Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

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Items 201–296 of 296

1. Comparison of in vitro approaches for predicting the metabolism of the selective androgen receptor modulator RAD140
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2. Biologically-Inspired Microphysiological Systems
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3. Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings
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4. The Development of 3D Primary Co-Culture Models of the Human Airway
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5. Using a Microfluidic Device for Culture and Drug Toxicity Testing of 3D Cells
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6. Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection
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7. FET-Based Integrated Charge Sensor for Organ-on-Chip Applications
   Hande Aydoğmuş, Milica Dostanić, Mojtaba Jahangiri, Rajarshi Sinha, William F. Quirós-Solano, Massimo Mastrangeli, Pasqualina Maria Sarro · 2020 · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ...
8. Systems engineering of microphysiometry
   Joachim Wiest · 2022 · Organs-on-a-Chip
9. State of the Art in Integrated Biosensors for Organ-on-a-Chip Applications
   Tanima Dey, Priya Mitra, Binita Chakraborty, Arka Sanyal, Aditi Acharjee, Anushikha Ghosh, Dindyal Mandal · 2024 · Smart nanomaterials technology
10. Design criteria and standardization of a microfluidic cell culture system for investigating cellular migration
    Young Lee, Gihyun Lee, Minkyung Cho, Je‐Kyun Park · 2019 · Journal of Micromechanics and Microengineering
11. Microphysiological systems in the evaluation of hematotoxicities during drug development
    Eva‐Maria Dehne, Annika Winter, Uwe Marx · 2019 · Current Opinion in Toxicology
12. Microphysiometry
    Martin Brischwein, Joachim Wiest · 2018 · Bioanalytical reviews
13. Application of complex in vitro models (CIVMs) in drug discovery for safety testing and disease modeling
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14. Technical aspects of megaureter repair.
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15. The effect of laminins on chemoresistance of colorectal cancer cells
    Diana V. Maltseva, Г. С. Захарова, Sergey Rodin, Alexander Tonevitsky · 2018 · Russian Chemical Bulletin
16. COVID-19 – prime time for microphysiological systems, as illustrated for the brain
    Ian Kang · 2021 · ALTEX
17. The use of human tissue in safety assessment
    Samuel J. Jackson, Helen M. Prior, Anthony M Holmes · 2018 · Journal of Pharmacological and Toxicological Methods
18. Research and Testing Without Animals: Where Are We Now and Where Are We Heading?
    Thomas Härtung · 2019 · BRILL eBooks
19. Development of a Novel Microphysiological System for Peripheral Neurotoxicity Prediction Using Human iPSC-Derived Neurons with Morphological Deep Learning
    Xiaobo B Han, Naoki Matsuda, Makoto Yamanaka, Ikuro Suzuki · 2024 · Toxics
20. The universal physiological template—a system to advance medicines
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21. A decade of toxicological trends: what the papers say
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22. Antibacterial, antidiabetic, acute toxicity, antioxidant, and nephroproductive competence of extracts of Lannea coromandelica fruit through in-vitro and in-vivo animal model investigation
    Hai-Anh Ha, Mohammad K. Al‐Sadoon, Mythili Saravanan, G.K. Jhanani · 2023 · Environmental Research
23. Automation and opportunities for industry scale-up of microphysiological systems
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24. Next-generation experimental and computational strategies for drug-drug interaction prophecy
    Aarika Kanukolanu, Lakshmi Vineela Nalla, Siva Nageswara Rao Gajula · 2025 · Drug Metabolism and Disposition
25. Mikroakışkan Çiplere Kök Hücre ve Doku Mühendisliği Perspektifinden Bakış
    Gülşah Torkay, Ayça Bal‐Öztürk · 2022 · Journal of Polytechnic
26. Organoids and Organ-On-Chip Models for COVID-19 Research and Its Application in Modernization of Traditional Chinese Medicine: Opportunities and Challenges
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27. Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity_suppl
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28. Microfluidic Systems and Organ (Human) on a Chip
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29. Towards Low-Cost Cell Culturing Platforms with Integrated Sensing Capabilities
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30. Advances in alternative non-animal testing methods represent a way to find new treatments for patients
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31. Causality analysis of toxicological mechanisms in networked systems such as adverse outcome pathway networks
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32. Application of the 3Rs principles in the development of pharmaceutical generics
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33. Open Innovation in the Life Science Industry
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34. miRNA as a Marker for In Vitro Neurotoxicity Testing and Related Neurological Disorders
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35. The challenges and considerations for emerging or future entrepreneurial researchers in microphysiological systems
    Francois Taute, Antoni Homs-Corbera, Pierre Gaudriault · 2021 · Open Research Europe
36. Bioreactors and microphysiological systems for adipose-based pharmacologic screening
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37. PiFlow: A Biocompatible Low-Cost Programmable Dynamic Flow Pumping System Utilizing a Raspberry Pi Zero and Commercial Piezoelectric Pumps
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38. Towards learning and memory risk assessment with human brain organoids: barriers and opportunities
    Ronit Mohapatra, Dowlette‐Mary Alam El Din, Hanyu Zhao, Thomas Härtung, Lena Smirnova · 2026 · Frontiers in Toxicology
39. Mechanical Microenvironment-Dependent Tumor Growth Intervention: Recent Advances and Translational Outlook
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40. Neuron-Glia Interactions Studied with In Vitro Co-Cultures
    Samantha Mancino, Melania Maria Serafini, Barbara Viviani · 2019 · Neuromethods
41. Radiation induced cardiovascular disease: An odyssey of bedside-bench-bedside approach
    Rishi Raj Rikhi, Gursharan Singh Samra, Michael Arustamyan, Jay Patel, Leon Zhou, Brandon Bungo, Rohit Moudgil · 2020 · Life Sciences in Space Research
42. Lessons and Insights From the First Microphysiological World Summit
    Nureddin A. Ashammakhi, Mustafa Nakipoğlu, Thomas Härtung · 2023 · Journal of Craniofacial Surgery Open
43. Three-Dimensional Cultivation a Valuable Tool for Modelling Canine Mammary Gland Tumour Behaviour In Vitro
    Mykhailo Huniadi, Natália Nosálová, Viera Almášiová, Ľubica Horňáková, Alexandra Valenčáková-Agyagosová, Nikola Hudáková, Dasa Cizkova · 2024 · Cells
44. Data-Driven Sustainable In Vitro Campaigns to Decipher Invasive Breast Cancer Features
    Lekha Shah, Valentina Breschi, Annalisa Tirella · 2025 · ACS Biomaterials Science & Engineering
45. Enabling 3D hepatocyte spheroids for microphysiometry
    Sebastian Eggert, F. A. Alexander, Joachim Wiest · 2017 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
46. Detection of Low-Abundant MicroRNAs with Hybridization Microchips
    M. Yu. Shkurnikov, Evgeny N. Knyazev, К. А. Фомичева, Mikhail Kasatkin, V. V. Arkov, Julia Alekseevna Makarova · 2019 · Bulletin of Experimental Biology and Medicine
47. Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data_suppl
    Alice Krebs · 2019 · ALTEX
48. Development of a three-dimensional haematopoietic stem cell-permissive bone marrow niche model using magnetic levitation
    Natasha S. Lewis · 2018 · Enlighten: Theses (The University of Glasgow)
49. Pathway‐Based Similarity Measurement to Quantify Transcriptomics Similarity Between Human Tissues and Preclinical Models
    Paarth Parekh, Jason S. Sherfey, Begum Alaybeyoglu, Murat Cirit · 2024 · Clinical Pharmacology & Therapeutics
50. Advancements in Drug Safety Evaluation and Pharmacogenomics for Special Populations
    Mohd. Wasiullah, Piyush Yadav, Mohit Vishwakarma Mohit Vishwakarma, Shikha Yadav Shikha Yadav · 2025 · International Journal of Pharmaceutical Research and Applications
51. An open-source microphysiological system for the evaluation of cardiovascular materials and devices under controlled flow conditions
    Jesús Ordoño, Carlos Aguilar Vega, Natalia Téllez Fouz, Guillermo Domínguez, Carmelo De Maria, Andrés Díaz Lantada, Jon Mikel Molina-Aldareguia, Mónica Echeverry‐Rendón · 2026 · Biomaterials Advances
52. Miniaturisierte menschliche Organe auf dem Chip
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53. 2017 Lush Science Prize
    Jenny McCann, Terry McCann · 2018 · Alternatives to Laboratory Animals
54. New horizons of microphysiological systems: India forging its path in human-relevant research
    Surat Parvatam, Kasturi Mahadik, Anushka A. Banerjee, Kadambari Patil, Vegesna Radha, Madhusudhana Rao · 2023 · Biology Open
55. Protective role of hepatic non-parenchymal cells against drug-induced hepatocyte toxicity using perfluoropolyether-based microfluidic devices
    Mengyang Wang, Qiyue Zhang, Kazuma Aoki, Yuriko Higuchi, Fumiyoshi Yamashita · 2025 · Toxicology Letters
56. AI-powered image standardization in microphysiological system platforms
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57. Autogenous Biofabrication of Nativelike, Scaffold-Free Human Skin Equivalents Using a Smart, Enzyme-Degradable Tissue Templating Coating
    Che J. Connon, Ricardo M. Gouveia · 2018 · ACS Applied Bio Materials
58. Toxicological Assessment In Vitro
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59. New European Union statistics on laboratory animal use – what really counts!_suppl
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60. Tissue Chips: Contemporary Applications and Advancements
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61. Organs-on-chips for the pharmaceutical development process: design perspectives and implementations
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62. Spatial control of oxygen delivery to 3D cultures alters cancer cell growth and gene expression
    William J. Wulftange, Michelle A. Rose, Marcial Garmendia‐Cedillos, Davi da Silva, Joanna E. Poprawski, Dhruv Srinivasachar, Taylor Sullivan, Langston Lim, Valery V. Bliskovsky, Matthew D. Hall et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
63. PLUTONIUM FUEL DEVELOPMENT FOR FAST REACTORS IN THE U.S.
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64. The Three Rs
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65. Microphysiological system for heart tissue - going from 2D to 3D culture
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66. Biophysics applications in drug discovery: Working toward a new integrative model
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67. Intronic miRNAs of Apoptosis Genes as Indicators of Cell Death
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68. Integration of Advanced Technologies into Regulatory Toxicology
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69. Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic–pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI)
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70. MicroRNA Pattern of Culture Medium as a Substrate for the Analysis of Lysis of Cell Subpopulations in Multiorgan Cell Models
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71. Safety science in the 21st century—a scientific revolution in its making
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72. Análise comparativa de diferentes sistemas de cultivo tridimensionais para estabelecimento de um modelo in vitro de câncer de bexiga para ensaios de eficácia terapêutica
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73. Avaliação da toxicidade e eficácia de ingredientes de uso tópico por métodos alternativos>i< in vitro>/i<: culturas 2D, 3D e microfluídica de orgãos-em-chip
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74. Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)_suppl
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75. Organ-on-chip in development: Towards a roadmap for organs-on-chip_suppl
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76. Chemical concentrations in cell culture compartments (C5) – free concentrations_suppl
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77. A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity_suppl1
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78. Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies_suppl
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79. A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays_suppl1
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80. Stem cells, organoids, and cellular therapy
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81. Cisplatin Induces Cell Death in Rat Adult Kidney Stem/ Progenitor Cell-Derived Kidney Organoids
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82. Assaying Proliferation Characteristics of Cells Cultured Under Static Versus Periodic Conditions
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83. Multiorgans-on-a-chip for acute toxicity
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84. Evaluating the Effect of Drug Compounds on Cardiac Spheroids Using the Cardiac Cell Outgrowth Assay in a Microphysiological System
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85. Organotypic on-chip models: Bridging the gap between traditional in vitro culture and animal testing
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86. Rat and dog quad-culture liver chip models: characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist
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87. Innovations in hydrocephalus modeling: bridging animal models, bioengineering platforms, and precision therapies
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88. Développement par génie tissulaire d’un modèle de peau humaine innervée, vascularisée et immunocompétente pour l’étude des réactions inflammatoires cutanées
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89. Development of a lung-liver in vitro coculture model for the risk assessment of inhaled xenobiotics
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90. Toward relational biosecurity: understanding AI-enabled biology as a connected system
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91. Cryopreservation of brain organoids - a tool for on-demand organoid banking
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92. From nanoengineering to microphysiology: Organ-on-chip platforms for next-generation drug delivery
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93. Case 4: Microfluidic Chip for Pharmacological Studies of Organotypic Teeth and Liver Cells
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94. Towards the One Exposome: harnessing artificial intelligence and digital health technologies across One Health toxicology, new approach methodologies, and environmental public health
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95. Bridging the GAP: Regulatory Frameworks and the Transition from Animal Models to Alternative Methods
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96. Skin-on-a-Chip for Cosmetic Safety Assessment: From Reconstructed Skin Models to Regulatory Translation
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