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RESISTANCE TRAINING AND CO-SUPPLEMENTATION WITH CREATINE AND PROTEIN IN OLDER SUBJECTS WITH FRAILTY
Abstract
Background: Studies assessing the effects co-supplementation with creatine and protein, along with resistance training, in older individuals with frailty are lacking. Objectives: This is an exploratory trial from the Pro-Elderly study (“Protein Intake and Resistance Training in Aging”) aimed at gathering knowledge on the feasibility, safety, and efficacy of co-supplementation with creatine and protein supplementation, combined with resistance training, in older individuals with frailty. Design: A 14-week, double-blind, randomized, parallel-group, placebo controlled exploratory trial. Setting, participants: The subjects were randomly assigned to whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) group. All subjects undertook a supervised exercise training program and were assessed at baseline and after 14 weeks. Measurements: Muscle function, body composition, blood parameters, and self-reported adverse events were assessed. Results: No interaction effects (between-group differences) were observed for any dependent variables (p > 0.05 for all). However, there were main time-effects in handgrip (WHEY+CR = 26.65 ± 31.29; WHEY = 13.84 ± 14.93 Kg; p = 0.0005), timed-up-and-go (WHEY+CR = -11.20 ± 9.37; WHEY = -17.76 ± 21.74 sec; p = 0.006), and timed-stands test (WHEY+CR = 47.50 ± 35.54; WHEY = 46.87 ± 24.23 reps; p = 0.0001), suggesting that WHEY+CR and WHEY were similarly effective in improving muscle function. All of the subjects showed improvements in at least two of the three functional tests, regardless of their treatments. Body composition and blood parameters were not changed (p > 0.05). No severe adverse effects were observed. Conclusions: Co-supplementation with creatine and whey protein was well-tolerable and free of adverse events in older subjects with frailty undertaking resistance training. Creatine supplementation did not augment the adaptive effects of resistance training along with whey protein on body composition or muscle function in this population. Clinicaltrials.gov: NCT01890382.
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“but there is lack of evidence that it can improve strength, lean body mass, muscle accretion, or functional ability in those who are classified as frail.”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [128]
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“Studies in frail older adults engaged in resistance training however show no added benefit of CrM.”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [128]
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Cited by
Interventions for Frailty Among Older Adults With Cardiovascular Disease
Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.11.029 · Cited by 412
Chilibeck, P., Kaviani, M., Candow, D., & Zello, G. A. (2017) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s123529 · Cited by 235
Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040488 · Cited by 149
Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain
Gualano, B., Rawson, E. S., Candow, D. G., & Chilibeck, P. D. (2016) · Amino Acids · doi:10.1007/s00726-016-2239-7 · Cited by 133
Self-citationCandow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00124 · Cited by 89
Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?
Dolan, E., Artioli, G. G., Pereira, R. M. R., & Gualano, B. (2019) · Biomolecules · doi:10.3390/biom9110642 · Cited by 72
Self-citationCreatine monohydrate supplementation for older adults and clinical populations
Candow, D. G., Ostojic, S. M., Chilibeck, P. D., Longobardi, I., Gualano, B., Tarnopolsky, M. A., Wallimann, T., Moriarty, T., Kreider, R. B., Forbes, S. C., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2534130 · Cited by 43
Self-citationCamargo, L. D. R., Doneda, D., & Oliveira, V. R. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110936 · Cited by 42
Forbes, S. C., Candow, D. G., Krentz, J. R., Roberts, M. D., & Young, K. C. (2019) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk4030062 · Cited by 38
Metadata
- Authors
- COLLINS, J., LONGHURST, G., ROSCHEL, H., & GUALANO, B.
- Venue
- Journal of Frailty & Aging
- Publisher
- Elsevier BV
- Published
- 2016
- Pages
- 1-9
- ISSN
- 2273-4309
- Cited by
- 11
- References
- 0
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