HPV and Cervical Cancer Epidemiology - Current Status of HPV Vaccination in India
Open accessAbstract
Cervical cancer (CaCx) is the second most fatal cancer contributing to 14% of cancers in Indian females, which account for 25.4% and 26.5% of the global burden of CaCx prevalence and mortality, respectively. Persistent infection with high-risk human papilloma virus (HPV- strains 16 and 18) is the most important risk factor for precursors of invasive CaCx. Comprehensive prevention strategies for CaCx should include screening and HPV vaccination. Three screening modalities for CaCx are cytology, visual inspection with acetic acid, and HPV testing. There is no Indian national policy on CaCx prevention, and screening of asymptomatic females against CaCx is practically non-existent. HPV vaccines can make a major breakthrough in the control of CaCx in India which has high disease load and no organized screening program. Despite the Indian Government's effort to introduce HPV vaccination in the National Immunization Program and bring down vaccine cost, challenges to implementing vaccination in India are strong such as: inadequate epidemiological evidence for disease prioritization, duration of vaccine use, parental attitudes, and vaccine acceptance. This paper reviews the current epidemiology of CaCx and HPV in India, and the current status of HPV vaccination in the country. This article stresses the need for more research in the Indian context, to evaluate interventions for CaCx and assess their applicability, success, scalability and sustainability within the constraints of the In…
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Uptake of HPV vaccination in general has been low in India due to misperceptions about HPV infection, cervical cancer and HPV vaccine, and due to cultural reasons.
“However, uptake of HPV vaccination in general has been low due to misperceptions about HPV infection, cervical cancer and HPV vaccine, and due to cultural reasons in India.”
From Human Papillomavirus Vaccine Acceptability among Parents of Adolescent Girls in a Rural Area, Mysore, India (2018) · cites this paper as [7]
Cultural factors, including stigma surrounding STIs and fear of judgment from family and community members, may negatively impact vaccine acceptability.
“Cultural factors, including stigma surrounding STIs and fear of judgment from family and community members, may negatively impact vaccine acceptability [7, 24].”
From Acceptability of HPV vaccination for cervical cancer prevention amongst emerging adult women in rural Mysore, India: a mixed-methods study (2024) · cites this paper as [7]
Participants in FGDs believed stigma around STIs could limit uptake.
“participants in FGDs believed stigma around STIs could limit uptake [7].”
From Acceptability of HPV vaccination for cervical cancer prevention amongst emerging adult women in rural Mysore, India: a mixed-methods study (2024) · cites this paper as [7]
Cites
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Health and economic impact of HPV 16 and 18 vaccination and cervical cancer screening in India
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Degarege, A., Krupp, K., Fennie, K., Srinivas, V., Li, T., Stephens, D. P., Marlow, L. A. V., Arun, A., & Madhivanan, P. (2018) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2018.07.008 · Cited by 34 · see citing works
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- Authors
- Chatterjee, S., & Chattopadhyay, A.
- Affiliations
- University of Nebraska Medical Center (US)
- Case Western Reserve University (US)
- ORCID
- Chattopadhyay, Amit
- Venue
- APJCP
- Publisher
- APJCP
- Published
- 2016
- Volume
- 17
- Issue
- 8
- Pages
- 3663-73
- OpenAlex
- W2546013036
- Cited by
- 52
- References
- 3
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 3
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- PubMed (publishedVersion)
- NRCT Data Center
- PubMed
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Health Sciences › Medicine › Surgery › Genital Health and Disease
- Keywords
- cervical cancer, HPV vaccination, human papillomavirus, India, cervical cancer epidemiology, cervical cancer screening, HPV testing, visual inspection with acetic acid, cervical cytology, vaccine acceptance, National Immunization Program
- MeSH terms
- Uterine Cervical Neoplasms, Female, Humans, India, Vaccination, Prevalence, Papillomavirus Infections, Human papillomavirus 18, Human papillomavirus 16, Papillomavirus Vaccines
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