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Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.
Open accessAbstract
Continuous cell lines that secrete both insulin and somatostatin were established by two cooperating groups of investiagtors from a serially transplantable, radiation-induced, rat islet cell tumor. The cell lines, named RIN-r and RIN-m, were initiated from tumors maintained in inbred rats or in athymic nude mice, respectively. The cultured cells are epithelioid, free of fibroblast contamination, and can be cloned. They have a hypodiploid chromosome number, are tumorigenic, and posses amine-handling properties, including high levels of L-dopa decarboxylase and formaldehyde-induced fluorescence. Preliminary analysis of clones revealed a spectrum of insulin secretion from undetectable to relatively high. These clonal cell lines provide important systems to study the biology of insulin and somatostatin.
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Cited by
Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903
Self-citationLAN, M. S., LU, J., GOTO, Y., & NOTKINS, A. L. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.505 · Cited by 320
Pancreatic beta cell lines and their applications in diabetes mellitus research
Skelin, M. (2010) · ALTEX · doi:10.14573/altex.2010.2.105 · Cited by 290
Garcia, E. P., McPherson, P. S., Chilcote, T. J., Takei, K., & De Camilli, P. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.1.105 · Cited by 266
Morgan, D. G., Kulkarni, R. N., Hurley, J. D., Wang, Z. L., Wang, R. M., Ghatei, M. A., Karlsen, A. E., Bloom, S. R., & Smith, D. M. (1998) · Diabetologia · doi:10.1007/s001250051095 · Cited by 79
Metadata
- Authors
- Gazdar, A. F., Chick, W. L., Oie, H. K., Sims, H. L., King, D. L., Weir, G. C., & Lauris, V
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-06
- Volume
- 77
- Issue
- 6
- Pages
- 3519-3523
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016073900
- Cited by
- 497
- References
- 0
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. https://app.cochat.ai/papers/10.1073/pnas.77.6.3519
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- Gazdar, A. F., Chick, W. L., Oie, H. K., Sims, H. L., King, D. L., Weir, G. C., & Lauris, V. (1980). Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.6.3519
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