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Cited by 23Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentGallbladder and Bile Duct Disorders

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Identification of Individuals at Increased Risk for Pancreatic Cancer in a Community-Based Cohort of Patients With Suspected Chronic Pancreatitis

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Jeon, Christie Y., Chen, Qiaoling, Yu, Wei, Dong, Elizabeth Y., Chung, Joanie, Pandol, Stephen J., Yadav, Dhiraj, Conwell, Darwin L., Wu, Bechien U.·2020·Clinical and Translational Gastroenterology
DOI 10.14309/ctg.0000000000000147PMC PMC7263650
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Abstract

OBJECTIVES: We lack reliable methods for identifying patients with chronic pancreatitis (CP) at increased risk for pancreatic cancer. We aimed to identify radiographic parameters associated with pancreatic cancer in this population. METHODS: We conducted a retrospective cohort study of patients with suspected CP within an integrated healthcare system in Southern California in 2006–2015. Patients were identified by a diagnostic code and confirmed by imaging findings (parenchymal calcification, ductal stones, glandular atrophy, pseudocyst, main duct dilatation, duct irregularity, abnormal side branch, or stricture) defined by the natural language processing of radiographic reports. We used Cox regression to determine the relationship of smoking, alcohol use, acute pancreatitis, diabetes, body mass index, and imaging features with the risk of incident pancreatic cancer at least 1 year after abnormal pancreas imaging. RESULTS: We identified 1,766 patients with a diagnostic code and an imaging feature for CP with a median follow-up of 4.5 years. There were 46 incident pancreatic cancer cases. Factors that predicted incident pancreatic cancer after 1-year of follow-up included obesity (hazard ratio 2.7, 95% confidence interval: 1.2–6.1) and duct dilatation (hazard ratio 10.5, 95% confidence limit: 4.0–27). Five-year incidence of pancreatic cancer in this population with duct dilatation was 6.3%. DISCUSSION: High incidence of pancreatic cancer in suspected patients with CP with pancreatic duct dilatation warrants regular surveillance for pancreatic cancer.

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Figure 1. Selection of patients with suspected chronic pancreatitis with abnormal radiographic pancreas imaging. KPSC, Kaiser Permanente Southern California.
Figure 1. Selection of patients with suspected chronic pancreatitis with abnormal radiographic pancreas imaging. KPSC, Kaiser Permanente Southern California.CC BY · PubMed Central
Figure 2. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis.
Figure 2. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis.CC BY · PubMed Central
Figure 3. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis by presence of ductal dilatation.
Figure 3. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis by presence of ductal dilatation.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 27

  1. Kirkegard, 2017, Chronic pancreatitis and pancreatic cancer risk: A systematic review and meta-analysis, Am J Gastroenterol, 112, 1366, 10.1038/ajg.2017.218 · DOI
  2. Malka, 2002, Risk of pancreatic adenocarcinoma in chronic pancreatitis, Gut, 51, 849, 10.1136/gut.51.6.849 · DOI
  3. Yadav, 2013, The epidemiology of pancreatitis and pancreatic cancer, Gastroenterology, 144, 1252, 10.1053/j.gastro.2013.01.068 · DOI · Paper page
  4. Bang, 2014, Mortality, cancer, and comorbidities associated with chronic pancreatitis: A Danish nationwide matched-cohort study, Gastroenterology, 146, 989, 10.1053/j.gastro.2013.12.033 · DOI
  5. Munigala, 2014, New diagnosis of chronic pancreatitis: Risk of missing an underlying pancreatic cancer, Am J Gastroenterol, 109, 1824, 10.1038/ajg.2014.318 · DOI
  6. Conwell, 2014, American pancreatic association practice guidelines in chronic pancreatitis: Evidence-based report on diagnostic guidelines, Pancreas, 43, 1143, 10.1097/MPA.0000000000000237 · DOI
  7. Chapman, 2011, Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm, J Biomed Inform, 44, 728, 10.1016/j.jbi.2011.03.011 · DOI
  8. Xiao, 2018, The use of International Classification of Diseases codes to identify patients with pancreatitis: A systematic review and meta-analysis of diagnostic accuracy studies, Clin Transl Gastroenterol, 9, 191, 10.1038/s41424-018-0060-1 · DOI
  9. Goldacre, 2008, Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: Record linkage study, Eur J Gastroenterol Hepatol, 20, 384, 10.1097/MEG.0b013e3282f4489f · DOI
  10. Karlson, 1997, The risk of pancreatic cancer following pancreatitis: An association due to confounding?, Gastroenterology, 113, 587, 10.1053/gast.1997.v113.pm9247480 · DOI
  11. Lowenfels, 1993, Pancreatitis and the risk of pancreatic cancer: International Pancreatitis Study Group, N Engl J Med, 328, 1433, 10.1056/NEJM199305203282001 · DOI
  12. Pedrazzoli, 2008, Survival rates and cause of death in 174 patients with chronic pancreatitis, J Gastrointest Surg, 12, 1930, 10.1007/s11605-008-0620-x · DOI
  13. Talamini, 1999, Incidence of cancer in the course of chronic pancreatitis, Am J Gastroenterol, 94, 1253, 10.1111/j.1572-0241.1999.01075.x · DOI
  14. Ueda, 2013, Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: A multicenter retrospective analysis, Surgery, 153, 357, 10.1016/j.surg.2012.08.005 · DOI
  15. Inoue, 2003, Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography, Gastrointest Endosc, 58, 510, 10.1067/S0016-5107(03)01962-X · DOI
  16. Lee, 2010, Periductal hypoechoic sign: An endosonographic finding associated with pancreatic malignancy, Gastrointest Endosc, 71, 249, 10.1016/j.gie.2009.08.023 · DOI
  17. Bracci, 2012, Obesity and pancreatic cancer: Overview of epidemiologic evidence and biologic mechanisms, Mol Carcinog, 51, 53, 10.1002/mc.20778 · DOI
  18. Genkinger, 2011, A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk, Int J Cancer, 129, 1708, 10.1002/ijc.25794 · DOI
  19. Aune, 2012, Body mass index, abdominal fatness and pancreatic cancer risk: A systematic review and non-linear dose-response meta-analysis of prospective studies, Ann Oncol, 23, 843, 10.1093/annonc/mdr398 · DOI
  20. Butler, 2010, Pancreatic duct replication is increased with obesity and type 2 diabetes in humans, Diabetologia, 53, 21, 10.1007/s00125-009-1556-8 · DOI
  21. Incio, 2016, Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy, Cancer Discov, 6, 852, 10.1158/2159-8290.CD-15-1177 · DOI
  22. Saligram, 2012, Analyses of hospital administrative data that use diagnosis codes overestimate the cases of acute pancreatitis, Clin Gastroenterol Hepatol, 10, 805, 10.1016/j.cgh.2012.03.025 · DOI
  23. Walsh, 1992, Minimal change chronic pancreatitis, Gut, 33, 1566, 10.1136/gut.33.11.1566 · DOI
  24. Witt, 2007, Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy, Gastroenterology, 132, 1557, 10.1053/j.gastro.2007.03.001 · DOI · Paper page
  25. Mehrabi, 2013, An efficient pancreatic cyst identification methodology using natural language processing, Stud Health Technol Inform, 192, 822
  26. Roch, 2015, Automated pancreatic cyst screening using natural language processing: A new tool in the early detection of pancreatic cancer, HPB (Oxford), 17, 447, 10.1111/hpb.12375 · DOI
  27. Al-Haddad, 2010, Natural language processing for the development of a clinical registry: A validation study in intraductal papillary mucinous neoplasms, HPB (Oxford), 12, 688, 10.1111/j.1477-2574.2010.00235.x · DOI

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Metadata

Authors
Jeon, C. Y., Chen, Q., Yu, W., Dong, E. Y., Chung, J., Pandol, S. J., Yadav, D., Conwell, D. L., & Wu, B. U.
Affiliations
  • Cedars-Sinai Medical Center (US)
  • Kaiser Permanente (US)
  • University of Pittsburgh Medical Center (US)
  • The Ohio State University Wexner Medical Center (US)
Corresponding author
Jeon, Christie Y.
ORCID
Venue
Clinical and Translational Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-04
Volume
11
Issue
4
Pages
e00147
ISSN
2155-384X (ISSN-L)
DOI
10.14309/ctg.0000000000000147
PMC
PMC7263650
OpenAlex
W3016150855
Cited by
23
References
1
Citations by year
2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical and Translational Gastroenterology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327, U01DK108306, U01DK108314)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
Keywords
chronic pancreatitis, pancreatic cancer risk, pancreatic duct dilatation, obesity, cancer surveillance, radiological features, risk factors, smoking, alcohol consumption, diabetes mellitus, body mass index
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Natural Language Processing, Pancreas, Pancreatic Neoplasms, Registries, Retrospective Studies, Tomography, X-Ray Computed, Incidence, Risk Assessment, Patient Selection, Pancreatitis, Chronic, Early Detection of Cancer, Electronic Health Records

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