Th1/Th2 balance and humoral immune response to potential antigens as early diagnostic method of equine Strongylus nematode infection
Open accessAbstract
AIM: The aim of this study was to investigate the early diagnosis of strongyle infection based on early changes in Th1 and Th2 cytokines beside the diagnostic accuracy values and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting profiles using prepared strongyles antigens. MATERIALS AND METHODS: (ESC). RESULTS: infected animals, TNF-α/IL-4 balance was approximately equal in apparently healthy group while it was low in moderate and high egg shedder groups. The diagnostic accuracy showed that the higher specificity (46.6%) and prevalence (95.40%) were recorded by CSS and ESC antigens, respectively. However, SDS-PAGE and western blotting profiling proved that the band at molecular weight 25 kDa is exhibited by CSS antigen. CONCLUSION: spp. at the base of serological and molecular investigation.
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Host-parasite interaction relies on the expressed cytokine profile which is modulated by the parasite itself.
“Host–parasite interaction relies on the expressed cytokine profile which is modulated by the parasite itself [15,16,17].”
From Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response (2022) · cites this paper as [16]
Helminth infections are usually associated with polarised Th2/Th1 immune responses.
“Helminths infections are usually associated with polarised Th2/Th1 immune responses [16,57].”
From Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response (2022) · cites this paper as [16]
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Self-citationEmergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response
Abo-Aziza, F. A. M., Hendawy, S. H. M., Abdullah, H. H. A. M., El Namaky, A., Laidoudi, Y., & Mediannikov, O. (2022) · Pathogens · doi:10.3390/pathogens11090979 · Cited by 4 · see citing works
“Helminths infections are usually associated with polarised Th2/Th1 immune responses [16,57].”
BackgroundSelf-citation
- Authors
- Abo-Aziza, F. A. M., Hendawy, S. H. M., El Namaky, A. H., & Ashry, H. M.
- Affiliations
- National Research Centre (EG)
- Corresponding author
- Abo-Aziza, Faten A. M.
- Venue
- Veterinary World
- Publisher
- Veterinary World
- Published
- 2017-06
- Volume
- 10
- Issue
- 6
- Pages
- 679-687
- ISSN
- 0972-8988 (ISSN-L)
- 2231-0916
- PMC
- PMC5499087
- OpenAlex
- W2683037107
- Cited by
- 21
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 2
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Veterinary World (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Centre
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Keywords
- Strongylus, Th1/Th2 balance, cytokines, TNF-α, IL-4, early diagnosis, serological diagnosis, diagnostic accuracy
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