The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review
Open accessAbstract
Background Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities in women. Due to the side effects of drugs, the tendency to use natural antioxidants and anti-inflammatory agents to regulate metabolism, hyperinsulinemia, and hyperlipidemia in PCOS patients has been increased. This review aimed to investigate the role of herbal substances on the treatment of PCOS. Methods The present review was carried out using keywords such as polycystic ovary syndrome and/or PCOS and/or herb. Databases including Web of Science, PubMed, and Science Direct were used to collect all related articles published from 1990 to 2019. We excluded studies unrelated to the PCOS and medical herbs. Results Overall, 361 records were identified through database searching. After primary screening and the full-texts assessment, 323 records were excluded, and 38 articles were finally included. The results indicate that some medicinal herbs may have a key role in treating PCOS. The compounds in these medical herbs can affect lipid profiles (Aloe vera, chamomile, and cinnamon), insulin resistance (cinnamon, chamomile, Aloe vera, and Camellia sinensis), blood glucose (Aloe vera, cinnamon, and Camellia sinensis), hormones (Aloe vera, silymarin, chamomile, fenugreek, Camellia sinensis, Heracleum persicum, Potentilla, Mentha spicata, Foeniculum vulgar, licorice, and Marrubium), and ovarian tissue (Aloe vera, chamomile, Camellia sinensis, Mentha spicata, and silymarin). Conclusion Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for PCOS. Further clinical trials are warranted to confirm their benefits and safety.
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In murine polycystic ovarian syndrome models, green tea and chamomile reduce the number of ovarian cysts observed in pelvic ultrasound.
“In murine PCOS models, green tea and chamomile were shown to reduce the number of ovarian cysts observed in pelvic ultrasound.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [80]
Mint and licorice counteract hirsutism, a common sign of polycystic ovarian syndrome due to hyperandrogenism.
“Mint and licorice counteract hirsutism, a common sign of PCOS due to hyperandrogenism.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [80]
Fennel lowers testosterone levels.
“Fennel lowers testosterone levels.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [80]
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References 69 · Cited by 68
Research works printed but not linked: 3
- Radha M, Padamnabhi N, Laxmipriya N. Evaluation of Aloe barbadensis mill. Gel on letrozole induced polycystic ovarian syndrome (pcos) rat model-a dose dependent study. Int J Pharm Sci Res. 2014;5(12):5293.
- Farideh ZZ, Bagher M, Ashraf A, Akram A, Kazem M. Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. J Reprod Infertil. 2010 Oct;11(3):169-74.
- Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to be Pregnant: A Randomized Clinical Trial. Biomolecules. 2019 Jun;9(6):215.
- Authors
- Ashkar, F., Rezaei, S., Salahshoornezhad, S., Vahid, F., Gholamalizadeh, M., Dahka, S. M., & Doaei, S.
- Affiliations
- Shiraz University (IR)
- Shiraz University of Medical Sciences (IR)
- Arak University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
- Guilan University of Medical Sciences (IR)
- Corresponding author
- Doaei, Saeid
- ORCID
- Venue
- BioMolecular Concepts
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 57-75
- ISSN
- 1868-5021 (ISSN-L)
- 1868-503X
- OpenAlex
- W3013355184
- Cited by
- 68
- References
- 69
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 14 · 2023: 15 · 2022: 13 · 2021: 10
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BioMolecular Concepts (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- polycystic ovary syndrome, insulin resistance, medicinal plants, herbal medicine, Aloe vera, cinnamon, green tea, Camellia sinensis, fenugreek, silymarin, chamomile, blood glucose, lipid profile, ovarian function, hyperinsulinemia, hyperlipidemia
- MeSH terms
- Aloe, Animals, Anti-Inflammatory Agents, Antioxidants, Cinnamomum zeylanicum, Female, Humans, Insulin Resistance, Plants, Medicinal, Polycystic Ovary Syndrome, Silymarin, Tea, Trigonella
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