Interventions for Frailty Among Older Adults With Cardiovascular Disease
Open accessAbstract
With the aging of the world's population, a large proportion of patients seen in cardiovascular practice are older adults, but many patients also exhibit signs of physical frailty. Cardiovascular disease and frailty are interdependent and have the same physiological underpinning that predisposes to the progression of both disease processes. Frailty can be defined as a phenomenon of increased vulnerability to stressors due to decreased physiological reserves in older patients and thus leads to poor clinical outcomes after cardiovascular insults. There are various pathophysiologic mechanisms for the development of frailty: cognitive decline, physical inactivity, poor nutrition, and lack of social supports; these risk factors provide opportunity for various types of interventions that aim to prevent, improve, or reverse the development of frailty syndrome in the context of cardiovascular disease. There is no compelling study demonstrating a successful intervention to improve a global measure of frailty. Emerging data from patients admitted with heart failure indicate that interventions associated with positive outcomes on frailty and physical function are multidimensional and include tailored cardiac rehabilitation. Contemporary cardiovascular practice should actively identify patients with physical frailty who could benefit from frailty interventions and aim to deliver these therapies in a patient-centered model to optimize quality of life, particularly after cardiovascular interventions.
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Malnutrition, cachexia, sarcopenia, and frailty are phenotypically distinct but interconnected conditions with interrelated pathophysiological processes that lead to different magnitudes of wasting and susceptibility to adverse outcomes.
“Malnutrition, cachexia, sarcopenia, and frailty are phenotypically distinct but interconnected conditions with interrelated pathophysiological processes that lead to different magnitudes of wasting and susceptibility to adverse outcomes.81–83”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [83]
The DOMAINS AND DEFINITIONS section links sarcopenia and unintentional weight loss to frailty and describes a nutritional domain of frailty. It does not establish that malnutrition, cachexia, sarcopenia, and frailty are four phenotypically distinct but interconnected conditions, or compare their magnitudes of wasting and susceptibility to adverse outcomes. Page numbers were not available in our copy. (LLM, conf=0.84)
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Is There an Association Between Metformin Exposure and Frailty?
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THE ESSENTIAL FRAILTY TOOLSET IN OLDER ADULTS UNDERGOING CABG
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Changes in frailty and incident cardiovascular disease in three prospective cohorts
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Self-citationFrailty and heart failure: State‐of‐the‐art review
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“Allied to that, physical frailty is a clinical state with increased susceptibility to stressors due to reduced accounts in multiple physiological systems, resulting in functional decline and increased mortality [3–14].”
Frailty and Cardiovascular Health
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Self-citationAccelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality
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“31,58 When older patients have a low burden of age-associated risks and PCI is not feasible, surgical revascularization can be considered in select patients with CS, multivessel coronary disease, and mechanical complications.”
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Geriatric Cardiology: Coming of Age
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Self-citationRole of Cognitive Frailty in Older Adults With Cardiovascular Disease
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Management of Hypertension in the Elderly and Frail Patient
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Exercise interventions for older people with cognitive frailty—a scoping review
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“Early-stage screening and reasonable prevention and treatment measures applied in a timely manner can delay the reduction of physiological reserve capacity and reduce the occurrence of adverse health events in older people [16].”
BackgroundChronological vs Biological Age in Interventional Cardiology
Damluji, A. A., Nanna, M. G., Rymer, J., Kochar, A., Lowenstern, A., Baron, S. J., Narins, C. R., & Alkhouli, M. (2024) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2024.01.284 · Cited by 53 · see citing works
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Tobacco and alcohol consumption and the risk of frailty and falling: a Mendelian randomisation study
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Brown, T. M., Pack, Q. R., Beregg, E. A., Brewer, L. C., Ford, Y. R., Forman, D. E., Gathright, E. C., Khadanga, S., Ozemek, C., & Thomas, R. J. (2024) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000930 · Cited by 47 · see citing works
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Damluji, A. A., Bernacki, G., Afilalo, J., Lyubarova, R., Orkaby, A. R., Kwak, M. J., Hummel, S., Kirkpatrick, J. N., Maurer, M. S., Wenger, N., et al. (2024) · JACC: Advances · doi:10.1016/j.jacadv.2024.100877 · Cited by 41 · see citing works
“4,26 The Essential Frailty Toolset, developed and validated in patients with severe AS, had the highest accuracy in predicting mortality among the instruments studied and is feasible to implement even in a busy clinical setting.”
BackgroundSelf-citationCardiac rehabilitation and frailty: a systematic review and meta-analysis
MacEachern, E., Quach, J., Giacomantonio, N., Theou, O., Hillier, T. W. R., Abel-Adegbite, I., González-Lara, M., & Kehler, D. S. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae239 · Cited by 39 · see citing works
Frailty and Cardiovascular Mortality: A Narrative Review
Ko, D., Bostrom, J., Qazi, S., Kramer, D. B., Kim, D. H., & Orkaby, A. R. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01847-0 · Cited by 38 · see citing works
Evans, N. R., Pinho, J., Beishon, L., Nguyen, T. N., Ganesh, A., Balasundaram, B., Munthe‐Kaas, R., Hewitt, J., Gandhi, D. B. C., Quinn, T. J., et al. (2025) · International Journal of Stroke · doi:10.1177/17474930251345295 · Cited by 38 · see citing works
Benefits of Cardiac Rehabilitation: Mechanisms to Restore Function and Clinical Impact
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Narrative Review: Clinical Implications and Assessment of Frailty in Patients With Advanced CKD
Kennard, A. L., Glasgow, N., Rainsford, S., & Talaulikar, G. S. (2023) · Kidney International Reports · doi:10.1016/j.ekir.2023.12.022 · Cited by 37 · see citing works
Use of frailty assessment instruments in nephrology populations: a scoping review
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“These trends pose substantial societal and economic challenges, such as soaring healthcare expenditures, a growing demand for long-term care services, and the pressing need for public health systems and policies that can adapt to the evolving needs of aging populations [5, 6].”
Sanchís, J. M., Bueno, H., García‐Blas, S., Alegre, O., Martí, D., Martínez‐Sellés, M., Domínguez-Pérez, L., Díez‐Villanueva, P., Barrabés, J. A., Marín, F. R., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.0809 · Cited by 31 · see citing works
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Alessandro de, S. I. R. E., Lippi, L., Aprile, V., Calafiore, D., Folli, A., D’Abrosca, F., Moalli, S., Lucchi, M., Ammendolia, A., & Invernizzi, M. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101626 · Cited by 31 · see citing works
“In addition, the COVID-19 pandemic has highlighted new challenges in the management of patients with COPD that were isolated for months at home with decreased physical activity levels and reduced health care delivery [175,176].”
BackgroundSurvivorship After Cardiogenic Shock
Hall, E. J., Agarwal, S., Cullum, C. M., Sinha, S. S., Ely, E. W., & FARR, M. A. (2025) · Circulation · doi:10.1161/circulationaha.124.068203 · Cited by 29 · see citing works
“50 Frailty often coexists with other sequelae of critical illness, including disability and cognitive impairment.”
InfluentialImpact of frailty on disease-specific health status in cardiovascular disease
Nguyen, D. D., & Arnold, S. V. (2023) · Heart · doi:10.1136/heartjnl-2022-321631 · Cited by 29 · see citing works
Healthy ageing in older adults with cardiovascular disease
Schmanske, N., Ngo, J. M., Kalra, K., Nanna, M. G., & Damluji, A. A. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf231 · Cited by 28 · see citing works
Self-citationDamluji, A. A., Ijaz, N., Chung, S.-E., Xue, Q., Hasan, R. K., Batchelor, W., Orkaby, A. R., Kochar, A., Nanna, M. G., Roth, D. L., et al. (2023) · JACC Advances · doi:10.1016/j.jacadv.2023.100318 · Cited by 28 · see citing works
Self-citationOrkaby, A. R., Huan, T., Intrator, O. K., Cai, S., Schwartz, A. W., Wieland, D., Hall, D. E., Figueroa, J. F., Strom, J. B., Kim, D. H., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad157 · Cited by 28 · see citing works
A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II
Nanna, M. G., Sutton, N. R., Kochar, A., Rymer, J. A., Lowenstern, A. M., Gackenbach, G., Hummel, S. L., Goyal, P., Rich, M. W., Kirkpatrick, J. N., et al. (2023) · JACC Advances · doi:10.1016/j.jacadv.2023.100421 · Cited by 28 · see citing works
Self-citationDamluji, A. A., Nanna, M. G., Mason, P., Lowenstern, A. M., Orkaby, A. R., Washam, J. B., Kolkailah, A. A., Beckie, T. M., Dangas, G., & Lawton, J. S. (2025) · Circulation · doi:10.1161/cir.0000000000001387 · Cited by 29 · see citing works
Self-citationManagement of Stable Angina in the Older Adult Population
Nanna, M. G., Wang, S. Y., & Damluji, A. A. (2023) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.122.012438 · Cited by 29 · see citing works
Self-citationThe role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review
Abeywickrama, H. M., Uchiyama, M., Sumiyoshi, T., Okuda, A., & Koyama, Y. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad094 · Cited by 26 · see citing works
“loss together with loss of MM and strength that makes older adults susceptible to disability.(4) The etiology of”
BackgroundLiu, H., Zhou, W., Liu, Q., Yu, J., & Wang, C. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-2035-5 · Cited by 25 · see citing works
“Additionally, tracking the potential psychological and social factors demonstrated in multidimensional frailty tools might help to better manage and accurately interpret the results of interventions aimed to prevent and reverse frailty as part of the hypertension management in older adults (1).”
InfluentialCardiovascular Concerns, Cancer Treatment, and Biological and Chronological Aging in Cancer
Ioffe, D., Bhatia-Patel, S., Gandhi, S., Hamad, E. A., & Dotan, E. (2024) · JACC CardioOncology · doi:10.1016/j.jaccao.2024.02.001 · Cited by 25 · see citing works
Vitolo, M., Ziveri, V., Gozzi, G., Busi, C., Imberti, J. F., Bonini, N., Muto, F., Mei, D. A., Menozzi, M., Mantovani, M., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm13010099 · Cited by 24 · see citing works
“The EFS is a valid and simple measuring instrument for identifying frailty in the clinical context [19].”
Challenges in the prevention, treatment and management of cardiovascular disease among older adults
Townsend, N. P., Timmis, A., Ērglis, A., Miličić, D., Filardi, P. P., Weidinger, F., Guzik, T. J., & Gale, C. P. (2025) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2025.101372 · Cited by 24 · see citing works
“80 However, the lack of consensus on the best tool for routine clinical use presents challenges, including in the translation of research findings into clinical practice.”
Takahara, M., Soga, Y., & Iida, O. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae207 · Cited by 23 · see citing works
Fernando, K., Connolly, D. L., Darcy, E., Evans, M., Hinchliffe, W., Holmes, P., & Strain, W. D. (2025) · Diabetes Therapy · doi:10.1007/s13300-025-01738-3 · Cited by 24 · see citing works
“Additionally, non-pharmacological strategies, such as cardiac rehabilitation programs evaluated in the REHAB-HF trial, show promise in improving physical function, quality of life and frailty metrics in older adults [82, 88].”
Midterm Outcomes of Underweight Patients Undergoing Transcatheter Aortic Valve Implantation
Tezuka, T., Higuchi, R., Hagiya, K., Saji, M., Takamisawa, I., Nanasato, M., Iguchi, N., Shimizu, A., Shimizu, J., Doi, S., et al. (2022) · JACC Asia · doi:10.1016/j.jacasi.2022.08.014 · Cited by 23 · see citing works
“Physical and nutritional interventions for frailty should also improve the outcomes of underweight patients.(28) STUDY LIMITATIONS.”
BackgroundFrailty after COVID ‐19: The wave after?
König, M., Gollasch, M., & Komleva, Y. (2023) · Aging Medicine · doi:10.1002/agm2.12258 · Cited by 23 · see citing works
Candeloro, M., Nisio, M. D., Potere, N., Pizio, L. D., Secinaro, E., Flaviis, C. D., Federici, C., Guglielmi, M. D., Pardi, S., Schulman, S., et al. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18001 · Cited by 22 · see citing works
Pan, M., Sun, Z., Zhang, Y., Chen, J., Zhao, Z., He, H., Zeng, H., Li, Q., & Gu, N. (2024) · Advanced Materials · doi:10.1002/adma.202412701 · Cited by 22 · see citing works
Kochar, B. D., Cheng, D. T.-Y., Lehto, H., Jain, N., Araka, E., Ritchie, C. S., Bernacki, R., & Orkaby, A. R. (2025) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19389 · Cited by 21 · see citing works
“There is increasing interest among specialties to use frailty in clinical care to identify patients at increased risk for adverse events [8, 9].”
Jamil, Y., Park, D. Y., Rao, S. V., Ahmad, Y., Sikand, N. V., Bosworth, H. B., Coles, T., Damluji, A. A., Nanna, M. G., & Samsky, M. D. (2024) · JACC Advances · doi:10.1016/j.jacadv.2024.100949 · Cited by 21 · see citing works
Self-citationMcDonagh, J., Ferguson, C., Hilmer, S. N., Hubbard, R. E., Lindley, R. I., Driscoll, A. L., Maiorana, A., Wu, L. E., Atherton, J. J., Bajorek, B. V., et al. (2025) · Heart Lung and Circulation · doi:10.1016/j.hlc.2025.01.012 · Cited by 20 · see citing works
Lippi, L., D’Abrosca, F., Folli, A., Molin, A. D., Moalli, S., Maconi, A., Ammendolia, A., Alessandro de, S. I. R. E., & Invernizzi, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159150 · Cited by 22 · see citing works
“During the COVID-19 pandemic, several frail patients became isolated at home with detrimental consequences in terms of their functional status and social participation [58,59].”
BackgroundPotential association between frailty and pTau in community-dwelling older adults
Zhou, L., Shi, H., Cheng, R., Ge, M., Hu, F., Hou, L., Xia, X., Liu, X., Liu, Y., Zhao, Y., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03454-0 · Cited by 20 · see citing works
Argyriou, C., Dimitriadou, I., Saridi, M., Toska, A. G., Lavdaniti, M., & Fradelos, Ε. C. (2024) · Psychogeriatrics · doi:10.1111/psyg.13160 · Cited by 20 · see citing works
Trajectories of cardiovascular ageing—from molecular mechanisms to clinical implementation
Ministrini, S., Wenzl, F. A., Lüscher, T. F., & Camici, G. G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae178 · Cited by 21 · see citing works
“10”
Uchmanowicz, I., Faulkner, K. M., Iovino, P., Kwaśny, A., Surma, S., Magi, C. E., Jakubiak, G. K., Longobucco, Y., Janczak, D. T., Rak-Pasikowska, A., et al. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1518774 · Cited by 19 · see citing works
Fountotos, R., Ahmad, F., Bharaj, N., Munir, H., Marsala, J., Rudski, L., Goldfarb, M., & Afilalo, J. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18228 · Cited by 21 · see citing works
“The extent to which these interventions are feasible and effective in hospitalized CVD patients remains uncertain.(13) Thus, the MulTicomponent Acute Intervention in FRail GEriatric PaTients with CVD using the Essential Frailty Toolset (TARGET-EFT) randomized clinical trial was designed to address this knowledge gap.”
MethodSu, J. J., Wong, A. K. C., He, X.-F., Zhang, L.-P., Cheng, J., Lu, L., Lan, L., Wang, Z., Lin, R. S. Y., & Baťalík, L. (2024) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2024.101365 · Cited by 21 · see citing works
“The inclusion criteria were [1]: adults aged ≥ 60 [2], diagnosed with CHD [4], able to communicate and read Chinese [5], owning a smart-phone, and [6] having no prescribed physical activity restriction.”
BackgroundAhmad, F., Fountotos, R., Goldfarb, M., Bharaj, N., Munir, H., Marsala, J., Rudski, L., & Afilalo, J. (2022) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcac050 · Cited by 18 · see citing works
Grieco, D., Bressi, E., Sedláček, K., Čurila, K., Vernooy, K., Fedele, E., Ruvo, E. D., Fagagnini, A., Kron, J., Padala, S. K., et al. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01174-4 · Cited by 17 · see citing works
Won, M. H., Choi, J., & Son, Y. (2022) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvac074 · Cited by 17 · see citing works
Holistic frailty prevention: The promise of movement‐based mind–body therapies
Loewenthal, J. V., Berning, M., Wayne, P. M., Eckstrom, E., & Orkaby, A. (2023) · Aging Cell · doi:10.1111/acel.13986 · Cited by 17 · see citing works
“Over 60 tools have been developed to measure frailty for both clinical and research purposes, and most derive from either the Fried or Rockwood approach (Ijaz et al., 2022).”
MethodQu, J., Liang, Y., Rao, Y., Pei, Y., Li, D., Zhang, Y., Chen, Y., & Sun, Y. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105310 · Cited by 16 · see citing works
Bakhtiari, M., Shaker, F., Shirmard, F. O., Jalali, A., Vakili‐Basir, A., Balabandian, M., Khamene, S. S., Khawajah, I. M., Shafiee, A., Badrkhahan, S. Z., et al. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03781-7 · Cited by 16 · see citing works
“Several mechanisms contribute to frailty development, such as poor nutritional support, physical dormancy, and cognitive decline, as well as comorbidities such as hypertension and diabetes mellitus [6, 8].”
BackgroundYuguchi, T., Nakajima, K., Takaoka, H., & Shimokawa, T. (2024) · Circulation Reports · doi:10.1253/circrep.cr-24-0009 · Cited by 17 · see citing works
“15 The CGA instruments (BI, MMSE, CCI, and CONUT) used in the present study are representative CGA instruments for each frailty domain.”
MethodXiong, Y.-J., Meng, X., Xu, H., & Zhu, X.-Y. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02348-4 · Cited by 16 · see citing works
“Extended author information available on the last page of the article psychosocial deficits [3].”
Arauna, D., Navarrete, S., Cecilia Albala, B., Wehinger, S., Pizarro-Mena, R. A., Palomo, I. F., & Eduardo Fuentes, Q. (2024) · Biomedicines · doi:10.3390/biomedicines12092004 · Cited by 15 · see citing works
“Also, frailty has a significant social component, with social isolation, depression, and a decline in the support network of family or friends increasing the risk of developing this syndrome [3].”
BackgroundInfluentialLiu, A., Lin, Y.-X., Li, G., Meng, T., Tian, P., Chen, J., Zhang, X., Xu, W., Zhang, Y. X., Zhang, D., et al. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-05752-9 · Cited by 16 · see citing works
“Nota-bly, the risk of CVD escalates with aging, underscoring the importance for CVD older adults to actively identify frailty and cognitive impairment [47, 50].”
Vest, A. R., DiDomenico, R. J., Lichtenstein, L., Slater, T., Ekpo, E., Damluji, A. A., Bohula, E., Alviar, C. L., on behalf of the American Heart Association Acute Cardiac Care and General Cardiology Committee of the Council on Clinical Cardiology, & Council on Cardiovascular and Stroke Nursing (2026) · Circulation · doi:10.1161/cir.0000000000001405 · Cited by 15 · see citing works
Self-citationPatient-Reported Frailty and Functional Status in Heart Failure With Preserved Ejection Fraction
Kaul, P., Rathwell, S., Lam, C. S. P., Westerhout, C. M., Spertus, J. A., Anstrom, K. J., Blaustein, R. O., Ezekowitz, J. A., Pieske, B. M., Roessig, L., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2022.11.015 · Cited by 15 · see citing works
The concurrent impact of mild cognitive impairment and frailty syndrome in heart failure
Uchmanowicz, I., Rosano, G. M. C., Piepoli, M. F., Vellone, E., Czapla, M., Lisiak, M., Diakowska, D., Prokopowicz, A., Aleksandrowicz, K., Nowak, B., et al. (2023) · Archives of Medical Science · doi:10.5114/aoms/162369 · Cited by 16 · see citing works
Disentangling Heart Failure and Physical Frailty
Metze, C., Iliadis, C., Körber, M. I., von Stein, J., Halbach, M., Baldus, S. E., & Pfister, R. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.04.011 · Cited by 15 · see citing works
Assessment and Management of Atrial Fibrillation in Older Adults with Frailty
Diaz, A. N. R., Troy, A. L., Kaplinskiy, V., Pritchard, A., Vani, R., Ko, D., & Orkaby, A. R. (2024) · Geriatrics · doi:10.3390/geriatrics9020050 · Cited by 15 · see citing works
“Briefer tools, such as 4-m gait speed or the Clinical Frailty Scale, a 9-point scale that assesses functional and health status in the 2 weeks prior, can be readily incorporated into routine clinical practice [32,33].”
BackgroundMethodLi, M., Ren, L., He, L., Lai, Y., Wang, J., Li, S., Peng, X., Zhao, M., Li, Q., Zhao, Z., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.03.394 · Cited by 15 · see citing works
Nakamaru, R., Nishimura, S., Kumamaru, H., Shoji, S., Nakatani, E., Yamamoto, H., Miyachi, Y., Miyata, H., & Kohsaka, S. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.123.010642 · Cited by 15 · see citing works
“28 Persistent efforts are required to develop evidence for further optimizing their integrated care.”
Cardiac Amyloidosis in Older Adults With a Focus on Frailty
Bart, N., Bianchi, G., Cuddy, S. A. M., Goyal, P., Griffin, J. M., Hummel, S. L., Macdonald, P. S., Maurer, M. S., MONTGOMERY, E. E., Nanne, M. G., et al. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101784 · Cited by 15 · see citing works
Self-citationTomii, D., Lanz, J., Heg, D., Möllmann, H., Kim, W.-K., Burgdorf, C., Linke, A. H.-P., Redwood, S. R., Hilker, M., Joner, M., et al. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101594 · Cited by 16 · see citing works
Invasive Management in Older Adults (≥80 Years) With Non-ST Elevation Myocardial Infarction
Fishman, B., Sharon, A., Itelman, E., Tsur, A. M., Fefer, P., Barbash, I. M., Segev, A., Matetzky, S., Guetta, V., Grossman, E., et al. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.03.021 · Cited by 14 · see citing works
Checa‐López, M., Costa‐Grille, A., Álvarez‐Bustos, A., Carnicero, J. A. C., Sinclair, A. J., Scuteri, A., Landi, F., Solano-Jaurrieta, J. J., Bellary, S., & Rodríguez‐Mañas, L. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13374 · Cited by 14 · see citing works
Fountotos, R., Lauck, S., Piazza, N., Martucci, G. J., Arora, R. C., Asgar, A., Forcillo, J., Kouz, R., Labinaz, M. X., Lamy, A. L., et al. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.11.037 · Cited by 14 · see citing works
Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology – 2024
Gualandro, D. M., Fornari, L. S., Caramelli, B., Abizaid, A., Gomes, B. R., Tavares, C. A. M., Fernandes, C. J. C. D. S., Polanczyk, C. A., Jardim, C., Vieira, C. L. Z., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240590i · Cited by 14 · see citing works
Fumagalli, C., Ponti, L., Smorti, M., Pozza, F., Argirò, A., Zampieri, M., Mario, C. D., Marfella, R., Sardu, C., Paolisso, G., et al. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-024-02750-6 · Cited by 13 · see citing works
Frailty trajectories after a cardiovascular event among community-dwelling older people
Phyo, A. Z. Z., Tonkin, A. M., Espinoza, S. E., Vishwanath, S., Murray, A. M., Woods, R. L., Callahan, K. E., Peters, R. K., & Ryan, J. L. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf095 · Cited by 13 · see citing works
Left main coronary disease: evolving management concepts
Armstrong, P. W., Bates, E., & Gaudino, M. F. L. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac542 · Cited by 13 · see citing works
Singh, N., Faye, A. S., Abidi, M. Z., Grant, S. J., DuMontier, C., Iyer, A. S., Jain, N., Kochar, B. D., Lieber, S. B., Litke, R. R., et al. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19268 · Cited by 12 · see citing works
Self-citationKhan, M., Nicholl, B. I., & Hanlon, P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102759 · Cited by 12 · see citing works
Gao, Q., Li, P., Lu, Z., Ma, M., Zhang, N., Lu, Y., & Yu, J. (2025) · BMC Public Health · doi:10.1186/s12889-025-22959-y · Cited by 12 · see citing works
Chehrehgosha, M., Sharifi, A., Meftah, A. M., Maleki, H., Sajjadi‐Jazi, S. M., Baharifar, H., Khoshnevisan, K., & Sharifi, F. (2024) · Maturitas · doi:10.1016/j.maturitas.2023.107905 · Cited by 12 · see citing works
Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia – 2024
Gualandro, D. M., Fornari, L. S., Caramelli, B., Abizaid, A., Gomes, B. R., Tavares, C. A. M., Fernandes, C. J. C. D. S., Polanczyk, C. A., Jardim, C., Vieira, C. L. Z., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240590 · Cited by 28 · see citing works
Leso, V., Scalfi, L., Giordano, A., Reppuccia, L., Guarino, D., Fedele, M., & Iavicoli, I. (2023) · Journal of Occupational Health · doi:10.1093/joccuh/uiad006 · Cited by 11 · see citing works
“41,42 In the study by Berner et al, 32 a group of measures including tests of gait speed, balance, and sit-to-stand were used to assess lower extremity function,and were significantly associated with WAS.”
MethodTehrani, B. N., Sherwood, M. W., Damluji, A. A., Epps, K., Bakhshi, H., Cilia, L. A., Dassanayake, I., Eltebaney, M., Gattani, R., Howard, E. W., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031504 · Cited by 11 · see citing works
“2,3, 19–21 It has been proposed that the factors associated with Virchow triad are implicated in RAO (namely, endothelial injury, stasis of blood, and hypercoagulability).”
BackgroundSelf-citationFrailty and Metabolic Vulnerability in Heart Failure: A Community Cohort Study
Kumar, S., Conners, K. M., Shearer, J. J., Joo, J., Turecamo, S. E., Sampson, M. L., Wolska, A. T., Remaley, A. T., Connelly, M. A., Otvos, J. D., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031616 · Cited by 11 · see citing works
Pu, X., Huang, H., Zhao, X., Liu, F., Leng, Y., Deng, Y., Huang, L., Zhou, X., Xu, F., Huang, Y., et al. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s460805 · Cited by 11 · see citing works
“4 The occurrence of frailty in cardiac surgery patients is as high as 20% to 50% and is apparently greater than that in noncardiac surgery patients.”
Background
- Authors
- Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., Forman, D. E., Resar, J. R., O’Connor, C. M., Gerstenblith, G., & Damluji, A. A.
- Affiliations
- Inova Health System (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- Corresponding author
- Damluji, Abdulla A.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 79
- Issue
- 5
- Pages
- 482-503
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC8852369
- OpenAlex
- W4210642841
- Cited by
- 412
- References
- 112
- Citations by year
- 2026: 87 · 2025: 126 · 2024: 105 · 2023: 66 · 2022: 28
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG021334)
- National Heart, Lung, and Blood Institute (K23HL153771)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- frailty, older adults, cardiovascular disease, frailty interventions, heart failure, cardiac rehabilitation, physical function, cognitive decline, physical inactivity, nutrition, social support, frailty prevention, quality of life
- MeSH terms
- Cardiac Rehabilitation, Frailty, Aged, Aging, Cardiovascular Diseases, Humans, Quality of Life, Risk Factors, Frail Elderly
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