The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
Open accessAbstract
The molecular mechanisms underlying major depressive disorder remain poorly understood, and current antidepressant treatments have many shortcomings. The recent discovery that a single intravenous infusion of ketamine at a subanesthetic dose had robust, rapid and sustained antidepressant effects in individuals with treatment-resistant depression inspired tremendous interest in investigating the molecular mechanisms mediating ketamine’s clinical efficacy as well as increased efforts to identify new targets for antidepressant action. We review the clinical utility of ketamine and recent insights into its mechanism of action as an antidepressant, including the roles of N-methyl-d-aspartate receptor inhibition, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor upregulation, activation of downstream synaptogenic signalling pathways and the production of an active ketamine metabolite, hydroxynorketamine. Emerging knowledge of the molecular mechanisms underlying both ketamine’s positive therapeutic and detrimental side effects will aid the development of a new generation of much-needed superior antidepressant agents.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“TrkB activation triggers ERK and mTORC1 cascades, extends protein synthesis windows, and supports dendritic spine maturation”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [339]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ketamine and psychedelics activate cortical AMPAR and subsequently stimulate BDNF and synaptic efficacy (111).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [111]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,525
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082
Flagged first, then by citations
Research works printed but not linked: 3
- Huynh NN, 2008, Prim Care Companion J Clin Psychiatry, 10, 91
- 10.1016/j.pneuro-bio.2015.12.001 · DOI
- Yang B, 2016, Psychopharmacology (Berl)
Cited by
Sorted by citations
Dendritic structural plasticity and neuropsychiatric disease
Forrest, M. P., Parnell, E., & Penzes, P. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.16 · Cited by 464
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408
“The dorsolateral prefrontal cortex (DLPFC) is responsible for attention, working memory and executive function and is positively correlated with working memory load in healthy controls [36].”
BackgroundInfluentialBahji, A., Vazquez, G. H., & Zarate, C. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.071 · Cited by 408
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Aleksandrova, L. R., & Phillips, A. G. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.08.003 · Cited by 276
Self-citationde Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269
Gregorio, D. D., Aguilar‐Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1659-20.2020 · Cited by 278
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209
Cutler, A. J., Mattingly, G. W., & Maletic, V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02514-2 · Cited by 156
Martinotti, G., Vita, A., Fagiolini, A., Maina, G., Bertolino, A., Dell'Osso, B., Siracusano, A., Clerici, M., Bellomo, A., Sani, G., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.043 · Cited by 146
The molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122
Depression: Biological markers and treatment
Erjavec, G. N., Šagud, M., Perković, M. N., Štrac, D. Š., Konjevod, M., Tudor, L., Uzun, S., & Pivac, N. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110139 · Cited by 127
The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction
Xu, L., Nan, J., & Lan, Y. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00037 · Cited by 123
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.007 · Cited by 114
Self-citationNovel drug developmental strategies for treatment‐resistant depression
Borbély, É., Simon, M., Fuchs, E., Wiborg, O., Czéh, B., & Helyes, Z. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15753 · Cited by 116
Perspectives for therapy of treatment‐resistant depression
Papp, M., Cubała, W. J., Święcicki, Ł., Newman‐Tancredi, A., & Willner, P. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15596 · Cited by 96
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2020) · Molecular Brain · doi:10.1186/s13041-020-00627-z · Cited by 85
Self-citationThe Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Zaretsky, T. G., Jagodnik, K. M., Barsic, R., Antonio, J. H., Bonanno, P. A., MacLeod, C., Pierce, C., Carney, H., Morrison, M. T., Saylor, C. F., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666231027111147 · Cited by 91
Lazarevic, V., Yang, Y., Flais, I., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01246-3 · Cited by 81
Targeting inflammation: a potential approach for the treatment of depression
Bhatt, S., Devadoss, T., Jha, N. K., Baidya, M., Gupta, G., Chellappan, D. K., Singh, S. K., & Dua, K. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01095-1 · Cited by 83
Visentin, A. P. V., Colombo, R., Scotton, E., Fracasso, D. S., Rosa, A. R., Branco, C. S., & Salvador, M. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2972968 · Cited by 77
Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors
Wang, Y., Ni, J., Zhai, L., Gao, C., Xie, L., Zhao, L., & Yin, X. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.015 · Cited by 75
Self-citationRawat, R., Tunc‐Ozcan, E., McGuire, T. L., Peng, C., & Kessler, J. A. (2022) · Nature Communications · doi:10.1038/s41467-022-30386-5 · Cited by 77
Bahji, A., Zarate, C. A., & Vázquez, G. H. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2047928 · Cited by 76
Chen, B. K., Luna, V. M., LaGamma, C. T., Xu, X., Deng, S., Suckow, R. F., Cooper, T. B., Shah, A., Brachman, R. A., Mendez‐David, I., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0714-z · Cited by 68
A Review of Nonanesthetic Uses of Ketamine
Pribish, A. M., Wood, N. J., & Kalava, A. (2020) · Anesthesiology Research and Practice · doi:10.1155/2020/5798285 · Cited by 73
Modulation of amygdala reactivity following rapidly acting interventions for major depression
Loureiro, J. R., Leaver, A. M., Vasavada, M. M., Sahib, A. K., Kubicki, A., Joshi, S. H., Woods, R. P., Wade, B., Congdon, E. L., Espinoza, R. T., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24895 · Cited by 64
Lullau, A. P. M., Haga, E. M. W., Ronold, E. H., & Dwyer, G. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223145 · Cited by 63
Chen, J., Lei, C., Li, X., Wu, Q., Liu, C., Ma, Q., & Chen, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.925514 · Cited by 63
Kawczak, P., Feszak, I. J., & Bączek, T. (2024) · Biomedicines · doi:10.3390/biomedicines12102283 · Cited by 66
Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review
Keeler, J. L., Treasure, J. L., Juruena, M. F., Kan, C., & Himmerich, H. (2021) · Nutrients · doi:10.3390/nu13114158 · Cited by 58
Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice
Xu, C., Xiong, Q., Tian, X., Liu, W., Sun, B., Ru, Q., & Shu, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213828 · Cited by 56
On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS)
Safron, A., Juliani, A., Reggente, N., Klimaj, V., & Johnson, M. W. (2025) · Neuroscience of Consciousness · doi:10.1093/nc/niae038 · Cited by 57
Understanding the Biological Relationship between Migraine and Depression
Viudez‐Martínez, A., Torregrosa, A. B., Navarrete, F., & García‐Gutiérrez, M. S. (2024) · Biomolecules · doi:10.3390/biom14020163 · Cited by 56
Wu, C., Wang, Y., Yang, H., Wu, S., Xie, Z., Zhang, J., He, L., Wang, Z., & He, L. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107136 · Cited by 50
Self-citationRéus, G. Z., de Moura, A. B., da Silva, R. H., Resende, W. R., & Quevedo, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170630164715 · Cited by 51
Wang, Y., Zhang, N., Liu, L., Jiang, H., Hu, D., Wang, Z., Chen, N., & Zhang, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.024 · Cited by 50
Self-citationWang, Y., Ni, J., Gao, T., Gao, C., Guo, L., & Yin, X. (2020) · Glia · doi:10.1002/glia.23850 · Cited by 42
Self-citationKetamine: The final frontier or another depressing end?
Sial, O. K., Parise, E. M., Parise, L. F., Gnecco, T., & Bolaños‐Guzmán, C. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112508 · Cited by 41
Yu, H., Li, M., Zhou, D., Lv, D., Liao, Q., Lou, Z., Shen, M., Wang, Z., Li, M., Xiao, X., et al. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.028 · Cited by 41
Li, Q., Wang, S.-Y., & Mei, X. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114396 · Cited by 32
Khushboo, Siddiqi, N. J., Pereira, M. D. L., & Sharma, B. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02780-z · Cited by 40
Golubeva, E. A., Lavrov, M. I., Radchenko, E. V., & Palyulin, V. A. (2022) · Biomolecules · doi:10.3390/biom13010056 · Cited by 36
Correia, A. S., & Vale, N. (2024) · International Journal of Translational Medicine · doi:10.3390/ijtm4010010 · Cited by 43
Adam, E. M., Kowalski, M., Akeju, O., Miller, E. K., Brown, E. N., McCarthy, M. M., & Kopell, N. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402732121 · Cited by 37
Ketamine and Calcium Signaling—A Crosstalk for Neuronal Physiology and Pathology
Lisek, M., Żylińska, L., & Boczek, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218410 · Cited by 40
Souza‐Marques, B., Santos‐Lima, C., Araújo-de-Freitas, L., Vieira, F., Jesus‐Nunes, A. P., Quarantini, L. C., & Sampaio, A. S. (2021) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000312 · Cited by 39
Maciel, A. L., Abelaira, H. M., de Moura, A. B., de Souza, T. G., Rosa, T., Matos, D., Tuon, T., Garbossa, L., Strassi, A. P., Fileti, M. E., et al. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.12.005 · Cited by 36
van Calker, D., Serchov, T., Normann, C., & Biber, K. P. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.014 · Cited by 35
Scotton, E., Antqueviezc, B., Vasconcelos, M., Dalpiaz, G., Géa, L. P., Goularte, J. F., Colombo, R., & Rosa, A. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114963 · Cited by 37
Bezdudnaya, T., Hormigo, K. M., Marchenko, V., & Lane, M. A. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.03.014 · Cited by 34
Maintenance Ketamine Therapy for Treatment-Resistant Depression
Archer, S., Chrenek, C., & Swainson, J. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000894 · Cited by 33
Barone, P. R. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000477 · Cited by 37
Pan, H., Steixner-Kumar, A. A., Seelbach, A., Deutsch, N. R., Ronnenberg, A., Tapken, D., von Ahsen, N., Mitjans, M., Worthmann, H., Trippe, R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0672-1 · Cited by 35
Advances in novel molecular targets for antidepressants
Wang, Q., & Dwivedi, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110041 · Cited by 33
The therapeutic role of ketamine and esketamine in treating psychopathological domains of depression
Jawad, M. Y., Vincenzo, J. D. D., Badulescu, S., Teopiz, K. M., Tabassum, A., Ceban, F., Mckenzie, A., Meshkat, S., Rosenblat, J. D., Ho, R., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109299 · Cited by 32
Effects of Ketamine on Rodent Fear Memory
Choi, K. H., Berman, R. Y., Zhang, M., Spencer, H. F., & Radford, K. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197173 · Cited by 31
Mechanisms of the Rapid Effects of Ketamine on Depression and Sleep Disturbances: A Narrative Review
Song, B., & Zhu, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.782457 · Cited by 31
Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System
Cao, Y., Ling-Ling, W., Li, X., Yuan, Y.-L., Zhao, W., Qi, J., Zhao, X.-Y., Ward, N., & Wang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010111 · Cited by 34
A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances
Song, B., & Zhu, J. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s341161 · Cited by 30
Chang, O. L. B., Kreuzer, M., Morgen, D. F., Possin, K. L., & García, P. S. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005875 · Cited by 29
Sachdeva, B., Sachdeva, P., Ghosh, S., Ahmad, F., & Sinha, J. K. (2023) · Ibrain · doi:10.1002/ibra.12094 · Cited by 31
Storm on predictive brain: A neurocomputational account of ketamine antidepressant effect
Bottemanne, H., Berkovitch, L., Gauld, C., Balcerac, A., Schmidt, L., Mouchabac, S., & Fossati, P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105410 · Cited by 30
Seo, M. K., Hiền, L. T. T., Park, M. K., Choi, A. J., Seog, D., Kim, S. H., Park, S. W., & Lee, J. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-58017-3 · Cited by 24
Halaris, A. E., & Cook, J. T. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_21 · Cited by 27
Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model
Mao, L., & Wang, J. Q. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14307 · Cited by 23
Derntl, B., Hornung, J., Şen, Z. D., Čolić, L., Li, M., & Walter, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00616 · Cited by 23
Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression
Wang, J. Q., Derges, J. D., Bodepudi, A., Pokala, N., & Mao, L. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2101025 · Cited by 23
Reelin has antidepressant-like effects after repeated or singular peripheral injections
Allen, J., Romay-Tallón, R., Mitchell, M. A., Brymer, K. J., Johnston, J. N., Sánchez-Lafuente, C. L., Pinna, G., Kalynchuk, L. E., & Caruncho, H. J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109043 · Cited by 22
Burgdorf, J. S., Zhang, X., Stanton, P. K., Moskal, J. R., & Donello, J. E. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac043 · Cited by 23
Kato, A., & Witkin, J. M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.09.015 · Cited by 22
Sartim, A. G., Marques, J., Silveira, K. M., Gobira, P. H., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108679 · Cited by 22
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2017) · Chronic Stress · doi:10.1177/2470547017743511 · Cited by 23
Self-citationPerić, I., Stanisavljević, A., Inta, D., Gass, P., Lang, U. E., Borgwardt, S., & Filipović, D. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.013 · Cited by 19
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Solecki, W., & Willner, P. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120967857 · Cited by 23
Strategies for Treatment-Resistant Depression: Lessons Learned from Animal Models
Réus, G. Z., de Moura, A. B., Borba, L. A., Abelaira, H. M., & Quevedo, J. (2019) · Complex Psychiatry · doi:10.1159/000500324 · Cited by 21
The neuroprotective effect and possible therapeutic application of xenon in neurological diseases
Zhang, M., Cui, Y., Cheng, Y., Wang, Q., & Sun, H. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24958 · Cited by 20
Kühn, M., Maier, J. G., Wolf, E., Mainberger, F., Feige, B., Maywald, S., Bredl, A., Michel, M., Sendelbach, N., Normann, C., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.08.052 · Cited by 20
Stress and Ketamine, Bimodal Influence on Cognitive Functions
Trofimiuk, E., Wielgat, P., Braszko, J. J., & Car, H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.030 · Cited by 20
Li, M., Cui, J., Xu, B., Wei, Y., Fu, C., Lv, X., Xiong, L., & Qin, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.827541 · Cited by 23
Phillips, A. G., Geyer, M. A., & Robbins, T. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.014 · Cited by 21
Self-citationSayson, L. V., Botanas, C. J., Custodio, R. J. P., Abiero, A., Kim, M., Lee, H. J., Kim, H. J., Yoo, S. Y., Lee, K. W., Ryu, H. W., et al. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05219-x · Cited by 19
McGrory, C. L., Ryan, K. M., Gallagher, B., & McLoughlin, D. M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.04.013 · Cited by 19
Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression
Dębowska, W., Więdłocha, M., Dębowska, M. D., Kownacka, Z., Marcinowicz, P., & Szulc, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1267647 · Cited by 23
Ouelhazi, A., Bharmauria, V., Chanauria, N., Bachatene, L., Lussiez, R., & Molotchnikoff, S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146462 · Cited by 16
Niquet, J., Nguyen, D. A., Furtado, M. D. A., & Lumley, L. A. (2023) · Epilepsia Open · doi:10.1002/epi4.12713 · Cited by 17
Genetic modulation of the HTR2A gene reduces anxiety-related behavior in mice
Rohn, T. T., Radin, D. I., Brandmeyer, T., Linder, B., Andriambeloson, E., Wagner, S., Kehler, J., Vasileva, A., Wang, H., Mee, J. L., et al. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad170 · Cited by 19
Hatano, M., Miyazaki, T., Ishiwata, Y., Nakajima, W., Arisawa, T., Kuroki, Y., Kobayashi, A., Takada, Y., Ogawa, M., Kawamura, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81002-3 · Cited by 18
Pennybaker, S. J., Roach, B. J., Fryer, S. L., Badathala, A., Wallace, A., Mathalon, D. H., & Marton, T. F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05939-z · Cited by 17
The roles of neuroinflammation and glutamatergic excitotoxicity in treatment-resistant depression
Candee, R., Wilkenson, R., Schreiber, M., & Decenzo, M. (2023) · JAAPA : official journal of the American Academy of Physician Assistants · doi:10.1097/01.jaa.0000921252.57819.4b · Cited by 9
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
Gokalp, D., & Ünal, G. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06571-3 · Cited by 16
Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape
Watts, D., Pfaffenseller, B., Wollenhaupt-Aguiar, B., Géa, L. P., Cardoso, T. D. A., & Kapczinski, F. P. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1581764 · Cited by 16
Marchetti, L., Lauria, M., Caberlotto, L., Musazzi, L., Popoli, M., Mathé, A. A., Domenici, E., & Carboni, L. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.11.004 · Cited by 17
Antidepressant Actions of Ketamine: Potential Role of L-Type Calcium Channels
Robinson, B. L., Gu, Q., & Kanungo, J. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00411 · Cited by 16
Gender-Specific Effects of Two Treatment Strategies in a Mouse Model of Niemann-Pick Disease Type C1
Holzmann, C., Witt, M., Rolfs, A., Antipova, V., & Wree, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052539 · Cited by 16
Liu, B., Du, Y., Xu, C. S., Liu, Q., & Zhang, L. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148375 · Cited by 18
Lu, Y., Zhang, J., Zhang, L., Dang, S., Su, Q., Zhang, H., Lin, T., Zhang, X., Zhang, Y., Sun, H., et al. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2393-7 · Cited by 17
Teng, Y., Niu, J., Liu, Y., Wang, H., Chen, J., Kong, Y., Wang, X., Lian, B., Wang, W., Sun, H., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114792 · Cited by 17
Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain
Cho, C., Michailidis, V., & Martin, L. J. (2018) · Neurobiology of Pain · doi:10.1016/j.ynpai.2018.03.002 · Cited by 16
The NMDA receptor antagonists memantine and ketamine as anti-migraine agents
Podkowa, K., Czarnacki, K., Borończyk, A., Borończyk, M., & Paprocka, J. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02444-2 · Cited by 18
Metadata
- Authors
- Aleksandrova, L. R., Phillips, A. G., & Wang, Y. T.
- Affiliations
- University of British Columbia (CA)
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2017-07
- Volume
- 42
- Issue
- 4
- Pages
- 222-229
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC5487269
- OpenAlex
- W2628731659
- Cited by
- 228
- References
- 63
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 20 · 2023: 29 · 2022: 35 · 2021: 31 · 2020: 31 · 2019: 16 · 2018: 14 · 2017: 7
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- ketamine, antidepressant mechanism, major depressive disorder, treatment-resistant depression, NMDA receptor antagonism, AMPA receptors, hydroxynorketamine, ketamine side effects, antidepressant drug development
- MeSH terms
- Animals, Antidepressive Agents, Depression, Humans, Ketamine, Models, Neurological, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review