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Cited by 30Parkinson's Disease Mechanisms and TreatmentsGut microbiota and healthGastrointestinal motility and disorders

Relationships Between Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease: Indication from Gut Microbiota Alterations

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Zhang, Pingchen, Huang, Pei, Li, Yuanyuan, Du, Juanjuan, Luo, Ningdi, He, Yixi, Liu, Jin, He, Guiying +6 more·2024·Aging and disease
DOI 10.14336/ad.2023.0518PMC PMC10796088
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Abstract

Rapid eye movement sleep behavior disorder (RBD) has a close relationship with Parkinson's disease (PD) and was even regarded as the most reliable hallmark of prodromal PD. RBD might have similar changes in gut dysbiosis to PD, but the relationship between RBD and PD in gut microbial alterations is rarely studied. In this study, we aim to investigate whether there were consistent changes between RBD and PD in gut microbiota, and found some specific biomarkers in RBD that might indicate phenoconversion to PD. Alpha-diversity showed no remarkable difference and beta-diversity showed significant differences based on the unweighted (R = 0.035, P = 0.037) and weighted (R = 0.0045, P = 0.008) UniFrac analysis among idiopathic RBD (iRBD), PD with RBD, PD without RBD and normal controls (NC). Enterotype distribution indicated iRBD, PD with RBD and PD without RBD were Ruminococcus-dominant while NC were Bacteroides-dominant. 7 genera (4 increased: Aerococcus, Eubacterium, Gordonibacter and Stenotrophomonas, 3 decreased: Butyricicoccus, Faecalibacterium and Haemophilus) were consistently changed in iRBD and PD with RBD. Among them, 4 genera (Aerococcus, Eubacterium, Butyricicoccus, Faecalibacterium) remained distinctive in the comparison between PD with RBD and PD without RBD. Through clinical correlation analysis, Butyricicoccus and Faecalibacterium were found negatively correlated with the severity of RBD (RBD-HK). Functional analysis showed iRBD had similarly increased staurosporine biosynthesis to PD with RBD. Our study indicates that RBD had similar gut microbial changes to PD. Decreased Butyricicoccus and Faecalibacterium might be potential hallmarks of phenoconversion of RBD to PD.

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  • Brain- and body-first PD subtypes could have distinct microbiome signatures.

    “The depletion of Butyricicoccus and Faecalobacteria have been shown to be specific to PD patients with RBD rather than those without – namely, it suggests that brain- and body-first PD subtypes could have distinct microbiome signatures [133].”

    From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [133]

  • There was a negative correlation between the levels of Butyricicoccus and Faecalibacterium and symptom severity scores for RBD.

    “Moreover, there was a negative correlation between the levels of these two bacterial species and symptom severity scores for RBD.”

    From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [133]

  • Depletion of Butyricicoccus and Faecalobacteria is specific to PD patients with RBD rather than those without.

    “The depletion of Butyricicoccus and Faecalobacteria have been shown to be specific to PD patients with RBD rather than those without – namely, it suggests that brain- and body-first PD subtypes could have distinct microbiome signatures [133].”

    From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [133]

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Cited by

Sorted by citations

Authors
Zhang, P., Huang, P., Li, Y., Du, J., Luo, N., He, Y., Liu, J., He, G., Cui, S., Zhang, W., Li, G., Shen, X., Jun, L., & Chen, S.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
  • Huang, Pei
  • Chen, Shengdi
ORCID
Venue
Aging and disease
Publisher
Aging and Disease
Published
2024
Volume
15
Issue
1
Pages
357
ISSN
2152-5250 (ISSN-L)
DOI
10.14336/ad.2023.0518
PMC
PMC10796088
OpenAlex
W4378077940
Cited by
30
References
3
Citations by year
2026: 10 · 2025: 12 · 2024: 8
FWCI
5.10
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging and Disease (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81971187, 82171401, 2018SHZDZX05, 81801267, 81971187, 82171401)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
rapid eye movement sleep behavior disorder, Parkinson's disease, gut microbiota, gut dysbiosis, phenoconversion, prodromal Parkinson's disease, Butyricicoccus, Faecalibacterium, Ruminococcus, Bacteroides, enterotypes, biomarkers
MeSH terms
Gastrointestinal Microbiome, Humans, Parkinson Disease, Biomarkers, REM Sleep Behavior Disorder

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