The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antimicrobial Peptides: Properties and Applicability
Abstract
All organisms need protection against microorganisms, e. g. bacteria, viruses and fungi. For many years, attention has been focused on adaptive immunity as the main antimicrobial defense system. However, the adaptive immune system, with its network of humoral and cellular responses is only found in higher animals, while innate immunity is encountered in all living creatures. The turning point in the appreciation of the innate immunity was the discovery of antimicrobial peptides in the early eighties. In general these peptides act by disrupting the structural integrity of the microbial membranes. It has become clear that membrane-active peptides and proteins play a crucial role in both the innate and the adaptive immune system as antimicrobial agents. This review is focused on the functional and structural features of the naturally occurring antimicrobial peptides, and discusses their potential as therapeutics.
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Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Wakabayashi, H., Abe, S., Okutomi, T., Tansho, S., Kawase, K., & Yamaguchi, H. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01147.x · Cited by 116
Cited by
Saliva – the defender of the oral cavity
Amerongen, A. N., & Veerman, E. (2002) · Oral Diseases · doi:10.1034/j.1601-0825.2002.1o816.x · Cited by 760
Self-citationCathelicidins - a family of multifunctional antimicrobial peptides
Bals, R., & Wilson, J. M. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-2186-9 · Cited by 427
Antimicrobial Peptides: Current Status and Therapeutic Potential
Koczulla, A. R., & Bals, R. (2003) · Drugs · doi:10.2165/00003495-200363040-00005 · Cited by 306
Hajisharifi, Z., Piryaiee, M., Mohammad Beigi, M., Behbahani, M., & Mohabatkar, H. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.08.037 · Cited by 294
Lien, S., & Lowman, H. B. (2003) · Trends in Biotechnology · doi:10.1016/j.tibtech.2003.10.005 · Cited by 209
Metadata
- Authors
- Hof, W. V. T., Veerman, E. C. I., Helmerhorst, E. J., & Amerongen, A. V. N.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2001-01-27
- Volume
- 382
- Issue
- 4
- Pages
- 597-619
- ISSN
- 1431-6730 (ISSN-L)
- OpenAlex
- W2039694750
- Cited by
- 354
- References
- 2
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hof, W. V. T., Veerman, E. C. I., Helmerhorst, E. J., & Amerongen, A. V. N. (2001). Antimicrobial Peptides: Properties and Applicability. Biological Chemistry. https://doi.org/10.1515/bc.2001.072
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