CoChat
Sign Up
Cited by 10,736Latin American and Latino StudiesLatin American Literature AnalysisLatin American history and culture

The DOI matches its Crossref record.

Borderlands/La Frontera: The New Mestiza

Anzaldúa, Gloria·2017·Censored
DOI 10.1515/9780773551886-027
Open this paper in CoChat — free account

Abstract

The chemokine receptor CCR9 and its only known ligand CCL25 play an important role in gut inflammation and autoimmune colitis. The function of CCR9-CCL25 in the migration of immune cells is well characterized. However, its role in the immune cell differentiation is mostly not known. Using dextran sodium sulfate (DSS)-induced gut inflammation model, we showed that CCR9+ dendritic cells (DCs) specifically CD11b- CD103+ DCs were significantly increased in the gut-associated lymphoid tissues (GALT) compared to control mice. These CCR9+ DCs express lower MHC II and CD86 molecules and had regulatory surface markers (FasL and latency-associated peptide, LAP) in the GALT. In the presence of CCL25, CCR9+ DCs promoted in vitro differentiation of Foxp3+ regulatory CD4+ T cells (Tregs). CCL25-induced differentiation of Tregs was due to intrinsic signaling in the DCs but not through CD4+ T cells, which was driven by the production of thymic stromal lymphopoietin (TSLP) and not IL-10. Furthermore, adoptive transfer of CCR9+ DCs in C57BL/6 mice promoted Tregs but reduced the Th17 cells in the GALT, and also suppressed the OVA-specific gut-allergic response. Our results suggest CCR9+ DCs have a regulatory function and may provide a new cellular therapeutic strategy to control gut inflammation and allergic immune reaction.

Overview

Integrity signals

Registry

Crossref · 10.1515/9780773551886-027

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 5,501–5,600 of 10,727

Related

See all

Metadata

Authors
Anzaldúa, G.
Corresponding author
Anzaldúa, Gloria
Venue
Censored
Publisher
McGill-Queen's University Press
Published
2017-09-05
Pages
381-399
DOI
10.1515/9780773551886-027
OpenAlex
W184192484
Cited by
10,736
References
0
Citations by year
2026: 21 · 2025: 581 · 2024: 722 · 2023: 724 · 2022: 727 · 2021: 755 · 2020: 714 · 2019: 645 · 2018: 587 · 2017: 449
FWCI
5434.34
Type
book chapter
Language
en
Open access
closed
Locations
McGill-Queen's University Press eBooks (publishedVersion)
Topics
  • Social Sciences › Cultural Studies › Latin American and Latino Studies
  • Social Sciences › Arts and Humanities › Literature and Literary Theory › Latin American Literature Analysis
  • Social Sciences › Arts and Humanities › History › Latin American history and culture
Keywords
borderlands, mestizaje, mestiza, race and ethnicity, identity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review