The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
An introduction to the molecular basics of aryl hydrocarbon receptor biology
Abstract
Depending on their chemical structure and properties, environmental chemicals and other xenobiotics that enter the cell can affect cellular function by either nonselective binding to cellular macromolecules or by interference with cellular receptors, which would initiate a more defined cell biological response. One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds. Numerous investigations have revealed that the AhR is not only a master regulator of drug metabolism activated by anthropogenic chemicals, but is also triggered by natural and endogenous ligands and can influence cell biological endpoints such as growth and differentiation. Cutting-edge research has identified new intriguing functions of the AhR, such as during proteasomal degradation of steroid hormone receptors, the cellular UVB stress response and the differentiation of certain T-cell subsets. In this review we provide both a survey of the fundamental basics of AhR biology and an insight into new functional aspects of AhR signaling to further stimulate research on this intriguing transcription factor at the interface between toxicology, cell biology and immunology.
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Cites
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Cited by
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.003 · Cited by 579
Molecular Mechanisms of Action of BPA
Acconcia, F., Pallottini, V., & Marino, M. (2015) · Dose-Response · doi:10.1177/1559325815610582 · Cited by 384
The Role of Astrocytes in Multiple Sclerosis
Ponath, G., Park, C., & Pitt, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00217 · Cited by 359
Recognizing the impact of ambient air pollution on skin health
Mancebo, S. E., & Wang, S. Q. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13250 · Cited by 190
Metadata
- Authors
- Abel, J., & Haarmann-Stemmann, T.
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2010-11-01
- Volume
- 391
- Issue
- 11
- Pages
- 1235-48
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- OpenAlex
- W2016629712
- Cited by
- 296
- References
- 139
- FWCI
- 18.29
- Type
- journal article
- Language
- en
- Open access
- closed
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