Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism

Tong, Kit I., Kobayashi, Akira, Katsuoka, Fumiki, Yamamoto, Masayuki·2006·Biological Chemistry
DOI 10.1515/bc.2006.164

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  73. BindingDB Entry 50001797: Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
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  74. BindingDB Entry 50008721: Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
    BindingDB · 2021 · UC San Diego
  75. BindingDB Entry 50016274: Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.
    BindingDB · 2023 · UC San Diego
  76. BindingDB Entry 50020171: Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    BindingDB · 2024 · UC San Diego
  77. BindingDB Entry 50009297: Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.
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  78. BindingDB Entry 50046773: Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
    BindingDB · 2016 · UC San Diego
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