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Cited by 14Pregnancy and preeclampsia studiesNeonatal and fetal brain pathologyNeonatal Respiratory Health Research

Cardiac output and blood flow volume redistribution during acute maternal hypoxia in fetal sheep

Tchirikov, Michael, Strohner, Miriam, Scholz, Alexander·2010·Journal of Perinatal Medicine
DOI 10.1515/jpm.2010.053
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Abstract

OBJECTIVE: Acute hypoxia is one of the main causes of poor neonatal outcome. The aim of this study was the investigation of cardiac output (CO) and blood flow redistribution following induction of acute hypoxia in a fetal sheep model. METHOD: We investigated 10 fetal sheep between 108 and 130 days of gestation. Acute hypoxia was induced by reducing the O(2) saturation in the ventilated gas mixture of the maternal sheep to approximately 75%. The CO, placental fraction of CO, Doppler parameters in the ductus venosus (DV), umbilical artery (UA) and vein (UV) were measured. RESULTS: The fetal pO(2) decreased from 47.1 (7.19; 7.35) to 6.89 (6.78; 7.11) mm Hg [P=0.01, median, (95% CI)] during hypoxia. Fetal pH and BE were also significantly reduced. The DV/UV fraction increased from 15.3 (11.5; 19.8) to 51.1 (35.9; 62.1) (P=0.0001). The combined cardiac output [1228.1 (1024.3; 1686.4) vs. 987.8 (834, 1261) mL min(-1)], the placental fraction of the CO [31.5 (26; 42.1) vs. 26.9 (20.6; 29.3)%] and the right to left (R/L) heart ratio [1.76 (1.5; 2.2) vs. 1.3 (1.1; 1.6)] significantly decreased during hypoxia. CONCLUSIONS: Acute hypoxia significantly increases the proportion of the placental blood passing through the DV and reduces the placental fraction of CO and the R/L heart ratio. These findings could be used as early signs of acute fetal hypoxia.

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  • Short-term hypoxic challenge induces changes in umbilical blood flow, with increases or decreases in flow immediately after the onset of maternal hypoxia depending on its severity.

    “This short-term type of hypoxic challenge also induces changes in umbilical blood flow, with increases or decreases in flow immediately after the onset of maternal hypoxia depending on its severity (380, 524).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [524]

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Authors
Tchirikov, M., Strohner, M., & Scholz, A.
Affiliations
University Medical Center of the Johannes Gutenberg University Mainz (DE)
ORCID
Tchirikov, Michael
Venue
Journal of Perinatal Medicine
Publisher
Walter de Gruyter GmbH
Published
2010-01-01
Volume
38
Issue
4
Pages
387-92
ISSN
  • 0300-5577 (ISSN-L)
  • 1619-3997
DOI
10.1515/jpm.2010.053
OpenAlex
W2014981125
Cited by
14
References
28
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 3 · 2015: 1 · 2012: 2
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Perinatal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
fetal hypoxia, cardiac output, blood flow redistribution, placental blood flow, ductus venosus, umbilical artery, umbilical vein, fetal sheep, fetal oxygenation, fetal acidosis, neonatal outcomes
MeSH terms
Acute Disease, Animals, Hypoxia, Blood Flow Velocity, Blood Volume, Cardiac Output, Disease Models, Animal, Female, Fetal Hypoxia, Fetus, Hemodynamics, Placenta, Pregnancy, Pregnancy Complications, Cardiovascular, Sheep, Ultrasonography

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