Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,184

Cloned Glutamate Receptors

Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541

Structure and Regulation of Voltage-Gated Ca 2+ Channels

Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,916

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

Olney, J. (1969) · Science · doi:10.1126/science.164.3880.719 · Cited by 1,885

Ionic dependence of glutamate neurotoxicity

Choi, D. W. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00369.1987 · Cited by 1,854

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,849

Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.

Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753

Hypoxia-Induced Activation ofN-methyl-D-aspartate Receptors Causes Retinal Ganglion Cell Death in the Neonatal Retina

Kaur, C., Viswanathan, S., Foulds, W. S., Luu, C. D., & Ling, E. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31824deb21 · Cited by 21

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Li, W., Chen, Y., Huang, P. C., Barnstable, C. J., Zhang, C., Lu, J. N., & Zhang, S. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s55407 · Cited by 21

Bupivacaine Indirectly Potentiates Glutamate-induced Intracellular Calcium Signaling in Rat Hippocampal Neurons by Impairing Mitochondrial Function in Cocultured Astrocytes

Yuan, X., Zhang, N., Zhang, W., & Ren, L. (2017) · Anesthesiology · doi:10.1097/aln.0000000000002003 · Cited by 21

Astaxanthin protects against kainic acid-induced seizures and pathological consequences

Chang, Y., Lü, C.-W., Chen, Y. J., Lin, T., Huang, S.-K., & Wang, S. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.02.008 · Cited by 21

Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension

Domin, H., Przykaza, Ł., Koźniewska, E., Boguszewski, P. M., & Śmiałowska, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.006 · Cited by 21

Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line

Lee, S. R., Song, J. H., Song, J.-H., Ko, H., Baek, J. Y., Trinh, T. A., Beemelmanns, C., Yamabe, N., & Kim, K. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092640 · Cited by 21

Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity

Zhang, W., Bianchi, L. K., Lee, W.-H., Wang, Y., Israel, S., & Driscoll, M. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.114 · Cited by 21

Differential Modulation of GABAA and NMDA Receptors by an α7-nicotinic Acetylcholine Receptor Agonist in Chronic Glaucoma

Zhou, X., Zong, Y., Zhang, R., Zhang, X., Zhang, S., Wu, J., & Sun, X. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00422 · Cited by 21

NMDA Receptors and Huntington’s Disease

Fernandes, H. B., & Raymond, L. A. (2008) · Frontiers in neuroscience · doi:10.1201/9781420044157.ch2 · Cited by 21

KDI tripeptide of γ1 laminin protects rat dopaminergic neurons from 6‐OHDA induced toxicity

Väänänen, A. J., Rauhala, P. V., Tuominen, R. K., & Liesi, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20961 · Cited by 21

Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockade

Canzoniero, L. M. T., Babcock, D., Gottron, F. J., Grabb, M. C., Manzerra, P., Snider, B. J., & Choi, D. W. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.10.013 · Cited by 21

Calcium Imaging in Neuron Cell Death

Calvo-Rodríguez, M., Villalobos, C., & Núñez, L. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2152-2_6 · Cited by 20

Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors

Li, Y., Yang, Q., Zhang, K., Guo, Y., Li, X., Yang, L., Zhao, M., & Wu, Y. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.09.009 · Cited by 20

KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion

Kinoshita, H., Maki, T., Yasuda, K., Kishida, N., Sasaoka, N., Takagi, Y., Kakizuka, A., & Takahashi, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-47993-w · Cited by 20

Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina

Centurião, F. B., Corte, C. L. D., Paixão, M. W., Braga, A. L., Zeni, G. R., Emanuelli, T., & da Rocha, J. B. T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.062 · Cited by 20

Glutamate signaling mediates C. elegans behavioral plasticity to pathogens

Yu, C., & Chang, H. C.-H. (2022) · iScience · doi:10.1016/j.isci.2022.103919 · Cited by 19

N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials

Sharma, R., Tikka, S. K., Bhute, A. R., & Bastia, B. K. (2022) · Addictive Behaviors · doi:10.1016/j.addbeh.2022.107283 · Cited by 19

Effective Components and Molecular Mechanism of Agarwood Essential Oil Inhalation and the Sedative and Hypnotic Effects Based on GC-MS-Qtof and Molecular Docking

Wang, C., Wang, Y., Gong, B., Wu, Y., Chen, X., Liu, Y., & Wei, J. (2022) · Molecules · doi:10.3390/molecules27113483 · Cited by 19

Spatiotemporal patterns of postsynaptic density (PSD)‐95 expression after rat spinal cord injury

Cheng, C., Gao, S., Zhao, J., Niu, S., Chen, M., Li, X., Qin, J., Shi, S., Guo, Z., & Shen, A. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00917.x · Cited by 19

SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3–JNK3 pathway following kainate stimulation

Zhu, Q., Xu, Y., Du, C., & Hou, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.048 · Cited by 19

Structural and functional alterations of cerebellum following fluid percussion injury in rats

Ai, J., Liu, E., Park, E., & BAKER, A. J. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0654-9 · Cited by 19

Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies

Prakāsh, C., Tyagi, J., Rabidas, S. S., Kumar, V., & Sharma, D. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08724-z · Cited by 20

Bilirubin enhances neuronal excitability by increasing glutamatergic transmission in the rat lateral superior olive

Li, C., Shi, H., Song, N., & Yin, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.010 · Cited by 19

Disruption of neuronal CXCR4 function by opioids: Preliminary evidence of Ferritin Heavy Chain as a potential etiological agent in neuroAIDS

Pitcher, J., Shimizu, S., Burbassi, S., & Meucci, O. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.006 · Cited by 18

PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

Binda, N. S., Carayon, C. P. P., Agostini, R. M., Pinheiro, A. C. D. N., Cordeiro, M. N., Romano‐Silva, M. A., da Silva, J. F., Pereira, E. M. R., Silva, C. D., de Castro, C. J., et al. (2016) · Toxins · doi:10.3390/toxins8030070 · Cited by 18

Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection

Yeh, C., Schulien, A. J., Molyneaux, B. J., & Aizenman, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176107 · Cited by 18

Transient Receptor Potential Channels of the Melastatin Family and Ischemic Responses of Central Neurons

MacDonald, J. F., & Jackson, M. F. (2007) · Stroke · doi:10.1161/01.str.0000251671.77351.e2 · Cited by 18

NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability

Liang, M., Yin, X., Wang, L., Yin, W.-H., Song, N., Shi, H., Li, C., & Yin, S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00021 · Cited by 18

Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10

Turovskaya, M. V., Зинченко, В. П., Babaev, A. A., Epifanova, E. A., Tarabykin, V. S., & Turovsky, E. A. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.07.019 · Cited by 18

In vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or -methyl--aspartate

Goñi‐Allo, B., RAMOS, M., Jordán, J., & Aguirre, N. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.010 · Cited by 18

Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis

Aharoni, R., Eilam, R., Lerner, S., Stein, E. S., Dori, A., Chapman, J., & Arnon, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413419 · Cited by 17

Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation

Lee, S.-E., Kim, J., Lim, C., & Cho, S. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00383-1 · Cited by 17

Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction

Rodríguez, J., Essig, D. J., Ma, S., Karer, N., Clemmensen, L. S., Pedersen, S. W., Joerger, A. C., Knapp, S., Østergaard, S., & Strømgaard, K. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01803 · Cited by 17

.BETA.-Citryl-L-glutamate Acts as an Iron Carrier to Activate Aconitase Activity

Hamada-Kanazawa, M., Narahara, M., Takano, M., Min, K. S., Tanaka, K., & Miyake, M. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1455 · Cited by 17

Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: Evidence favouring cell cycle re-activation in concert with oxidative stress

Chen, M. J., Ng, J. M. J., Peng, Z. F., Manikandan, J., Yap, Y. W., Llanos, R. M., Beart, P. M., & Cheung, N. S. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.015 · Cited by 17

Neuroprotective effects of a protein tyrosine phosphatase inhibitor against hippocampal excitotoxic injury

Kim, U. J., Lee, B. H., & Lee, K. H. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.027 · Cited by 17

Selective overexpression of γ1 laminin in astrocytes in amyotrophic lateral sclerosis indicates an involvement in ALS pathology

Wikstén, M., Väänänen, A. J., & Liesi, P. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21314 · Cited by 17

Increased tyrosine phosphorylation of α1C subunits of L-type voltage-gated calcium channels and interactions among Src/Fyn, PSD-95 and α1C in rat hippocampus after transient brain ischemia

Hou, X., Zhang, G., Yan, J.-Z., & Liu, Y. U. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02845-2 · Cited by 17

Differential expression patterns of mGluR1α in monkey nigral dopamine neurons

Kaneda, K., Imanishi, M., Nambu, A., Shigemoto, R., & Takada, M. (2003) · Neuroreport · doi:10.1097/00001756-200305230-00008 · Cited by 16

Defining the Kv2.1–syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

Yeh, C., Ye, Z., Moutal, A., Gaur, S., Henton, A., Kouvaros, S., Saloman, J. L., Hartnett, K. A., Tzounopoulos, T., Khanna, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903401116 · Cited by 16

Proteomics and Protein-Protein Interactions

Waksman, G. (2005) · Springer eBooks · doi:10.1007/b105866 · Cited by 16

Haloperidol Induces Calcium Ion Influx Via L-Type Calcium Channels in Hippocampal HN33 Cells and Renders the Neurons More Susceptible to Oxidative Stress

Kim, H. S., Yumkham, S., Choi, J. H., Kim, E., Kim, Y. S., Ryu, S. H., & Suh, P. (2006) · Molecules and Cells · doi:10.1016/s1016-8478(23)17390-0 · Cited by 16

Glutamate receptor and transporter modifications in rat organotypic hippocampal slice cultures exposed to oxygen–glucose deprivation: The contribution of cyclooxygenase-2

Llorente, I. L., Landucci, E., Pellegrini-Giampietro, D. E., & Fernández‐López, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.040 · Cited by 15

Protective effect of resveratrol against corticosterone-induced neurotoxicity in PC12 cells

Zhang, Y., He, Y., Deng, N., Chen, Y., Huang, J., & Xie, W. (2019) · Translational Neuroscience · doi:10.1515/tnsci-2019-0038 · Cited by 15

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

Liu, S., Lin, F. L., Wang, J., Pan, X., Sun, L., & Wu, W. (2022) · Molecules · doi:10.3390/molecules27134181 · Cited by 15

Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-d-aspartate receptor channels into mitochondria

Fukumori, R., Takarada, T., Nakamichi, N., Kambe, Y., Kawagoe, H., Nakazato, R., & Yoneda, Y. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.08.009 · Cited by 15

Kainic acid triggers oligodendrocyte precursor cell proliferation and neuronal differentiation from striatal neural stem cells

Redondo, C., López-Toledano, M. A., Lobo, M. V. T., Gonzalo‐Gobernado, R., Reimers, D., Herranz, A. S., Paı́no, C. L., & Bazán, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21245 · Cited by 15

Electroencephalographic analysis in soman‐exposed 21‐day‐old rats and the effects of midazolam or LY293558 with caramiphen

Furtado, M. D. A., Aroniadou‐Anderjaska, V., Figueiredo, T. H., Apland, J. P., & Braga, M. F. M. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14331 · Cited by 15

Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice

Shen, H., Chen, K., Marino, R. A. M., McDevitt, R. A., & Xi, Z. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173104 · Cited by 15

Riluzole is a Promising Pharmacological Inhibitor of Bilirubin‐Induced Excitotoxicity in the Ventral Cochlear Nucleus

Han, G., Li, C., Shi, H., Wang, J., Su, K., Yin, X., & Yin, S. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12355 · Cited by 15

Protective Effect of Retinal Ischemia by Blockers of Voltage-dependent Calcium Channels and Intracellular Calcium Stores

Massote, P. D., Pinheiro, A. C. N., Fonseca, C. G., Prado, M. A. M., Guimarães, A. L. S., Massensini, A. R., & Gomez, M. V. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9243-0 · Cited by 15

Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section

Atkinson, L., Shigetomi, E., Kato, F., & Deuchars, J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02797-5 · Cited by 15

A Review of the Potential Use of Antioxidants in Spinal Cord Injuries

Nowacka, A., Śniegocki, M., & Ziółkowska, E. (2025) · Antioxidants · doi:10.3390/antiox14091081 · Cited by 14

Evaluating the role of astrocytes on β-estradiol effect on seizures of Pilocarpine epileptic model

Sarfi, M., Salmani, M. E., Goudarzi, I., bluki, T. L., & Abrari, K. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.01.005 · Cited by 14

The Neuroprotective Potential of Endophytic Fungi and Proposed Molecular Mechanism: A Current Update

Semwal, P., Painuli, S., Anand, J., Martins, N. A., Machado, M., Sharma, R., Batiha, G. E., Yaro, C. A., Lorenzo, J. M., & Rahman, M. M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6214264 · Cited by 14

Glutamatergic agents in Autism Spectrum Disorders: Current trends

Canitano, R., & Scandurra, V. (2014) · Research in Autism · doi:10.1016/j.rasd.2013.12.009 · Cited by 14

Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits

Rambousek, L., Kletečková, L., Kubesova, A., Jirák, D., Valeš, K., & Fritschy, J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.035 · Cited by 14

Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides

Chiu, L. S., Anderton, R. S., Knuckey, N. W., & Meloni, B. P. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0287-3 · Cited by 14

Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model

Jin, M., Kim, K.-M., Lim, C., Cho, S., & Kim, Y. K. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.06.012 · Cited by 14

Induced tolerance to glutamate neurotoxicity through down‐regulation of NR2 subunits of N‐methyl‐D‐aspartate receptors in cultured rat striatal neurons

Kambe, Y., Nakamichi, N., Takarada, T., Fukumori, R., & Yoneda, Y. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22388 · Cited by 14

Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: Their possible correlation in astrocytes

Hwang, I. K., Yoo, K., Kim, D. W., Lee, B., Kang, T., Choi, S. Y., Han, B. H., Kim, J. S., & Won, M. H. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.012 · Cited by 14

Methamphetamine exacerbates the toxic effect of kainic acid in the adult rat retina

Rodrigues, L. G., Tavares, M. A., Wood, J., SCHMIDT, K., & Osborne, N. N. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.06.011 · Cited by 14

The neuroprotective KDI domain of γ1‐laminin is a universal and potent inhibitor of ionotropic glutamate receptors

Möykkynen, T. P., Liebkind, R., Sjöberg, J., Korpi, E. R., & Liesi, P. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20523 · Cited by 14

Ketamine induced cell death can be mediated by voltage dependent calcium channels in PC12 cells

Bustamante, J., Acosta, L. H., Karadayian, A. G., & Lores‐Arnaiz, S. (2019) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2019.104318 · Cited by 13

AMPA receptor-induced intracellular calcium response in the paraventricular nucleus is modulated by nitric oxide: Calcium imaging in a hypothalamic organotypic cell culture model

Roychowdhury, S., Noack, J., Engelmann, M., Wolf, G. L., & Horn, T. F. W. (2006) · Nitric Oxide · doi:10.1016/j.niox.2005.12.001 · Cited by 13

Agonist-induced down-regulation of AMPA receptors in oligodendrocyte progenitors

Hossain, S., Liu, H., Fragoso, G., & Almazán, G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.020 · Cited by 13

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors

Liu, Y.-W., Li, C., Luo, J., Li, W., Fu, H., Lao, Y., Liu, L.-J., Pang, Y., Chang, D. C., Li, Z.-W., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.133 · Cited by 13

Elemental anomalies in the hippocampal formation after repetitive electrical stimulation: an X-ray fluorescence microscopy study

Chwiej, J. G., Gabryś, H. S., Janeczko, K. J., Kutorasinska, J., Gzieło, K., Matusiak, K., Appel, K., & Setkowicz, Z. (2014) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1177-7 · Cited by 13

Sleep deprivation: Neural regulation and consequences

Chittora, R., Jain, A., Suhalka, P., Sharma, C., Jaiswal, N., & Bhatnagar, M. (2015) · Sleep and Biological Rhythms · doi:10.1111/sbr.12110 · Cited by 13

Changes in the Neuronal Glutamate Transporter EAAT 3 in Rat Brain after Exposure to Methamphetamine

Kerdsan-Phusan, W., Thanoi, S., & Nudmamud‐Thanoi, S. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00899.x · Cited by 13

A patient with epilepsia partialis continua with anti-glutamate receptor ε2 antibodies

Kumakura, A., Miyajima, T., Fujii, T., Takahashi, Y., & Ito, M. (2003) · Pediatric Neurology · doi:10.1016/s0887-8994(03)00151-6 · Cited by 13

Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and GABA in Stroke Recovery and Treatment

Nikbakhtzadeh, M., Bordbar, S., Seyedi, S., Ranjbaran, M., Ashabi, G., & Kheradmand, A. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249302594240801171612 · Cited by 12

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

Carles, A., Freyssin, A., Guehairia, S., Reguero, T., Vignes, M., Hirbec, H., Rubinstenn, G., & Maurice, T. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01648-9 · Cited by 12

Neuroprotective effect of pseudoginsenoside-F11 on permanent cerebral ischemia in rats by regulating calpain activity and NR2A submit-mediated AKT-CREB signaling pathways

Liu, Y., Fu, X., Liu, Y., Zhang, T., Cui, P., Wang, S., Liu, L., Hou, Z., Wang, H., Zhao, Y., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153847 · Cited by 12

In vitro effects of glutamate and N‐methyl‐ d ‐aspartate receptor (NMDAR) antagonism on human tendon derived cells

Dean, B. J. F., Snelling, S. J. B., Dakin, S. G., Javaid, M. K., & Carr, A. J. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22923 · Cited by 12

Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans

Sun, C.-L., Kim, E. S., & Crowder, C. M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.176 · Cited by 12

Gyroxin, a toxin from Crotalus durissus terrificus snake venom, induces a calcium dependent increase in glutamate release in mice brain cortical synaptosomes

Ferrari, C. Z., Ribeiro, R., de Lima, A. M., Soares, A. M., Cavalcante, W. L. G., & Vieira, L. B. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102081 · Cited by 12

Ionotropic glutamate receptors in platelets: opposing effects and a unifying hypothesis

Kalev‐Zylinska, M. L., Morel‐Kopp, M., Wård, C., Hearn, J. I., Hamilton, J. R., & Bogdanova, A. Y. (2020) · Platelets · doi:10.1080/09537104.2020.1852542 · Cited by 12

Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria

Laranjinha, J. A. N. (2006) · Frontiers in bioscience · doi:10.2741/2129 · Cited by 12

Apoptotic mechanisms after repeated noise trauma in the mouse medial geniculate body and primary auditory cortex

Fröhlich, F., Ernst, A., Strübing, I., Basta, D., & Gröschel, M. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-5091-4 · Cited by 12

Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4

Ogura, M., Kikuchi, H., Shakespear, N., Suzuki, T., Yamaki, J., Homma, Y., Oshima, Y., & Homma, Y. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.008 · Cited by 12

Soluble KDI domain of γ1 laminin protects adult hippocampus from excitotoxicity of kainic acid

Wikstén, M., Väänänen, A. J., Liebkind, R., Rauhala, P. V., & Liesi, P. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20158 · Cited by 12

Global ischemia downregulates the function of metabotropic glutamate receptor subtype 5 in hippocampal CA1 pyramidal neurons

Yeh, T., & Wang, H. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.001 · Cited by 12

Biological response of stainless steel surface modified by N2O/O2 glow discharge plasma

Chen, M., Osaki, S., & Zamora, P. O. (2009) · Applied Surface Science · doi:10.1016/j.apsusc.2009.03.079 · Cited by 11

Time course of cell death due to acoustic overstimulation in the mouse medial geniculate body and primary auditory cortex

Gröschel, M., Fröhlich, F., Basta, D., Strübing, I., & Ernst, A. (2017) · Noise and Health · doi:10.4103/nah.nah_10_17 · Cited by 11

Cytoprotection by endogenous zinc in the vertebrate retina

Anastassov, I., Ripps, H., & Chappell, R. L. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12627 · Cited by 11

Ecophysiology of neuronal metabolism in transiently oxygen-depleted environments: Evidence that GABA is accumulated pre-synaptically in the cerebellum

Renshaw, G. M. C., Wise, G. E., & Dodd, P. R. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.10.039 · Cited by 11

Memantine Prevents Sensitivity to Excitotoxic Cell Death of Rat Cortical Neurons Expressing Human Truncated Tau Protein

Cente, M., Mandakova, S., & Filipčík, P. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9379-1 · Cited by 11

Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?

Wang, K., & Wang, Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00039 · Cited by 11

KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids

Berlind, J. E., Lai, J. D., Lie, C., Vicente, J., Lam, K., Guo, S., Chang, J., Yu, V. L., & Ichida, J. K. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.001 · Cited by 10

Interplay Among Synaptic Glutamate Release and Excitotoxicity: Neuronal Damage and Graphene-Based Materials Related Protection

Cellot, G., & Ballerini, L. (2025) · Life · doi:10.3390/life15111776 · Cited by 10

Age Associated Sleep Loss: A Trigger For Alzheimer's Disease

Sharma, V., Sharma, P. M., Deshmukh, R. R., & Singh, R. (2015) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20140909070449 · Cited by 10

Chromatin condensation during glutamate-induced excitotoxicity of celebellar granule neurons precedes disintegration of nuclear DNA into high molecular weight DNA fragments

Bezvenyuk, Z., Miettinen, R. A., & Solovyan, V. T. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00587-9 · Cited by 10

Effects of Blood Glutamate Scavenging on Cortical Evoked Potentials

Nagy, D., Knapp, L., Marosi, M., Farkas, T., Kis, Z., Vécsei, L., Teichberg, V. I., & Toldi, J. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9542-8 · Cited by 10

Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats

Xu, Z., Jia, K., Xu, B., He, A., Li, J., Deng, Y. L., & Zhang, F. (2010) · Toxicology and Industrial Health · doi:10.1177/0748233709359275 · Cited by 10

H2S prevents peripheral immune cell invasion, increasing [Ca2+]i and excessive phagocytosis following hypoxia-ischemia injury in neonatal mice

Li, T., Chu, X., Xin, D., Ke, H., Wang, S., Liu, D., Chen, W., & Wang, Z. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111207 · Cited by 10

Water Extract of Mixed Mushroom Mycelia Grown on a Solid Barley Medium Is Protective against Experimental Focal Cerebral Ischemia

Jeong, J. H., Kim, S. H., Park, M. N., Park, J. Y., Park, H. Y., Song, C. E., Moon, J. H., Choi, A. L., Kim, K. D., Lee, N., et al. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43010030 · Cited by 10

Influence of magnesium supplementation on movement side effects related to typical antipsychotic treatment in rats

Kronbauer, M., Metz, V. G., Roversi, K., Dias, V. T., Antoniazzi, C. T. D. D., Barcelos, R. C. S., & Bürger, M. E. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.049 · Cited by 10

The role of S‐nitrosylation of kainate‐type of ionotropic glutamate receptor 2 in epilepsy induced by kainic acid

Wang, L., Liu, Y., Lu, R., Dong, G., Chen, X., Yun, W., & Zhou, X. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14266 · Cited by 10

Cell Culture Models for Studying Epilepsy

Dichter, M. A., & Pollard, J. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012088554-1/50005-0 · Cited by 10

Excitotoxic cell death

Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,329

Molecular mechanisms of calcium-dependent excitotoxicity

Sattler, R., & Tymianski, M. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000077 · Cited by 477

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

Arundine, M., & Tymianski, M. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00141-6 · Cited by 846

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Sánchez‐Gómez, M. V., & Matute, C. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0264 · Cited by 150

Excitotoxicity

Henchcliffe, C., & Beal, M. F. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)83027-2 · Cited by 2