Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane
Abstract
Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs’ structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.
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VDAC is a 32-kDa beta barrel protein.
“VDAC is a 32-kDa beta barrel protein and has been implicated in numerous cellular processes, ranging from cellular energetics to apoptosis (96).”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [96]
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- Authors
- Mertins, B., Psakis, G., & Essen, L.-O.
- Affiliations
- Philipps University of Marburg (DE)
- University of Huddersfield (GB)
- Corresponding author
- Essen, Lars-Oliver
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2014-12-01
- Volume
- 395
- Issue
- 12
- Pages
- 1435-1442
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- OpenAlex
- W2332959585
- Cited by
- 43
- References
- 28
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 10 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Huddersfield Research Portal (University of Huddersfield) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft ((Grant/Award Number: ‘ES 152/8-1’))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- voltage-dependent anion channel, mitochondrial outer membrane, metabolite exchange, apoptosis
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Ions, Models, Molecular, Molecular Sequence Data, Protein Conformation, Signal Transduction, Apoptosis, Mitochondrial Membrane Transport Proteins, Voltage-Dependent Anion Channels, Mitochondrial Membranes, Protein Interaction Maps
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