The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Remodeling and Inflammation of Bronchi in Asthma and Chronic Obstructive Pulmonary Disease
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are pathologically distinct in terms of their predominant inflammatory cells and structural alterations (i.e., remodeling). However, there are many cases of functional and pathologic overlap, supporting the author's view that use of the terms asthma or COPD is oversimplistic and fails to identify the range of phenotypes that exist. In general, there is epithelial fragility and thickening of the reticular basement membrane, even in mild asthma; increased airway smooth muscle mass, hypertrophy of mucus-secreting glands, increased vascularity, greater numbers of fibroblasts, and increased deposition of collagen in severe asthma and COPD; and mucous metaplasia, squamous metaplasia, and parenchymal destruction in COPD. Because of increased neutrophilia, patterns of inflammation become similar when exacerbations of asthma and COPD result in hospitalization. Moreover, in mild COPD, exacerbations of bronchitis are associated with mucosal eosinophilia and upregulation of RANTES, two features normally associated with asthma. The overlap may also be seen in intermediate thickening of the reticular basement membrane and eosinophilia in patients with COPD who demonstrate reversibility to oral steroid. Importantly, a recent study of “eosinophilic bronchitis” demonstrates a thickened reticular basement membrane and challenges our current concept of the histopathologic distinctions between asthma and COPD.
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Cites
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
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Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
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Self-citationRemodeling in Asthma and Chronic Obstructive Lung Disease
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Cited by
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Gosens, R., Zaagsma, J., Meurs, H., & Halayko, A. J. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-73 · Cited by 409
Airway remodeling in asthma: what really matters
Fehrenbach, H., Wagner, C., & Wegmann, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2566-8 · Cited by 406
IKKα Causes Chromatin Modification on Pro-Inflammatory Genes by Cigarette Smoke in Mouse Lung
Yang, S.-R., Valvo, S., Yao, H., Kode, A., Rajendrasozhan, S., Edirisinghe, I., Caito, S., Adenuga, D., Henry, R., Fromm, G., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0379oc · Cited by 98
Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice
Bracke, K. R., Dentener, M. A., Papakonstantinou, E., Vernooy, J. H. J., Demoor, T., Pauwels, N. S., Cleutjens, J., van Suylen, R. J., Joos, G. F., Brusselle, G. G., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0424oc · Cited by 59
Metadata
- Authors
- Jeffery, P. K.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-01
- Volume
- 1
- Issue
- 3
- Pages
- 176-183
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W2017944609
- Cited by
- 347
- References
- 82
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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