Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
Abstract
A transgenic mouse bearing mutant transgenes linked to familial forms of Alzheimer's disease (AD) for the amyloid precursor protein and presenilin-1 (TASTPM) showed Abeta plaque deposition and age-related histological changes in associated brain pathology. The Abeta present was of multiple forms, including species with a C-terminus at position 40 or 42, as well as an N-terminus at position 1 or truncated in a pyro-3-glutamate form. Endogenous rodent Abeta was also present in the deposits. Laser capture microdissection extracts showed that multimeric forms of Abeta were present in both plaque and tissue surrounding plaques. Associated with the Abeta deposits was evidence of an inflammatory response characterised by the presence of astrocytes. Also present in close association with the deposits was phosphorylated tau and cathepsin D immunolabelling. The incidence of astrocytes and of phosphorylated tau and cathepsin D load showed that both of these potential disease markers increased in parallel to the age of the mice and with Abeta deposition. Immunohistochemical labelling of neurons in the cortex and hippocampus of TASTPM mice suggested that the areas of Abeta deposition were associated with the loss of neurons. TASTPM mice, therefore, exhibit a number of the pathological characteristics of disease progression in AD and may provide a means for assessment of novel therapeutic agents directed towards modifying or halting disease progression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both TASTPM and P301L mouse models are known to demonstrate a proinflammatory phenotype.
“Both mouse models are known to demonstrate a proinflammatory phenotype (17, 18).”
From The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease (2019) · cites this paper as [18]
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · see citing works
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
Chishti, M. A., Yang, D.-S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100710200 · Cited by 955 · see citing works
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W. K., Teter, B., Tran, T., Ubeda, O. J., Ashe, K. H., Frautschy, S. A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05709.2000 · Cited by 876 · see citing works
Microglial response to amyloid plaques in APPsw transgenic mice.
Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B. T., Saido, T. C., Hsiao, K., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 592 · see citing works
Yan, Q., Zhang, J., Liu, H., Babu-Khan, S., Vassar, R., Biere, A. L., Citron, M., & Landreth, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07504.2003 · Cited by 469 · see citing works
Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review
Szekely, C. A., Thorne, J. E., Zandi, P. P., Ek, M., Messias, E., Breitner, J. C. S., & Goodman, S. N. (2004) · Neuroepidemiology · doi:10.1159/000078501 · Cited by 394 · see citing works
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
Nixon, R. A., Cataldo, A. M., & Mathews, P. M. (2000) · Neurochemical Research · doi:10.1023/a:1007675508413 · Cited by 315 · see citing works
Schmitz, C., Rutten, B. P. F., Pielen, A., Schäfer, S., Wirths, O., Tremp, G., Czech, C., Blanchard, V., Multhaup, G., Rezaie, P., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63235-x · Cited by 281 · see citing works
Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H. G., Wiederhold, K.-H., Walker, L., Staufenbiel, M., & Jucker, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00515.2002 · Cited by 213 · see citing works
Howlett, D. R., Richardson, J. C., Austin, A., Parsons, A. A., Bate, S. T., Davies, D. C., & Gonzalez, M. I. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.029 · Cited by 212 · see citing works
Redwine, J. M., Kosofsky, B. E., Jacobs, R. E., Games, D., Reilly, J. F., Morrison, J. H., Young, W. G., & Bloom, F. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242746599 · Cited by 201 · see citing works
Kuo, Y.-M., Emmerling, M. R., Woods, A. S., Cotter, R. J., & Roher, A. E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7083 · Cited by 178 · see citing works
Inflammatory cytokines in the brain: Does the CNS shape immune responses?
Owens, T., Renno, T., Taupin, V., & Krakowski, M. L. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90218-6 · Cited by 174 · see citing works
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases
Braak, H., Rüb, U., Schultz, C., & Tredici, K. D. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s305 · Cited by 163 · see citing works
Ribé, E. M., Pérez, M., Puig, B., Gich, I., Lim, F., Cuadrado, M., Sesma, T., Catena, S., Sánchez, B., Nieto, M., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.027 · Cited by 162 · see citing works
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
Koike, M., Shibata, M., Ohsawa, Y., Nakanishi, H., Koga, T., Kametaka, S., Waguri, S., Momoi, T., Kominami, E., Peters, C., et al. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00035-6 · Cited by 153 · see citing works
Ranaivo, H. R., Craft, J. M., Hu, W., Guo, L., Wing, L. K., Eldik, L. J. V., & Watterson, D. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4652-05.2006 · Cited by 137 · see citing works
Cognitive decline strongly correlates with cortical atrophy in Alzheimer’s dementia
Mouton, P. R., Martin, L. J., Calhoun, M. E., Forno, G. D., & Price, D. L. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00080-3 · Cited by 128 · see citing works
Dewachter, I., Dorpe, J. V., Smeijers, L., Gilis, M., Kuipéri, C., Laenen, I., Caluwaerts, N., Moechars, D., Checler, F., Vanderstichele, H., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06452.2000 · Cited by 104 · see citing works
Kurt, M. A., Davies, D. C., Kidd, M., Duff, K., Rolph, S. C., JENNINGS, K. H., & Howlett, D. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7717 · Cited by 88 · see citing works
Richardson, J. C., Kendal, C., Anderson, R., Priest, F., Gower, E., Soden, P. E., Gray, R., Topps, S., Howlett, D. R., Lavender, D., et al. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00389-0 · Cited by 85 · see citing works
The topographic distribution of brain atrophy in Alzheimer's disease
Mann, D. M. A. (1991) · Acta Neuropathologica · doi:10.1007/bf00294434 · Cited by 74 · see citing works
Novel Cathepsin D Inhibitors Block the Formation of Hyperphosphorylated Tau Fragments in Hippocampus
Bi, X., Haque, T. S., Zhou, J., Skillman, A. G., Lin, B., Lee, C. E., Kuntz, I. D., Ellman, J. A., & LYNCH, G. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741469.x · Cited by 70 · see citing works
Kurt, M. A., Davies, D. C., & Kidd, M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7096 · Cited by 57 · see citing works
Tekirian, T. L., Yang, A., Glabe, C. G., & Geddes, J. W. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731584.x · Cited by 53 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Kinsey, A., Güntert, A., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.78 · Cited by 405 · see citing works
Lee, J. K., Jin, H. K., Endo, S., Schuchman, E. H., Carter, J., & Bae, J.-S. (2009) · Stem Cells · doi:10.1002/stem.277 · Cited by 303 · see citing works
Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., Nahaboo Solim, M. A., Moens, T. G., Paublete, R. M., Ali, S. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.041 · Cited by 290 · see citing works
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease
Pereira, J. B., Janelidze, S., Ossenkoppele, R., Kvartsberg, H., Brinkmalm, A., Mattsson, N., Stomrud, E., Smith, R. A., Zetterberg, H., Blennow, K., et al. (2020) · Brain · doi:10.1093/brain/awaa395 · Cited by 201 · see citing works
Arbel‐Ornath, M., Hudry, E., Boivin, J. R., Hashimoto, T., Takeda, S., Kuchibhotla, K. V., Hou, S. S., Lattarulo, C. R., Belcher, A. M., Shakerdge, N. B., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0169-9 · Cited by 168 · see citing works
Activation of mTOR: a culprit of Alzheimer’s disease?
Cai, Z., Zhou, Y., Xiao, M., Yan, L.-J., & He, W. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75717 · Cited by 161 · see citing works
Elia, C. A., Tamborini, M., Rasile, M., Desiato, G., Marchetti, S., Swuec, P., Mazzitelli, S., Clemente, F., Anselmo, A., Matteoli, M., et al. (2019) · Cells · doi:10.3390/cells8091059 · Cited by 142 · see citing works
A unifying hypothesis for Alzheimer's disease: from plaques to neurodegeneration
Edwards, F. A. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.003 · Cited by 140 · see citing works
Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease
Chakroborty, S., Briggs, C. A., Miller, M. B., Goussakov, I. V., Schneider, C., Kim, J. S., Wicks, J. M., Richardson, J. C., Conklin, V., Cameransi, B. G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052056 · Cited by 136 · see citing works
Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease
Takahashi, H., Brasnjevic, I., Rutten, B. P. F., Van Der Kolk, N., Perl, D. P., Bouras, C., Steinbusch, H. W. M., Schmitz, C., Hof, P. R., & Dickstein, D. L. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0242-4 · Cited by 124 · see citing works
Grillo, S. L., Duggett, N. A., Ennaceur, A., & Chazot, P. L. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.02.015 · Cited by 113 · see citing works
Maheswaran, S., Barjat, H., Rueckert, D., Bate, S. T., Howlett, D. R., Tilling, L. C., Smart, S., Pohlmann, A., Richardson, J. C., Hartkens, T., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.045 · Cited by 103 · see citing works
Inflammation in transgenic mouse models of neurodegenerative disorders
Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.013 · Cited by 97 · see citing works
Mattana, S., Caponi, S., Tamagnini, F., Fioretto, D., & Palombo, F. (2017) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545817420019 · Cited by 92 · see citing works
Jiang, Y., Wang, Z., Liu, X., Wan, M., Liu, Y., Jiao, B., Liao, X., Luo, Z., Wang, Y., Hong, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202105316 · Cited by 87 · see citing works
Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics
Aluise, C. D., Sowell, R. A., Beckett, T. L., Murphy, M. P., Cai, J., Pierce, W. M. J., Markesbery, W. R., & Butterfield, D. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.04.011 · Cited by 83 · see citing works
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease
Bonham, L. W., Sirkis, D. W., & Yokoyama, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01170 · Cited by 83 · see citing works
Cummings, D. M., Liu, W., Portelius, E., Bayram, S., Yasvoina, M. V., Ho, H., Smits, H., Ali, S. S., Steinberg, R., Pegasiou, C.-M., et al. (2015) · Brain · doi:10.1093/brain/awv127 · Cited by 81 · see citing works
Sánchez‐Mejías, E., Nuñez‐Diaz, C., Sanchez-Varo, R. M., Gómez-Arboledas, Á., García‐León, J. A., Fernandez-Valenzuela, J. J., Mejias‐Ortega, M., Trujillo‐Estrada, L., Baglietto‐Vargas, D., Moreno‐González, I., et al. (2019) · Brain Pathology · doi:10.1111/bpa.12785 · Cited by 77 · see citing works
Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease
Abeti, R., & Duchen, M. R. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0895-x · Cited by 78 · see citing works
APP transgenic mice: their use and limitations
Balducci, C., & Forloni, G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8141-7 · Cited by 79 · see citing works
Cheng, Z., Zhang, J., Liu, H., Li, Y., Zhao, Y., & Yang, E. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033324 · Cited by 68 · see citing works
PET Imaging of Copper Trafficking in a Mouse Model of Alzheimer Disease
Torres, J. B., Andreozzi, E. M., Dunn, J., Siddique, M., Szanda, I., Howlett, D. R., Sunassee, K., & Blower, P. J. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.162370 · Cited by 67 · see citing works
Modeling Alzheimer’s disease: from past to future
Saraceno, C., Musardo, S., Marcello, E. E., Pelucchi, S., & Luca, M. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00077 · Cited by 61 · see citing works
Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease
Willuweit, A., Velden, J., Godemann, R., Manook, A., Jetzek, F., Tintrup, H., Kauselmann, G., Zevnik, B., Henriksen, G., Drzezga, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007931 · Cited by 60 · see citing works
Metabonomic Profiling of TASTPM Transgenic Alzheimer’s Disease Mouse Model
Hu, Z., Browne, E. R., Liu, T., Angel, T. E., Ho, P. C., & Chan, E. C. Y. (2012) · Journal of Proteome Research · doi:10.1021/pr300666p · Cited by 58 · see citing works
Medhurst, A. D., Roberts, J., Lee, J., Chen, C., Brown, S., Roman, S. A., & Lai, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00075.x · Cited by 57 · see citing works
18F-FDG-PET in Mouse Models of Alzheimer's Disease
Bouter, C., & Bouter, Y. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00071 · Cited by 51 · see citing works
Xiao, M., Xiang, W., Chen, Y., Peng, N., Du, X., Lu, S., Zuo, Y., Li, B., Hu, Y., & Li, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.852433 · Cited by 55 · see citing works
Howlett, D. R., Hortobágyi, T., & Francis, P. T. (2013) · Brain Pathology · doi:10.1111/bpa.12057 · Cited by 51 · see citing works
Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease
Fernández-Martos, C. M., Atkinson, R. A. K., Chuah, M. I., King, A. E., & Vickers, J. C. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.11.002 · Cited by 50 · see citing works
Scullion, G. A., Kendall, D. A., Marsden, C. A., Sunter, D., & Pardon, M. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.002 · Cited by 44 · see citing works
Palombo, F., Tamagnini, F., Jeynes, J. C. G., Mattana, S., Swift, I. J., Nallala, J., Hancock, J. M., Brown, J. T., Randall, A. D., & Stone, N. (2017) · The Analyst · doi:10.1039/c7an01747b · Cited by 39 · see citing works
Fernandez-Martos, C. M., King, A. E., Atkinson, R. A. K., Woodhouse, A., & Vickers, J. C. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.003 · Cited by 38 · see citing works
Aman, Y., Pitcher, T., Simeoli, R., Ballard, C. G., & Malcangio, M. (2016) · Pain · doi:10.1097/j.pain.0000000000000644 · Cited by 33 · see citing works
Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
Rodríguez-Jiménez, F. J., Ureña‐Peralta, J. R., Jendelová, P., & Erceg, S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.006 · Cited by 33 · see citing works
F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice
Hafez, D. M., Huang, J., Richardson, J. C., Masliah, E., Peterson, D. A., & Marr, R. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.07.038 · Cited by 29 · see citing works
Analysis of serial magnetic resonance images of mouse brains using image registration
Maheswaran, S., Barjat, H., Bate, S. T., Aljabar, P., Hill, D., Tilling, L. C., Upton, N., James, M. F., Hajnal, J. V., & Rueckert, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.016 · Cited by 30 · see citing works
Palombo, F., Masia, F., Mattana, S., Tamagnini, F., Borri, P., Langbein, W., & Fioretto, D. (2018) · The Analyst · doi:10.1039/c8an01291a · Cited by 29 · see citing works
Medawar, E., Benway, T. A., Liu, W., Hanan, T. A., Haslehurst, P., James, O. T., Yap, K., Muessig, L., Moroni, F., Nahaboo Solim, M. A., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.006 · Cited by 26 · see citing works
Deleye, S., Waldron, A., Richardson, J. C., Schmidt, M. E., Langlois, X., Stroobants, S. G., & Staelens, S. G. (2016) · Molecular Imaging · doi:10.1177/1536012115624919 · Cited by 26 · see citing works
Characterisation of amyloid-induced inflammatory responses in the rat retina
Howlett, D. R., Bate, S. T., Collier, S., Lawman, A. J., Chapman, T. D., Ashmeade, T. E., Marshall, I. C. B., Anderson, P. J., Philpott, K. L., Richardson, J. C., et al. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2819-4 · Cited by 22 · see citing works
Forster, D. M., James, M. F., & Williams, S. R. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1712 · Cited by 22 · see citing works
Autoradiographical imaging of PPARγ agonist effects on PBR/TSPO binding in TASTPM mice
Roberts, J. C., Friel, S. L., Roman, S. A., Perren, M. J., Harper, A. J., Davis, J. B., Richardson, J. C., Virley, D. J., & Medhurst, A. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.002 · Cited by 21 · see citing works
Waldron, A., Wyffels, L., Verhaeghe, J. A. J., Richardson, J. C., Schmidt, M. E., Stroobants, S. G., Langlois, X., & Staelens, S. G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160760 · Cited by 20 · see citing works
Aman, Y., Pitcher, T., Ballard, C. G., & Malcangio, M. (2018) · European Journal of Pain · doi:10.1002/ejp.1288 · Cited by 20 · see citing works
Rattray, I., Scullion, G. A., Soulby, A., Kendall, D. A., & Pardon, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.037 · Cited by 20 · see citing works
Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice
Côtel, M.-C., Bayer, T. A., & Wirths, O. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.052 · Cited by 19 · see citing works
A dual magnetic resonance imaging/fluorescent contrast agent for Cathepsin‐D detection
Ta, R. M., Suchý, M., Tam, J. H. K., Li, A. X., Martínez‐Santiesteban, F., Scholl, T. J., Hudson, R. H. E., Bartha, R., & Pasternak, S. (2012) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1502 · Cited by 17 · see citing works
Region-specific neuron and synapse loss in the hippocampus of APPSL/PS1 knock-in mice
Brasnjevic, I., Lardenoije, R., Schmitz, C., van der Kolk, N. M., Dickstein, D. L., Takahashi, H., Hof, P. R., Steinbusch, H. W. M., & Rutten, B. P. F. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0111-8 · Cited by 16 · see citing works
Chan, M., Eacott, M. J., Sanderson, D. J., Wang, J., Sun, M., & Easton, A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00214 · Cited by 15 · see citing works
Critical thinking of Alzheimer’s transgenic mouse model: current research and future perspective
Li, X., Quan, M., Wei, Y., Wang, W., Xu, L., Wang, Q., & Jia, J. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2357-x · Cited by 14 · see citing works
Chadi, G., Maximino, J. R., & de Oliveira, G. P. (2009) · Journal of Molecular Histology · doi:10.1007/s10735-009-9235-0 · Cited by 13 · see citing works
Dassie, E., Andrews, M. R., Bensadoun, J., Cacquevel, M., Schneider, B. L., Aebischer, P., Wouters, F. S., Richardson, J. C., Hussain, I., Howlett, D. R., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.011 · Cited by 12 · see citing works
Near infra-red light treatment of Alzheimer’s disease
Han, M., Wang, Q., Wang, X., Zeng, Y., Huang, Y., Meng, Q., Zhang, J., & Wei, X. (2017) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545817500122 · Cited by 12 · see citing works
Babiloni, C., Noce, G., Bonaventura, C. D., Lizio, R., Pascarelli, M. T., Tucci, F., Soricelli, A., Ferri, R., Nobili, F. M., Famà, F., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.514136 · Cited by 12 · see citing works
Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?
Filippenkov, I. B., Владимирович, Х. А., Mozgovoy, I. V., Dergunova, L. V., & Limborska, S. A. (2023) · Biomedicines · doi:10.3390/biomedicines11102727 · Cited by 7 · see citing works
Xiao, M., Yao, C., Liu, F., Xiang, W., Zuo, Y., Feng, K., Lu, S., Li, X., Li, M., Li, X., et al. (2021) · NeuroSci · doi:10.3390/neurosci3010002 · Cited by 9 · see citing works
Models of Dementia: an introductory overview
Graham, L., & Sutherland, C. D. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390851 · Cited by 4 · see citing works
Lopez, S., Percio, C. D., Forloni, G., Frasca, A., Drinkenburg, W. H. I. M., Lizio, R., Noce, G., Ferri, R., Soricelli, A., Stocchi, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239072 · Cited by 4 · see citing works
Bone-Derived Factors: Regulating Brain and Treating Alzheimer’s Disease
Guan, Q., Cao, Y., Zou, J., & Zhang, L. (2025) · Biology · doi:10.3390/biology14091112 · Cited by 3 · see citing works
Ongoing Electroencephalographic Rhythms Related to Exploratory Movements in Transgenic TASTPM Mice
Percio, C. D., Drinkenburg, W. H. I. M., Lopez, S., Pascarelli, M. T., Lizio, R., Noce, G., Ferri, R., Bastlund, J. F., Laursen, B., Christensen, D. Z., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190351 · Cited by 3 · see citing works
Li, Y., Xu, X., Tang, L., & Initiative, O. B. O. T. A. D. N. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1629389 · Cited by 1 · see citing works
Gimeno-Ferrer, F., Eitner, A., Noora, N., Bauer, R., Schmidt‐Hieber, C., Schaible, H., & Richter, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-57868-4 · Cited by 1 · see citing works
Characterisation of transgenic mouse models of Alzheimer's disease
Graham, L. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
- Authors
- Howlett
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2008-01-01
- Volume
- 23
- Issue
- 1
- Pages
- 67-76
- OpenAlex
- W439849972
- Cited by
- 65
- References
- 32
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2013: 4 · 2012: 6
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta deposition, APP/PS1 mice, amyloid precursor protein, presenilin 1, amyloid plaques, astrocytes, neuroinflammation, phosphorylated tau, cathepsin D, neuronal loss, disease markers, familial Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Cathepsin D, Cerebral Cortex, Disease Models, Animal, Hippocampus, Male, Mice, Transgenic, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Disease Progression, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review