15. IRON AND ITS ROLE IN CANCER DEFENSE: A DOUBLE-EDGED SWORD
Abstract
Vanadium compounds have been known to have beneficial therapeutic properties since the turn of the century, but it was not until 1965 when it was discovered that those effects could be extended to treating cancer. Some vanadium compounds can combat common markers of cancer, which include metabolic processes that are important to initiating and developing the phenotypes of cancer. It is appropriate to consider vanadium as a treatment option due to the similarities in some of the metabolic pathways utilized by both diabetes and cancer and therefore is among the few drugs that are effective against more than one disease. The development of vanadium compounds as protein phosphatase inhibitors for the treatment of diabetes may be useful for potential applications as an anticancer agent. Furthermore, the ability of vanadium to redox cycle is also important for biological properties and is involved in the pathways of reactive oxygen species. Early agents including vanadocene and peroxovanadium compounds have been investigated in detail, and the results can be used to gain a better understanding of how some vanadium compounds are modifying the metabolic pathways potentially developing cancer. Considering the importance of coordination chemistry to biological responses, it is likely that proper consideration of compound formulation will improve the efficacy of the drug. Future development of vanadium-based drugs should include consideration of drug formulation at earlier stages of drug development.
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The role of iron for cancer development is tightly linked to its ability to modulate innate and adaptive immune responses of macrophages or T cells.
“The role of iron for cancer development is tightly linked to its ability to modulate innate and adaptive immune responses of macrophages or T cells.”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [53]
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- Authors
- Thévenod, F.
- Corresponding author
- Thévenod, Frank
- ORCID
- Thévenod, Frank
- Venue
- Metallo-Drugs: Development and Action of Anticancer Agents
- Publisher
- De Gruyter
- Published
- 2018-02-05
- Volume
- 18
- Pages
- 437-468
- OpenAlex
- W2789262487
- Cited by
- 82
- References
- 0
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 7 · 2022: 15 · 2021: 15 · 2020: 10 · 2019: 19 · 2018: 8
- FWCI
- 30.06
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- De Gruyter eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Vanadium and Halogenation Chemistry
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- vanadium compounds, anticancer agents, protein phosphatase inhibitors, diabetes mellitus, redox cycling, reactive oxygen species, vanadocene, cancer metabolism, coordination chemistry, drug formulation
- MeSH terms
- Animals, Antineoplastic Agents, Drug Compounding, Humans, Neoplasms, Structure-Activity Relationship, Molecular Structure, Anticarcinogenic Agents, Vanadium Compounds, Dietary Supplements, Drug Discovery, Coordination Complexes
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