A retrospective multicenter study of bone mineral density in adolescents and adults with Turner syndrome in Japan
Open accessAbstract
Osteoporosis is one of the clinical features of women with Turner syndrome (TS). The reasons for low bone mineral density (BMD) and increased bone fragility are multifactorial, including estrogen deficiency, X-chromosome abnormalities, and environmental factors. Few, large-scale studies on bone mineral density in either adolescents or adults with TS have been done in Japan. The goal of the present study was to investigate spinal BMD in women with TS, assess its relationship with clinical parameters, especially estrogen replacement therapy, and investigate its longitudinal changes. The spinal BMD and clinical data of 149 Japanese women with TS aged 15 to 49 years who were followed at the four participating hospitals were retrospectively analyzed. The BMD Z-scores of the women with TS ranged from -5.30 to +1.89. Women with TS aged 15-39 years had lower BMD than healthy Japanese women (p < 0.01) while women with spontaneous menstruation had a significantly higher BMD Z-score than those without spontaneous menstruation (-0.73 ± 1.11 vs. -1.67 ± 1.18, p < 0.01). In women without spontaneous menstruation, BMD Z-scores correlated with the duration of their estrogen therapy (r = 0.167, p < 0.01). Women aged 15-39 years with TS had low BMD, which was associated with primary amenorrhea and short estrogen replacement therapy duration.
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No studies have rigorously defined the effect of dose on BMI, height, weight, or lipids.
“To date, no studies have rigorously defined the effect of dose on BMI, height, weight, or lipids.327-331”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [329]
Earlier initiation of HRT affects BMD with higher BMD/better bone quality/greater trabecular bone score.
“Earlier initiation of HRT does affect BMD with higher BMD/better bone quality/greater trabecular bone score”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [329]
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Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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“According to the literature, karyotype and GH therapy were not related to osteoporosis [40, 41, 45].”
BackgroundResult
- Authors
- Itonaga, T., Koga, E., Nishigaki, S., Kawai, M., Sakakibara, H., & Hasegawa, Y.
- Affiliations
- Oita University (JP)
- Yokohama City University Medical Center (JP)
- Osaka City University (JP)
- Osaka Women's and Children's Hospital (JP)
- Tokyo Metropolitan Children's Medical Center (JP)
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2020
- Volume
- 67
- Issue
- 10
- Pages
- 1023-1028
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W3036716454
- Cited by
- 16
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, bone mineral density, osteoporosis, estrogen replacement therapy, primary amenorrhea, estrogen deficiency, bone fragility, Japanese women, adolescents
- MeSH terms
- Adolescent, Adult, Amenorrhea, Female, Humans, Japan, Longitudinal Studies, Lumbar Vertebrae, Menstruation, Middle Aged, Osteoporosis, Retrospective Studies, Turner Syndrome, Absorptiometry, Photon, Bone Density, Estrogen Replacement Therapy, Young Adult
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