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Cited by 10,736Latin American and Latino StudiesLatin American Literature AnalysisLatin American history and culture

The DOI matches its Crossref record.

Borderlands/La Frontera: The New Mestiza

Anzaldúa, Gloria·2017·Censored
DOI 10.1515/9780773551886-027
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Abstract

The chemokine receptor CCR9 and its only known ligand CCL25 play an important role in gut inflammation and autoimmune colitis. The function of CCR9-CCL25 in the migration of immune cells is well characterized. However, its role in the immune cell differentiation is mostly not known. Using dextran sodium sulfate (DSS)-induced gut inflammation model, we showed that CCR9+ dendritic cells (DCs) specifically CD11b- CD103+ DCs were significantly increased in the gut-associated lymphoid tissues (GALT) compared to control mice. These CCR9+ DCs express lower MHC II and CD86 molecules and had regulatory surface markers (FasL and latency-associated peptide, LAP) in the GALT. In the presence of CCL25, CCR9+ DCs promoted in vitro differentiation of Foxp3+ regulatory CD4+ T cells (Tregs). CCL25-induced differentiation of Tregs was due to intrinsic signaling in the DCs but not through CD4+ T cells, which was driven by the production of thymic stromal lymphopoietin (TSLP) and not IL-10. Furthermore, adoptive transfer of CCR9+ DCs in C57BL/6 mice promoted Tregs but reduced the Th17 cells in the GALT, and also suppressed the OVA-specific gut-allergic response. Our results suggest CCR9+ DCs have a regulatory function and may provide a new cellular therapeutic strategy to control gut inflammation and allergic immune reaction.

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Metadata

Authors
Anzaldúa, G.
Corresponding author
Anzaldúa, Gloria
Venue
Censored
Publisher
McGill-Queen's University Press
Published
2017-09-05
Pages
381-399
DOI
10.1515/9780773551886-027
OpenAlex
W184192484
Cited by
10,736
References
0
Citations by year
2026: 21 · 2025: 581 · 2024: 722 · 2023: 724 · 2022: 727 · 2021: 755 · 2020: 714 · 2019: 645 · 2018: 587 · 2017: 449
FWCI
5434.34
Type
book chapter
Language
en
Open access
closed
Locations
McGill-Queen's University Press eBooks (publishedVersion)
Topics
  • Social Sciences › Cultural Studies › Latin American and Latino Studies
  • Social Sciences › Arts and Humanities › Literature and Literary Theory › Latin American Literature Analysis
  • Social Sciences › Arts and Humanities › History › Latin American history and culture
Keywords
borderlands, mestizaje, mestiza, race and ethnicity, identity

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