Cited by 231Cellular Mechanics and InteractionsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Lung Extracellular Matrix and Fibroblast Function

Open access

White, Eric S.·2015·Annals of the American Thoracic Society

DOI 10.1513/annalsats.201406-240mgPMC PMC4430981

Open this paper in CoChat — free account

Abstract

Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides physical support to tissues and is essential for normal organ function. In the lung, ECM plays an active role in shaping cell behavior both in health and disease by virtue of the contextual clues it imparts to cells. Qualities including dimensionality, molecular composition, and intrinsic stiffness all promote normal function of the lung ECM. Alterations in composition and/or modulation of stiffness of the focally injured or diseased lung ECM microenvironment plays a part in reparative processes performed by fibroblasts. Under conditions of remodeling or in disease states, inhomogeneous stiffening (or softening) of the pathologic ECM may both precede modifications in cell behavior and be a result of disease progression. The ability of ECM to stimulate further ECM production by fibroblasts and drive disease progression has potentially significant implications for mesenchymal stromal cell–based therapies; in the setting of pathologic ECM stiffness or composition, the therapeutic intent of progenitor cells may be subverted. Taken together, current data suggest that lung ECM actively contributes to health and disease; thus, mediators of cell–ECM signaling or factors that influence ECM stiffness may represent viable therapeutic targets in many lung disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1513/annalsats.201406-240mg

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666
A tense situation: forcing tumour progression
Butcher, D. T., Alliston, T. N., & Weaver, V. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2544 · Cited by 2,026
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
Naba, A., Clauser, K. R., Hoersch, S., Liu, H., Carr, S. A., & Hynes, R. O. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014647 · Cited by 1,354
Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
Hynes, R. O., & Naba, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004903 · Cited by 1,349
Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 828

Show all 46 references

Sorted by citations

Items 101–200 of 231

Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets
Li, J., Dang, Y.-M., Liu, M., Gao, L., & Lin, H. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.102297 · Cited by 15
Integrating structural heterogeneity, fiber orientation, and recruitment in multiscale ECM mechanics
Li, H., Mattson, J. M., & Zhang, Y. (2018) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2018.12.023 · Cited by 15
Discovery of cell-internalizing artificial nucleic acid aptamers for lung fibroblasts and targeted drug delivery
Uemachi, H., Kasahara, Y., Tanaka, K., Okuda, T., Yoneda, Y., & Obika, S. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104321 · Cited by 15
Advanced single-cell technologies to guide the development of bioengineered lungs
Wanczyk, H., Jensen, T., Weiss, D. J., & Finck, C. M. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00089.2021 · Cited by 16
Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts
Aloufi, N., Namkung, Y., Traboulsi, H., Wilson, E. T., Laporte, S. A., Kaplan, B. L. F., Ross, M. K., Nair, P., Eidelman, D. H., & Baglole, C. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.852029 · Cited by 13
Silicon dioxide-induced endoplasmic reticulum stress of alveolar macrophages and its role on the formation of silicosis fibrosis: a review article
Li, S., Zhao, J., Han, G., Zhang, X., Li, N., & Zhang, Z. (2023) · Toxicology Research · doi:10.1093/toxres/tfad099 · Cited by 17
Combustion-derived particles inhibit in vitro human lung fibroblast-mediated matrix remodeling
Bové, H., Devoght, J., Rasking, L., Peters, M., Slenders, E., Roeffaers, M. B. J., Jorge-Peñas, Á., Oosterwyck, H. V., & Ameloot, M. M. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0410-x · Cited by 14
Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective
Cavallaro, D., Guerrieri, M., Cattelan, S., Fabbri, G., Croce, S., Armati, M., Bennett, D., Fossi, A., Voltolini, L., Luzzi, L., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10123277 · Cited by 14
Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration
Kong, X., Hu, R., Zhang, P., Li, Q., Song, K., Gu, H., Zheng, J., Liu, S., Liu, L., Jin, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202507178 · Cited by 15
Impact of the Amyotrophic Lateral Sclerosis Disease on the Biomechanical Properties and Oxidative Stress Metabolism of the Lung Tissue Correlated With the Human Mutant SOD1G93A Protein Accumulation
Aydemir, D., Malik, A. N., Kulaç, İ., Başak, A. N., Lazoğlu, İ., & Ulusu, N. N. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.810243 · Cited by 14
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation
Tian, X., Jia, Y., Guo, Y., Liu, H., Cai, X., Li, Y., Tian, Z., & Sun, C. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13691 · Cited by 13
Antifibrotic Drugs against Idiopathic Pulmonary Fibrosis and Pulmonary Fibrosis Induced by COVID-19: Therapeutic Approaches and Potential Diagnostic Biomarkers
Perez-Favila, A., Veloz, I. G., Hernandez-Marquez, L. S., Gutierrez-Vela, E. F., Flores‐Morales, V., & Martínez‐Fierro, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031562 · Cited by 13
Surface Tension-Based Open Microfluidic Platform Using Micropillars to Recreate the 3D Lung Cellular Microenvironment
Nguyen, T. T., Lee, J., Choi, S., & Jeon, N. L. (2024) · BioChip Journal · doi:10.1007/s13206-024-00171-1 · Cited by 13
Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation
Macklin, M., Thompson, C., Kawano-Dourado, L. B., Ventura, I. B., Weschenfelder, C., Trostchansky, A., Marcadenti, A., & Tighe, R. M. (2023) · Cells · doi:10.3390/cells12182206 · Cited by 13
Microfluidic strategies for biomimetic lung chip establishment and SARS-CoV2 study
Wang, H., Wen, T., Zhu, W., Li, K., Gong, X., & Li, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100905 · Cited by 13
A miniaturized multicellular platform to mimic the 3D structure of the alveolar-capillary barrier
Licciardello, M., Traldi, C., Cicolini, M., Bertana, V., Marasso, S. L., Cocuzza, M., Tonda‐Turo, C., & Ciardelli, G. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1346660 · Cited by 12
Effect of the elastin-derived peptides (VGVAPG and VVGPGA) on breast (MCF-7) and lung (A549) cancer cell lines in vitro
Szychowski, K. A., Skóra, B., & Pomianek, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113149 · Cited by 12
The underappreciated role of resident epithelial cell populations in metastatic progression: contributions of the lung alveolar epithelium
Christenson, J. L., Williams, M. M., & Richer, J. K. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00181.2022 · Cited by 12
Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression
Aloufi, N., Haidar, Z., Ding, J., Nair, P. K., Benedetti, A., Eidelman, D. H., Gallouzi, I., Marco, S. D., Hussain, S. N. A., & Baglole, C. J. (2021) · Cells · doi:10.3390/cells11010022 · Cited by 12
Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts
Clevenger, A. J., Jimenez‐Vergara, A. C., Tsai, E. H., Righes, G. D. B., Díaz‐Lasprilla, A. M., Ramírez‐Caballero, G. E., & Munoz‐Pinto, D. J. (2022) · Gels · doi:10.3390/gels9010028 · Cited by 11
The Role of the Extracellular Matrix in the Pathogenesis and Treatment of Pulmonary Emphysema
Cantor, J. O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910613 · Cited by 10
Thrombospondin‐1 and micro RNA ‐1 expression in response to multiwalled carbon nanotubes in alveolar epithelial cells
Pacurari, M., Kafoury, R., Turner, T., Taylor, S., & Tchounwou, P. B. (2017) · Environmental Toxicology · doi:10.1002/tox.22387 · Cited by 11
500 Million Alveoli from 30,000 Feet: A Brief Primer on Lung Anatomy
McKleroy, W., & Lyn-Kew, K. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8570-8_1 · Cited by 11
Paraquat-Induced Oxidative Stress and Lung Inflammation
Tyagi, N., & Singh, R. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_11 · Cited by 11
Tenascin‐C Activation of Lung Fibroblasts in a 3D Synthetic Lung Extracellular Matrix Mimic
Kundu, A. N., Dougan, C. E., Mahmoud, S., Kilic, A., Panagiotou, A., Richbourg, N. R., Irakoze, N., & Peyton, S. R. (2023) · Advanced Materials · doi:10.1002/adma.202301493 · Cited by 12
How Do Mechanics Guide Fibroblast Activity? Complex Disruptions during Emphysema Shape Cellular Responses and Limit Research
Leslie, M. N., Chou, J., Young, P. M., Traini, D., Bradbury, P., & Ong, H. X. (2021) · Bioengineering · doi:10.3390/bioengineering8080110 · Cited by 11
Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults
Sánchez‐Sánchez, J. L., Ader, I., Jeanson, Y., Planat‐Benard, V., Vellas, B. J., Casteilla, L., & Barreto, P. D. S. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac226 · Cited by 10
Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice
Wang, H., Zhang, W., Liu, R., Zheng, J., Yao, X., Chen, H., Wang, J., Weber, H. C., Qin, X., Xiang, Y., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201368 · Cited by 10
YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations
Cunningham, R., Jia, S., Purohit, K. P., Salem, O., Hui, N. S., Lin, Y., Carragher, N. O., & Hansen, C. G. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1190 · Cited by 11
In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response
Chen, X., Haribowo, A. G., Baik, A. H., Fossati, A., Stevenson, E. J., Chen, Y. R., Reyes, N. S., Peng, T., Matthay, M. A., Traglia, M., et al. (2023) · Science Advances · doi:10.1126/sciadv.adj4884 · Cited by 10
Role of the extracellular matrix in the genesis of ventilator-induced lung injury
Cruz, F. F., Rocco, P. R. M., & Pelosi, P. P. (2017) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-017-0376-8 · Cited by 9
Metabolism of the Extracellular Matrix in Bronchial Asthma (Review)
Eliseeva, T. I., Tush, Е. V., Krasilnikova, S. V., Kuznetsova, S. V., Larin, R. A., Kubysheva, N. I., Khaletskaya, О. V., Потемина, Т. Е., Ryazantsev, S. V., & Ignatov, S. K. (2018) · Современные технологии в медицине · doi:10.17691/stm2018.10.4.25 · Cited by 9
Factors influencing the mechanical properties of soft elastomer substrates for traction force microscopy
Lua, A. M. R., Hopf, R., & Mazza, E. (2020) · Mechanics Of Soft Materials · doi:10.1007/s42558-020-00021-8 · Cited by 9
Aging-related changes in the mechanical properties of single cells
Singam, A., Bhattacharya, C., & Park, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32974 · Cited by 8
COL4A3expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
Nemani, S. S. P., Vermeulen, C. J., Pech, M., Faiz, A., Oliver, B. G. G., van den Berge, M., Burgess, J. K., Kopp, M., & Weckmann, M. (2021) · ERJ Open Research · doi:10.1183/23120541.00802-2020 · Cited by 8
Toxicogenomic assessment of in vitro macrophages exposed to profibrotic challenge reveals a sustained transcriptomic immune signature
Morikka, J., Federico, A., Möbus, L., Inkala, S., Pavel, A., Sani, S., Vaani, M., Peltola, S. K., Serra, A., & Greco, D. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.10.010 · Cited by 8
Phytochemicals and Their Nanoformulations for Targeting Hepatocellular Carcinoma: Exploring Potential and Targeting Strategies
Rab, S. O., Roopashree, R., Altalbawy, F. M. A., Kumar, M. R., Chahar, M., Singh, M., Kubaev, A., Alamir, H. T. A., Mohammed, F., KADHIM, A. J., et al. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.70013 · Cited by 10
The effect of the mechanodynamic lung environment on fibroblast phenotype via the Flexcell
Yazeedi, S. A., Abokor, A. F., Brussow, J., Thiam, F., Phogat, S., & Osei, E. T. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03167-7 · Cited by 8
Binary fabrication of decellularized lung extracellular matrix hybridgels for in vitro chronic obstructive pulmonary disease modeling
Antczak, L.-A. M., Moore, K. N., Hendrick, T. E., & Heise, R. L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.014 · Cited by 8
An integrated in silico–in vitro approach for bioprinting core–shell bioarchitectures
Guazzelli, N., Cacopardo, L., Corti, A., & Ahluwalia, A. D. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.771 · Cited by 7
Profiling of gene expression using microarray in acrolein-treated human pulmonary fibroblasts
Park, H. R., Lee, S. E., Son, G. W., Yun, H. D., Park, C., Ahn, H., Cho, J.-J., Lee, J., & Park, Y. S. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0005-x · Cited by 7
Fibroblast function in COVID-19
Şahi̇n, M., & Akkuş, E. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153353 · Cited by 7
A gel-coated air-liquid-interface culture system with tunable substrate stiffness matching healthy and diseased lung tissues
He, Z., Chu, C., Dickson, R. C., Okuda, K., & Cai, L. (2024) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00153.2023 · Cited by 8
TNF signaling mediates lipopolysaccharide-induced lung epithelial progenitor cell responses in mouse lung organoids
Li, D., Kortekaas, R. K., Douglas, K. B. I., Douwenga, W., Eisel, U. L. M., Melgert, B. N., Gosens, R., & Schmidt, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117704 · Cited by 6
Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms
Yazeedi, S. A., Guo, T. J. F., Sohd, J., Abokor, F. A., Baher, J. Z., Yee, L., Cheung, C. Y., Sin, D. D., & Osei, E. T. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1552803 · Cited by 7
Knockdown of versican 1 in lung fibroblasts aggravates Lipopolysaccharide-induced acute inflammation through up-regulation of the SP1-Toll-like Receptor 2-NF-κB Axis: a potential barrier to promising Versican-targeted therapy
Xu, L., Hu, W., Zhang, J., & Qu, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110406 · Cited by 6
Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure
Fonseca, V. C., Van, V., & Ip, B. C. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00809-y · Cited by 5
Extracellular Matrix Oxidised by the Granulocyte Oxidants Hypochlorous and Hypobromous Acid Reduces Lung Fibroblast Adhesion and Proliferation In Vitro
Papanicolaou, M., He, P., Rutting, S., Ammit, A. J., Xenaki, D., van Reyk, D. M., & Oliver, B. G. G. (2021) · Cells · doi:10.3390/cells10123351 · Cited by 6
Layer-by-Layer Fabrication of PAH/PAMAM/Nano-CaCO3 Composite Films and Characterization for Enhanced Biocompatibility
Shifeta, N. T., Hamukwaya, S. L., An, Q., Hao, H., & Mashingaidze, M. M. (2022) · International Journal of Biomaterials · doi:10.1155/2022/6331465 · Cited by 6
A method for TAT-Cre recombinase-mediated floxed allele modification in ex vivo tissue slices
Cheong, S., Luis, T. C., Stewart, M. E., Hillier, R., Hind, M. D., & Dean, C. H. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050267 · Cited by 6
α2-ADRENORECEPTOR ANTAGONIST AMELIORATES SEPSIS-ASSOCIATED PULMONARY FIBROSIS BY SUPPRESSING NOREPINEPHRINE-MEDIATED FIBROBLAST DIFFERENTIATION VIA INHIBITING PKC ACTIVATION
Su, X., Lu, F., Chen, Y., Wang, M., Tang, G., Lin, W., Liu, Y., Wang, H., Yin, H., & Wang, Y. (2023) · Shock · doi:10.1097/shk.0000000000002240 · Cited by 6
ECM Mechanoregulation in Malignant Pleural Mesothelioma
Panzetta, V., Musella, I., Fusco, S., & Netti, P. A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.797900 · Cited by 6
Biodegradable Nanofiber Membranes for Air–Liquid Interface Culture: Advancing Airway In Vitro Models
Tuncer, S., Can, S. S., Bilgiç, H. A., Kilic, B., Günal, G., Aydın, H. M., & Karaaslan, Ç. (2025) · ACS Omega · doi:10.1021/acsomega.5c03198 · Cited by 5
Genipin-Crosslinked Gelatin Hydrogels with Controlled Molecular Weight: A Strategy to Balance Processability and Performance
Castro-María, Á., Fernandéz‐Blázquez, J. P., & Patterson, J. (2025) · Gels · doi:10.3390/gels11120980 · Cited by 5
Targeting pleuro-alveolar junctions reverses lung fibrosis in mice
Fischer, A., Han, W., Hu, S., Mück-Häusl, M., Wannemacher, J., Kadri, S., Lin, Y., Dai, R., Christ, S., Su, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55596-x · Cited by 6
Pulmonary Fibrosis; Risk Factors and Molecular Triggers, Insight for Neo Therapeutic Approach
Marzoog, B. A. (2022) · Current Respiratory Medicine Reviews · doi:10.2174/1573398x18666220806124019 · Cited by 5
A Review: The Potential Involvement of Growth Arrest-Specific 6 and Its Receptors in the Pathogenesis of Lung Damage and in Coronavirus Disease 2019
Apostolo, D., Ferreira, L. L., Tizio, A. D., Ruaro, B., Patrucco, F., & Bellan, M. (2023) · Microorganisms · doi:10.3390/microorganisms11082038 · Cited by 5
Take my breath away: studying pathogen invasion of the human lung using primary tissue models
Dragan, A. L., & Voth, D. E. (2021) · Pathogens and Disease · doi:10.1093/femspd/ftab016 · Cited by 5
Epigenetic Control of CXCL10: Regulating the Counterregulator in Idiopathic Pulmonary Fibrosis
Roman, J., & Mutsaers, S. E. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0389ed · Cited by 5
Remodeling of the Aged and Emphysematous Lungs: Roles of Microenvironmental Cues
Suki, B., Bates, J. H. T., & Bartolák‐Suki, E. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210033 · Cited by 12
Caspase inhibition restores collagen Iα1 and fibronectin release in cigarette smoke extract-exposed human lung fibroblasts
Mensa, A. L., Buscetta, M., Woldhuis, R. R., Cimino, M., Giuffrè, M. R., Cristaldi, M., Dino, P., Fiore, L., Fucarino, A., Iacono, G. L., et al. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00214.2024 · Cited by 4
A Review on Bioengineering the Bovine Mammary Gland: The Role of the Extracellular Matrix and Reconstruction Prospects
Júnior, F. C., da Silva, T. S., Meirelles, F. V., Monzani, P. S., Laurindo, L. F., Barbalho, S. M., & Miglino, M. A. (2025) · Bioengineering · doi:10.3390/bioengineering12050501 · Cited by 5
Idiopathic Pulmonary Comorbidities and Mechanisms
Pacurari, M., Mitra, A. K., & Turner, T. (2021) · International Journal of Inflammation · doi:10.1155/2021/3963659 · Cited by 4
Potential network markers and signaling pathways for B cells of COVID-19 based on single-cell condition-specific networks
Li, Y., Han, L., Li, P., Ge, J., Xue, Y., & Chen, L. (2023) · BMC Genomics · doi:10.1186/s12864-023-09719-1 · Cited by 4
A Single-Step Protein Extraction for Lung Extracellular Matrix Proteomics Enabled by the Photocleavable Surfactant Azo and timsTOF Pro
Towler, A. G., Perciaccante, A. J., Aballo, T. J., Zhu, Y., Wang, F., Lloyd, S., Kadoya, K., He, Y., Tian, Y., & Ge, Y. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.100950 · Cited by 4
COPD affected lung tissue remodelling due to the local distribution of MMP-2, TIMP-2, TGF-β1 and HSP-70
Vitenberga-Verza, Z., Pilmane, M., & Babjoniševa, A. (2017) · Papers on Anthropology · doi:10.12697/poa.2017.26.2.16 · Cited by 4
Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation
Xu, Z., Zhou, T. H., Wang, Y., Zhu, L., Tu, J., Xu, Z., Li, L., & Li, Y. (2022) · Aging · doi:10.18632/aging.204258 · Cited by 5
Dynamic Reciprocity: The Role of the Extracellular Matrix Microenvironment in Amplifying and Sustaining Pathological Lung Fibrosis
Burgess, J. K., Muizer, K., Brandsma, C., & Heijink, I. H. (2018) · Molecular and translational medicine · doi:10.1007/978-3-319-98143-7_9 · Cited by 4
Novel Assay Analyzing Tropism between Adipose-Derived Stem Cells and Breast Cancer Cells Reveals a Low Oncogenic Response
Sauter, M. A., Brett, E. A., Müller, C. M., Machens, H., & Duscher, D. (2019) · Breast Care · doi:10.1159/000503411 · Cited by 4
A chronic murine model of pulmonary Acinetobacter baumannii infection enabling the investigation of late virulence factors, long-term antibiotic treatments, and polymicrobial infectionsPreprint
Jackson-Litteken, C. D., Venanzio, G. D., Janet-Maitre, M., Castro, Í. A., Mackel, J. J., Rosen, D. A., López, C. B., & Feldman, M. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613469 · Cited by 4
MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis
Yao, L., Wang, Z., Jiang, X., Jiang, B., Chen, S.-J., Hua, Z.-D., Gao, D.-D., Zheng, Q., Zhu, S., Qian, M., et al. (2024) · Respiratory Research · doi:10.1186/s12931-024-03007-6 · Cited by 3
Bioprinted Human Lung Cancer-Mimics for Tissue Diagnostics Applications
Wang, M., Li, W., Flores, R. S., Cai, L., Garciamendez‐Mijares, C. E., Gill, S., Snyder, D., Millabas, J., Chafin, D. R., Zhang, Y. S., et al. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2023.0149 · Cited by 3
Collagen–Mesenchymal Stem Cell Microspheres Embedded in Hyaluronic Acid Solutions as Biphasic Stem Niche Delivery Systems for Pulmonary Differentiation
Sala, F. D., Longobardo, G., & Borzacchiello, A. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c01218 · Cited by 3
Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
Uhler, C., & Shivashankar, G. V. (2020) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2020.100874 · Cited by 3
Decellularization
Kwon, T., & Moon, K. H. (2017) · Springer eBooks · doi:10.1007/978-981-10-2723-9_6 · Cited by 3
Defining lung pathogenesis in a murine model of mucopolysaccharidosis Type I by proteomic analysis
Ngai, Y. T., Young, C., Parkinson-Lawrence, E. J., Wimmer-Kleikamp, S. H., Mittal, P., Beard, H., Briggs, M. T., Klingler‐Hoffmann, M., Brooks, D. A., Orgeig, S., et al. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109231 · Cited by 2
Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues
Espinosa, A. M. D., Wellmerling, J. H., Vanegas, N.-D. P., Rodriguez-Lopez, J., Choi, K. M., Schussler, N. A., Link, P. A., Rodríguez, L. R., Barringer, G., Rojas, M. M., et al. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00177.2025 · Cited by 2
Pulmonary fibroblast activation during Aspergillus fumigatus infection enhances lung defense via immunomodulation and tissue remodeling
Guirao-Abad, J. P., Kasprovic, D. A., Seo, D., Ozdemir, M., Shearer, S. M., Wen, B.-Y., Bowden, J. J., Grisham, C., Wang, Y., Tranter, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71027-5 · Cited by 2
Extracellular Matrix-Derived Matrikines: Circulating Peptides as Candidate Mediators of Lung-to-Brain Signaling
Klegeris, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073339 · Cited by 2
Cellular response of lung fibroblasts and epithelial cells to particulate matter10 treatment examined via comparative transcriptome analysis
Park, K., Kim, K., Ryu, T. Y., Lee, J., Lee, M., Son, M., Lee, S., Park, Y., Cho, H., & Kim, D. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12598 · Cited by 2
Quantification of Lung Stiffness Using Magnetic Resonance Elastography (MRE): Clinical Validation for Smokers
Bensamoun, S. F., McGee, K. P., Chakouch, M. K., Pouletaut, P., & Charleux, F. (2025) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2025.3553375 · Cited by 4
Study on the changes of extracellular matrix morphology and components in COPD animal model by using lung decellularized scaffold
Li, Y., Dai, Y., Jin, T., Liu, X., & Xie, L. (2025) · The FASEB Journal · doi:10.1096/fj.202401522rr · Cited by 1
Human Organotypic Respiratory Models
Svensson, M., & Chen, P. (2018) · Current topics in microbiology and immunology · doi:10.1007/82_2018_91 · Cited by 2
Dutch Summary — Nederlandse Samenvatting
Moyakine, E. (2017) · Intersentia eBooks · doi:10.1017/9781780685632.008 · Cited by 2
Adaption of Lung Fibroblasts to Fluoro-Edenite Fibers: Evaluation of Molecular and Physiological Dynamics
Graziano, A. C. E., Ledda, C., Loreto, C., & Cardile, V. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000379 · Cited by 2
Three dimensional lung models - Three dimensional extracellular matrix models
Nizamoglu, M., Joglekar, M. M., de Hilster, R. H. J., Ngassie, M. L. K., Teitsma, G. J., Migulina, N., Blokland, K. E. C., & Burgess, J. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90871-9.00012-7 · Cited by 3
Substrate Nanotopography and Stiffness Modulation of Cell Behaviors for Disease Detection and Modeling
Shi, L. (2017) · doi:10.33915/etd.6632 · Cited by 2
Bioprinted 3-dimensional lung organoids for respiratory disease modeling and therapeutic applications
Jang, J., & Yang, S. (2025) · Organoid · doi:10.51335/organoid.2025.5.e8 · Cited by 1
Scar wars: the viral menace
Kass-Gergi, S., Holcomb, N. P., Maiden, M. M., Eisenlohr, L. C., & Vaughan, A. E. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00189.2025 · Cited by 1
Targeting integrin beta 4 in diacetyl-induced anoikis of the airway epithelium
Kim, S.-Y., Pitonzo, A., Huyck, H. L., Pryhuber, G., Mariani, T. J., & McGraw, M. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-02980-9 · Cited by 1
PDE4 inhibitor DC591017 ameliorates pulmonary fibrosis through modulating fibroblasts-epithelial cells-alternatively activated macrophages crosstalk
Lei, S., Li, J., Yang, T., Peng, Z., Xu, Y., Hui, Z., Yan, M., Feng, C., Liu, H., & Tang, W. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178707 · Cited by 2
Unraveling the therapeutic mechanisms of Polygonum cuspidatum in pulmonary fibrosis: Modulation of M2 macrophage polarization and glycolysis pathways
Gao, Y., Ng, C. Y. J., Ni, K., Hu, Q., Shi, X., Si, T., Zhang, X., Yang, J., Yang, J., & Xu, T. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121461 · Cited by 1
Multifaceted regulation of immune cells in radiation-induced pulmonary fibrosis: from mechanistic insights to targeted therapies
Shen, L., Zhang, W., Yang, Y., Du, Z., Fu, S., Huang, F. S., Yang, X., Li, J., Ran, Y., & 郝玉徽 (2026) · Inflammation Research · doi:10.1007/s00011-026-02221-w · Cited by 1
Beyond the epithelium: multicellular niches in lung regeneration and disease
Koç-Günel, S., Ryan, A. L., Hynds, R. E., & Kathiriya, J. J. (2026) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00419.2025 · Cited by 1
Engineering a multilayer microfluidic airway-on-a-chip with tunable GelMA hydrogel for physiologically relevant aerosol exposure studies
Bennet, T. J., Randhawa, A., Pieters, A., Caffrey, T. M., Solomon, T., Lyall, E., Huff, R. D., Schwartz, C., Xi, Y., Carlsten, C., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-69468-5 · Cited by 1
Identifying a Role for the Sodium Hydrogen Exchanger Isoform 1 in Idiopathic Pulmonary Fibrosis: A Potential Strategy to Modulate Profibrotic Pathways
Nguyentu, T. T., Vigilante, D., Manchanda, M., Iyer, M. S., Desalegne, S., & Provost, J. J. (2025) · Biomedicines · doi:10.3390/biomedicines13040959 · Cited by 1
Author response: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
Jones, M. G., Andriotis, O. G., Roberts, J., Lunn, K., Tear, V. J., Cao, L., Ask, K., Smart, D. E., Bonfanti, A., Johnson, P., et al. (2018) · eLife · doi:10.7554/elife.36354.018 · Cited by 1
E-cigarette vapour induces cellular senescence in primary lung fibroblasts and may contribute to lung pathologyPreprint
Bozier, J., Wang, B., de Vries, M., Brandsma, C., van den Berge, M., Timens, W., Heijink, I. H., Oliver, B. G. G., & Woldhuis, R. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555286 · Cited by 1
The role of nicotine, a7 nicotinic acetylcholine receptors and extracellular matrix remodeling in pulmonary fibrosis.
Vicary, G. W. (2016) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2589
Innate immune memory in fibroblasts
Crowley, T. E. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)

Authors: White, E. S.
Affiliations: University of Michigan (US)
Corresponding author: White, Eric S.
ORCID: White, Eric S.
Venue: Annals of the American Thoracic Society
Publisher: Oxford University Press (OUP)
Published: 2015-03-01
Volume: 12
Issue: Supplement_1
Pages: S30-S33
ISSN: 2325-6621 (ISSN-L)
2329-6933
DOI: 10.1513/annalsats.201406-240mg
PMC: PMC4430981
OpenAlex: W1970148422
Cited by: 231
References: 46
Citations by year: 2026: 22 · 2025: 20 · 2024: 29 · 2023: 28 · 2022: 23 · 2021: 29 · 2020: 20 · 2019: 16 · 2018: 24 · 2017: 11 · 2016: 8
FWCI: 1.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Annals of the American Thoracic Society (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (U01HL111016, R01HL109118)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: lung extracellular matrix, lung fibroblasts, extracellular matrix stiffness, pulmonary fibrosis, tissue remodeling, lung repair, therapeutic target
MeSH terms: Extracellular Matrix, Fibroblasts, Humans, Lung

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lung Extracellular Matrix and Fibroblast Function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks