The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling
Open accessAbstract
Cell migration is a process which is essential during embryonic development, throughout adult life and in some pathological conditions. Cadherins, and more specifically the neural cell adhesion molecule N-cadherin, play an important role in migration. In embryogenesis, N-cadherin is the key molecule during gastrulation and neural crest development. N-cadherin mediated contacts activate several pathways like Rho GTPases and function in tyrosine kinase signalling (for example via the fibroblast growth factor receptor). In cancer, cadherins control the balance between suppression and promotion of invasion. E-cadherin functions as an invasion suppressor and is downregulated in most carcinomas, while N-cadherin, as an invasion promoter, is frequently upregulated. Expression of N-cadherin in epithelial cells induces changes in morphology to a fibroblastic phenotype, rendering the cells more motile and invasive. However in some cancers, like osteosarcoma, N-cadherin may behave as a tumour suppressor. N-cadherin can have multiple functions: promoting adhesion or induction of migration dependent on the cellular context.
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Cites
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Cited by
Taube, J. H., Herschkowitz, J. I., Komurov, K., Zhou, A. Y., Gupta, S., Yang, J., Hartwell, K., Onder, T. T., Gupta, P. B., Evans, K. W., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004900107 · Cited by 1,041
Transitions between epithelial and mesenchymal states in development and disease
Baum, B., Settleman, J., & Quinlan, M. P. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.02.001 · Cited by 398
Hellner, K., Mar, J., Fang, F., Quackenbush, J., & Münger, K. (2009) · Virology · doi:10.1016/j.virol.2009.05.036 · Cited by 94
Tumor-stroma interactions in tumorigenesis lessons from stem cell biology
Friedrich, K. (2012) · Frontiers in Bioscience · doi:10.2741/e509 · Cited by 10
Metadata
- Authors
- Derycke, L. D. M., & Bracke, M. E.
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 2004
- Volume
- 48
- Issue
- 5-6
- Pages
- 463-476
- ISSN
- 0214-6282 (ISSN-L)
- OpenAlex
- W2082905439
- Cited by
- 408
- References
- 128
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Derycke, L. D. M., & Bracke, M. E. (2004). N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. The International Journal of Developmental Biology. https://doi.org/10.1387/ijdb.041793ld
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
