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Helminth therapy: Advances in the use of parasitic worms against Inflammatory Bowel Diseases and its challenges

Maruszewska-Cheruiyot, M., Donskow-Łysoniewska, K., Doligalska, M.·2018·Helminthologia
DOI 10.1515/helm-2017-0048PMC PMC6799527
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Abstract

Summary: Development of modern medicine and better living conditions in the 20th century helped in reducing a number of cases of infectious diseases. During the same time, expansion of autoimmunological disorders was noticed. Among other are Inflammatory Bowel Diseases (IBD) including ulcerative colitis and Crohn’s disease which are chronic and relapsing inflammation of the gastrointestinal tract. Absence of effective treatment in standard therapies effects the search for alternative opportunities. As per hygienic hypothesis increasing number of cases of autoimmune diseases is as a result of reduced exposure to pathogens, especially parasites. Thus, one of the promising remedial acts against IBD and other allergic and autoimmune disorders is “helminth therapy”. Cure with helminths seems to be the most effective therapy of IBD currently proposed. Helminth therapy focuses on advantageous results that have been obtained from the clinical trials, but its mechanisms are still unclear. Explanation of this phenomenon would help to develop new drugs against IBD based on helminth immunomodulatory molecules.

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Metadata

Authors
Maruszewska-Cheruiyot, M., Donskow-Łysoniewska, K., & Doligalska, M.
Venue
Helminthologia
Publisher
Walter de Gruyter GmbH
Published
2018-01-27
Volume
55
Issue
1
Pages
1-11
ISSN
  • 1336-9083
  • 0440-6605
DOI
10.1515/helm-2017-0048
PMC
PMC6799527
Cited by
38
References
1
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/3.0 (unspecified)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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