrated critical importance of cortical-chromaffin crosstalk for adrenal function and disease. Thus, chromaffin cells regulate steroid-hormone release by the adrenal cortex and steroids induce catecholamine production in the medulla. Consequently, disorders of the adrenal cortex have been shown to affect chromaffin cell function and vice versa. Mouse models of adrenal cortical dysfunction, such as the targeted disruption of the 21-hydroxylase- or the CRHR1 genes, show alterations in chromaffin cell function, while disruption of tyrosine hydroxylase, a key enzyme in catecholamine synthesis, impairs adrenal cortical function. Accordingly, patients with congenital adrenal hyperplasia (CAH) and Addison’s disease show reduced catecholamine biosynthesis. Im…

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  • Normal development of the adrenal medulla depends on exposure to cortisol produced from the adrenal cortex, with crosstalk between cortical and medullary cells.

    “Normal development of the medulla, the major site of production of epinephrine, depends on exposure to cortisol produced from the cortex, with important crosstalk occurring between cells of the cortex and medulla (5,6).”

    From Decreased adrenomedullary function in infants with classical congenital adrenal hyperplasia. (2014) · cites this paper as [6]

  • A normal adrenal cortex is necessary for adrenomedullary development and function in the fetus.

    “A normal adrenal cortex is necessary for adrenomedullary development and function in the fetus (5-8), and although older patients with CAH have an adrenal medulla that is morphologically and functionally abnormal (2, 9, 10), it is not known when this adrenomedullary disruption begins.”

    From Decreased adrenomedullary function in infants with classical congenital adrenal hyperplasia. (2014) · cites this paper as [6]

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Metadata

Authors
Schinner, S., & Bornstein, S. R.
Affiliations
  • Düsseldorf University Hospital (DE)
  • Technische Universität Dresden (DE)
Corresponding author
Bornstein, Stefan R.
ORCID
Bornstein, Stefan R.
Venue
Endocrine Pathology
Publisher
Springer Science and Business Media LLC
Published
2005
Volume
16
Issue
2
Pages
091-098
ISSN
1046-3976 (ISSN-L)
DOI
10.1385/ep:16:2:091
OpenAlex
W2080362739
Cited by
67
References
46
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 2
FWCI
2.69
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Endocrine Pathology (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion, cc-by)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Keywords
adrenal cortex, adrenal medulla, chromaffin cells, adrenocortical cells, catecholamine synthesis, steroidogenesis, congenital adrenal hyperplasia, Addison's disease, 21-hydroxylase, CRHR1, tyrosine hydroxylase
MeSH terms
Adrenal Cortex, Adrenal Gland Diseases, Adrenal Medulla, Animals, Cell Communication, Humans, Chromaffin Cells, Receptor Cross-Talk

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