The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Pancreatic beta cell lines and their applications in diabetes mellitus research
Open accessAbstract
During the past 30 years great effort has been put into establishing an insulin-secreting beta cell line that retains normal regulation of insulin secretion, but only few of these attempts have been successful. To overcome the limited availability of primary beta cells and to include the principles of the 3Rs into the field of diabetes mellitus research, numerous investigators used X-rays or viruses to induce insulinomas, in vitro transformation, derivation of cells from transgenic mice or even non-islet cells to produce immortalised beta cell lines. The most widely used insulin-secreting cell lines are RIN, HIT, MIN, INS-1 and TC cells. These cells produce insulin and small amounts of glucagon and somatostatin. Some of them are only poorly responsive to glucose, others respond to glucose well, but their concentration-dependence curve is markedly shifted to higher sensitivity. Despite problems associated with beta cell cultures, these cell lines have provided some valuable information about physiological processes. However, an urgent need to establish a "normal" beta cell line of human or pig origin remains.
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International Journal of Pharmaceutical Sciences and Research
(2025) · International Journal of Pharmaceutical Sciences and Research · doi:10.13040/ijpsr.0975-8232 · Cited by 2,638
Hilderink, J., Spijker, S., Carlotti, F., Lange, L., Engelse, M., van Blitterswijk, C., de Koning, E., Karperien, M., & van Apeldoorn, A. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12555 · Cited by 83
Fluorescent exendin-4 derivatives for pancreatic β-cell analysis
Clardy, S. M., Keliher, E. J., Mohan, J. F., Sebas, M., Benoist, C., Mathis, D., & Weissleder, R. (2014) · Bioconjugate Chemistry · doi:10.1021/bc4005014 · Cited by 41
Metadata
- Authors
- Skelin, M.
- Venue
- ALTEX
- Publisher
- ALTEX Edition
- Published
- 2010
- Volume
- 27
- Issue
- 2
- Pages
- 105-113
- ISSN
- 0946-7785 (ISSN-L)
- 1868-596X
- OpenAlex
- W52690082
- Cited by
- 290
- References
- 31
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
