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Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants
Abstract
Adjuvant and haemolytic activities of 47 saponins purified from medicinal and food plants were examined. The compounds showed various levels of both adjuvant and haemolytic activities. Soyasaponins and lablabosides showed strong adjuvant activity but little haemolytic activity. Jujubosides showed strong adjuvant and haemolytic activities. Escins showed weaker adjuvant activity than the adjuvant-control, but strong haemolytic activity. Comparison of the functional groups of each saponin revealed that the acyl residue in saponin, the aldehyde group at carbon 4 in aglycone, and branched sugar chains attached to aglycone, were not essential for adjuvant activity. Furthermore, saponins with an acyl residue or oxide-ring moiety tended to show haemolytic activity. These results suggest that the adjuvant activity of saponins does not relate with haemolytic activity. It is considered that not only the functional groups themselves, but the overall conformation harmoniously consisting of such functional groups, affects adjuvant activity of saponins.
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Cited by
Biological activities and distribution of plant saponins
Sparg, S. G., Light, M. E., & van Staden, J. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.05.016 · Cited by 1,446
Saponins: Properties, Applications and Processing
Güçlü-Üstündağ, Ö., & Mazza, G. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600698197 · Cited by 1,043
Molecular activities, biosynthesis and evolution of triterpenoid saponins
Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Saponins from Edible Legumes: Chemistry, Processing, and Health Benefits
Shi, J., Arunasalam, K., Yeung, D., Kakuda, Y., Mittal, G., & Jiang, Y. (2004) · Journal of Medicinal Food · doi:10.1089/109662004322984734 · Cited by 479
Saponins as Natural Raw Materials for Increasing the Safety of Bodywash Cosmetic Use
Nizioł‐Łukaszewska, Z., & Bujak, T. (2018) · Journal of Surfactants and Detergents · doi:10.1002/jsde.12168 · Cited by 49
Metadata
- Authors
- Oda, K., Matsuda, H., Murakami, T., Katayama, S., Ohgitani, T., & Yoshikawa, M.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2000-01-28
- Volume
- 381
- Issue
- 1
- Pages
- 67-74
- ISSN
- 1431-6730 (ISSN-L)
- OpenAlex
- W2043567210
- Cited by
- 291
- References
- 0
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oda, K., Matsuda, H., Murakami, T., Katayama, S., Ohgitani, T., & Yoshikawa, M. (2000). Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants. Biological Chemistry. https://doi.org/10.1515/bc.2000.009
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