Cited by 154Chronic Disease Management StrategiesPharmaceutical Practices and Patient OutcomesDiabetes Management and Education

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis

Open access

Kastner, Monika, Cardoso, Roberta, Lai, Yonda, Treister, Victoria, Hamid, Jemila S., Hayden, Leigh, Wong, Geoff, Ivers, Noah M., Liu, Barbara, Marr, Sharon, Holroyd-Leduc, Jayna, Straus, Sharon E.·2018·Canadian Medical Association Journal

DOI 10.1503/cmaj.171391PMC PMC6110649

Open this paper in CoChat — free account Open PDF

Abstract

INTRODUCTION: More than half of older adults (age ≥ 65 yr) have 2 or more high-burden multimorbidity conditions (i.e., highly prevalent chronic diseases, which are associated with increased health care utilization; these include diabetes [DM], dementia, depression, chronic obstructive pulmonary disease [COPD], cardiovascular disease [CVD], arthritis, and heart failure [HF]), yet most existing interventions for managing chronic disease focus on a single disease or do not respond to the specialized needs of older adults. We conducted a systematic review and meta-analysis to identify effective multimorbidity interventions compared with a control or usual care strategy for older adults. METHODS: We searched bibliometric databases for randomized controlled trials (RCTs) evaluating interventions for managing multiple chronic diseases in any language from 1990 to December 2017. The primary outcome was any outcome specific to managing multiple chronic diseases as reported by studies. Reviewer pairs independently screened citations and full-text articles, extracted data and assessed risk of bias. We assessed statistical and methodological heterogeneity and performed a meta-analysis of RCTs with similar interventions and components. RESULTS: We included 25 studies (including 15 RCTs and 6 cluster RCTs) (12 579 older adults; mean age 67.3 yr). In patients with [depression + COPD] or [CVD + DM], care-coordination strategies significantly improved depressive symptoms (standardized mean difference −0.41; 95% confidence interval [CI] −0.59 to −0.22; I2 = 0%) and reduced glycosylated hemoglobin (HbA1c) levels (mean difference −0.51; 95% CI −0.90 to −0.11; I2 = 0%), but not mortality (relative risk [RR] 0.79; 95% CI 0.53 to 1.17; I2 = 0%). Among secondary outcomes, care-coordination strategies reduced functional impairment in patients with [arthritis + depression] (between-group difference −0.82; 95% CI −1.17 to −0.47) or [DM + depression] (between-group difference 3.21; 95% CI 1.78 to 4.63); improved cognitive functioning in patients with [DM + depression] (between-group difference 2.44; 95% CI 0.79 to 4.09) or [HF + COPD] (p = 0.006); and increased use of mental health services in those with [DM + (CVD or depression)] (RR 2.57; 95% CI 1.90 to 3.49; I2 = 0%). INTERPRETATION: Subgroup analyses showed that older adults with diabetes and either depression or cardiovascular disease, or with coexistence of chronic obstructive pulmonary disease and heart failure, can benefit from care-coordination strategies with or without education to lower HbA1c, reduce depressive symptoms, improve health-related functional status, and increase the use of mental health services. Protocol registration: PROSPERO-CRD42014014489

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1503/cmaj.171391

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
The qualitative content analysis process
Elo, S., & Kyngäs, H. (2008) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2007.04569.x · Cited by 22,617
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.006 · Cited by 10,578
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285
Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study
Barnett, K., Mercer, S. W., Norbury, M., Watt, G., Wyke, S., & Guthrie, B. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60240-2 · Cited by 6,972
PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement
McGowan, J., Sampson, M., Salzwedel, D. M., Cogo, E., Foerster, V., & Lefebvre, C. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.01.021 · Cited by 5,700
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374

Show all 72 references

Research works printed but not linked: 3

[25]25. Shojania KG, Ranji SR, Shaw LK, et al. AHRQ technical reviews. In: Closing the quality gap: a critical analysis of quality improvement strategies. Vol. 2: Diabe- tes care. Rockville (MD): Agency for Healthcare Research and Quality; 2004.
[35]35. Begrambekova Y, Mareev V, Lomonosov M. Role of depression in effectiveness of disease management programs [abstract]. Eur Journal Heart Failure 2015;17(Suppl 1): 5-441.
[51]51. Scalvini S, Bernocchi P, Baratti D, et al. Multidisciplinary telehealth program for patients affected by chronic heart failure and chronic obstructive pulmonary disease [abstract]. Proceedings from the European Society of Cardiology Heart Failure 2016 conference; 2016 May 21-24; Florence (Italy). Eur J Heart Failure 2016 (Suppl 1):94.

Sorted by citations

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860
Mapping the evidence on the effectiveness of telemedicine interventions in diabetes, dyslipidemia, and hypertension: An umbrella review of systematic reviews and meta-analyses
Timpel, P., Oswald, S., Schwarz, P. E. H., & Harst, L. (2020) · Journal of Medical Internet Research · doi:10.2196/16791 · Cited by 243
Underlying mechanisms of complex interventions addressing the care of older adults with multimorbidity: a realist review
Kastner, M., Hayden, L., Wong, G., Lai, Y., Makarski, J., Treister, V., Chan, J., Lee, J. H., Ivers, N. M., Holroyd-Leduc, J. M., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025009 · Cited by 89
Self-citation
Interventions and management on multimorbidity: An overview of systematic reviews
Zhou, Y., Dai, X., Ni, Y., Zeng, Q., Cheng, Y., Carrillo-Larco, R. M., Yan, L. L., & Xu, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101901 · Cited by 75
Combining volunteers and primary care teamwork to support health goals and needs of older adults: a pragmatic randomized controlled trial
Dolovich, L. R., Oliver, D., Lamarche, L., Thabane, L., Valaitis, R. K., Agarwal, G., Carr, T., Foster, G., Griffith, L. E., Javadi, D., et al. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.181173 · Cited by 74
Self-citation
Multimorbidity Patterns and Unplanned Hospitalisation in a Cohort of Older Adults
Akugizibwe, R., Calderón‐Larrañaga, A., Roso‐Llorach, A., Onder, G., Marengoni, A., Zucchelli, A., Rizzuto, D., & Vetrano, D. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124001 · Cited by 69
What works in managing complex conditions in older people in primary and community care? A state‐of‐the‐art review
Frost, R., Rait, G., Wheatley, A., Wilcock, J., Robinson, L. A., Dening, K. H., Allan, L. M., Banerjee, S., Manthorpe, J., Walters, K. R., et al. (2020) · Health & Social Care in the Community · doi:10.1111/hsc.13085 · Cited by 65
Healthcare for Older Adults with Multimorbidity: A Scoping Review of Reviews
Wu, J., Zhang, H., Shao, J., Chen, D., Xue, E., Huang, S., Fu, Y., Tang, L., & Ye, Z. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s425576 · Cited by 55
Assessment of an Interactive Digital Health–Based Self-management Program to Reduce Hospitalizations Among Patients With Multiple Chronic Diseases
Lear, S. A., Norena, M., Banner, D., Whitehurst, D. G. T., Gill, S., Burns, J., Kandola, D. K., Johnston, S., Horvat, D., Vincent, K., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.40591 · Cited by 56
In simulated data and health records, latent class analysis was the optimum multimorbidity clustering algorithm
Nichols, L., Taverner, T., Crowe, F. L., Richardson, S. T., Yau, C., Kiddle, S. J., Kirk, P., Barrett, J., Nirantharakumar, K., Griffin, S. J., et al. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2022.10.011 · Cited by 47
Risk Factors and Precipitants of Severe Disability Among Community-Living Older Persons
Gill, T. M., Han, L., Gahbauer, E. A., Leo-Summers, L. S., & Murphy, T. E. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.6021 · Cited by 46
Physical literacy as a determinant of physical activity level among late adolescents
Öztürk, Ö., Aydoğdu, O., Yıkılmaz, S. K., Feyzioğlu, Ö., & Pişirici, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285032 · Cited by 55
Models of integrated care for multi-morbidity assessed in systematic reviews: a scoping review
Rohwer, A. C., Toews, I., Nicol, J. U., Nyirenda, J. L. Z., Niyibizi, J. B., Akiteng, A. R., Meerpohl, J. J., Bavuma, C. M., Kredo, T., & Young, T. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-09894-7 · Cited by 41
Optimizing Older Adult Mental Health in Support of Healthy Ageing: A Pluralistic Framework to Inform Transformative Change across Community and Healthcare Domains
Horgan, S. A., Prorok, J. C., Ellis, K., Mullaly, L., Cassidy, K.-L., Seitz, D. P., & Checkland, C. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21060664 · Cited by 44
Effects of Pilates Training on Physiological and Psychological Health Parameters in Healthy Older Adults and in Older Adults With Clinical Conditions Over 55 Years: A Meta-Analytical Review
Meikis, L., Wicker, P. V., & Donath, L. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.724218 · Cited by 41
Implementing post diagnostic dementia care in primary care: a mixed-methods systematic review
Frost, R., Rait, G., Aw, S., Brunskill, G., Wilcock, J., Robinson, L., Knapp, M., Hogan, N., Harrison Dening, K., Allan, L., et al. (2021) · Aging & Mental Health · doi:10.1080/13607863.2020.1818182 · Cited by 39
eHealth in Care Coordination for Older Adults Living at Home: Scoping Review
Fjellså, H. M. H., Husebø, A. M. L., & Storm, M. (2022) · Journal of Medical Internet Research · doi:10.2196/39584 · Cited by 39
Factors influencing interprofessional team collaboration when delivering care to community-dwelling seniors: A metasynthesis of Canadian interventions
Johnson, J., Hermosura, B. J., Price, S., & Gougeon, L. (2020) · Journal of Interprofessional Care · doi:10.1080/13561820.2020.1758641 · Cited by 38
Framing physical literacy for aging adults: an integrative review
Petrusevski, C., Morgan, A. R., MacDermid, J. C., Wilson, M. G., & Richardson, J. A. (2021) · Disability and Rehabilitation · doi:10.1080/09638288.2021.2012841 · Cited by 42
Empowering Patients Through Virtual Care Delivery: Qualitative Study With Micropractice Clinic Patients and Health Care Providers
Burton, L., Rush, K. L., Smith, M. A., Davis, S., Echeverria, P. R., Hidalgo, L. S., & Görges, M. (2022) · JMIR Formative Research · doi:10.2196/32528 · Cited by 35
Identifying multimorbidity clusters with the highest primary care use: 15 years of evidence from a multi-ethnic metropolitan population
Bori, M. S., Bisquera, A., Ashworth, M., Wang, Y., Durbaba, S., Dodhia, H., & Fox-Rushby, J. A. (2021) · British Journal of General Practice · doi:10.3399/bjgp.2021.0325 · Cited by 34
Logistic burdens of cancer care: A qualitative study
Dona, A. C., Jewett, P. I., Hwee, S., Brown, K. A., Solomon, M., Gupta, A., Teoh, D. G. K., Yang, G., Wolfson, J. A., Fan, Y., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300852 · Cited by 34
Effectiveness of a nurse-led hospital-to-home transitional care intervention for older adults with multimorbidity and depressive symptoms: A pragmatic randomized controlled trial
Markle‐Reid, M., McAiney, C. A., Fisher, K., Ganann, R., Gauthier, A. P., Heald-Taylor, G., McElhaney, J. E., McMillan, F., Petrie, P., Ploeg, J., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254573 · Cited by 39
Clinical and Physiologic Implications of Negative Cardiopulmonary Interactions in Coexisting Chronic Obstructive Pulmonary Disease-Heart Failure
Neder, J. A., Rocha, A., Berton, D. C., & O’Donnell, D. E. (2019) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2019.02.006 · Cited by 31
Self-management program versus usual care for community-dwelling older adults with multimorbidity: A pragmatic randomized controlled trial in Ontario, Canada
Fisher, K., Markle‐Reid, M., Ploeg, J., Bartholomew, A., Griffith, L. E., Gafni, A., Thabane, L., & Yous, M. (2020) · Journal of Comorbidity · doi:10.1177/2235042x20963390 · Cited by 39
Tailored or adapted interventions for adults with chronic obstructive pulmonary disease and at least one other long-term condition: a mixed methods review
Dennett, E. J., Janjua, S., Stovold, E. M., Harrison, S. L., McDonnell, M. J., & Holland, A. E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013384.pub2 · Cited by 27
Organisational models in primary health care to manage chronic conditions: A scoping review
Longhini, J., Canzan, F., Mezzalira, E., Saiani, L., & Ambrosi, E. (2021) · Health & Social Care in the Community · doi:10.1111/hsc.13611 · Cited by 28
Effectiveness of care models for chronic disease management: A scoping review of systematic reviews
Kroenke, K., Corrigan, J. D., Ralston, R. K., ZAFONTE, R. D., Brunner, R. C., Giacino, J. T., Hoffman, J. M., Esterov, D., Cifu, D. X., Mellick, D., et al. (2023) · PM&R · doi:10.1002/pmrj.13027 · Cited by 30
Mobile Health Apps, Family Caregivers, and Care Planning: Scoping Review
Kelley, M. M., Powell, T. P., Camara, D. S., Shah, N., Norton, J. M., Deitelzweig, C., Vaidy, N., Hsiao, C., Wang, J., & Bierman, A. S. (2024) · Journal of Medical Internet Research · doi:10.2196/46108 · Cited by 33
Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel
Hempel, S., Ganz, D. A., Saluja, S., Bolshakova, M., Kim, T., Turvey, C., Cordasco, K. M., Basu, A., Page, T., Mahmood, R., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2021-060232 · Cited by 28
Barriers and facilitators to acceptance and implementation of eMental-health intervention among older adults: A qualitative systematic review
Peng, R., Li, X., Guo, Y., Ning, H., Huang, J., Jiang, D., Feng, H., & Liu, Q. (2024) · Digital Health · doi:10.1177/20552076241234628 · Cited by 26
Improving KT tools and products: development and evaluation of a framework for creating optimized, Knowledge-activated Tools (KaT)
Kastner, M., Makarski, J., Hayden, L., Lai, Y., Chan, J., Treister, V., Harris, K., Munce, S., Holroyd-Leduc, J. M., Graham, I. D., et al. (2020) · Implementation Science Communications · doi:10.1186/s43058-020-00031-7 · Cited by 29
Self-citation
Gardening Is Associated With Better Cardiovascular Health Status Among Older Adults in the United States: Analysis of the 2019 Behavioral Risk Factor Surveillance System Survey
Veldheer, S., Tuan, W., Al‐Shaar, L., Wadsworth, M. E., Sinoway, L. I., Schmitz, K. H., Sciamanna, C., & Gao, X. (2022) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2022.10.018 · Cited by 24
Multimorbidity of chronic non-communicable diseases and its models of care in low- and middle-income countries: a scoping review protocol
Eyowas, F. A., Schneider, M., Yirdaw, B. A., & Ambaw, F. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-033320 · Cited by 27
Experience of living with multimorbidity and health workers perspectives on the organization of health services for people living with multiple chronic conditions in Bahir Dar, northwest Ethiopia: a qualitative study
Eyowas, F. A., Schneider, M., Alemu, S., & Getahun, F. A. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-09250-9 · Cited by 19
Contribution of Frailty to Multimorbidity Patterns and Trajectories: Longitudinal Dynamic Cohort Study of Aging People
Carrasco-Ribelles, L. A., Cabrera‐Bean, M., Danés-Castells, M., Zabaleta‐del‐Olmo, E., Roso‐Llorach, A., & Violán, C. (2023) · JMIR Public Health and Surveillance · doi:10.2196/45848 · Cited by 25
The Influence of Multimorbidity on Health Care Utilization at the End of Life for Patients with Chronic Conditions
Wagner, E., Patrick, D. L., Khandelwal, N., Brumback, L. C., Starks, H. E., Fausto, J. A., Dunlap, B. S., Lober, W. B., Sibley, J., Loggers, E. T., et al. (2019) · Journal of Palliative Medicine · doi:10.1089/jpm.2018.0349 · Cited by 22
Effectiveness of a Psychoeducational Group Intervention Carried Out by Nurses for Patients with Depression and Physical Comorbidity in Primary Care: Randomized Clinical Trial
Raya‐Tena, A., Martin, M., Martín‐Royo, J., Casañas, R., Valmaña, G. S., Cols-Sagarra, C., Navas-Méndez, E., Masa-Font, R., Casajuana‐Closas, M., Boreu, Q. F., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18062948 · Cited by 23
Interventions to address sedentary behaviour for older adults: a scoping review
Petrusevski, C., Choo, S., Wilson, M. L., MacDermid, J. C., & Richardson, J. A. (2020) · Disability and Rehabilitation · doi:10.1080/09638288.2020.1725156 · Cited by 26
Self-management of depression and anxiety amongst frail older adults in the United Kingdom: A qualitative study
Nair, P., Walters, K. R., Aw, S., Gould, R. L., Kharicha, K., Buszewicz, M., & Frost, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264603 · Cited by 21
The primary care and other health system use of home care patients: a retrospective cohort analysis
Jones, A., Bronskill, S. E., Agarwal, G., Seow, H. Y., Feeny, D. H., & Costa, A. P. (2019) · CMAJ Open · doi:10.9778/cmajo.20190038 · Cited by 18
Efficacy of community-based self-care interventions to improve biophysical, psychosocial or behavioural outcomes among community-dwelling older adults with type 2 diabetes: A systematic review and meta-analysis
Seah, S. J., Zheng, H., & Lim, R. B. T. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108411 · Cited by 18
Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial
Metzner, G., Horstmeier, L. M., Bengel, J., Bitzer, E. M., Dreher, E., Frank, F., Göhner, A., Heimbach, B., Himmelsbach, I., Kaier, K., et al. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03797-2 · Cited by 17
Allostatic load and physical performance in older adults: Findings from the International Mobility in Aging Study (IMIAS)
Germano, M. L., Gomes, C. D. S., Barbosa, J. F. D. S., Neto, N. J., Pereira, D. S., Ahmed, T., Borrero, C. L. C., & Guerra, R. O. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.104961 · Cited by 17
Extreme Consumers of Health Care: Patterns of Care Utilization in Patients with Multiple Chronic Conditions Admitted to a Novel Integrated Clinic
Rafiq, M., Keel, G., Mazzocato, P., Spaak, J., Guttmann, C., Lindgren, P., & Savage, C. (2019) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s214770 · Cited by 17
Experiences of older people with multimorbidity regarding self‐management of diseases: A systematic review and qualitative meta‐synthesis
Tian, J., Wang, H. Y., Peng, S. H., Tao, Y. M., Cao, J. M., & Zhang, X. (2024) · International Journal of Nursing Practice · doi:10.1111/ijn.13289 · Cited by 16
Landscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study
Huang, K., Duan, J., Wang, R., Ying, H., Feng, Q., Zhu, B., Yang, C., & Yang, L. (2023) · mSystems · doi:10.1128/msystems.00515-23 · Cited by 17
Magnitude, pattern and correlates of multimorbidity among patients attending chronic outpatient medical care in Bahir Dar, northwest Ethiopia: The application of latent class analysis model
Eyowas, F. A., Schneider, M., Alemu, S., Pati, S., & Ambaw, F. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267208 · Cited by 15
Demographics and Oral Health Care Utilization for Older Adults
Calabrese, J. M., & Rawal, K. (2021) · Dental Clinics of North America · doi:10.1016/j.cden.2020.11.003 · Cited by 14
Effectiveness of integrated care interventions for patients with long-term conditions: a review of systematic reviews
Mansour, M. H. H., Pokhrel, S., & Anokye, N. (2022) · Integrated Healthcare Journal · doi:10.1136/ihj-2021-000083 · Cited by 13
Associations of the Charlson comorbidity index with depression and mortality among the U.S. adults
Wang, Y., Xue, C., Ma, C., & Liu, A. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1404270 · Cited by 12
Families’ opinions about their involvement in care during hospitalization: a mixed-methods study
Woldring, J. M., Paans, W., Gans, R. O. B., van der Werf, H. M., & Luttik, M. L. (2025) · BMC Nursing · doi:10.1186/s12912-024-02664-8 · Cited by 14
US Older Adults with Multiple Chronic Conditions Perceptions of Provider-Patient Communication: Trends and Racial Disparities from MEPS 2013–2019
Davis–Ajami, M. L., Lu, K., & Wu, J. (2022) · Journal of General Internal Medicine · doi:10.1007/s11606-022-07899-2 · Cited by 11
Multimorbidity in Hospitalized Patients Admitted to General Practice Departments and Its Implications for the General Practice Healthcare System: A Four-Year Longitudinal Study in China
Zhou, Z., Shi, M., Liu, M., Gu, J., Tarimo, C. S., Wu, J., & Miao, Y. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.760792 · Cited by 10
Putting a Population Health Lens to Multimorbidity in Ontario
Rosella, L. C., & Kornas, K. (2018) · Healthcare Quarterly · doi:10.12927/hcq.2018.25709 · Cited by 10
Cost-effectiveness of a Medical Care Coordination Program for People With HIV in Los Angeles County
Flash, M. J. E., Garland, W., Martey, E. B., Schackman, B. R., Oksuzyan, S., Scott, J. A., Jeng, P. J., Rubio, M., Losina, E., Freedberg, K. A., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz537 · Cited by 10
The effects of mindfulness-based stress reduction therapy combined with intensive education on the effectiveness of the care and the awareness rate in patients with arthritis and diabetes.
Chen, Q., Yang, G., Lin, S., Li, M., Liu, Z., Fu, Y., & Chen, Y. (2021) · PubMed Central · Cited by 10
Characterization of Patients with Chronic Diseases and Complex Care Needs: A New High-Risk Emergent Population
Bernabeu Wittel, M., Garcia Romero, L., Murcia Zaragoza, J., Gamez Mancera, R., Aparicio Santos, R., Diez Manglano, J., Lopez de la Fuente, M., Sánchez, E. A. V., Marzo, M. V., Aquilino Tari, A., et al. (2022) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1601 · Cited by 10
Physiological measures variability and risks of heart disease and stroke: evidence from three cohort studies
Liu, W., Fan, L., Shi, D., Yu, L., Song, J., Liang, R., Lai, X., Wang, H., Zhang, Y., Wan, S., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03805-1 · Cited by 9
Effects of healthcare interventions on psychosocial factors of patients with multimorbidity: A systematic review and meta-analysis
Lee, H.-J., Lee, M., Ha, J.-H., Lee, Y., & Yun, J. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104241 · Cited by 9
Functional Effects of Intervening Illnesses and Injuries After Critical Illness in Older Persons
Gill, T. M., Han, L., Gahbauer, E. A., Leo-Summers, L. S., Murphy, T. E., & Ferrante, L. E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004829 · Cited by 10
Spatial and Temporal Patterns of Chronic Disease Burden in the U.S., 2018–2021
Hunyadi, J. V., Zhang, K., Xiao, Q., Strong, L. L., & Bauer, C. (2024) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2024.08.022 · Cited by 9
Effectiveness of Nurse-led Heart Failure Transitional Care Services in Improving Clinical Outcomes and Applicability to Low-resource Settings: A Meta-analysis
Koontalay, A., Samai, T., Samutalai, C., Onthuam, W., & Fonghiranrat, D. (2024) · WHO South-East Asia Journal of Public Health · doi:10.4103/who-seajph.who-seajph_26_23 · Cited by 8
Current approaches to medical care optimization for patients with multimorbidity
Diachuk, D. D., Hidzynska, I. M., Moroz, G. Z., & Tkachuk, І. М. (2020) · Medicni perspektivi · doi:10.26641/2307-0404.2020.4.221220 · Cited by 8
Caring for high-need patients
Hempel, S., Bolshakova, M., Hochman, M. E., Jimenez, E. E., Thompson, G., Motala, A., Ganz, D. A., Gabrielian, S. E., Edwards, S. T., Zenner, J., et al. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-10236-w · Cited by 8
Integriertes Versorgungsmanagement für chronisch erkrankte ältere Menschen in der eigenen Häuslichkeit: Evidenz aus Cochrane-Reviews
Göhner, A., Bitzer, E. M., Dreher, E., Farin‐Glattacker, E., Heimbach, B., Kohler, K., Maun, A., Metzner, G., & Voigt-Radloff, S. (2020) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-020-01796-1 · Cited by 7
The effects of exercise on secondary prevention and health-related quality of life in people with existing vascular disease: systematic review and meta-analysis of randomised controlled trials
Broderick, C. A., Stewart, M. C. W., Thomson, K., Sellers, C., Fenton, C., Cowie, J., Wei, X., St-Jean, C., Charteris, K., Nundy, M., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103201 · Cited by 6
Care Navigation and Coordination Program on Reducing Hospital Use for Adults with Complex Health and Psychosocial Needs in South West Sydney, Australia
Hartati, A., Jarrett, M., McDougall, B., Kent, M., Ljubojevic, M., & Stolzenhein, K. (2024) · International Journal of Integrated Care · doi:10.5334/ijic.7739 · Cited by 6
Measuring care coordination in German primary care – adaptation and psychometric properties of the Medical Home Care Coordination Survey
Ringwald, A., Goetz, K., Steinhaeuser, J., Fleischmann, N., Schüssler, A., & Flaegel, K. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-07100-0 · Cited by 6
Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
Rosella, L. C., Negatu, E., Kornas, K., Chu, C., Zhou, L., & Buajitti, E. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01362-x · Cited by 6
Recovery from Severe Disability that Develops Progressively Versus Catastrophically: Incidence, Risk Factors, and Intervening Events
Gill, T. M., Gahbauer, E. A., Leo-Summers, L. S., & Murphy, T. E. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16567 · Cited by 6
Functional Effects of Intervening Illnesses and Injuries After Hospitalization for Major Surgery in Community-living Older Persons
Gill, T. M., Han, L., Gahbauer, E. A., Leo-Summers, L. S., Murphy, T. E., & Becher, R. D. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004438 · Cited by 6
Exploring the therapeutic potential of Chinese herbs on comorbid type 2 diabetes mellitus and Parkinson's disease: A mechanistic study
Wang, Y., Gao, P.-P., Wu, Z., Jiang, B., Wang, Y., He, Z., Zhao, B., Tian, X., Gao, H., Cai, L., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119095 · Cited by 6
Age Friendly Care: What do Community Aging Services Professionals Need to Know?
Korte, M., Graupner, J., Thompson, K., & Gleason, L. J. (2022) · Gerontology & Geriatrics Education · doi:10.1080/02701960.2022.2151443 · Cited by 5
You're Not Who You Used to Be
Young, S. W., Smith, M., Shafique, S., & Piamjariyakul, U. (2023) · Home Healthcare Now · doi:10.1097/nhh.0000000000001165 · Cited by 6
Interventions Addressing Symptoms in Older Adults with Multimorbidity: An Umbrella Review
Cheng, C., & Christensen, M. (2024) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s452426 · Cited by 5
Effect of family doctor contract services on non-communicable disease management among the elderly: a systematic review and meta-analysis
Wu, R., Fei, F., Lu, T., Zhu, J., & Hu, D. (2025) · Frontiers in Health Services · doi:10.3389/frhs.2025.1462806 · Cited by 5
Effectiveness of continuity of care in reducing depression symptoms in elderly: A systematic review and meta‐analysis
Li, C., Wu, M., Qiao, G., Gao, X., Hu, T., Zhao, X., Zhu, X., & Yang, F. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5894 · Cited by 5
The Knowledge and Practices of Self-Care Capabilities among Geriatric Population
Koirala, J. (2019) · International Journal of Biochemistry & Physiology · doi:10.23880/ijbp-16000144 · Cited by 5
Assessment in pulmonary rehabilitation
Nyberg, A., Probst, V. S., & Vaes, A. W. (2021) · European Respiratory Society eBooks · doi:10.1183/2312508x.10017520 · Cited by 5
What we need to learn about multimorbidity
Flegel, K. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.181046 · Cited by 5
“You can because you do and you do, because you can”: Using interpretative description to examine what it means to be a physically literate adult living with multiple chronic conditions
Petrusevski, C., Joy, M. C., Wilson, M., & Richardson, J. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297261 · Cited by 4
Implementation of the virtual transitional care stroke intervention for older adults with stroke and multimorbidity: A qualitative descriptive study
Markle‐Reid, M., Fisher, K., Walker, K. M., Cameron, J. I., Dayler, D., Fleck, R., Gafni, A., Ganann, R., Hajas, K., Koetsier, B., et al. (2025) · Journal of Multimorbidity and Comorbidity · doi:10.1177/26335565251323748 · Cited by 4
Demographics and Oral Health Care Utilization for Older Adults
Calabrese, J. M., & Rawal, K. (2023) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2023.01.003 · Cited by 4
Demographic and Clinical Characteristics of Hospitalized Patients with Type 2 Diabetes Mellitus and Comorbid Parkinson’s Disease in Spain: A Nationwide Observational Study (2017–2023)
Gómez‐Mayordomo, V., Jiménez‐García, R., Zamorano‐León, J. J., Carabantes-Alarcón, D., Bodas-Pinedo, A., Hernández‐Barrera, V., López‐de‐Andrés, A., & Cuadrado‐Corrales, N. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134679 · Cited by 5
Healthcare providers' perspectives on the organization of health services to manage people with multiple long-term conditions in primary care settings in Kerala, India: a qualitative exploratory study
Lekha, T. R., Joseph, L., Sasidharan, N., Krishnan, A., Davies, J., Gill, P. S., Greenfield, S., Harikrishnan, S., Thulaseedharan, J. V., Valamparampil, M. J., et al. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1480710 · Cited by 2
Critical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy
Gill, T. M., Zang, E. X., Leo-Summers, L. S., Gahbauer, E. A., Becher, R. D., Ferrante, L. E., & Han, L. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.4208 · Cited by 3
Socioemotional and behavioural difficulties in children with chronic physical conditions: analysis of the Longitudinal Study of Australian Children
David-Wilathgamuwa, S., Hu, N., Meyers, T., O’Loughlin, R., & Lingam, R. (2023) · Archives of Disease in Childhood · doi:10.1136/archdischild-2022-325069 · Cited by 3
Characterizing multimorbidity in ALIVE: comparing single and ensemble clustering methods
Rudolph, J. E., Lau, B. M., Genberg, B. L., Sun, J., Kirk, G. D., & Mehta, S. H. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae031 · Cited by 3
Learning from suicide deaths in Harris County, Texas
DeMello, A. S., Yang, Y., Schulte, J., Wolf, D. A., Holcomb, J. B., Bless, B., DeMeter, K., Wade, C. E., & Drake, S. A. (2020) · Death Studies · doi:10.1080/07481187.2020.1776790 · Cited by 4
Experiences of Navigator, a Finnish patient-segmentation service, in primary care: A mixed-methods study
Riihimies, R., Kosunen, E., & Koskela, T. (2021) · Finnish Journal of eHealth and eWelfare · doi:10.23996/fjhw.107245 · Cited by 6
Depression and Neurovascular Disease
Jaywant, A., & Gunning, F. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-49586-2_15 · Cited by 3
Patient-Physician Communication Experience Modifies Racial/Ethnic Health Care Disparities Among Surveillance, Epidemiology, and End Results-Consumer Assessment of Healthcare Providers and Systems Participants With Colorectal Cancer and Multiple Chronic Conditions
Navarro, S., Le, J. T., Tsui, J., Barzi, A., Stern, M. C., Pickering, T. A., & Farias, A. J. (2024) · Medical Care · doi:10.1097/mlr.0000000000002112 · Cited by 2
A Single-Center Prospective Study on Adverse Drug Reactions Associated With Polypharmacy in Elderly Outpatients
Khurshid, M., Amjad, A., Qamar, S., Amir, M., Khan, A., Khattak, M. I., Umer, M. R., & Mirza, T. I. (2025) · Cureus · doi:10.7759/cureus.98532 · Cited by 2
Days at Home After Serious Health Events Among Community‐Living Older Persons
Gill, T. M., Leo-Summers, L. S., Gahbauer, E. A., Becher, R. D., Ferrante, L. E., & Han, L. (2026) · Journal of the American Geriatrics Society · doi:10.1111/jgs.70376 · Cited by 2
Nationally funded health management projects for older adults in China and the United States: Comparative analysis based on data from two principal institutions
Yao, X., Zheng, Z., Wang, Z., Yuan, Q., Yin, H. Y., & Zhang, W. (2022) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2022.12.013 · Cited by 2
Evaluation of the Impact of Discharge Clinic Follow-Up Interventions on 30-Day Readmission Rates
Sass, J., Hampton, D. C., Edward, J., & Cardarelli, R. (2024) · Population Health Management · doi:10.1089/pop.2023.0273 · Cited by 2
Collaboration Between Nurse Practitioners in Response to the Needs of Frail Patients at Home: A Qualitative Study in the French Alps
Sacchetti, A., Couvant, L., & Lecroisey, C. (2025) · Home Health Care Management & Practice · doi:10.1177/10848223241302068 · Cited by 3
Health-related preferences of older patients with multimorbidity: the protocol for an evidence map
González‐González, A. I., Schmucker, C. M., Blom, J. W., van den Akker, M., Nguyen, T. S., Nothacker, J., Meerpohl, J. J., Röttger, K., Wegwarth, O., Hoffmann, T., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029724 · Cited by 2
Self-citation
Diabetes in Old Age: Particularities and Specifics
Weber, P., Weberová, D., & Meluzínová, H. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1002479 · Cited by 2

Authors: Kastner, M., Cardoso, R., Lai, Y., Treister, V., Hamid, J. S., Hayden, L., Wong, G., Ivers, N. M., Liu, B., Marr, S., Holroyd-Leduc, J., & Straus, S. E.
Affiliations: St. Michael's Hospital (CA)
ORCID: Kastner, Monika
Cardoso, Roberta
Hamid, Jemila S.
Hayden, Leigh
Wong, Geoff
Ivers, Noah M.
Liu, Barbara
Marr, Sharon
Holroyd-Leduc, Jayna
Straus, Sharon E.
Venue: Canadian Medical Association Journal
Publisher: CMA Impact Inc.
Published: 2018-08-26
Volume: 190
Issue: 34
Pages: E1004-E1012
ISSN: 0820-3946 (ISSN-L)
1488-2329
DOI: 10.1503/cmaj.171391
PMC: PMC6110649
OpenAlex: W2888528917
Cited by: 154
References: 72
Citations by year: 2026: 13 · 2025: 12 · 2024: 26 · 2023: 29 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 16 · 2018: 2
FWCI: 2.08
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Canadian Medical Association Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords: multimorbidity, chronic disease management, older adults, care coordination, depression, diabetes mellitus, chronic obstructive pulmonary disease, cardiovascular disease, heart failure, arthritis, dementia, functional disability, cognitive function, HbA1c, mortality, quality of life, health care utilization, intervention effectiveness, usual care comparison, secondary care, hospital readmission
MeSH terms: Physical Functional Performance, Aged, Chronic Disease, Depression, Humans, Mental Health Services, Patient Care Management, Quality of Life, Comorbidity, Randomized Controlled Trials as Topic, Cost of Illness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks