The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Molecular Mechanisms of Action of BPA
Open accessAbstract
Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, nonhuman primates, and cell culture test systems. The BPA concentration derived from these experiments were used by government regulatory agencies to determine the safe exposure levels of BPA in humans. However, accumulating literature in vivo and in vitro indicate that at concentrations lower than that reported in toxicological studies, BPA could elicit a different endocrine-disrupting capacity. To further complicate this picture, BPA effects rely on several and diverse mechanisms that converge upon endocrine and reproductive systems. If all or just few of these mechanisms concur to the endocrine-disrupting potential of low doses of BPA is at present still unclear. Thus, taking into account that the incidence and/or prevalence of health problems associated with endocrine disruption have increased worldwide, the goal of the present review is to give an overview of the many mechanisms of BPA action in order to decipher whether different mechanisms are at the root of the effect of low dose of BPA on endocrine system.
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Cited by
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., & Oriente, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165761 · Cited by 478
Bruno, K. A., Mathews, J. E., Yang, A. L., Frisancho, J. A., Scott, A. J., Greyner, H. D., Molina, F. A., Greenaway, M. S., Cooper, G. M., Bucek, A., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00598 · Cited by 73
A signature of Neanderthal introgression on molecular mechanisms of environmental responses
Findley, A. S., Zhang, X., Boye, C., Lin, Y. L., Kalita, C. A., Barreiro, L., Lohmueller, K. E., Pique-Regi, R., & Luca, F. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009493 · Cited by 14
Dias, G. R. M., Giusti, F. C. V., de Novais, C. O., de Oliveira, M. A. L., Paiva, A. G., Kalil-Cutti, B., Mahoney, M. M., & Graceli, J. B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1571689 · Cited by 14
Metadata
- Authors
- Acconcia, F., Pallottini, V., & Marino, M.
- Venue
- Dose-Response
- Publisher
- SAGE Publications
- Published
- 2015-10-01
- Volume
- 13
- Issue
- 4
- Pages
- 1559325815610582-1559325815610582
- ISSN
- 1559-3258 (ISSN-L)
- OpenAlex
- W2282954994
- Cited by
- 384
- References
- 93
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- gold
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