Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response
Abstract
In order to expand the prospects of developing novel antidepressants for treatment-resistant populations, animal models should incorporate not only various stress-induced behavioural, neurochemical and endocrine parallels to major depressive disorder (MDD), but also aspects of heightened stress susceptibility and resistance to conventional drugs. This review focuses on the available literature supporting the Wistar-Kyoto (WKY) rat as a model of endogenous stress susceptibility and depression, and the role of synaptic plasticity in depression and antidepressant response in the context of this model. Accumulating evidence implicates a dysregulation of synaptic plasticity in the etiology of depression, leading to synaptic weakening and neuronal atrophy in vulnerable brain regions (hippocampus, prefrontal cortex). Furthermore, novel antidepressant treatments, particularly ketamine, may reverse the stress-induced loss of connectivity in these key neural circuits by engaging synaptic plasticity processes to "reset the system". Incorporating synaptic plasticity into the current framework of antidepressant action may serve to bridge understanding of an antidepressant's molecular and cellular effects with those related to regional structural plasticity and neural circuit functioning.
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Cell loss, neuronal atrophy, and alterations in synapse density are observed in depression animal models.
“Cell loss, neuronal atrophy, and alterations in synapse density are also observed in depression animal models.257”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [257]
Cites
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
Murray, D. D., Suzuki, K., Law, M. G., Trebicka, J., Neuhaus, J., Wentworth, D. N., Johnson, M. A., Vjecha, M. J., Kelleher, A. D., Emery, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139981 · Cited by 2,740 · see citing works
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
Cognitive impairment in depression: a systematic review and meta-analysis
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014) · Psychological Medicine · doi:10.1017/s0033291713002535 · Cited by 2,161 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653 · see citing works
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Sex differences in anxiety and depression clinical perspectives
Altemus, M., Sarvaiya, N., & Neill Epperson, C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.004 · Cited by 1,413 · see citing works
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046 · see citing works
Self-citationThe chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
BDNF - a key transducer of antidepressant effects
Björkholm, C., & Monteggia, L. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.034 · Cited by 958 · see citing works
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 879 · see citing works
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Monroe, S. M., & Harkness, K. L. (2005) · Psychological Review · doi:10.1037/0033-295x.112.2.417 · Cited by 693 · see citing works
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works
Precision psychiatry: a neural circuit taxonomy for depression and anxiety
Williams, L. M. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00579-9 · Cited by 641 · see citing works
Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression.
Newport, D. J., Carpenter, L. L., McDonald, W. M., Potash, J. B., Tohen, M., Nemeroff, C. B., & The APA Council of Research Task Force on Novel Biomarkers and Treatments (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15040465 · Cited by 598 · see citing works
Water associated zero maze: a novel rat test for long term traumatic re-experiencing
Ritov, G., & Richter‐Levin, G. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00001 · Cited by 579 · see citing works
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works
Role of brain norepinephrine in the behavioral response to stress
Morilak, D. A., Barrera, G., Echevarria, D. J., Garcia, A. S., Hernandez, A., Ma, S., & Petre, C. O. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.007 · Cited by 570 · see citing works
Spike avalanches in vivo suggest a driven, slightly subcritical brain state
Priesemann, V. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00108 · Cited by 559 · see citing works
Floresco, S., Todd, C. L., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04915.2001 · Cited by 556 · see citing works
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553 · see citing works
Signaling pathways underlying the rapid antidepressant actions of ketamine
Duman, R. S., Li, N., Liu, R.-J., Duric, V., & Aghajanian, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.044 · Cited by 537 · see citing works
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works
Behavioural stress facilitates the induction of long-term depression in the hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 509 · see citing works
Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K. D., Gray, N. A., Zarate, C. A., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00117-3 · Cited by 499 · see citing works
Stress and Plasticity in the Limbic System
Sapolsky, R. M. (2003) · Neurochemical Research · doi:10.1023/a:1026021307833 · Cited by 489 · see citing works
Lener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468 · see citing works
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989) · Science · doi:10.1126/science.2704997 · Cited by 458 · see citing works
Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454 · see citing works
Behavioral stress impairs long-term potentiation in rodent hippocampus
Foy, M. R., Stanton, M. E., Levine, S., & Thompson, R. F. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90664-9 · Cited by 436 · see citing works
Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.
Kim, J. J., Foy, M. R., & Thompson, R. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4750 · Cited by 435 · see citing works
The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
Godsil, B. P., Kiss, J., Spedding, M., & Jay, T. M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.10.018 · Cited by 434 · see citing works
The validity of animal models of predisposition to depression
Willner, P., & Mitchell, P. J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200205000-00001 · Cited by 430 · see citing works
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422 · see citing works
Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421 · see citing works
Stress and the brain: Individual variability and the inverted-U
Sapolsky, R. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4109 · Cited by 413 · see citing works
Shining light on motivation, emotion, and memory processes
Ilango, A., & Lobo, M. K. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00001 · Cited by 402 · see citing works
Zhou, W., Wang, N., Yang, C., Li, X.-M., Zhou, Z.-Q., & Yang, J.-J. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2013.10.005 · Cited by 390 · see citing works
Synaptic plasticity and mood disorders
Duman, R. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001016 · Cited by 363 · see citing works
Kishimoto, T., Chawla, J. M., Hagi, K., Zarate, C. A., Kane, J. M., Bauer, M., & Correll, C. U. (2016) · Psychological Medicine · doi:10.1017/s0033291716000064 · Cited by 359 · see citing works
Miller, O. H., Yang, L., Wang, C.-C., Hargroder, E. A., Zhang, Y., Delpire, E., & Hall, B. J. (2014) · eLife · doi:10.7554/elife.03581 · Cited by 358 · see citing works
Hot and cold cognition in depression
Roiser, J. P., & Sahakian, B. J. (2013) · CNS Spectrums · doi:10.1017/s1092852913000072 · Cited by 354 · see citing works
Strain Differences in the Behavioral Effects of Antidepressant Drugs in the Rat Forced Swimming Test
López‐Rubalcava, C. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00100-1 · Cited by 346 · see citing works
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Panja, D., & Bramham, C. R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.024 · Cited by 336 · see citing works
Synaptic plasticity in depression: molecular, cellular and functional correlates.
Marsden, W. N. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 321 · see citing works
Myers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318 · see citing works
Panksepp, J. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/jpanksepp · Cited by 307 · see citing works
Maroun, M., & Richter-Levin, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04406.2003 · Cited by 293 · see citing works
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Gerhard, D. M., Wohleb, E. S., & Duman, R. S. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.016 · Cited by 287 · see citing works
Burgdorf, J., Zhang, X.-L., Nicholson, K. L., Balster, R. L., David Leander, J., Stanton, P. K., Gross, A. L., Kroes, R. A., & Moskal, J. R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.246 · Cited by 284 · see citing works
Stress, anxiety, and dendritic spines: What are the connections?
Leuner, B., & Shors, T. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.021 · Cited by 284 · see citing works
Acute suppression of spontaneous neurotransmission drives synaptic potentiation
Nosyreva, E., Szabla, K., Autry, A. E., Ryazanov, A. G., Monteggia, L. M., & Kavalali, E. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4998-12.2013 · Cited by 283 · see citing works
Ketamine and the next generation of antidepressants with a rapid onset of action
Machado‐Vieira, R., Salvadore, G., Diazgranados, N., & Zarate, C. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.010 · Cited by 275 · see citing works
McKlveen, J. M., Myers, B., & Herman, J. P. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12272 · Cited by 273 · see citing works
Open field, learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats
Paré, W. P. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90097-3 · Cited by 264 · see citing works
Gómez-Oliver, F., Lahmame, A., de Kloet, E. R., & Armario, A. (2008) · Neuroendocrinology · doi:10.1159/000126973 · Cited by 264 · see citing works
Burgdorf, J., Panksepp, J., & Moskal, J. R. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.011 · Cited by 258 · see citing works
Synaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine
Kavalali, E. T., & Monteggia, L. M. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040531 · Cited by 258 · see citing works
Artola, A., von Frijtag, J. C., Fermont, P. C. J., Gispen, W. H., Schrama, L. H., Kamal, A., & Spruijt, B. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04552.x · Cited by 253 · see citing works
Duman, R. S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/rduman · Cited by 249 · see citing works
Xu, L., Hölscher, C., Anwyl, R., & Rowan, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.6.3204 · Cited by 248 · see citing works
Neighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248 · see citing works
Stephens, M. A. C., Mahon, P. B., McCaul, M. E., & Wand, G. S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.021 · Cited by 245 · see citing works
GABA Potency at GABAA Receptors Found in Synaptic and Extrasynaptic Zones
Mortensen, M., Patel, B., & Smart, T. G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00001 · Cited by 244 · see citing works
Chapter 8 Synaptic plasticity in learning and memory: Stress effects in the hippocampus
Howland, J. G., & Wang, Y. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00008-8 · Cited by 238 · see citing works
Self-citationModeling Depression in Animal Models
Overstreet, D. H. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_7 · Cited by 236 · see citing works
Role of the ventral subiculum in stress integration
Herman, J. P., & Mueller, N. K. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.035 · Cited by 235 · see citing works
Pavlides, C., Ogawa, S., Kimura, A., & McEwen, B. S. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00776-7 · Cited by 234 · see citing works
Aleksandrova, L. R., Phillips, A. G., & Wang, Y. T. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160175 · Cited by 228 · see citing works
Self-citationBelujon, P., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.014 · Cited by 225 · see citing works
Will, C. C., Aird, F., & Redei, E. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001345 · Cited by 225 · see citing works
Yamamoto, S., Morinobu, S., Fuchikami, M., Kurata, A., Kozuru, T., & Yamawaki, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301605 · Cited by 224 · see citing works
Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment
Wong, T. P., Howland, J. G., Robillard, J. M., Ge, Y., Yu, W. K., Titterness, A. K., Brebner, K., Liu, L., Weinberg, J., Christie, B. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702308104 · Cited by 218 · see citing works
Self-citationPardon, M.-C., Gould, G., Garcia, A., Phillips, L., Cook, M. C., Miller, S. A., Mason, P. A., & Morilak, D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00364-0 · Cited by 218 · see citing works
Learned helplessness: Validity and reliability of depressive-like states in mice
Chourbaji, S., Zacher, C., Sanchis-Segura, C., Dormann, C., Vollmayr, B., & Gass, P. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.09.002 · Cited by 216 · see citing works
Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., Hohoff, C., Schöning, S., Kersting, A., Baune, B. T., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008973 · Cited by 216 · see citing works
Perrone, R., & da Silva, A. C. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00001 · Cited by 210 · see citing works
BDNF protects against stress‐induced impairments in spatial learning and memory and LTP
Radecki, D. T., Brown, L. M., Martinez, J., & Teyler, T. J. (2004) · Hippocampus · doi:10.1002/hipo.20048 · Cited by 209 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Panksepp, J., & Watt, D. (2011) · Psychiatry: Interpersonal and Biological Processes · doi:10.1521/psyc.2011.74.1.5 · Cited by 207 · see citing works
Amplified behavioral and endocrine responses to forced swim stress in the Wistar–Kyoto rat
Rittenhouse, P. A., López‐Rubalcava, C., Stanwood, G. D., & Lucki, I. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00052-x · Cited by 207 · see citing works
Sagvolden, T., Johansen, E. B., Wøien, G., Walaas, S. I., Storm‐Mathisen, J., Bergersen, L. H., Hvalby, Ø., Jensen, V., Aase, H., Russell, V. A., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.004 · Cited by 206 · see citing works
Carreno, F. R., Donegan, J. J., Boley, A. M., Shah, A., DeGuzman, M., Frazer, A., & Lodge, D. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.176 · Cited by 205 · see citing works
Cornwell, B. R., Salvadore, G., Furey, M., Marquardt, C. A., Brutsché, N. E., Grillon, C., & Zarate, C. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.029 · Cited by 200 · see citing works
The nature of clinical depression: Symptoms, syndromes, and behavior analysis
Kanter, J. W., Busch, A. M., Weeks, C. E., & Landes, S. J. (2008) · The Behavior Analyst · doi:10.1007/bf03392158 · Cited by 189 · see citing works
Yang, C., Huang, C., & Hsu, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0406-05.2005 · Cited by 181 · see citing works
Fukumoto, K., Iijima, M., & Chaki, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.233 · Cited by 174 · see citing works
Enhanced Long-Term Synaptic Depression in an Animal Model of Depression
Holderbach, R., Clark, K., Moreau, J., Bischofberger, J., & Normann, C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.007 · Cited by 174 · see citing works
Yang, C., Hu, Y.-M., Zhou, Z.-Q., Zhang, G.-F., & Yang, J.-J. (2013) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.724118 · Cited by 173 · see citing works
Tizabi, Y., Bhatti, B. H., Manaye, K. F., Das, J. R., & Akinfiresoye, L. R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.052 · Cited by 172 · see citing works
Musazzi, L., Treccani, G., Mallei, A., & Popoli, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.009 · Cited by 172 · see citing works
Machado-Vieira, R., Manji, H. K., & Zarate, C. A. (2009) · The Neuroscientist · doi:10.1177/1073858409336093 · Cited by 171 · see citing works
Yang, C., Huang, C., & Hsu, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3968-04.2004 · Cited by 166 · see citing works
Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders
Zarate, C. A., Du, J., Quiroz, J. A., GRAY, N. A., Denicoff, K. D., Singh, J., Charney, D. S., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.017 · Cited by 164 · see citing works
Kendler, K. S., & Gardner, C. (2016) · Psychological Medicine · doi:10.1017/s0033291716000349 · Cited by 164 · see citing works
Taube, J., & Schwartzkroin, P. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01632.1988 · Cited by 162 · see citing works
Yang, C., Qu, Y., Abe, M., Nozawa, D., Chaki, S., & Hashimoto, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.020 · Cited by 162 · see citing works
Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring
Yang, J., Han, H., Cao, J., Li, L., & Xu, L. (2006) · Hippocampus · doi:10.1002/hipo.20181 · Cited by 161 · see citing works
Sanacora, G., & Schatzberg, A. F. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.261 · Cited by 160 · see citing works
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski, P., & Duman, R. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.057 · Cited by 157 · see citing works
New targets for rapid antidepressant action
Machado‐Vieira, R., Henter, I. D., & Zarate, C. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.001 · Cited by 156 · see citing works
Learned helplessness: unique features and translational value of a cognitive depression model
Vollmayr, B., & Gass, P. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1654-2 · Cited by 155 · see citing works
Levy, B. H., & Tasker, J. G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00024 · Cited by 153 · see citing works
Depressive behavior and stress ulcer in Wistar Kyoto rats
Paré, W. P., & Redei, E. E. (1993) · Journal of Physiology-Paris · doi:10.1016/0928-4257(93)90010-q · Cited by 150 · see citing works
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence
Neto, F. L. M., Borges, G., Torres-Sánchez, S., Micó, J. A., & Berrocoso, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376262 · Cited by 150 · see citing works
Akinfiresoye, L. R., & Tizabi, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3153-2 · Cited by 149 · see citing works
Are We Getting Closer to Valid Translational Models for Major Depression?
Berton, O., Hahn, C.-G., & Thase, M. E. (2012) · Science · doi:10.1126/science.1222940 · Cited by 148 · see citing works
Strain-dependent modification of behavior following antidepressant treatment
Tejani‐Butt, S. M., Kluczynski, J., & Paré, W. P. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00308-1 · Cited by 146 · see citing works
Learned helplessness and social avoidance in the Wistar-Kyoto rat
Nam, H., Clinton, S. M., Jackson, N. L., & Kerman, I. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00109 · Cited by 144 · see citing works
Expanding the horizons of depression: beyond the monoamine hypothesis
Hindmarch, I. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.288 · Cited by 143 · see citing works
Are Wistar-Kyoto rats a genetic animal model of depression resistant to antidepressants?
Lahmame, A., del Arco, C., Pazos, Á., Yritia, M., & Armario, A. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01276-4 · Cited by 142 · see citing works
Solberg, L. C., Olson, S. L., Turek, F. W., & Redei, E. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r786 · Cited by 141 · see citing works
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141 · see citing works
Treatment-resistant depression: are animal models of depression fit for purpose?
Willner, P., & Belzung, C. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4034-7 · Cited by 140 · see citing works
Neuronal Correlates of Depression
Chaudhury, D., Liu, H., & Han, M.-H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 139 · see citing works
Chronic mild stress for modeling anhedonia
Wiborg, O. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1664-0 · Cited by 138 · see citing works
McCarty, R. C., & Kopin, I. J. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90132-4 · Cited by 135 · see citing works
Dwyer, J. M., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.011 · Cited by 134 · see citing works
Ampuero, E., Rubio, F. J., Falcon, R., Sandoval, M., Diaz-Veliz, G., Gonzalez, R. E., Earle, N., Dagnino-Subiabre, A., Aboitiz, F., Orrego, F., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.035 · Cited by 132 · see citing works
Garza, R. D. L., & Mahoney, J. J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.052 · Cited by 131 · see citing works
Czéh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L., Højgaard, K., Henningsen, K., Bouzinova, E. V., Miseta, A., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00148 · Cited by 129 · see citing works
Neurobiology of Major Depressive Disorder
Villanueva, R. (2013) · Neural Plasticity · doi:10.1155/2013/873278 · Cited by 127 · see citing works
Yang, J., Hou, C., Ma, N., Liu, J., Zhang, Y., Zhou, J., Xu, L., & Li, L. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.09.001 · Cited by 127 · see citing works
The role of NMDA receptors in the pathophysiology and treatment of mood disorders
Ghasemi, M., Phillips, C., Trillo, L., Miguel, Z. D., Das, D., & Salehi, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.017 · Cited by 126 · see citing works
Berton, O., Ramos, A., Chaouloff, F., & Mormède, P. (1997) · Behavior Genetics · doi:10.1023/a:1025641509809 · Cited by 122 · see citing works
Ketamine enantiomers in the rapid and sustained antidepressant effects
Muller, J., Pentyala, S., Dilger, J., & Pentyala, S. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316631267 · Cited by 122 · see citing works
Maggio, N., & Segal, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1901-09.2009 · Cited by 119 · see citing works
Ketamine for treatment-resistant depression: recent developments and clinical applications
Kirshenbaum, J. S., Murrough, J. W., & Iosifescu, D. V. (2016) · Evidence-Based Mental Health · doi:10.1136/eb-2016-102355 · Cited by 117 · see citing works
Sex differences and stress response of WKY rats.
Paré, W., & Redei, E. (1993) · Physiology and Behavior · doi:10.1016/0031-9384(93)90345-g · Cited by 116 · see citing works
Tejani‐Butt, S. M., Paré, W. P., & Yang, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91045-6 · Cited by 116 · see citing works
Genzel, L., Dresler, M., Cornu, M., Jäger, E., Konrad, B. N., Adamczyk, M., Frieß, E., Steiger, A., Czisch, M., & Goya‐Maldonado, R. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.004 · Cited by 111 · see citing works
Abdallah, C. G., Averill, C. L., Salas, R., Averill, L. A., Baldwin, P. R., Krystal, J. H., Mathew, S. J., & Mathalon, D. H. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.006 · Cited by 111 · see citing works
Shirayama, Y., & Hashimoto, K. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx108 · Cited by 111 · see citing works
Prohedonic effect of cannabidiol in a rat model of depression
Shoval, G., Shbiro, L., Hershkovitz, L., Hazut, N., Zalsman, G., Mechoulam, R., & Weller, A. (2016) · Neuropsychobiology · doi:10.1159/000443890 · Cited by 110 · see citing works
How does ketamine elicit a rapid antidepressant response?
Kavalali, E. T., & Monteggia, L. M. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.005 · Cited by 109 · see citing works
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression
Holm, M. M., Nieto-González, J. L., Vardya, I., Henningsen, K., Jayatissa, M. N., Wiborg, O., & Jensen, K. (2010) · Hippocampus · doi:10.1002/hipo.20758 · Cited by 107 · see citing works
Belzung, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.342 · Cited by 106 · see citing works
Lahmame, A., & Armario, A. (1996) · Psychopharmacology · doi:10.1007/bf02246177 · Cited by 105 · see citing works
Strain differences in hypothalamic-pituitary-adrenal activity and stress ulcer
Redei, E., Paré, W. P., Aird, F., & Kluczynski, J. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.2.r353 · Cited by 102 · see citing works
Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression
Dugovic, C., Solberg, L. C., Redei, E. E., Reeth, O. V., & Turek, F. W. (2000) · Neuroreport · doi:10.1097/00001756-200002280-00038 · Cited by 101 · see citing works
Cornwell, B. R., Salvadore, G., Colon-Rosario, V., Latov, D. R., Holroyd, T., Carver, F. W., Coppola, R., Manji, H. K., Zarate, C. A., & Grillon, C. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050614 · Cited by 98 · see citing works
Chronic psychosocial stress-induced impairment of hippocampal LTP: Possible role of BDNF
Aleisa, A. M., Alzoubi, K. H., Gerges, N. Z., & Alkadhi, K. A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.005 · Cited by 97 · see citing works
Vinod, K. Y., Xie, S., Psychoyos, D., Hungund, B. L., Cooper, T. B., & Tejani‐Butt, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036743 · Cited by 97 · see citing works
O'Mahony, C. O., Clarke, G., Gibney, S., Dinan, T., & Cryan, J. (2011) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.012 · Cited by 97 · see citing works
“Behavioral despair” test predicts stress ulcer in WKY rats
Paré, W. P. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90025-5 · Cited by 96 · see citing works
Rapid avoidance acquisition in Wistar–Kyoto rats
Servatius, R. J., Jiao, X., Beck, K. D., Pang, K. C. H., & Minor, T. R. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.006 · Cited by 95 · see citing works
Behavioral Effects of Acute and Chronic Fluoxetine in Wistar–Kyoto Rats
Griebel, G., Cohen, C., Perrault, G., & Sanger, D. J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00298-4 · Cited by 92 · see citing works
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 91 · see citing works
The C. elegans Rab Family: Identification, Classification and Toolkit Construction
Gallegos, M. E., Balakrishnan, S., Chandramouli, P., Arora, S., Azameera, A., Babushekar, A., Bargoma, E., Bokhari, A. A., Chava, S. K., Das, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049387 · Cited by 90 · see citing works
Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat
Burke, N. N., Coppinger, J., Deaver, D. R., Roche, M., Finn, D. P., & Kelly, J. P. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.08.031 · Cited by 90 · see citing works
Willner, P., Gruca, P., Łasoń, M., Tota-Glowczyk, K., Litwa, E., Niemczyk, M., & Papp, M. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000431 · Cited by 88 · see citing works
Falowski, S. M., Sharan, A. D., Reyes, B. A. S., Sikkema, C. L., Szot, P., & Bockstaele, E. J. V. (2011) · Neurosurgery · doi:10.1227/neu.0b013e3182237346 · Cited by 87 · see citing works
Gilad, G. M., Rabey, J., Tizabi, Y., & Gilad, V. H. (1987) · Brain Research · doi:10.1016/0006-8993(87)91675-1 · Cited by 87 · see citing works
Strain differences in the distribution of dopamine transporter sites in rat brain
Jiao, X., Paré, W. P., & Tejani‐Butt, S. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00150-7 · Cited by 84 · see citing works
The Role of the Hippocampus in Avoidance Learning and Anxiety Vulnerability
Cominski, T. P., Jiao, X., Catuzzi, J. E., Stewart, A. L., & Pang, K. C. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00273 · Cited by 84 · see citing works
Two different putative genetic animal models of childhood depression—A review
Malkesman, O., & Weller, A. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.03.003 · Cited by 79 · see citing works
Zhang‐James, Y., Middleton, F. A., & Faraone, S. V. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00002.2013 · Cited by 78 · see citing works
Long-term increases in dentate granule cell responsivity accompany operant conditioning
Skelton, R. W., Scarth, A., Wilkie, D. M., Miller, J., & Phillips, A. G. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03081.1987 · Cited by 76 · see citing works
Self-citationJett, J. D., Boley, A. M., Girotti, M., Shah, A., Lodge, D. J., & Morilak, D. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3957-3 · Cited by 75 · see citing works
Reward and anxiety in genetic animal models of childhood depression
Malkesman, O., Braw, Y., Zagoory‐Sharon, O., Golan, O., Lavi‐Avnon, Y., Schroeder, M., Overstreet, D. H., Yadid, G., & Weller, A. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.023 · Cited by 75 · see citing works
Yang, Y., Ju, W., Zhang, H., & Sun, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00229 · Cited by 75 · see citing works
Lahmame, A., Grigoriadis, D. E., Souza, E. B. D., & Armario, A. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01368-6 · Cited by 72 · see citing works
Maggio, N., & Segal, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.026 · Cited by 72 · see citing works
What Are the Implications of the STAR*D Trial for Primary Care?
Huynh, N., & McIntyre, R. S. (2008) · The Primary Care Companion to The Journal of Clinical Psychiatry · doi:10.4088/pcc.v10n0201 · Cited by 72 · see citing works
Central monoamine levels differ between rat strains used in studies of depressive behavior
Scholl, J. L., Renner, K. J., Forster, G. L., & Tejani‐Butt, S. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.003 · Cited by 72 · see citing works
Differences in the Stress Response of Wistar-Kyoto (WKY) Rats from Different Vendors
Paré, W. P., & Kluczynski, J. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00191-1 · Cited by 71 · see citing works
Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains
Paré, W. P., & Tejani‐Butt, S. M. (1996) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02699783 · Cited by 70 · see citing works
Jiao, X., Pang, K., Beck, K., Minor, T., & Servatius, R. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.029 · Cited by 70 · see citing works
Han, X., Wu, H., Yin, P., Chen, Z., Cao, X., Duan, Y., Xu, J., Lao, L., & Xu, S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.03.004 · Cited by 70 · see citing works
Serotonin Reuptake Inhibition by Citalopram in Rat Strains Differing for Their Emotionality
Pollier, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00092-5 · Cited by 69 · see citing works
Wistar-Kyoto rats in the Morris water maze: Impaired working memory and hyper-reactivity to stress
Grauer, E., & Kapon, Y. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90161-i · Cited by 67 · see citing works
Diana, G., Domenici, M. R., Loizzo, A., de Carolis, A. S., & Sagratella, S. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90618-1 · Cited by 66 · see citing works
Martı́, J., & Armario, A. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02104-3 · Cited by 65 · see citing works
Sands, S. A., Strong, R., Corbitt, J., & Morilak, D. A. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00255-7 · Cited by 64 · see citing works
Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action
Du, J., Machado-Vieira, R., Maeng, S., Martinowich, K., Manji, H. K., & Zarate, C. A. (2006) · Drug Discovery Today: Therapeutic Strategies · doi:10.1016/j.ddstr.2006.11.012 · Cited by 64 · see citing works
Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats
Tizabi, Y., Hauser, S. R., Tyler, K. Y., Getachew, B., Madani, R., Sharma, Y., & Manaye, K. F. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.024 · Cited by 63 · see citing works
Metaplastic Effects of Subanesthetic Ketamine on CA1 Hippocampal Function
Izumi, Y., & Zorumski, C. F. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.002 · Cited by 63 · see citing works
Zafar, H. M., Paré, W. P., & Tejani‐Butt, S. M. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00140-8 · Cited by 63 · see citing works
Courvoisier, H., Moisan, M., Sarrieau, A., Hendley, E. D., & Mormède, P. (1996) · Brain Research · doi:10.1016/s0006-8993(96)01023-2 · Cited by 63 · see citing works
von Frijtag, J. C., Kamal, A., Reijmers, L. G. J. E., Schrama, L. H., van den Bos, R., & Spruijt, B. M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02062-6 · Cited by 62 · see citing works
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Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Aleksandrova, L. R., & Phillips, A. G. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.08.003 · Cited by 276 · see citing works
Self-citationYuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“257 MiRNAs may mediate these effects in depression by in fl uencing neuronal production, differentiation, proliferation and synaptic plasticity.”
BackgroundDeng, D., Cui, Y., Gan, S., Xie, Z., Cui, S., Cao, K., Wang, S., Shi, G., Yang, L., Bai, S., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154395 · Cited by 109 · see citing works
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications
Highland, J. N., Zanos, P., Riggs, L. M., Georgiou, P., Clark, S. M., Morris, P. J., Moaddel, R., Thomas, C. J., Zarate, C. A., Pereira, E. F. R., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000149 · Cited by 92 · see citing works
Perspectives for therapy of treatment‐resistant depression
Papp, M., Cubała, W. J., Święcicki, Ł., Newman‐Tancredi, A., & Willner, P. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15596 · Cited by 92 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2020) · Molecular Brain · doi:10.1186/s13041-020-00627-z · Cited by 85 · see citing works
Self-citationShen, C., Cao, K., Cui, S., Cui, Y., Mo, H., Wen, W., Dong, Z., Lin, H., Bai, S., Yang, L., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109787 · Cited by 71 · see citing works
Lai, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110234 · Cited by 71 · see citing works
Potential role of insulin on the pathogenesis of depression
Zou, X.-H., Sun, L.-H., Yang, W., Li, B.-J., & Cui, R.-J. (2020) · Cell Proliferation · doi:10.1111/cpr.12806 · Cited by 66 · see citing works
Millard, S. J., Weston-Green, K., & Newell, K. A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109908 · Cited by 62 · see citing works
Kopelman, J., Keller, T. A., Panny, B., Griffo, A., Degutis, M., Spotts, C., Cruz, N., Bell, E., Do-Nguyen, K., Wallace, M. L., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02451-0 · Cited by 60 · see citing works
Effects of Ginseng on Neurological Disorders
Hou, W., Wang, Y., Zheng, P., & Cui, R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00055 · Cited by 60 · see citing works
Self-citationTargeting metaplasticity mechanisms to promote sustained antidepressant actions
Brown, K. A., & Gould, T. D. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02397-1 · Cited by 49 · see citing works
Tang, Y., Su, H., Nie, K., Wang, H., Gao, Y., Shen, C., Lu, F., & Dong, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116012 · Cited by 49 · see citing works
Impaired Brain Energy Metabolism: Involvement in Depression and Hypothyroidism
Głombik, K., Detka, J., Kurek, A., & Budziszewska, B. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.586939 · Cited by 45 · see citing works
Wang, Y., Wang, X., Wang, Z., Lan, L., Hu, D., & Zhang, Y. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154558 · Cited by 44 · see citing works
Self-citationWang, R., Hu, X., Liu, S., Wang, J., Xiong, F., Zhang, X., Ye, W., & Wang, H. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16283 · Cited by 43 · see citing works
The Wistar Kyoto Rat: A Model of Depression Traits
Redei, E. E., Udell, M. E., Woods, L. C. S., & Chen, H. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221129120902 · Cited by 35 · see citing works
Hormonal Regulation of Oxidative Phosphorylation in the Brain in Health and Disease
Głombik, K., Detka, J., & Budziszewska, B. (2021) · Cells · doi:10.3390/cells10112937 · Cited by 32 · see citing works
Jin, Y., Pang, H., Zhao, L., Zhao, F., Cheng, Z., Liu, Q., Cui, R., Yang, W., & Li, B. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154425 · Cited by 32 · see citing works
Głombik, K., Detka, J., Bobula, B., Bąk, J., Kusek, M., Tokarski, K., & Budziszewska, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041599 · Cited by 31 · see citing works
Liang, X., Tang, J., Qi, Y., Luo, Y., Yang, C., Dou, X., Jiang, L. H., Xiao, Q., Zhang, L., Chao, F., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114103 · Cited by 31 · see citing works
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
Fitzgibbon, M., Kerr, D. M., Henry, R. J., Finn, D. P., & Roche, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.006 · Cited by 27 · see citing works
Li, X., Yu, C., Ding, Y., Chen, Z., Zhuang, W., Liu, Z., Fan, J., Yan, H., Xu, W., Zhu, G., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.085 · Cited by 25 · see citing works
A naturalistic method to test depression: Anticipation of play
Burke, C. J., Modlińska, K., Mauro, M. H., Aleksandrova, L. R., Pellis, S. M., Phillips, A. G., & Euston, D. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112975 · Cited by 24 · see citing works
Self-citationKolasa, M., Nikiforuk, A., Korlatowicz, A., Solich, J., Potasiewicz, A., Dziedzicka‐Wasylewska, M., Bugno, R., Hogendorf, A. S., Bojarski, A. J., & Faron‐Górecka, A. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06644-3 · Cited by 23 · see citing works
Liao, J., Zeng, G., Fang, W., Huang, W., Dai, X., Ye, Q., Zhang, J., & Chen, X. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113197 · Cited by 23 · see citing works
Preclinical models of treatment-resistant depression: challenges and perspectives
Kolasa, M., & Faron‐Górecka, A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00542-9 · Cited by 22 · see citing works
Li, Q., Gao, Y., Li, H., Liu, H., Wang, D., Pan, W. X., Liu, S., & Xu, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.037 · Cited by 21 · see citing works
Liu, S.-Z., Yang, J., Chen, L., Wang, P., & Li, L. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175385 · Cited by 21 · see citing works
Role of Semaphorin 3A in common psychiatric illnesses such as schizophrenia, depression, and anxiety
Yang, Y., Guan, W., Sheng, X.-M., & Gu, H. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116358 · Cited by 20 · see citing works
Yang, Y., Chen, C., Zhan, J., Liu, Q.-S., Liu, Y., Jiang, S.-Z., & Wei, B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.765664 · Cited by 20 · see citing works
Takahashi, K., Kurokawa, K., Hong, L., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.06.001 · Cited by 19 · see citing works
Armario, A., Belda, X., Gagliano, H., Fuentes, S., Molina, P., Serrano, S., & Nadal, R. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221129102852 · Cited by 19 · see citing works
Li, G., Bo, B., Wang, P., Qian, P., Li, M., Li, Y., Tong, C., Zhang, K., Zhang, B., Jiang, T., et al. (2023) · eLife · doi:10.7554/elife.84693 · Cited by 19 · see citing works
Transient Dose-dependent Effects of Ketamine on Neural Oscillatory Activity in Wistar-Kyoto Rats
Manduca, J. D., Thériault, R.-K., Williams, O. O. F., Rasmussen, D. J., & Perreault, M. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.012 · Cited by 18 · see citing works
Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models
Jenkins, B. W., & Khokhar, J. Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.597725 · Cited by 18 · see citing works
Wu, X., Zhang, Y., Wang, J., Qin, L., Li, Y., He, Q., Zhang, T., Wang, Y., Song, L., Ji, L., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156120 · Cited by 17 · see citing works
Self-citationFrom Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s–2025)
Tanaka, M. (2025) · Biomedicines · doi:10.3390/biomedicines14010035 · Cited by 15 · see citing works
Głombik, K., Detka, J., & Budziszewska, B. (2021) · Cells · doi:10.3390/cells10061394 · Cited by 15 · see citing works
Alves, R. L., Portugal, C. C., Lopes, I. M., Oliveira, P., Alves, C. J., Barbosa, F., Summavielle, T., & Magalhães, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02220-5 · Cited by 14 · see citing works
Riggs, L. M., Pereira, E. F. R., Thompson, S. M., & Gould, T. D. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00326.2023 · Cited by 14 · see citing works
Zhang, Y., Wei, C., Wang, P., Zheng, L.-C., Cheng, Y., Ren, Z., Jin, Y., Yao, Y., & Liu, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-76226-y · Cited by 14 · see citing works
Carboni, E., & Carta, A. R. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105144 · Cited by 14 · see citing works
Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats
Korlatowicz, A., Pabian, P., Solich, J., Kolasa, M., Latocha, K., Dziedzicka‐Wasylewska, M., & Faron‐Górecka, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03103-y · Cited by 14 · see citing works
Liu, X., Wei, Z., Li, L., Li, J., Deng, Y., Liu, Y., Li, H., Peng, D., Wan, X., & Wu, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.002 · Cited by 13 · see citing works
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Newman‐Tancredi, A., & Depoortère, R. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06389-5 · Cited by 13 · see citing works
Yoshii, T., Oishi, N., Sotozono, Y., Watanabe, A., Sakai, Y., Yamada, S., Matsuda, K., Kido, M., Ikoma, K., Tanaka, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53103-2 · Cited by 12 · see citing works
Sun, Z., Yang, L., Zhao, L., Cui, R., & Yang, W. (2020) · Neural Plasticity · doi:10.1155/2020/8814531 · Cited by 12 · see citing works
Mamedova, D. I., Nedogreeva, O. A., Манолова, А. О., Ovchinnikova, V. O., Kostryukov, P. A., Лазарева, Н. А., Moiseeva, Y. V., Tret’yakova, L. V., Kvichansky, A. A., Onufriev, M. V., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79677-5 · Cited by 11 · see citing works
Głombik, K., Detka, J., Kukla‐Bartoszek, M., Maciejska, A., & Budziszewska, B. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00395-8 · Cited by 11 · see citing works
Papp, M., Gruca, P., Litwa, E., Łasoń, M., & Willner, P. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110715 · Cited by 11 · see citing works
Garrett, A. S., Chang, K., Singh, M. K., Armstrong, C. C., Walshaw, P. D., & Miklowitz, D. J. (2021) · Bipolar Disorders · doi:10.1111/bdi.13045 · Cited by 11 · see citing works
Wang, Z., van Bruggen, R., Sandini, T. M., Hagen, E. V., Li, X., & Zhang, Y. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110825 · Cited by 10 · see citing works
Li, Q., Zhao, W., Liu, S., Zhao, Y., Pan, W. X., Wang, X., Liu, Z., & Xu, Y. J. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.04.010 · Cited by 10 · see citing works
Zhu, P., Luo, Y., Li, Y., Tang, J., Liu, L., Deng, Y., Li, J., Jiang, L. H., Yang, W., Xiao, Q., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03495-0 · Cited by 9 · see citing works
The ABCs of psychedelics: a preclinical roadmap for drug discovery
Kwan, A. C., Mantsch, J. R., & McCorvy, J. D. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.07.017 · Cited by 9 · see citing works
From Fat to Brain: Adiponectin as a Mediator of Neuroplasticity in Depression
Genini, P., D’Aprile, I., Petrillo, G., Benedetto, M. G. D., Begni, V., Cattane, N., & Cattaneo, A. (2025) · Biomolecules · doi:10.3390/biom15121642 · Cited by 9 · see citing works
Deng, F., Li, X., Tang, C., Chen, J., Fan, B., Liang, J., Zhen, X., Tao, R., Zhang, S., Cong, Z., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115631 · Cited by 9 · see citing works
Virijević, K., Spasojević, N., Stefanović, B., Ferizović, H., Janković, M., Vasiljevic, P. J., & Dronjak, S. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137709 · Cited by 9 · see citing works
Liao, J., Mi, X., Zeng, G., Wei, Y., Dai, X., Ye, Q., Chen, X., & Zhang, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.086 · Cited by 9 · see citing works
Wang, Z., Robbins, B., Zhuang, R., van Bruggen, R., Sandini, T. M., Li, X., & Zhang, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-03383-z · Cited by 8 · see citing works
Hu, S., Zhu, L., & Zhang, X. (2025) · Psychological Medicine · doi:10.1017/s0033291725100664 · Cited by 8 · see citing works
Advances of paeoniflorin in depression: the molecular mechanism and formula application
Hou, Y., Li, H., Zhu, L., Tian, Q., Feng, X., Li, Y., Bian, Y., & Wei, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1614429 · Cited by 8 · see citing works
Tendilla‐Beltrán, H., Garcés‐Ramírez, L., Martínez-Vásquez, E., Bernal, A. N., Gómez-Villalobos, M. D. J., & Flores, G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04074-9 · Cited by 8 · see citing works
Hilal, F. F., Jeanblanc, J., Deschamps, C., Naassïla, M., Pierrefiche, O., & Hamida, S. B. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02757-3 · Cited by 8 · see citing works
Wang, P., Wang, M., Xie, Z., Zhi, Z., Wang, Y., Liu, F., Liu, Y., & Zhao, L. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s501569 · Cited by 8 · see citing works
Self-citationZhang, J.-R., Zhang, J., Sun, Q.-Y., Chen, C., Yang, J., Cheng, N., Guo, Z., Shuang, R., Gu, W., Zhai, M.-Y., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104121 · Cited by 7 · see citing works
Mansari, M. E., Hamoudeh, R. A., Daniels, S., & Blier, P. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231209235 · Cited by 7 · see citing works
Wu, X., Liu, C., Wang, J., Zhang, Y., Li, Y., Wang, Y., Song, L., Qin, L., Zhang, T., & He, Q. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118448 · Cited by 7 · see citing works
Self-citationKorlatowicz, A., Kolasa, M., Pabian, P., Solich, J., Latocha, K., Dziedzicka‐Wasylewska, M., & Faron‐Górecka, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065941 · Cited by 7 · see citing works
A new pharmacological strategy against treatment-resistant depression
Pineda-Gómez, J. P., Millón, C., Cantero-García, N., Flores-Gómez, M., de Guevara‐Miranda, D. L., Flores‐Burgess, A., & Dı́az-Cabiale, Z. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111191 · Cited by 6 · see citing works
Zebrafish models: Charting promising platform and illuminating the depths of depression
Yang, B., Han, Y., Yang, Y., Li, Y., & Zhu, X. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174097 · Cited by 5 · see citing works
Farinha‐Ferreira, M., Magalhães, D. M., Neuparth‐Sottomayor, M., Rafael, H., Miranda‐Lourenço, C., & Sebastião, A. M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16083 · Cited by 5 · see citing works
Jia, L., Jian, L., Jin, S. K., Manshu, Z., Yajie, J., & Yuhong, W. (2022) · Digital Chinese Medicine · doi:10.1016/j.dcmed.2022.06.010 · Cited by 5 · see citing works
Li, C., Ren, H., Liu, H., Li, T., Liu, Y., Wu, B., Han, K. Q., Zang, S., Zhao, G., & Wang, X. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.070 · Cited by 4 · see citing works
Hoppanová, L., Filipova, A., Bukatová, S., Ondáčová, K., Tomko, M., Jurkovičová-Tarabová, B., Dubovický, M., Dremencov, E., & Lacinová, Ľ. (2025) · Scientia Pharmaceutica · doi:10.3390/scipharm93020017 · Cited by 4 · see citing works
Knott, M. V., Ngwenya, L. B., Correll, E. A., Bohnert, J., Ziemba, N. J., Allgire, E., Hopkins, T., & McGuire, J. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158086 · Cited by 4 · see citing works
Riggs, L. M., Aronson, S., Mou, T.-C. M., Pereira, E. F. R., Thompson, S. M., & Gould, T. D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115743 · Cited by 3 · see citing works
Park, D., Lee, G., Kim, B. S., Seong, M., & Kim, J. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02288-9 · Cited by 3 · see citing works
Inavally, A. T., & Sadananda, M. (2024) · Indian Journal of Physiology and Pharmacology · doi:10.25259/ijpp_431_2023 · Cited by 3 · see citing works
Valencia-Flores, K., Yahel Vidal de la, O., Paz-Trejo, D. B., & Sánchez-Castillo, H. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.05.001 · Cited by 3 · see citing works
Selinger, M. C., Compton, D. M., Morris, H., & Canty, T. J. (2023) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2023.1312016 · Cited by 3 · see citing works
Wang, C. K., Kim, G., Aleksandrova, L. R., Panenka, W. J., & Barr, A. M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1387158 · Cited by 3 · see citing works
Self-citationLi, X., Chen, M., Wei, D., PengSheng, W., Jiang, Y., Chen, J., duan, X., Wang, Z., Zhang, Y., Bai, D., et al. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04419-6 · Cited by 3 · see citing works
Diferencias fenotípicas ante la devaluación y omisión de una recompensa esperada
Serafini, M., Ifrán, M. C., Kamenetzky, G., & Cuenya, L. (2020) · Revista de psicología · doi:10.5354/0719-0581.2020.54743 · Cited by 3 · see citing works
Fang, Y., Sui, X., Zheng, D., Sun, J., Chen, T., Jia, J., Yao, J., Wang, J., chen, C., & Zhang, Z. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111488 · Cited by 2 · see citing works
Selecting an appropriate stress model of depression in rodents
Lu, X.-X., Tang, H., & Li, X. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i12.113433 · Cited by 2 · see citing works
Banjac, A., Elersič, K., Živin, M., & Zorović, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-27298-x · Cited by 2 · see citing works
Wang, Y., Zhang, Y., 王君明, Wu, X., Li, Y., Sun, W., Song, L., Gong, M., He, Q., Qin, L., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121428 · Cited by 2 · see citing works
Self-citationPalombelli, G., Zecca, V., Boffa, M., Carola, C., Singh, T., Risio, L. D., Pettorruso, M., Zoratto, F., & Canese, R. (2026) · Scientific Reports · doi:10.1038/s41598-026-45121-z · Cited by 2 · see citing works
Li, R., Zhang, Y., Zhang, H., Wang, C., Duan, H., Sun, S., Xiang, D., & Liu, Z. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115495 · Cited by 2 · see citing works
From microRNA to protein, linking the neurotrophic hypothesis of depression to the Wistar Kyoto rat
Kaadt, E., Hedemann, N., Damgaard, C. K., Müller, H. K., & Elfving, B. (2023) · Neuroscience Applied · doi:10.1016/j.nsa.2023.101131 · Cited by 2 · see citing works
Zeng, X., Yin, X., Cui, K., Xu, W., Li, W., Zhang, W., Li, W., & Xu, S. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149409 · Cited by 2 · see citing works
Qi, Z., Qin, L., Gao, M., Yang, R., Liu, C., Wang, N., Li, W., Huang, Y., Wu, L., & Liu, T. (2025) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2025.05.002 · Cited by 2 · see citing works
Ma, Q., Ma, Y., Sun, S., Yang, L., Shi, T., Zhang, B., Shang, B., Zhou, R., Liu, J., He, J., et al. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01856-6 · Cited by 1 · see citing works
Fattore, L. (2023) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-323-88534-8.00010-9 · Cited by 1 · see citing works
Electroacupuncture improves depression with constipation by balancing gut microbiota in WKY rats
Li, X., Li, G., Cui, K., Yin, X., Yang, W., Li, W., & Xu, S. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1680596 · Cited by 1 · see citing works
Wu, X., Liu, S., Xiao, Q., Tang, J., Luo, H.-F., Ren, X.-Y., Jiang, L., Liang, X., Huang, D., Zhou, C., et al. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110907 · Cited by 1 · see citing works
Stefanović, B., Virijević, K., Spasojević, N., Ferizović, H., Janković, M., Vasiljevic, P. J., & Dronjak, S. (2023) · Kragujevac Journal of Science · doi:10.5937/kgjsci2345149s · Cited by 1 · see citing works
- Authors
- Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Wang, Yu Tian
- Phillips, Anthony G.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 105
- Pages
- 1-23
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2962912563
- Semantic Scholar
- 309773830ee3353cbf1ed2bd10ef02a7501a4838
- Cited by
- 114
- References
- 284
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 12 · 2020: 12 · 2019: 1
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-09-01)
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Wistar-Kyoto rats, animal models of depression, major depressive disorder, synaptic plasticity, antidepressant response, stress vulnerability, stress tolerance, ketamine, hippocampus, prefrontal cortex, neuronal atrophy, neuronal connectivity, treatment-resistant depression
- MeSH terms
- Animals, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Disease Models, Animal, Hippocampus, Ketamine, Nerve Net, Neuronal Plasticity, Rats, Inbred WKY, Prefrontal Cortex, Rats
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