Evaluation of a new generation of plastic evacuated blood-collection tubes in clinical chemistry, therapeutic drug monitoring, hormone and trace metal analysis
Abstract
Polyethylene terephthalate (PET) tubes have several advantages over glass tubes: they are unbreakable, lighter and more easily disposed of. Despite a steady increase in their use and an expansion of the range of available tubes, few studies validating their use have been published in the literature. This paper describes the various studies that have been performed to compare VENOJECT glass, VENOSAFE PET and VENOSAFE PET/heparin tubes for the assay of a panel of analytes in routine clinical chemistry, immunochemistry, hormone and tumor marker analysis and trace metal determination. These studies demonstrate that VENOSAFE PET tubes are a suitable alternative to glass tubes.
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Differences between serum and plasma are known for other biomarkers, due to release of intracellular substances caused by sample clotting.
“Differences between serum and plasma are known for other biomarkers, according to the release of intracellular substances caused by sample clotting (14).”
From A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies (2022) · cites this paper as [14]
Cites
Rodushkin, I., & Ödman, F. (2001) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/s0946-672x(01)80025-0 · Cited by 48 · see citing works
Hill, B. M., Laessig, R. H., Koch, D. D., & Hassemer, D. J. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.8.1474 · Cited by 35 · see citing works
Morita, H., Kita, T., Umeno, M., Morita, M., Yoshinaga, J., & OKAMOTO, K. (1994) · The Science of The Total Environment · doi:10.1016/0048-9697(94)90481-2 · Cited by 23 · see citing works
A new plastic evacuated tube with plasma separator
Landt, M., Wilhite, T. R., & Smith, C. H. (1995) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860090205 · Cited by 20 · see citing works
Evaluation of polyethylene terephthalate for ABO and Rh typing and alloantibody screening
Anderson, D. R., Wiseman, J., MacLeod, J., Burton, E., & Zayed, E. (2000) · Transfusion · doi:10.1046/j.1537-2995.2000.40060669.x · Cited by 6 · see citing works
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Interferences from blood collection tube components on clinical chemistry assays
Bowen, R. A. R., & Remaley, A. T. (2014) · Biochemia Medica · doi:10.11613/bm.2014.006 · Cited by 321 · see citing works
Impact of blood collection devices on clinical chemistry assays
Bowen, R. A. R., Hortin, G. L., Csákó, G., Otañez, O. H., & Remaley, A. T. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.10.001 · Cited by 241 · see citing works
Sejbaek, T., Nielsen, H. H., Penner, N., Plavina, T., Mendoza, J. P., Martin, N. A., Elkjaer, M. L., Ravnborg, M. H., & Illes, Z. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321321 · Cited by 108 · see citing works
Effect of Blood Collection Tubes on Total Triiodothyronine and Other Laboratory Assays
Bowen, R. A. R., Chan, Y., Cohen, J., Rehak, N. N., Hortin, G. L., Csákó, G., & Remaley, A. T. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.043349 · Cited by 79 · see citing works
Environmental applications of single collector high resolution ICP-MS
Krachler, M. (2007) · Journal of Environmental Monitoring · doi:10.1039/b703823m · Cited by 50 · see citing works
Rübsamen, N., Willemse, E. A. J., Leppert, D., Wiendl, H., Nauck, M., Karch, A., Kuhle, J., & Berger, K. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.894119 · Cited by 27 · see citing works
“Differences between serum and plasma are known for other biomarkers, according to the release of intracellular substances caused by sample clotting (14).”
BackgroundJones, A. W., & Ericsson, E. (2016) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2016.02.002 · Cited by 27 · see citing works
Kulkarni, P. D., KARANAM, A. B., Gurjar, M., Dhoble, S., Naik, A. B., Vidhun, B. H., & Gota, V. (2016) · SpringerPlus · doi:10.1186/s40064-016-3770-4 · Cited by 27 · see citing works
Sex steroid hormone stability in serum tubes with and without separator gels
Hepburn, S., Wright, M., Boyder, C., Sahertian, R. C., Lu, B., Zhang, R., White, C., & Horvath, A. R. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-1133 · Cited by 25 · see citing works
Bowen, R. A. R., Vu, C., Remaley, A. T., Hortin, G. L., & Csákó, G. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.11.020 · Cited by 23 · see citing works
State of the art in therapeutic drug monitoring
Fernández, E. L., Llorach-Parés, L., Ajuria-Morentin, I., Bandrés, F., Castanyer, B., Campos, F., Farré, C., Pou, L., Queraltó, J. M., & To‐Figueras, J. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2010.111 · Cited by 22 · see citing works
Therapeutic Drug Monitoring in Clinical Research
Neef, C., Touw, D. J., & Stolk, L. M. (2008) · Pharmaceutical Medicine · doi:10.1007/bf03256708 · Cited by 21 · see citing works
Different collection tubes in cardiac biomarkers detection
Daves, M., Trevisan, D., & Cemin, R. (2008) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20277 · Cited by 20 · see citing works
Xie, K., Yu, S., Wang, P., & Chen, P. (2021) · International Journal of Polymer Science · doi:10.1155/2021/6694105 · Cited by 19 · see citing works
Quality, origins and limitations of common therapeutic drug reference intervals
McCudden, C. R. (2018) · Diagnosis · doi:10.1515/dx-2018-0001 · Cited by 18 · see citing works
Assay Interferences from Blood Collection Tubes: A Cautionary Note
Stanković, A. K., & Parmar, G. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.069997 · Cited by 18 · see citing works
Hashmi, G. M. M., & Shah, M. H. (2011) · Biological Trace Element Research · doi:10.1007/s12011-011-9220-9 · Cited by 16 · see citing works
Kumar, P., Agrawal, P., & Chatterjee, K. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.07.020 · Cited by 15 · see citing works
Scherf‐Clavel, M., Baumann, P., Hart, X. M., Schneider, H., Schoretsanitis, G., Steimer, W., Zernig, G., & Zurek, G. (2023) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000001092 · Cited by 14 · see citing works
Yan, R., Colantonio, D., Wong, P.-Y., & Chen, Y. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202466 · Cited by 14 · see citing works
Comparative Evaluation of Trace Metals in the Blood of Hepatitis C Patients and Healthy Donors
Saghir, M., Shaheen, N., & Shah, M. H. (2011) · Biological Trace Element Research · doi:10.1007/s12011-010-8930-8 · Cited by 14 · see citing works
Effects of Blood Collection Tubes, including Pediatric Devices, on 16 Common Immunoassays
Wang, S., Ho, V., Roquemore-Goins, A., & Smith, F. A. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.068361 · Cited by 13 · see citing works
Influence of collection and storage materials on glycol ether concentrations in urine and blood
Borgatta, M., Hechon, J., Wild, P. P., & Hopf, N. B. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148196 · Cited by 10 · see citing works
A comparative study on the effect of blood collection tubes on stress oxidative markers
Bastin, A., Fooladi, S., Doustimotlagh, A. H., Vakili, S., Aminizadeh, A. H., Faramarz, S., Shiri, H., & Nematollahi, M. H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266567 · Cited by 10 · see citing works
Tolan, N. V., Sierra, R. J., & Moyer, T. P. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.10.012 · Cited by 8 · see citing works
Oh, S.-H., & Ki, C. (2007) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2007.27.1.69 · Cited by 8 · see citing works
Trace elements: functions and assessment of status through laboratory testing
DELVIN, E. E., & Levy, E. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815499-1.00047-8 · Cited by 6 · see citing works
Effects of Pre-analytical Variables in Therapeutic Drug Monitoring
Bush, V. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385467-4.00002-6 · Cited by 3 · see citing works
Choe, K., Gajek, R., Waldman, J. M., & She, J. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.126946 · Cited by 3 · see citing works
Farklı Kan Toplama Tüplerinde Digoksin Seviyeleri ve Stabilitesi
Arslan, F. D., Karakoyun, İ., Başok, B. İ., Solmaz, H., Akşit, M. Z., Baysoy, A., & Duman, C. (2020) · Journal of Academic Research in Medicine · doi:10.4274/jarem.galenos.2019.2597 · Cited by 1 · see citing works
Dukić, L., Šimundić, A.-M., & Malogorski, D. (2014) · Biochemia Medica · doi:10.11613/bm.2014.016 · Cited by 1 · see citing works
Chang, J.-B., Huang, C.-H., Chiu, J.-S., Chuang, M., Tien, H.-L., & Wang, Y. (2007) · doi:10.6332/anms.2004.004
An Analysis of Zinc-Toxicological Profiling from Forensic Biological Evidence-Urine
(2019) · Journal of Forensic Sciences and Digital Investigation · doi:10.29199/2637-7136/fsdi-201023
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Almalki, S., Al-Ahmadi, B., Alhothali, S., & Almasoudi, A. (2023) · International Journal of Research Publication and Reviews · doi:10.55248/gengpi.4.823.51086
Lee, H.-W., & Park, H. (2026) · Annals of Laboratory Medicine · doi:10.3343/alm.2025.0409
- Authors
- Boeynaems, J.-M., Leener, A. D., Dessars, B., Villa-Lobos, H. R., Aubry, J.-C., Cotton, F., & Thiry, P.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Publisher
- Walter de Gruyter GmbH
- Published
- 2004-01-16
- Volume
- 42
- Issue
- 1
- Pages
- 67-71
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W1993391036
- Cited by
- 36
- References
- 5
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2014: 4 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Various Chemistry Research Topics
- Keywords
- clinical chemistry analytes, therapeutic drug monitoring, hormone analysis, trace metal analysis, immunochemistry
- MeSH terms
- Blood Specimen Collection, Glass, Heparin, Hormones, Humans, Metals, Polyethylene Terephthalates, Water, Drug Monitoring, Clinical Chemistry Tests
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