The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment
Abstract
Cancer treatment by conventional chemotherapy is hindered by toxic side effects and the frequent development of multi-drug resistance by cancer cells. Cationic antimicrobial peptides (CAPs) are a promising new class of natural-source drugs that may avoid the shortcomings of conventional chemotherapy because certain CAPs exhibit selective cytotoxicity against a broad spectrum of human cancer cells, including neoplastic cells that have acquired a multi-drug-resistant phenotype. Tumour cell killing by CAPs is usually by a cell membrane-lytic effect, although some CAPs can trigger apoptosis in cancer cells via mitochondrial membrane disruption. Furthermore, certain CAPs are potent inhibitors of blood vessel development (angiogenesis) that is associated with tumour progression. This article reviews the mechanisms by which CAPs exert anticancer activity and discusses the potential application of selected CAPs as therapeutic agents for the treatment of human cancers.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
Cathelicidins, multifunctional peptides of the innate immunity
Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988
The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
Kwok, J. C., & Richardson, D. R. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00213-x · Cited by 215 · cited 1×
“Although mastoparan kills both transformed and untransformed cells by the potent induction of mitochondrial permeability transition [108], targeted delivery of mastoparan or other CAPs that are toxic to healthy cells via transferrin-modified fusogenic liposomes is expected to minimise nonspecific toxicity by specifica…”
BackgroundRoy, M. K., Kuwabara, Y., Hara, K., Watanabe, Y., & Tamai, Y. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74284-7 · Cited by 74
Cited by
Studies on anticancer activities of antimicrobial peptides
Hoskin, D. W., & Ramamoorthy, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.11.008 · Cited by 1,296
Self-citationToward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Kenny, R. G., & Marmion, C. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00271 · Cited by 636
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
Hilchie, A. L., Wuerth, K., & Hancock, R. E. W. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1393 · Cited by 601
Mookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 462
Antimicrobial Peptides: Primeval Molecules or Future Drugs?
Peters, B. M., Shirtliff, M. E., & Jabra-Rizk, M. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001067 · Cited by 425
Metadata
- Authors
- Mader, J. S., & Hoskin, D. W.
- Venue
- Expert Opinion on Investigational Drugs
- Publisher
- Informa UK Limited
- Published
- 2006-07-21
- Volume
- 15
- Issue
- 8
- Pages
- 933-946
- ISSN
- 1354-3784 (ISSN-L)
- 1744-7658
- OpenAlex
- W2103567156
- Cited by
- 430
- References
- 5
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
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