The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients
Abstract
Blood plasma samples from HIV-1-infected persons contain elevated glutamate concentrations up to 6-fold the normal level and relatively low concentrations of acid-soluble thiol (i.e. decreased cysteine concentrations). The intracellular glutathione concentration in peripheral blood-mononuclear cells (PBMC) and monocytes from HIV antibody-positive persons are also significantly decreased. Therapy with azidothymidine (AZT) causes a substantial recovery of the plasma thiol levels; but glutamate levels remain significantly elevated and intracellular glutathione levels remain low. Cell culture experiments with approximately physiological amino-acid concentrations revealed that variations of the extracellular cysteine concentration have a strong influence on the intracellular glutathione level and the rate of DNA synthesis [( 3H]thymidine incorporation) in T cell clones and human and murine lymphocyte preparations even in the presence of several-fold higher cystine and methionine concentrations. Cysteine cannot be replaced by a corresponding increase of the extracellular cystine or methionine concentration. These experiments suggest strongly that the low cysteine concentration in the plasma of HIV-infected persons may play a role in the pathogenetic mechanism of the acquired immunodeficiency syndrome.
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The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
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Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Self-citationDithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
Schreck, R., Meier, B., Männel, D. N., Dröge, W., & Baeuerle, P. A. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.5.1181 · Cited by 1,508
Self-citationFunctions of glutathione and glutathione disulfide in immunology and immunopathology
Dröge, W., Schulze‐Osthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H., Roth, S., & Gmünder, H. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.14.7958618 · Cited by 444
Self-citationN-Acetylcystei ne: Pharmacological Considerations and Experimental and Clinical Applications
Cotgreave, I. A. (1996) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60985-0 · Cited by 438
Glutathione Deficiency and Human Immunodeficiency Virus Infection
Staal, F. J. T., Ela, S. W., Roederer, M., Anderson, M. T., Herzenberg, L. A., & Herzenberg, L. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)90939-z · Cited by 404
Metadata
- Authors
- ECK, H.-P., GMÜNDER, H., HARTMANN, M., PETZOLDT, D., DANIEL, V., & DRÖGE, W.
- Venue
- Biological Chemistry Hoppe-Seyler
- Publisher
- Walter de Gruyter GmbH
- Published
- 1989-01
- Volume
- 370
- Issue
- 1
- Pages
- 101-108
- ISSN
- 0177-3593 (ISSN-L)
- OpenAlex
- W2010479937
- Cited by
- 339
- References
- 1
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients. https://app.cochat.ai/papers/10.1515/bchm3.1989.370.1.101
- The paper
- ECK, H.-P., GMÜNDER, H., HARTMANN, M., PETZOLDT, D., DANIEL, V., & DRÖGE, W. (1989). Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients. Biological Chemistry Hoppe-Seyler. https://doi.org/10.1515/bchm3.1989.370.1.101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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