The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study
Abstract
Objectives Prokinetics are considered the preferred treatment option for gastroparesis, but evidence of their efficacy is scarce. Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist used in the treatment of constipation, is able to enhance the gastric emptying rate. In a double-blind, randomized, placebo-controlled crossover study, we evaluated the efficacy of prucalopride to improve the gastric emptying rate and symptoms in patients with gastroparesis. Methods Thirty-four patients with gastroparesis (28 idiopathic, 7 men, mean age 42 ± 13 years) were evaluated in a double-blind crossover trial of 4-week treatment periods with placebo or prucalopride 2 mg q.d., separated by 2 weeks of washout. The primary end point was the change in symptom severity, assessed by the Gastroparesis Cardinal Symptom Index; secondary end points comprised the Patient Assessment of Upper Gastrointestinal Disorders-Symptom Severity Index, the Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life, and daily diaries, and the gastric emptying rate was assessed by the C-octanoic acid breath test. Results Three patients were lost to follow-up. One serious adverse event occurred (small bowel volvulus in the prucalopride group), and 3 patients dropped out because of adverse events of nausea and headache (all prucalopride). For the entire patient group, compared with placebo, prucalopride significantly improved the total Gastroparesis Cardinal Symptom Index (1.65 ± 0.19 vs 2.28…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The selective 5‑HT4 receptor agonist prucalopride may improve nausea, early satiety, bloating, and quality of life in selected patients, though it carries gastrointestinal side effects and requires individualization [49, 124, 125].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [125]
Citations
Cites
Stool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244
Stanghellini, V., Chan, F. K. L., Hasler, W. L., Malagelada, J. R., Suzuki, H., Tack, J., & Talley, N. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.011 · Cited by 1,572
Self-citationRevicki, D. A., Rentz, A. M., Dubois, D., Kahrilas, P., Stanghellini, V., Talley, N. J., & Tack, J. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000021689.86296.e4 · Cited by 418
Self-citationRentz, A. M., Kahrilas, P., Stanghellini, V., Tack, J., Talley, N. J., De la loge, C., Trudeau, E., Dubois, D., & Revicki, D. A. (2004) · Quality of Life Research · doi:10.1007/s11136-004-9567-x · Cited by 406
Self-citationRevicki, D. A., Rentz, A. M., Dubois, D., Kahrilas, P. J., Stanghellini, V., Talley, N. J., & Tack, J. F. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01612.x · Cited by 382
Self-citationArts, J., Holvoet, L., Caenepeel, P., Bisschops, R., Sifrim, D., Verbeke, K., Janssens, J., & Tack, J. (2007) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2007.03467.x · Cited by 362
Self-citationTack, J., van Outryve, M., Beyens, G., Kerstens, R., & Vandeplassche, L. (2009) · Gut · doi:10.1136/gut.2008.162404 · Cited by 347
Self-citationBouras, E. P., Camilleri, M., Burton, D., Thomforde, G., Mckinzie, S., & Zinsmeister, A. (2001) · Gastroenterology · doi:10.1053/gast.2001.21166 · Cited by 306
Tack, J., Camilleri, M., Chang, L., Chey, W. D., Galligan, J. J., Lacy, B. E., Müller‐Lissner, S., Quigley, E. M. M., Schuurkes, J., De Maeyer, J. H., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05011.x · Cited by 286
Self-citationJanssen, P., Harris, S. M., Jones, M., Masaoka, T., Farré, R., Törnblom, H., Oudenhove, L. V., Simrén, M., & Tack, J. F. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.118 · Cited by 263
Self-citation
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Carbone, 2014, The effect of prucalopride on gastric accommodation in healthy volunteers, UEG J, 2, 1S
Cited by
Sorted by citations
Ford, A. C., Mahadeva, S., Carbone, F., Lacy, B. E., & Talley, N. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30469-4 · Cited by 587
Self-citationACG Clinical Guideline: Gastroparesis
Camilleri, M., Kuo, B., Nguyen, L., Vaughn, V. M., Petrey, J., Greer, K., Yadlapati, R., & Abell, T. L. (2022) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001874 · Cited by 332
Gastroparesis: a turning point in understanding and treatment
Grover, M., Farrugia, G., & Stanghellini, V. (2019) · Gut · doi:10.1136/gutjnl-2019-318712 · Cited by 256
British Society of Gastroenterology guidelines on the management of functional dyspepsia
Black, C. J., Paine, P., Agrawal, A., Aziz, I., Eugenicos, M. P., Houghton, L. A., Hungin, P., Overshott, R., Vasant, D. H., Rudd, S., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327737 · Cited by 216
The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy
Guzel, T., & Mirowska-Guzel, D. M. (2022) · Molecules · doi:10.3390/molecules27051680 · Cited by 176
Metadata
- Authors
- Carbone, F., Van den Houte, K., Clevers, E., Andrews, C. N., Papathanasopoulos, A., Holvoet, L., Van Oudenhove, L., Caenepeel, P., Arts, J., Vanuytsel, T., & Tack, J.
- Affiliations
- KU Leuven (BE)
- Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium.
- Corresponding author
- Tack, Jan
- Venue
- American Journal of Gastroenterology
- Published
- 2019-07-08
- Volume
- 114
- Issue
- 8
- Pages
- 1265-1274
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2958890085
- Cited by
- 206
- References
- 32
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 25 · 2023: 30 · 2022: 27 · 2021: 39 · 2020: 33 · 2019: 9
- FWCI
- 24.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- prucalopride, gastroparesis, prokinetic agents, 5-HT4 receptor agonist, gastric emptying, Gastroparesis Cardinal Symptom Index, quality of life, idiopathic gastroparesis, nausea and vomiting, small bowel volvulus, adverse events, gastric emptying half-time, crossover trial
- MeSH terms
- Adult, Benzofurans, Breath Tests, Double-Blind Method, Female, Gastric Emptying, Humans, Male, Quality of Life, Severity of Illness Index, Gastroparesis, Cross-Over Studies, Serotonin 5-HT4 Receptor Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
