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Novel Opioid Peptides Derived from Casein (β-Casomorphins). I. Isolation from Bovine Casein Peptone
Abstract
A material which displayed opioid activity in the guinea pig ileum longitudinal muscle-myenteric plexus preparation was extracted from an enzymatic casein digest into chloroform/methanol. The extract was roughly purified by adsorption/desorption procedures using charcoal and Amberlite XAD-2 resin as adsorbents. A high degree of purity was achieved by high-pressure liquid chromatography of the material on muBondapak C18 and mu-Porasil columns and finally by gel filtration chromatography on a Bio-Gel P-2 column. Several pronase-resistant compounds with opioid activity were obtained.
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Citations
Cited by
Bioactive milk peptides: a prospectus.
Clare, D. A., & Swaisgood, H. E. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74983-6 · Cited by 718
Autism and gastrointestinal symptoms
Horvath, K., & Perman, J. A. (2002) · Current Gastroenterology Reports · doi:10.1007/s11894-002-0071-6 · Cited by 260
Opioid activities and structures of alpha-casein-derived exorphins.
Loukas, S., Varoucha, D., Zioudrou, C., Streaty, R. A., & Klee, W. A. (1983) · Biochemistry · doi:10.1021/bi00288a034 · Cited by 167
Fiat, A.-M., & Joll�s, P. (1989) · Molecular and Cellular Biochemistry · doi:10.1007/bf00421079 · Cited by 163
Biologically active casein peptides implicated in immunomodulation.
Migliore-Samour, D., Floc'h, F., & Jollès, P. (1989) · Journal of Dairy Research · doi:10.1017/s0022029900028806 · Cited by 163
Metadata
- Authors
- BRANTL, V., TESCHEMACHER, H., HENSCHEN, A., & LOTTSPEICH, F.
- Venue
- Hoppe-Seyler´s Zeitschrift für physiologische Chemie
- Publisher
- Walter de Gruyter GmbH
- Published
- 1979-01
- Volume
- 360
- Issue
- 2
- Pages
- 1211-1224
- ISSN
- 0018-4888 (ISSN-L)
- OpenAlex
- W2312818416
- Cited by
- 419
- References
- 0
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Novel Opioid Peptides Derived from Casein (β-Casomorphins). I. Isolation from Bovine Casein Peptone. https://app.cochat.ai/papers/10.1515/bchm2.1979.360.2.1211
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- BRANTL, V., TESCHEMACHER, H., HENSCHEN, A., & LOTTSPEICH, F. (1979). Novel Opioid Peptides Derived from Casein (β-Casomorphins). I. Isolation from Bovine Casein Peptone. Hoppe-Seyler´s Zeitschrift für physiologische Chemie. https://doi.org/10.1515/bchm2.1979.360.2.1211
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
