Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
Tong, Kit I., Kobayashi, Akira, Katsuoka, Fumiki, Yamamoto, Masayuki·2006·Biological Chemistry
Cited by (480)
Items 301–400 of 480
- Unlocking peak performance: The role of Nrf2 in enhancing exercise outcomes and training adaptation in humansMiriam Martinez‐Canton, Víctor Galván-Álvarez, Marcos Martín-Rincón, José A. L. Calbet, Ángel Gallego-Selles · 2024 · Free Radical Biology and Medicine
- Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interactionSumi Lee, Dhulfiqar Ali Abed, Mai-Uyen Nguyen, Michael Paul Verzi, Longqin Hu · 2022 · European Journal of Medicinal Chemistry
- Modulation of NRF2/KEAP1-Mediated Oxidative Stress for Cancer Treatment by Natural Products Using Pharmacophore-Based Screening, Molecular Docking, and Molecular Dynamics StudiesAbdulrahim Altoam Alzain, Rua M. Mukhtar, Nihal Abdelmoniem, Tagyedeen H. Shoaib, Wadah Osman, Marwa Alsulaimany, Ahmed K. B. Aljohani, Sara A. Almadani, Baiaan Alsaadi, Maryam M. Althubyani et al. · 2023 · Molecules
- Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genesMeng Wang, Lu Qiu, Xufang Ru, YiJiang Song, Yiguo Zhang · 2019 · Scientific Reports
- Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL FamilyGregory A. Shilovsky, Daria V. Dibrova · 2023 · Life
- Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progressJing Chen, Disheng Feng, Rui Zhu, Hua Li, Lixia Chen · 2025 · Redox Biology
- Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary ciliaTetsuro Ishii, Eiji Warabi, Giovanni E. Mann · 2021 · Redox Biology
- Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activityShuang Guo, Xiwen Cheng, Jun-Hee Lim, Yu Liu, Hung‐Ying Kao · 2014 · Molecular Biology of the Cell
- Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseasesCuadrado, Antonio, Cazalla, Eduardo, Bach, Anders, Bathish, Boushra, Naidu, Sharadha Dayalan, DeNicola, Gina M., Dinkova-Kostova, Albena T., Fernández-Ginés, Raquel, Grochot-Przeczek, Anna, Hayes, John D. et al. · 2025 · Redox Biology
- Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other CancersSyed K. Hasan, Sundarraj Jayakumar, Eliezer Espina Barroso, Anup Jha, Gianfranco Catalano, Santosh K. Sandur, Nélida I. Noguera · 2025 · Cells
- The C-Terminal Domain of Nrf1 Negatively Regulates the Full-Length CNC-bZIP Factor and Its Shorter Isoform LCR-F1/Nrf1β; Both Are Also Inhibited by the Small Dominant-Negative Nrf1γ/δ Isoforms that Down-Regulate ARE-Battery Gene ExpressionYiguo Zhang, Lu Qiu, Shaojun Li, Yuancai Xiang, Jiayu Chen, Yonggang Ren · 2014 · PLoS ONE
- ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung CancerSteffan Vartanian, James Lee, Christiaan N. Klijn, Florian Gnad, Maria Bagniewska, Gabriele Schaefer, Donglu Zhang, Jenille Tan, Sara A. Watson, Liling Liu et al. · 2019 · Cancer Research
- KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and DegradationNa Shao, Hong Huang, Muhammad Idris, Peng Xu, Feng Xu, Shiwu Dong, Chungang Liu · 2020 · Advanced Science
- Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell DiseaseWaseem Chauhan, Rahima Zennadi · 2023 · Antioxidants
- Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory NetworksHan Xiao, Feng-Lin Lu, Derek Stewart, Yiguo Zhang · 2013 · Current Chemical Biology
- A Crosstalk between the Biorhythms and Gatekeepers of Longevity: Dual Role of Glycogen Synthase Kinase-3Gregory A. Shilovsky, T. S. Putyatina, Моргунова Галина Васильевна, А. В. Селиверстов, Vasily V. Ashapkin, Е. В. Сорокина, Alexander V Markov, Vladimir P. Skulachev · 2021 · Biochemistry (Moscow)
- Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element SystemHiroshi Yukitake, Masayuki Takizawa, Haruhide Kimura · 2017 · Oxidative Medicine and Cellular Longevity
- Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expressionMichelle S. Bousquet, Ranjala Ratnayake, Jillian L. Pope, Qi-Yin Chen, Fanchao Zhu, Sixue Chen, Thomas J. Carney, Raad Z. Gharaibeh, Christian Jobin, Valerie Jean Paul et al. · 2019 · Free Radical Biology and Medicine
- Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathwayMingfang Tao, Rong Li, Tingting Xu, Zhuo Zhang, Dan Zheng, Zhenzhen Xia, Ting Wu, Siyi Pan, Xiaoyun Xu · 2023 · International Journal of Food Sciences and Nutrition
- Neurotoxicity and physiological stress in brain of zebrafish chronically exposed to tributyltinPing Li, Zhi‐Hua Li · 2020 · Journal of Toxicology and Environmental Health
- Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang et al. · 2024 · Experimental & Molecular Medicine
- Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase ActivityScott A. Reisman, Iván L. Csanaky, Ronnie L. Yeager, Curtis D. Klaassen · 2009 · Toxicological Sciences
- Nrf2K.M. Kim, Sung Hwan Ki · 2017 · Elsevier eBooks
- Xiaochaihutang Inhibits the Activation of Hepatic Stellate Cell Line T6 Through the Nrf2 PathwayRui Hu, Wei-yi Jia, Shangfu Xu, Zhi-wei Zhu, Zhi Xiao, Shouyang Yu, Jin Li · 2019 · Frontiers in Pharmacology
- Piceatannol-3′-O-β-D-glucopyranoside attenuates colistin-induced neurotoxicity by suppressing oxidative stress via the NRF2/HO-1 pathwayLiguang Xiong, Debiao Xiang, Fang Yuan, Huan Tong, Rui Yang, Lili Zhou, Bing Xu, Changhui Deng, Xin Li · 2023 · Biomedicine & Pharmacotherapy
- Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression: A study of phytotherapeutic-based modulationJiao Wang, Tapan Behl, Tarapati Rana, Aayush Sehgal, Pranay Wal, Bhagawati Saxena, Shivam Yadav, Syam Mohan, Md. Khalid Anwer, Sridevi Chigurupati et al. · 2024 · Phytomedicine
- Redox-dependent signaling system Nrf2/ARE in inflammationМеньщикова Елена Брониславовна, Victor Tkachev, Н. К. Зенков · 2010 · Molecular Biology
- Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation SpectroscopyYuki Yoshizaki, Takayasu Mori, Mari Ishigami‐Yuasa, Eriko Kikuchi, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Yutaro Mori, Yuya Araki, Fumiaki Ando et al. · 2017 · Scientific Reports
- NRF2 signaling in cytoprotection and metabolismShohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi · 2023
- Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5′-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cellsMin Wang, Jingyu Zhu, Shuo Chen, Ying Qing, Dong Wu, Ying‐Min Lin, Jizhuang Luo, Wei Han, Yanqing Li · 2014 · Oncology Letters
- Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription UnitsUpayan Patra, Urbi Mukhopadhyay, Arpita Mukherjee, Rakesh Sarkar, Mamta Chawla‐Sarkar · 2020 · Oxidative Medicine and Cellular Longevity
- New era for drug discovery and development in renal diseaseToshio Miyata, Katsushi Kikuchi, Hideyasu Kiyomoto, Charles van Ypersele de Strihou · 2011 · Nature Reviews Nephrology
- Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defenseYan Wang, Guanqin Ma, Xuefeng Wang, Na Lei, Xing Yuan Guo, Jiaqi Zhang, Cong Liu, Cheng Du, Ting Qi, Yuezhi Lin et al. · 2022 · PLoS Pathogens
- Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosisXinxin Wang, Wenzhi Chen, Cheng Li, Renshi Xu · 2024 · Reviews in the Neurosciences
- Exploring new strategies for grafting binding peptides onto protein loops using a consensus‐designed tetratricopeptide repeat scaffoldSarah K. Madden, Albert Perez‐Riba, Laura S. Itzhaki · 2019 · Protein Science
- The Keap1-Nrf2 pathway: From mechanism to medical applicationsLiam Baird, Masayuki P. Yamamoto · 2019 · Elsevier eBooks
- RETRACTED: Moschus exerted protective activity against H2O2-induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathwaysDanni Xie, Ting Deng, Zhenwei Zhai, Tao Qin, Caiyou Song, Ying Xu, Tao Sun · 2023 · Biomedicine & Pharmacotherapy · Retracted
- Sulfiredoxin-1 alleviates high glucose-induced podocyte injury though promoting Nrf2/ARE signaling via inactivation of GSK-3β.Yan Shen, Sheng-Nan Chen, Yan Zhao · 2019 · Biochemical and Biophysical Research Communications - BBRC
- Maslinic acid induces HO-1 and NOQ1 expression via activation of Nrf2 transcription factorWei Hsum Yap, Kong Soo Khoo, Anthony Siong Hock Ho, Yang Mooi Lim · 2012 · Biomedicine & Preventive Nutrition
- The potentially protective role of ATP-binding cassette transporters in preeclampsia via Nrf2Lu Yu, Ting Wang, Rongcheng Que, Jillian Yang, Zhijun Kevin Wang, Xuehua Jiang, Ling Wang · 2019 · Pregnancy Hypertension
- The Complex Roles of Redox and Antioxidant Biology in CancerMakiko Hayashi, Keito Okazaki, Thales Papgiannakopoulos, Hozumi Motohashi · 2024 · Cold Spring Harbor Perspectives in Medicine
- Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectivesYangguo Zhou, Qiong Zhang, Ziquan Zhao, Xiuqi Hu, Qidong You, Zhengyu Jiang · 2024 · European Journal of Medicinal Chemistry
- Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactionsHamid R. Nasiri, Sandra Linge, Dirk Ullmann · 2015 · Bioorganic & Medicinal Chemistry Letters
- Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells.Sun Young Park, Young Hun Kim, Geuntae Park · 2016 · PubMed
- Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stressJiazhen Wang, Kechun Liu, Cailian Mo, О. H. Minchenko, Yun Liang Zhang, Jung‐Ren Chen, Chung‐Der Hsiao, Qing Zhu, Qiuxia He · 2020 · Drug and Chemical Toxicology
- Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease geneticsAnthony J. Asmar, David B. Beck, Achim A Werner · 2020 · Experimental Cell Research
- The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseasesSybil Akua Okyerewa Obuobi, Sanzhar Karatayev, Christina L. L. Chai, Pui Lai Rachel Ee, Péter Mátyus · 2016 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of InflammationElango Bhakkiyalakshmi, Dornadula Sireesh, Kunka Mohanram Ramkumar · 2017 · Elsevier eBooks
- Nrf2: LA HISTORIA DE UN NUEVO FACTOR DE TRANSCRIPCIÓN QUE RESPONDE A ESTRÉS OXIDATIVO*Mina Königsberg Fainstein · 2007 · REB. Revista de educación bioquímica
- GPR30 Activation by 17β-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor α Protein Expression by Inducing Its Release from a Complex Formed with KEAP1Chia-Lung Tsai, Chiao‐Yun Lin, Angel Chao, Yun‐Shien Lee, Ren‐Chin Wu, Chi‐Neu Tsai, Chih‐Feng Yen, An‐Shine Chao · 2021 · Journal of Personalized Medicine
- The Complicated Role of Nuclear Factor Erythroid-Derived 2-Like 2 in Allergy and AsthmaCheryl Elizabeth Rockwell, Yining Jin, Allison P. Boss, Luca M. Kaiser, Saamera Awali · 2021 · Drug Metabolism and Disposition
- Cell‐specific overactivation of nuclear erythroid 2 p45‐related factor 2–mediated gene expression in myeloid cells decreases hepatic ischemia/reperfusion injuryLung‐Yi Lee, Calvin A. Harberg, Kristina A. Matkowskyj, Shelly M. Cook, Drew A. Roenneburg, Sabine Werner, Delinda A. Johnson, Jeffrey Allan Johnson, David P. Foley · 2016 · Liver Transplantation
- Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterizationSatoshi Sogabe, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, Junichi Sakamoto · 2017 · Biochemical and Biophysical Research Communications
- Nrf2 in Host Defense: Over the RainbowHye‐Youn Cho, Mi‐Kyoung Kwak, Jingbo Pi · 2013 · Oxidative Medicine and Cellular Longevity
- Chemical modulation of transcription factorsBianca M. Wiedemann, Jörn Weisner, Daniel Rauh · 2018 · MedChemComm
- The leaves of Scutellaria baicalensis Georgi attenuate brain aging in D-galactose-induced rats via regulating glutamate metabolism and Nrf2 signaling pathwayMengru Li, Linlin Yang, Li Gao, Guanhua Du, Xuemei Qin, Yuzhi Zhou · 2022 · Experimental Gerontology
- Nrf2-Keap1 Activation, A Promising Strategy in the Prevention of CancerOluwafemi Adeleke Ojo, Basiru Olaitan Ajiboye, Adewale Oluwaseun Fadaka, Promise Taro, Mohammad Ali Shariati · 2016 · Free Radicals and Antioxidants
- Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glueNilotpal Roy, Tine L Wyseure, I‐Chung Lo, Justine Metzger, Christie L. Eissler, Steffen M. Bernard, Ilah Bok, Aaron Nathan Snead, Albert Parker, Jason C. Green et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- NRF2 has a splicing regulatory function involving the survival of motor neuron (SMN) in non-small cell lung cancerQinqin Cui, Wei Wang, Akhileshwar Namani, Hongyan Wang, Ahmed Hammad, Pu Huang, Yang Gao, Mohamed Elshaer, Yihe Wu, Xiu Jun Wang et al. · 2023 · Oncogene
- Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12Andrew J. Ingersoll, Devlon M. McCloud, Jane G. Hu, Michael Rapé · 2025 · Cell Reports
- Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor OccurrenceDo-Kyung Yun, June Lee, Young-Sam Keum · 2013 · Biomolecules & Therapeutics
- CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Yu Kigoshi, Tomomi Fukuda, Tomoyuki Endo, Nami Hayasaka, Shun‐ichiro Iemura, Tohru Natsume, Fuminori Tsuruta, Tomoki Chiba · 2015 · Scientific Reports
- Maf regulates the overexpression of CYP307A1, which is involved in the fitness advantage of bistrifluron-resistant Spodoptera litura (Fab.) (Noctuidae: Lepidoptera)Changwei Gong, Yumeng Wang, Qian Huang, Zhengze Xu, Yuming Zhang, Ali Hasnain, Xiaoxu Zhan, Yunfeng He, Tianyi Zhang, Litao Shen et al. · 2022 · Ecotoxicology and Environmental Safety
- Human DPP III – Keap1 Interactions: A Combined Experimental And Computational StudyMario Gundić, Antonija Tomić, Rebecca C. Wade, Mihaela Matovina, Zrinka Karačić, Saša Kazazić, Sanja Tomić · 2016 · Croatica Chemica Acta
- Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 ActivationShanshan Liu, Shengmei Xu, Renrong Wei, Zhizhong Cui, Xiaoyun Wu, Renxiong Wei, Li Xie, Yingye Zhou, Wenjuan Li, Weimin Chen · 2019 · BioMed Research International
- Regulatory factors of Nrf2 in age-related macular degeneration pathogenesisZi-Ling Hu, Zi-Yue Lin, Wen-Shuo Ren, Bo Liu, Hui Zhao, Qiong Qin · 2024 · International Journal of Ophthalmology
- Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer TherapyRamia J. Salloom, Iman M. Ahmad, Dania Z. Sahtout, Michael J. Baine, Maher Y. Abdalla · 2024 · International Journal of Molecular Sciences
- Thioredoxin Reductase 1 as an Anticancer Drug TargetEdward E. Schmidt, Elias S.J. Arnér · 2016 · Springer eBooks
- Insights into the Molecular Basis of Genome Stability and Pristine Proteostasis in Naked Mole-RatsVikram Narayan, Mary E. McMahon, Jonathon J. O’Brien, Fiona Elizabeth McAllister, Rochelle Buffenstein · 2021 · Advances in experimental medicine and biology
- A mechanistic investigation about hepatoxic effects of borneol using zebrafishLongji Liu, Yanan Yang, F Yang, Y Lin, Kangdi Liu, Xixin Wang, Y Zhang · 2023 · Human & Experimental Toxicology
- Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1BMaysa Ahmed Mobasher, Ángela M. Valverde · 2014 · Archives of Physiology and Biochemistry
- New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancerJérôme Gouge, Alessandro Vannini · 2017 · Transcription
- Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1−nuclear factor erythroid 2-related factor 2 (Keap1−Nrf2) protein−protein interaction inhibitors for ulcerative colitis managementZiquan Zhao, Hongjin Lu, Junjie Wang, Tingting Wu, Shicheng Xu, Yuxin Ge, Qidong You, Zhengyu Jiang, Mengchen Lu · 2025 · European Journal of Medicinal Chemistry
- The crosstalk between Nrf2 and pyroptosis in diseasesXiaomei Wang, Marzieh Monemi, Fatemeh Mortazavi Moghadam, Ahmad Fazilat, Salomeh Roshani, Mohammad Valilo · 2025 · Pathology - Research and Practice
- NRF2 activation in cancer and overview of NRF2 small molecule inhibitorsHoang Hai Ngo, Bo-Yeong Yu, Jeong‐Eun Lee, Hyun Woo Kim, Young‐Sam Keum · 2025 · Archives of Pharmacal Research
- New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutationsLiangkai Cheng, Huihui Wang, Shehan Li, Zhongqiu Liu, Caiyan Wang · 2021 · Life Sciences
- Role of Nrf2-Keap1 signaling in the antioxidant defense response induced by low salinity in the kuruma shrimp (Marsupenaeus japonicus)Haixin Ou, Jianyong Liu · 2022 · Aquaculture International
- Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer CellsMaria Narożna, Violetta Krajka‐Kuźniak, Robert Kleszcz, Wanda Baer‐Dubowska · 2022 · International Journal of Molecular Sciences
- Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1Halema Khan, Ryan C. Killoran, Anne M. Brickenden, Jing‐Song Fan, Daiwen Yang, Wing‐Yiu Choy · 2015 · Biochemical Journal
- Saeng-Kankunbi-Tang (生肝健脾汤) protects liver against oxidative damage through activation of ERK/Nrf2 pathwayIn Woo Lee, Hee Yoon Choi, Ju‐Hee Lee, Sun‐Dong Park, Sae‐Kwang Ku, Sae Kwang Ku, Rongjie Zhao, Young Woo Kim, Young Woo Kim, Hong Sik Choi · 2016 · Chinese Journal of Integrative Medicine
- Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation StudyI-Chung Cheng, Ya‐Jyun Chen, Chia‐Wei Ku, Yu-Wen Huang, Chia‐Ning Yang · 2015 · Journal of Chemical Information and Modeling
- Pharmacological Modulations of Nrf2 and Therapeutic Implications in Aneurysmal Subarachnoid HemorrhageZhang Qia, Jianmin Zhang, Jun Mo · 2023 · Molecules
- Ropivacaine regulates the expression and function of heme oxygenase-1Xiangbiao Yan, Yu Li, Xuechang Han, Dong Xu, Yajie Zhang, Qunzhi Xing · 2018 · Biomedicine & Pharmacotherapy
- The role of Nrf2 in autoimmunity and infectious disease: Therapeutic possibilitiesRobert Arthur Freeborn, Cheryl Elizabeth Rockwell · 2021 · Advances in pharmacology
- Patenting perspective on Keap1 inhibitors (2019–2024)Yongfu Luo, Wenlong Yang, Yuan Zhang, Shutong Jiang, Jingyu Zhu, Xiangyang Li, Qidong You, Mengchen Lu · 2025 · Expert Opinion on Therapeutic Patents
- Cloning and expression analysis of Keap1 of golden pompano (Trachinotus ovatus) and response to oxidized fish oil and LPS administrationJiajun Xie, Xu Chen, Xuanshu He, Jin Niu · 2020 · Aquaculture Reports
- Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 ActivatorsDerek D. Poore, Glenn A. Hofmann, Lawrence A. Wolfe, Hongwei Qi, Ming Jiang, Michael Fischer, Zining Wu, Thomas D. Sweitzer, Subhas J. Chakravorty, Brian T. Donovan et al. · 2018 · SLAS DISCOVERY
- Drug screening assay based on the interaction of intact Keap1 and Nrf2 proteins in cancer cellsBo O. Zhou, Xiaolei Zhang, Guiren Wang, Karen W. Barbour, Franklin G. Berger, Qian Wang · 2018 · Bioorganic & Medicinal Chemistry
- The Role of Drug Metabolism in ToxicityUmesh Hanumegowda, Carl D. Davis · 2022 · Wiley eBooks
- Transcription Factor NRF2 in Endothelial FunctionsN. D. Kondratenko, Liudmila A. Zinovkina, Roman A. Zinovkin · 2023 · Molecular Biology
- 11,12-Diacetyl-carnosol Protects SH-SY5Y Cells from Hydrogen Peroxide Damage through the Nrf2/HO-1 PathwayQingyi Luo, Weiyan Hu, Hao-Fei Yu, Rongping Zhang, Xinglong Chen · 2022 · Evidence-based Complementary and Alternative Medicine
- Neuroprotection and NRF2 signaling cascade analysis of new synthetic cinnamic acid-Eugenol hybridsAbdolrahim Pourparizi, Fatemeh Pourrajab, Hamid Nadri, Alireza Moradi, Naser Rezaei, Maryam Moghadamnia · 2023 · Journal of Molecular Structure
- Nrf2 Activation, an Innovative Therapeutic Alternative in Cerebral IschemiaCarlos Alfredo Silva‐Islas, A. Ricardo, Ana L., Perla D. · 2012 · InTech eBooks
- Plant Phenolic Compounds: Modulation of Cytoprotective Enzymes and Nrf2/ARE SignalingSiwang Yu, Ka Lung Cheung, Wenge Li, Ah‐Ng Tony Kong · 2009 · Wiley eBooks
- Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challengesMengchen Lu, Ziyu Yang, Yabing Xin, Yuan Zhang, Shutong Jiang, Jingyu Zhu, Qidong You, Ziquan Zhao, Zhengyu Jiang · 2026 · Journal of Advanced Research
- Acute heat stress upregulates Akr1b3 through Nrf-2 to increase endogenous fructose leading to kidney injuryShuai Wang, Xuan Pang, Yujuan Cai, Xue Tian, Jingyi Bai, Mingchuan Xi, Jiaxue Cao, Long Jin, Xun Wang, Tao Wang et al. · 2024 · Journal of Biological Chemistry
- Nrf2 – Two Faces of Antioxidant System RegulationMichal Pastorek, Petr Müller, Bořivoj Vojtěšek · 2015 · Klinicka onkologie
- RNA-binding Motif Protein 45 (Rbm45)/Developmentally Regulated RNA-binding Protein-1 (Drbp1): Association with Neurodegenerative DisordersAndrew G. Eck, Kevin Lopez, Jeffrey Odell Henderson · 2018 · Journal of Student Research
- NRF2: A potential target for the treatment of diabetic nephropathyJiahui Zhang, Fnu Anshul, Joshua D. Breidenbach, Jing Liu, James Shaffner · 2021 · Diabetic Nephropathy
- Comparative analysis of sulfiredoxin and total oxidative stress levels in diabetic individuals with periodontitis: A case‐control studyFayiza TK, Ravi J Rao, Srirangarajan Sridharan, Srikumar Prabhu, Vinaya Rudresh, Deepika Oradiyath · 2022 · Journal of Periodontology