A case of renin-producing adrenocortical cancer
Open accessAbstract
Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.
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Other rare paraneoplastic syndromes are hyperreninemic hyperaldosteronism, erythropoietin-associated polycythemia, and leukocytosis (caused by chemokine release from the tumor).
“Other rare paraneoplastic syndromes are hyperreninemic hyperaldosteronism, erythropoietin-associated polycythemia, and leukocytosis (caused by chemokine release from the tumor) (82–84).”
From Adrenocortical carcinoma (2014) · cites this paper as [82]
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- Authors
- YAMANAKA, K., IITAKA, M., INABA, M., MORITA, T., SASANO, H., & KATAYAMA, S.
- Affiliations
- Saitama Medical University (JP)
- Tohoku University (JP)
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2000
- Volume
- 47
- Issue
- 2
- Pages
- 119-125
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2001879293
- Cited by
- 14
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenocortical carcinoma, hyperaldosteronism, hypokalemia, hypertension, diabetes mellitus, suprarenal mass, cervical lymph node metastasis, trilostane, mitotane, cytochrome P450
- MeSH terms
- Adrenal Cortex Neoplasms, Biopsy, Needle, Catecholamines, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Female, Glucocorticoids, Humans, Hydrocortisone, Hypertension, Hypokalemia, Middle Aged, Mitotane, Neoplasm Metastasis, Renin, Gonadal Steroid Hormones, Dihydrotestosterone, Thirst, Tomography, X-Ray Computed, 17-Hydroxycorticosteroids, 17-Ketosteroids, 3-Hydroxysteroid Dehydrogenases, Muscle Weakness
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