The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
RECAM: A New and Improved, Computerized Causality Assessment Tool for DILI Diagnosis
Abstract
Hayashi, Paul H. MD, MPH, FAASLD; Lucena, M. Isabel MD, PhD; Fontana, Robert J. MD, FAASLD Author Information
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In 194 DILI cases from the Spanish and DILIN registries, the area under the operator curves for identifying at least a probable causality category was the same for RUCAM and RECAM.
“Hayashi et al. 49 compared RECAM with RUCAM for correlation with expert opinion in 194 DILI cases from the Spanish and the DILIN registries. The area under the operator curves (AUC) for identifying at least a probable causality category was the same for RUCAM and RECAM”
From Methods for causality assessment of idiosyncratic drug‐induced liver injury (2025) · cites this paper as [49]
RECAM showed better overall agreement with expert opinion than RUCAM (.62 vs .56 weighted kappa, p = .14) and had greater sensitivity for extreme causality results.
“although RECAM showed better overall agreement with expert opinion (.62 vs. .56 weighted kappa, p = .14), and had greater sensitivity for extreme causality results.”
From Methods for causality assessment of idiosyncratic drug‐induced liver injury (2025) · cites this paper as [49]
RECAM requires external validation from regions other than US and Spain because it was developed based on case data from DILIN and the Spanish DILI Registry.
“However, this method requires external validation from regions other than US and Spain since it was developed based on case data from Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI Registry [61].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [61]
Citations
Cites
Björnsson, E. S., Bergmann, O. M., Björnsson, H. K., Kvaran, R. B., & Olafsson, S. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.006 · Cited by 865
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., Xu, J., Niu, J., Liu, J., Watkins, P. B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.002 · Cited by 615
Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network
Navarro, V. J., Barnhart, H., Bonkovsky, H. L., Davern, T., Fontana, R. J., Grant, L., Reddy, R. K., Seeff, L. B., Serrano, J., Sherker, A. H., et al. (2014) · Hepatology · doi:10.1002/hep.27317 · Cited by 418
Self-citationA revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, P. H., Lucena, M. I., Fontana, R. J., Bjornsson, E. S., Aithal, G. P., Barnhart, H., Gonzalez‐Jimenez, A., Yang, Q., Gu, J., Andrade, R. J., et al. (2022) · Hepatology · doi:10.1002/hep.32327 · Cited by 160
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Flagged first, then by citations
Research works printed but not linked: 9
- Danan, 1993, Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries, J Clin Epidemiol, 46, 1323, 10.1016/0895-4356(93)90101-6 · DOI · Paper page
- Benichou, 1993, Causality assessment of adverse reactions to drugs--II. An original model for validation of drug causality assessment methods: Case reports with positive rechallenge, J Clin Epidemiol, 46, 1331, 10.1016/0895-4356(93)90102-7 · DOI · Paper page
- Garcia-Cortes, 2011, Causality assessment methods in drug induced liver injury: Strengths and weaknesses, J Hepatol, 55, 683, 10.1016/j.jhep.2011.02.007 · DOI · Paper page
- Hayashi, 2009, Causality assessment in drug-induced liver injury, Semin Liver Dis, 29, 348, 10.1055/s-0029-1240003 · DOI
- Rockey, 2010, Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the roussel-Uclaf causality assessment method, Hepatology, 51, 2117, 10.1002/hep.23577 · DOI · Paper page
- Fontana, 2009, Drug-induced liver injury Network (DILIN) prospective study: Rationale, design and conduct, Drug Saf, 32, 55, 10.2165/00002018-200932010-00005 · DOI · Paper page
- Stephens, 2021, Comprehensive analysis and insights gained from long-term experience of the Spanish DILI registry, J Hepatol, 75, 86, 10.1016/j.jhep.2021.01.029 · DOI · Paper page
- Barritt, 2010, Detective work in drug-induced liver injury: Sometimes it is all about interviewing the right witness, Clin Gastroenterol Hepatol, 8, 635, 10.1016/j.cgh.2010.03.020 · DOI
- Medina-Caliz, 2018, Herbal and dietary supplement-induced liver injuries in the Spanish DILI registry, Clin Gastroenterol Hepatol, 16, 1495, 10.1016/j.cgh.2017.12.051 · DOI · Paper page
Cited by
Sorted by citations
Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update
Mao, Y., Ma, S., Liu, C., Liu, X., Su, M., Li, D., Li, Y., Chen, G., Chen, J., Chen, J., et al. (2024) · Hepatology International · doi:10.1007/s12072-023-10633-7 · Cited by 62
Methods for causality assessment of idiosyncratic drug‐induced liver injury
García‐Cortés, M., Matilla‐Cabello, G., & Lucena, M. I. (2025) · Liver International · doi:10.1111/liv.16083 · Cited by 15
Self-citationAtorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge
Singh, H., Khalaf, A., Kunkle, B. F., Gholami, S., Lewis, J. H., & Rangnekar, A. S. (2025) · ACG Case Reports Journal · doi:10.14309/crj.0000000000001570 · Cited by 3
Metadata
- Authors
- Hayashi, P. H., Lucena, M. I., & Fontana, R. J.
- Affiliations
- Division of Hepatology and Nutrition, Food and Drug Administration, Silver Spring, Maryland, USA;
- Servicio de Farmacologia Clinica, Instituto de Investigacion Biomedica de Malaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Malaga, Malaga Spain. CIBERehd, Madrid, Spain;
- Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
- Venue
- American Journal of Gastroenterology
- Published
- 2022-05-25
- Volume
- 117
- Issue
- 9
- Pages
- 1387-1389
- ISSN
- 0002-9270
- 1572-0241
- Cited by
- 28
- References
- 4
- Language
- en
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